{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:16:52Z","timestamp":1780327012417,"version":"3.54.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Auton Res"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Baroreflex activation therapy (BAT) has been shown to lower blood pressure in patients with resistant hypertension. The purpose of this study was to analyze whether this translates into a reduction of more relevant clinical endpoints.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients with resistant hypertension were treated with the second-generation BAT system. Records on hospitalization (dates of admission and discharge, main diagnosis) were obtained from medical insurance companies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Records on hospitalization were available for a period of 1 year before BAT in two patients and 2 years in 22 patients. The total number of hospitalizations per patient was 3.3\u2009\u00b1\u20093.5\/year before BAT and 2.2\u2009\u00b1\u20092.7\/year after BAT (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). Hospitalizations related to hypertension were significantly decreased from 1.5\u2009\u00b1\u20091.6\/year before BAT to 0.5\u2009\u00b1\u20090.9\/year after BAT (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The cumulative duration of hypertension-related hospital stays was significantly reduced from 8.0\u2009\u00b1\u20098.7\u00a0days\/year before BAT to 1.8\u2009\u00b1\u20094.8\u00a0days\/year after BAT (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Office cuff blood pressure was 183\u2009\u00b1\u200927\u00a0mmHg over 102\u2009\u00b1\u200917\u00a0mmHg under 6.6\u2009\u00b1\u20092.0 antihypertensive drugs before BAT and 157\u2009\u00b1\u200932\u00a0mmHg over 91\u2009\u00b1\u200920\u00a0mmHg (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) under 5.9\u2009\u00b1\u20091.9 antihypertensive drugs (<jats:italic>p<\/jats:italic>\u2009=\u20090.09 for number of drugs) at latest follow-up. Daytime ambulatory blood pressure was 164\u2009\u00b1\u200921\u00a0mmHg over 91\u2009\u00b1\u200914\u00a0mmHg before BAT and 153\u2009\u00b1\u200921\u00a0mmHg (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) over 89\u2009\u00b1\u200915\u00a0mmHg (<jats:italic>p<\/jats:italic>\u2009=\u20090.56) at latest follow-up. Heart rate was 75\u2009\u00b1\u200916\u00a0bpm before BAT and 72\u2009\u00b1\u200912\u00a0bpm at latest follow-up (<jats:italic>p<\/jats:italic>\u2009=\u20090.35).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Rate and duration of hypertension-related hospitalizations in patients with severe resistant hypertension were lowered after BAT. Whether the response is mediated through improvements in blood pressure control requires further studies.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10286-020-00670-9","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T14:02:46Z","timestamp":1581516166000},"page":"541-548","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Baroreflex activation therapy reduces frequency and duration of hypertension-related hospitalizations in patients with resistant hypertension"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6361-5825","authenticated-orcid":false,"given":"Marcel","family":"Halbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grothaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Madershahian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Kuhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Reuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"issue":"9349","key":"670_CR1","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","volume":"360","author":"S Lewington","year":"2002","unstructured":"Lewington S et al (2002) Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. 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N.M. is a paid consultant of CVRx Inc. We received no specific grants for the present work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures adhered to the principles of the Declaration of Helsinki and Title 45, U.S. Code of Federal Regulations, Part 46, Protection of Human Subjects, revised November 13, 2001, effective December 13, 2001. The study protocol was approved by an institutional review committee, and patients gave written informed consent for collection and analysis of all data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}