{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:43:47Z","timestamp":1769762627553,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Auton Res"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s10286-020-00672-7","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T13:03:34Z","timestamp":1582203814000},"page":"223-230","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Longitudinal change in autonomic symptoms predicts activities of daily living and depression in Parkinson\u2019s disease"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6031-4763","authenticated-orcid":false,"given":"Miriam","family":"Sklerov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hao","family":"Shih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Browner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose-Alberto","family":"Palma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Styner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eran","family":"Dayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,20]]},"reference":[{"key":"672_CR1","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","volume":"79","author":"J Jankovic","year":"2008","unstructured":"Jankovic J (2008) Parkinson\u2019s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79:368\u2013376. https:\/\/doi.org\/10.1136\/jnnp.2007.131045","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"672_CR2","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1001\/archneur.1997.00550150024011","volume":"54","author":"ED Louis","year":"1997","unstructured":"Louis ED, Marder K, Cote L, Tang M, Mayeux R (1997) Mortality from Parkinson disease. Arch Neurol 54:260\u2013264","journal-title":"Arch Neurol"},{"key":"672_CR3","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1001\/archneur.56.3.334","volume":"56","author":"ED Louis","year":"1999","unstructured":"Louis ED, Tang MX, Cote L, Alfaro B, Mejia H, Marder K (1999) Progression of parkinsonian signs in Parkinson disease. Arch Neurol 56:334\u2013337","journal-title":"Arch Neurol"},{"key":"672_CR4","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1212\/01.wnl.0000183359.50822.f2","volume":"65","author":"G Alves","year":"2005","unstructured":"Alves G, Wentzel-Larsen T, Aarsland D, Larsen JP (2005) Progression of motor impairment and disability in Parkinson disease: a population-based study. Neurology 65:1436\u20131441. https:\/\/doi.org\/10.1212\/01.wnl.0000183359.50822.f2","journal-title":"Neurology"},{"key":"672_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.parkreldis.2010.08.012","volume":"17","author":"S-E Soh","year":"2011","unstructured":"Soh S-E, Morris ME, McGinley JL (2011) Determinants of health-related quality of life in Parkinson\u2019s disease: a systematic review. Parkinsonism Relat Disord 17:1\u20139. https:\/\/doi.org\/10.1016\/j.parkreldis.2010.08.012","journal-title":"Parkinsonism Relat Disord"},{"key":"672_CR6","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1001\/jamaneurol.2017.1125","volume":"74","author":"E De Pablo-Fernandez","year":"2017","unstructured":"De Pablo-Fernandez E, Tur C, Revesz T, Lees AJ, Holton JL, Warner TT (2017) Association of autonomic dysfunction with disease progression and survival in Parkinson disease. JAMA Neurol 74:970\u2013976. https:\/\/doi.org\/10.1001\/jamaneurol.2017.1125","journal-title":"JAMA Neurol"},{"key":"672_CR7","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1002\/mds.22834","volume":"24","author":"WK Gray","year":"2009","unstructured":"Gray WK, Wood BH, Walker RW (2009) Do autonomic function tests in people with Parkinson\u2019s disease predict survival rates at 7 years follow-up? Mov Disord Off J Mov Disord Soc 24:2432\u20132434. https:\/\/doi.org\/10.1002\/mds.22834","journal-title":"Mov Disord Off J Mov Disord Soc"},{"key":"672_CR8","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1002\/acn3.317","volume":"3","author":"T Simuni","year":"2016","unstructured":"Simuni T, Long JD, Caspell-Garcia C, Coffey CS, Lasch S, Tanner CM, Jennings D, Kieburtz KD, Marek K, Investigators PPMI (2016) Predictors of time to initiation of symptomatic therapy in early Parkinson\u2019s disease. Ann Clin Transl Neurol 3:482\u2013494. https:\/\/doi.org\/10.1002\/acn3.317","journal-title":"Ann Clin Transl Neurol"},{"key":"672_CR9","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1111\/j.1524-4733.2008.00430.x","volume":"12","author":"M Visser","year":"2009","unstructured":"Visser M, Verbaan D, van Rooden S, Marinus J, van Hilten J, Stiggelbout A (2009) A longitudinal evaluation of health-related quality of life of patients with Parkinson\u2019s disease, value health. J Int Soc Pharmacoecon Outcomes Res 12:392\u2013396. https:\/\/doi.org\/10.1111\/j.1524-4733.2008.00430.x","journal-title":"J Int Soc Pharmacoecon Outcomes Res"},{"key":"672_CR10","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/mds.27268","volume":"33","author":"A Merola","year":"2018","unstructured":"Merola A, Romagnolo A, Rosso M, Suri R, Berndt Z, Maule S, Lopiano L, Espay AJ (2018) Autonomic dysfunction in Parkinson\u2019s disease: a prospective cohort study. Mov Disord Off J Mov Disord Soc 33:391\u2013397. https:\/\/doi.org\/10.1002\/mds.27268","journal-title":"Mov Disord Off J Mov Disord Soc"},{"issue":"2008","key":"672_CR11","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1002\/mds.21853","volume":"23","author":"C Marras","year":"2008","unstructured":"Marras C, McDermott MP, Rochon PA, Tanner CM, Naglie G, Lang AE (2008) Predictors of deterioration in health-related quality of life in Parkinson\u2019s disease: results from the DATATOP trial. Mov Disord Off J Mov Disord Soc 23(2008):653\u2013659. https:\/\/doi.org\/10.1002\/mds.21853","journal-title":"Mov Disord Off J Mov Disord Soc"},{"key":"672_CR12","doi-asserted-by":"publisher","first-page":"e102294","DOI":"10.1371\/journal.pone.0102294","volume":"9","author":"BJ Lawrence","year":"2014","unstructured":"Lawrence BJ, Gasson N, Kane R, Bucks RS, Loftus AM (2014) Activities of daily living, depression, and quality of life in Parkinson\u2019s disease. PLoS ONE 9:e102294. https:\/\/doi.org\/10.1371\/journal.pone.0102294","journal-title":"PLoS ONE"},{"key":"672_CR13","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1212\/01.wnl.0000268695.63392.10","volume":"69","author":"B Ravina","year":"2007","unstructured":"Ravina B, Camicioli R, Como PG, Marsh L, Jankovic J, Weintraub D, Elm J (2007) The impact of depressive symptoms in early Parkinson disease. Neurology 69:342\u2013347. https:\/\/doi.org\/10.1212\/01.wnl.0000268695.63392.10","journal-title":"Neurology"},{"key":"672_CR14","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.pneurobio.2011.09.005","volume":"95","author":"PPM Initiative","year":"2011","unstructured":"Initiative PPM (2011) The Parkinson progression marker initiative (PPMI). Prog Neurobiol 95:629\u2013635. https:\/\/doi.org\/10.1016\/j.pneurobio.2011.09.005","journal-title":"Prog Neurobiol"},{"key":"672_CR15","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1002\/mds.20153","volume":"19","author":"M Visser","year":"2004","unstructured":"Visser M, Marinus J, Stiggelbout AM, Van Hilten JJ (2004) Assessment of autonomic dysfunction in Parkinson\u2019s disease: the SCOPA-AUT. Mov Disord Off J Mov Disord Soc 19:1306\u20131312. https:\/\/doi.org\/10.1002\/mds.20153","journal-title":"Mov Disord Off J Mov Disord Soc"},{"key":"672_CR16","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1002\/mds.22340","volume":"23","author":"CG Goetz","year":"2008","unstructured":"Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, Poewe W, Sampaio C, Stern MB, Dodel R, Dubois B, Holloway R, Jankovic J, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Schrag A, Teresi JA, van Hilten JJ, LaPelle N (2008) Movement Disorder Society UPDRS Revision Task Force, Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord Off J Mov Disord Soc 23:2129\u20132170. https:\/\/doi.org\/10.1002\/mds.22340","journal-title":"Mov Disord Off J Mov Disord Soc"},{"key":"672_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","volume":"17","author":"JA Yesavage","year":"1982","unstructured":"Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO (1982) Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 17:37\u201349","journal-title":"J Psychiatr Res"},{"key":"672_CR18","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","volume":"53","author":"ZS Nasreddine","year":"2005","unstructured":"Nasreddine ZS, Phillips NA, B\u00e9dirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H (2005) The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53:695\u2013699. https:\/\/doi.org\/10.1111\/j.1532-5415.2005.53221.x","journal-title":"J Am Geriatr Soc"},{"key":"672_CR19","volume-title":"Introduction to mediation, moderation, and conditional process analysis: a regression-based approach","author":"AF Hayes","year":"2017","unstructured":"Hayes AF (2017) Introduction to mediation, moderation, and conditional process analysis: a regression-based approach. Guilford Publications, New York"},{"key":"672_CR20","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.parkreldis.2019.07.008","volume":"66","author":"I Stankovi\u0107","year":"2019","unstructured":"Stankovi\u0107 I, Petrovi\u0107 I, Pekmezovi\u0107 T, Markovi\u0107 V, Stojkovi\u0107 T, Draga\u0161evi\u0107-Mi\u0161kovi\u0107 N, Svetel M, Kosti\u0107 V (2019) Longitudinal assessment of autonomic dysfunction in early Parkinson\u2019s disease. Parkinsonism Relat Disord 66:74\u201379. https:\/\/doi.org\/10.1016\/j.parkreldis.2019.07.008","journal-title":"Parkinsonism Relat Disord"},{"key":"672_CR21","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.parkreldis.2014.03.020","volume":"20","author":"A Sagna","year":"2014","unstructured":"Sagna A, Gallo JJ, Pontone GM (2014) Systematic review of factors associated with depression and anxiety disorders among older adults with Parkinson\u2019s disease. Parkinsonism Relat Disord 20:708\u2013715. https:\/\/doi.org\/10.1016\/j.parkreldis.2014.03.020","journal-title":"Parkinsonism Relat Disord"},{"key":"672_CR22","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1093\/brain\/awh445","volume":"128","author":"P Remy","year":"2005","unstructured":"Remy P, Doder M, Lees A, Turjanski N, Brooks D (2005) Depression in Parkinson\u2019s disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain J Neurol 128:1314\u20131322. https:\/\/doi.org\/10.1093\/brain\/awh445","journal-title":"Brain J Neurol"},{"key":"672_CR23","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1212\/01.wnl.0000336340.89821.b3","volume":"72","author":"M Menza","year":"2009","unstructured":"Menza M, Dobkin RD, Marin H, Mark MH, Gara M, Buyske S, Bienfait K, Dicke A (2009) A controlled trial of antidepressants in patients with Parkinson disease and depression. Neurology 72:886\u2013892. https:\/\/doi.org\/10.1212\/01.wnl.0000336340.89821.b3","journal-title":"Neurology"},{"key":"672_CR24","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jns.2011.06.047","volume":"310","author":"Y Sharabi","year":"2011","unstructured":"Sharabi Y, Goldstein DS (2011) Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease. J Neurol Sci 310:123\u2013128. https:\/\/doi.org\/10.1016\/j.jns.2011.06.047","journal-title":"J Neurol Sci"},{"key":"672_CR25","doi-asserted-by":"publisher","first-page":"e2051","DOI":"10.1212\/WNL.0000000000005641","volume":"90","author":"E Dayan","year":"2018","unstructured":"Dayan E, Sklerov M, Browner N (2018) Disrupted hypothalamic functional connectivity in patients with PD and autonomic dysfunction. Neurology 90:e2051\u2013e2058. https:\/\/doi.org\/10.1212\/WNL.0000000000005641","journal-title":"Neurology"},{"key":"672_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-018-0577-0","author":"M Sklerov","year":"2018","unstructured":"Sklerov M, Dayan E, Browner N (2018) Functional neuroimaging of the central autonomic network: recent developments and clinical implications. Clin Auton Res Off J Clin Auton Res Soc. https:\/\/doi.org\/10.1007\/s10286-018-0577-0","journal-title":"Clin Auton Res Off J Clin Auton Res Soc"},{"key":"672_CR27","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.biopsych.2011.01.029","volume":"70","author":"L Gerritsen","year":"2011","unstructured":"Gerritsen L, Comijs HC, van der Graaf Y, Knoops AJG, Penninx BWJH, Geerlings MI (2011) Depression, hypothalamic pituitary adrenal axis, and hippocampal and entorhinal cortex volumes\u2013the SMART Medea study. Biol Psychiatry 70:373\u2013380. https:\/\/doi.org\/10.1016\/j.biopsych.2011.01.029","journal-title":"Biol Psychiatry"},{"key":"672_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jad.2008.11.021","volume":"117","author":"V Lorenzetti","year":"2009","unstructured":"Lorenzetti V, Allen NB, Fornito A, Y\u00fccel M (2009) Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies. J Affect Disord 117:1\u201317. https:\/\/doi.org\/10.1016\/j.jad.2008.11.021","journal-title":"J Affect Disord"},{"key":"672_CR29","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1093\/brain\/awx348","volume":"141","author":"M Sommerauer","year":"2018","unstructured":"Sommerauer M, Fedorova TD, Hansen AK, Knudsen K, Otto M, Jeppesen J, Frederiksen Y, Blicher JU, Geday J, Nahimi A, Damholdt MF, Brooks DJ, Borghammer P (2018) Evaluation of the noradrenergic system in Parkinson\u2019s disease: an 11C-MeNER PET and neuromelanin MRI study. Brain J Neurol 141:496\u2013504. https:\/\/doi.org\/10.1093\/brain\/awx348","journal-title":"Brain J Neurol"},{"key":"672_CR30","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1136\/jnnp-2019-320846","volume":"90","author":"A Pilotto","year":"2019","unstructured":"Pilotto A, Romagnolo A, Tuazon JA, Vizcarra JA, Marsili L, Zibetti M, Rosso M, Rodriguez-Porcel F, Borroni B, Rizzetti MC, Rossi C, Vizcarra-Escobar D, Molano JR, Lopiano L, Ceravolo R, Masellis M, Espay AJ, Padovani A, Merola A (2019) Orthostatic hypotension and REM sleep behaviour disorder: impact on clinical outcomes in \u03b1-synucleinopathies. J Neurol Neurosurg Psychiatry 90:1257\u20131263. https:\/\/doi.org\/10.1136\/jnnp-2019-320846","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"672_CR31","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.archger.2010.02.005","volume":"52","author":"ES Oh","year":"2011","unstructured":"Oh ES, Lee JH, Seo JG, Sohn EH, Lee AY (2011) Autonomic and cognitive functions in Parkinson\u2019s disease (PD). Arch Gerontol Geriatr 52:84\u201388. https:\/\/doi.org\/10.1016\/j.archger.2010.02.005","journal-title":"Arch Gerontol Geriatr"},{"key":"672_CR32","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s10286-005-0253-z","volume":"15","author":"C Magerkurth","year":"2005","unstructured":"Magerkurth C, Schnitzer R, Braune S (2005) Symptoms of autonomic failure in Parkinson\u2019s disease: prevalence and impact on daily life. Clin Auton Res Off J Clin Auton Res Soc 15:76\u201382. https:\/\/doi.org\/10.1007\/s10286-005-0253-z","journal-title":"Clin Auton Res Off J Clin Auton Res Soc"},{"key":"672_CR33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.parkreldis.2016.09.013","volume":"33","author":"A Merola","year":"2016","unstructured":"Merola A, Romagnolo A, Rosso M, Lopez-Castellanos JR, Wissel BD, Larkin S, Bernardini A, Zibetti M, Maule S, Lopiano L, Espay AJ (2016) Orthostatic hypotension in Parkinson\u2019s disease: does it matter if asymptomatic? Parkinsonism Relat Disord 33:65\u201371. https:\/\/doi.org\/10.1016\/j.parkreldis.2016.09.013","journal-title":"Parkinsonism Relat Disord"}],"container-title":["Clinical Autonomic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-020-00672-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10286-020-00672-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-020-00672-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T19:44:35Z","timestamp":1613763875000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10286-020-00672-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,20]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["672"],"URL":"https:\/\/doi.org\/10.1007\/s10286-020-00672-7","relation":{},"ISSN":["0959-9851","1619-1560"],"issn-type":[{"value":"0959-9851","type":"print"},{"value":"1619-1560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,20]]},"assertion":[{"value":"24 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Jose-Alberto Palma has been an advisory board member\/consultant for Lundbeck, Biogen, PTC Therapeutics, and Dr. Reddy\u2019s Laboratories. He receives research funding from the NINDS, the Michael J. Fox Foundation, and the Familial Dysautonomia Foundation. He is the principal investigator in clinical trials funded by Biohaven and Theravance. Nina Browner has received Parkinson Foundation speakers and travel fees. Miriam Sklerov, Chia-Hao Shih, Styner, and Eran Dayan report no disclosures. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Data used in this manuscript were obtained from the Parkinson\u2019s Progression Markers Initiative (PPMI), a publicly available dataset. All study procedures were approved by the appropriate ethics committees at each participating site. All participants gave informed consent prior to inclusion in PPMI. For up-to-date information on the study, visit\u00a0.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}