{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:08:24Z","timestamp":1776445704111,"version":"3.51.2"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Auton Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Multiple system atrophy (MSA) and Parkinson\u2019s disease (PD) are sporadic neurodegenerative diseases characterized by an accumulation of misfolded \u03b1-synuclein. Cardiovascular autonomic failure develops in both MSA and PD, although studies indicate different sites of autonomic nervous system lesion. However, it is unclear whether this could potentially aid the differential diagnosis of these diseases. Here we determined whether cardiovascular autonomic function testing (CAFT) can discriminate between the parkinsonian variant of MSA (MSA-P) and PD based on either an expert-based blinded evaluation or a systematic comparison of cardiovascular autonomic function indices.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We included 22 patients aged 55\u201380 with neurogenic orthostatic hypotension (nOH) who had been diagnosed with either clinically probable MSA-P (<jats:italic>n<\/jats:italic>\u2009=\u200911) according to current consensus criteria or clinically definite PD (<jats:italic>n<\/jats:italic>\u2009=\u200911) according to the Queen Square criteria. Three physicians with expertise in CAFT were blinded to the neurological diagnosis and were asked to identify the correct neurological diagnosis by applying a self-created evaluation scheme to the CAFT recordings. Afterwards, a systematic comparison of clinical\u2013demographic characteristics and CAFT parameters was carried out.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Neither the raters (overall diagnostic accuracy: 58.46%) nor the evaluation scheme created post hoc (72.73%) showed reliable discriminatory capacity. The inter-rater reliability was slight (<jats:italic>\u03ba<\/jats:italic>\u2009=\u20090.01). We observed no statistically significant differences in cardiovascular autonomic indices between PD and MSA-P patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>CAFT is the gold standard for assessing the presence and severity of cardiovascular autonomic failure, but the results of our pilot study suggest that CAFT might be of limited value in the differential diagnosis between MSA-P and PD once nOH is present.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10286-020-00691-4","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T15:06:40Z","timestamp":1589555200000},"page":"255-263","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cardiovascular autonomic function testing in multiple system atrophy and Parkinson\u2019s disease: an expert-based blinded evaluation"],"prefix":"10.1007","volume":"30","author":[{"given":"Fabian","family":"Leys","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Fanciulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Ndayisaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Granata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Struhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9077-1666","authenticated-orcid":false,"given":"Gregor K.","family":"Wenning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"issue":"14","key":"691_CR1","first-page":"1375","volume":"372","author":"A Fanciulli","year":"2015","unstructured":"Fanciulli A, Wenning GK (2015) Multiple-system atrophy. 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Disclosure statement for the last 12\u00a0months: Dr. Leys reports no disclosures. Dr. Fanciulli reports royalties from Springer Nature, speaker fees and honoraria from the Ordensklinikum Linz, Austrian Parkinson Society, International Parkinson Disease and Movement Disorders Society, and Theravance, and research grants from the Stichting ParkinsonFond and the \u00d6sterreichischer Austausch Dienst, outside of the submitted work. Dr. Phil Ndayisaba reports no disclosures. Dr. Granata reports no disclosures. Dr. Struhal reports royalties from Springer, Manz, and Oxford University Press, payment for lectures from AbbVie, Ever, Pfizer, Austrian Parkinson Society, and the Kardinal K\u00f6nig Haus, and board membership of Lilly and Boehringer. Dr. Wenning reports research grants from the Austrian Science Foundation, Austrian National Bank Jubilee Fonds, Parkinson Fonds Austria, MSA Coalition, and the Tyrolean Science Foundation, consulting fees from Biohaven, Biogen, Lundbeck, Minoryx, Ono, Prana, and Teva, and speaker fees from Biohaven, Novartis, International Movement Disorder Society, and Scandinavian MDS.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Given the retrospective nature of this study, according to Austrian law, neither an approval by the local ethical committee nor a written informed consent was due. The local ethical committee was informed about the present study. Details that might disclose the identity of the subjects under study were removed. Data was archived and analyzed in a de-identified way.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}