{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:51:33Z","timestamp":1788288693524,"version":"build-2803163510"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Innsbruck and Medical University of Innsbruck"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Auton Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The diagnosis of probable multiple system atrophy relies on the presence of severe cardiovascular or urogenital autonomic failure. Erectile dysfunction is required to fulfil the latter criterion in men, whereas no corresponding item is established for women. In this study, we aimed to investigate sexual dysfunction in women with multiple system atrophy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We administered the Female Sexual Function Index questionnaire and interviewed women with multiple system atrophy and age-matched controls regarding the presence of \u201cgenital hyposensitivity.\u201d<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We recruited 25 women with multiple system atrophy and 42 controls. Female Sexual Function Index scores in sexually active women with multiple system atrophy were significantly lower (multiple system atrophy\u2009=\u200910; 15.4, 95% CI [10.1, 22.1], controls\u2009=\u200937; 26.1 [24.1, 28.1], <jats:italic>p<\/jats:italic>\u2009=\u20090.0004). The lowest scores concerned the domains of desire, arousal and lubrication. Genital hyposensitivity was reported by 56% of the patients with multiple system atrophy and 9% controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Sexual dysfunction is highly prevalent in women with multiple system atrophy. Screening for disturbances in specific sexual domains should be implemented in the clinical evaluation of women with suggestive motor symptoms.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10286-021-00825-2","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T07:02:55Z","timestamp":1630998175000},"page":"713-717","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Female sexual dysfunction in multiple system atrophy: a prospective cohort study"],"prefix":"10.1007","volume":"31","author":[{"given":"Cecilia","family":"Raccagni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-8630","authenticated-orcid":false,"given":"Elisabetta","family":"Indelicato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Sidoroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Daniaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Bader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Toth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas A.","family":"Jelisejevas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarethe","family":"Hochleitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Fanciulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Leys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Eschlboeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Kaindlstorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Boesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor K.","family":"Wenning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"825_CR1","doi-asserted-by":"crossref","unstructured":"Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ et al (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology [Internet]. 71(9):670\u2013676. https:\/\/pubmed.ncbi.nlm.nih.gov\/18725592\/. Accessed 30 Dec 2020","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"issue":"6","key":"825_CR2","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s10286-018-0550-y","volume":"29","author":"R Sakakibara","year":"2019","unstructured":"Sakakibara R, Panicker J, Simeoni S, Uchiyama T, Yamamoto T, Tateno F et al (2019) Bladder dysfunction as the initial presentation of multiple system atrophy: a prospective cohort study. Clin Auton Res 29(6):627\u2013631","journal-title":"Clin Auton Res"},{"key":"825_CR3","doi-asserted-by":"crossref","unstructured":"Hasan S, Mielke MM, Ahlskog JE, Bower J, Turcano P, Savica R (2019) Erectile dysfunction preceding clinically diagnosed \u03b1-synucleinopathies: a case-control study in Olmsted County. Parkinsons Dis [Internet]. https:\/\/pubmed.ncbi.nlm.nih.gov\/31093326\/. Accessed 30 Dec 2020","DOI":"10.1155\/2019\/6303945"},{"issue":"4","key":"825_CR4","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/sj.ijir.3901014","volume":"15","author":"K Kirchhof","year":"2003","unstructured":"Kirchhof K, Apostolidis AN, Mathias CJ, Fowler CJ (2003) Erectile and urinary dysfunction may be the presenting features in patients with multiple system atrophy: a retrospective study. Int J Impot Res 15(4):293\u2013298","journal-title":"Int J Impot Res"},{"key":"825_CR5","doi-asserted-by":"crossref","unstructured":"McKay JH, Cheshire WP (2018) First symptoms in multiple system atrophy. Clin Auton Res","DOI":"10.1007\/s10286-017-0500-0"},{"key":"825_CR6","doi-asserted-by":"crossref","unstructured":"Oertel WH, W\u00e4chter T, Quinn NP, Ulm G, Brandst\u00e4dter D (2003) Reduced genital sensitivity in female patients with multiple system atrophy of parkinsonian type. Mov Disord [Internet] 18(4):430\u2013432. https:\/\/pubmed.ncbi.nlm.nih.gov\/12671951\/. Accessed 30 Dec 2020","DOI":"10.1002\/mds.10384"},{"key":"825_CR7","doi-asserted-by":"crossref","unstructured":"Wenning GK, Tison F, Seppi K, Sampiao C, Diem A, Yekhlef F et al (2004) Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS). Mov Disord [Internet] 19(12):1391\u20131402. https:\/\/pubmed.ncbi.nlm.nih.gov\/15452868\/. Accessed 30 Dec 2020","DOI":"10.1002\/mds.20255"},{"key":"825_CR8","doi-asserted-by":"crossref","unstructured":"Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R et al (2000) The female sexual function index (Fsfi): A multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther [Internet] 26(2):191\u2013205. https:\/\/pubmed.ncbi.nlm.nih.gov\/10782451\/. Accessed 30 Dec 2020","DOI":"10.1080\/009262300278597"},{"issue":"4","key":"825_CR9","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s00415-019-09684-4.Accessed2Jan2021","volume":"267","author":"E Indelicato","year":"2020","unstructured":"Indelicato E, Fanciulli A, Nachbauer W, Eigentler A, Amprosi M, Ndayisaba JP et al (2020) Cardiovascular autonomic testing in the work-up of cerebellar ataxia: insight from an observational single center study. J Neurol [Internet] 267(4):1097\u20131102. https:\/\/doi.org\/10.1007\/s00415-019-09684-4.Accessed2Jan2021","journal-title":"J Neurol [Internet]"},{"key":"825_CR10","unstructured":"Nusbaum MRH, Hamilton C, Lenahan P (2003) Chronic illness and sexual functioning. Am Fam Phys 67(2):347\u2013354+357"},{"key":"825_CR11","unstructured":"Nusbaum MRH, Gamble GR, Pathman DE (2021) Seeking medical help for sexual concerns: frequency, barriers, and missed opportunities"},{"key":"825_CR12","doi-asserted-by":"crossref","unstructured":"Graziottin A (2004) Sexual arousal: similarities and differences between men and women. J Men\u2019s Health Gender 1","DOI":"10.1016\/j.jmhg.2004.07.026"},{"key":"825_CR13","doi-asserted-by":"crossref","unstructured":"Schellino R, Boido M, Vercelli A (2020) The dual nature of onuf\u2019s nucleus: neuroanatomical features and peculiarities, in health and disease. Front Neuroanat","DOI":"10.3389\/fnana.2020.572013"},{"key":"825_CR14","unstructured":"Seehusen DA, Baird DC, Bode DV (2014) Dyspareunia in Women. Am Fam Phys [Internet] 90(7):465\u2013470. www.aafp.org\/afpAmericanFamilyPhysician465. Accessed 20 Aug 2021"}],"container-title":["Clinical Autonomic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-021-00825-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10286-021-00825-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-021-00825-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T10:09:50Z","timestamp":1638180590000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10286-021-00825-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,7]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["825"],"URL":"https:\/\/doi.org\/10.1007\/s10286-021-00825-2","relation":{},"ISSN":["0959-9851","1619-1560"],"issn-type":[{"value":"0959-9851","type":"print"},{"value":"1619-1560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,7]]},"assertion":[{"value":"7 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No funding source to be reported.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Raw data are available upon request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data Availability"}},{"value":"CR and EI conceived the study. VS, FL, AF, SE, CK, RG, SB and GKW recruited female patients with MSA. MD, AB, MH, BT, and LAJ recruited control subjects. EI performed the statistical analysis. CR and EI wrote the first draft, which was reviewed, implemented and approved by all authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}},{"value":"No financial disclosure of conflict of interest to declare related to the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial Disclosure\/Conflict of Interest"}},{"value":"This study was approved by the local ethics committee (study number: 1232\/2017).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Written informed consent was given by the patients and controls prior to inclusion.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All co-authors have read the manuscript and agreed with its content.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}