{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:03:23Z","timestamp":1782299003831,"version":"3.54.5"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Auton Res"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s10286-021-00841-2","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T04:20:21Z","timestamp":1638159621000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Independent effect of neurogenic orthostatic hypotension on mild cognitive impairment in Parkinson\u2019s disease"],"prefix":"10.1007","volume":"32","author":[{"given":"Sung Hoon","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jin","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungyeun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-4863","authenticated-orcid":false,"given":"Seong-Beom","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"841_CR1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s10286-006-0317-8","volume":"16","author":"DS Goldstein","year":"2006","unstructured":"Goldstein DS (2006) Orthostatic hypotension as an early finding in Parkinson\u2019s disease. Clin Auton Res 16:46\u201354. https:\/\/doi.org\/10.1007\/s10286-006-0317-8","journal-title":"Clin Auton Res"},{"key":"841_CR2","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1002\/mds.25431","volume":"28","author":"JA Palma","year":"2013","unstructured":"Palma JA, Carmona-Abellan MM, Barriobero N et al (2013) Is cardiac function impaired in premotor Parkinson\u2019s disease? A retrospective cohort study. Mov Disord 28:591\u2013596. https:\/\/doi.org\/10.1002\/mds.25431","journal-title":"Mov Disord"},{"key":"841_CR3","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/s1474-4422(16)30079-5","volume":"15","author":"AJ Espay","year":"2016","unstructured":"Espay AJ, LeWitt PA, Hauser RA et al (2016) Neurogenic orthostatic hypotension and supine hypertension in Parkinson\u2019s disease and related synucleinopathies: prioritisation of treatment targets. Lancet Neurol 15:954\u2013966. https:\/\/doi.org\/10.1016\/s1474-4422(16)30079-5","journal-title":"Lancet Neurol"},{"key":"841_CR4","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1007\/s10072-020-04277-w","volume":"41","author":"F Mu","year":"2020","unstructured":"Mu F, Jiao Q, Du X, Jiang H (2020) Association of orthostatic hypotension with Parkinson\u2019s disease: a meta-analysis. Neurol Sci 41:1419\u20131426. https:\/\/doi.org\/10.1007\/s10072-020-04277-w","journal-title":"Neurol Sci"},{"key":"841_CR5","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/j.1750-3639.2009.00369.x","volume":"20","author":"D Aarsland","year":"2010","unstructured":"Aarsland D, Kurz MW (2010) The epidemiology of dementia associated with Parkinson\u2019s disease. Brain Pathol 20:633\u2013639. https:\/\/doi.org\/10.1111\/j.1750-3639.2009.00369.x","journal-title":"Brain Pathol"},{"key":"841_CR6","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1001\/jamaneurol.2015.0703","volume":"72","author":"SM Fereshtehnejad","year":"2015","unstructured":"Fereshtehnejad SM, Romenets SR, Anang JB et al (2015) New clinical subtypes of Parkinson disease and their longitudinal progression: a prospective cohort comparison with other phenotypes. JAMA Neurol 72:863\u2013873. https:\/\/doi.org\/10.1001\/jamaneurol.2015.0703","journal-title":"JAMA Neurol"},{"key":"841_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/mds.27902","volume":"35","author":"C Baiano","year":"2020","unstructured":"Baiano C, Barone P, Trojano L, Santangelo G (2020) Prevalence and clinical aspects of mild cognitive impairment in Parkinson\u2019s disease: a meta-analysis. Mov Disord 35:45\u201354. https:\/\/doi.org\/10.1002\/mds.27902","journal-title":"Mov Disord"},{"key":"841_CR8","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1136\/jnnp-2016-314123","volume":"87","author":"SJ Udow","year":"2016","unstructured":"Udow SJ, Robertson AD, MacIntosh BJ et al (2016) \u2018Under pressure\u2019: is there a link between orthostatic hypotension and cognitive impairment in \u03b1-synucleinopathies? J Neurol Neurosurg Psychiatry 87:1311\u20131321. https:\/\/doi.org\/10.1136\/jnnp-2016-314123","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"841_CR9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.parkreldis.2019.10.023","volume":"69","author":"CE Cicero","year":"2019","unstructured":"Cicero CE, Raciti L, Monastero R et al (2019) Cardiovascular autonomic function and MCI in Parkinson\u2019s disease. Parkinsonism Relat Disord 69:55\u201358. https:\/\/doi.org\/10.1016\/j.parkreldis.2019.10.023","journal-title":"Parkinsonism Relat Disord"},{"key":"841_CR10","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3389\/fneur.2020.00897","volume":"11","author":"K Longardner","year":"2020","unstructured":"Longardner K, Bayram E, Litvan I (2020) Orthostatic hypotension is associated with cognitive decline in Parkinson disease. Front Neurol 11:897. https:\/\/doi.org\/10.3389\/fneur.2020.00897","journal-title":"Front Neurol"},{"key":"841_CR11","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1136\/jnnp-2019-320846","volume":"90","author":"A Pilotto","year":"2019","unstructured":"Pilotto A, Romagnolo A, Tuazon JA et al (2019) Orthostatic hypotension and REM sleep behaviour disorder: impact on clinical outcomes in \u03b1-synucleinopathies. J Neurol Neurosurg Psychiatry 90:1257\u20131263. https:\/\/doi.org\/10.1136\/jnnp-2019-320846","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"841_CR12","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1002\/mds.26632","volume":"31","author":"C McDonald","year":"2016","unstructured":"McDonald C, Newton JL, Burn DJ (2016) Orthostatic hypotension and cognitive impairment in Parkinson\u2019s disease: causation or association? Mov Disord 31:937\u2013946. https:\/\/doi.org\/10.1002\/mds.26632","journal-title":"Mov Disord"},{"key":"841_CR13","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1002\/mds.26048","volume":"29","author":"AJ Espay","year":"2014","unstructured":"Espay AJ, LeWitt PA, Kaufmann H (2014) Norepinephrine deficiency in Parkinson\u2019s disease: the case for noradrenergic enhancement. Mov Disord 29:1710\u20131719. https:\/\/doi.org\/10.1002\/mds.26048","journal-title":"Mov Disord"},{"key":"841_CR14","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fnbeh.2012.00048","volume":"6","author":"EM Vazey","year":"2012","unstructured":"Vazey EM, Aston-Jones G (2012) The emerging role of norepinephrine in cognitive dysfunctions of Parkinson\u2019s disease. Front Behav Neurosci 6:48. https:\/\/doi.org\/10.3389\/fnbeh.2012.00048","journal-title":"Front Behav Neurosci"},{"key":"841_CR15","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/ana.25170","volume":"83","author":"L Norcliffe-Kaufmann","year":"2018","unstructured":"Norcliffe-Kaufmann L, Kaufmann H, Palma JA et al (2018) Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies. Ann Neurol 83:522\u2013531. https:\/\/doi.org\/10.1002\/ana.25170","journal-title":"Ann Neurol"},{"key":"841_CR16","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1056\/NEJMcp074189","volume":"358","author":"R Freeman","year":"2008","unstructured":"Freeman R (2008) Clinical practice. Neurogenic orthostatic hypotension. New Engl J Med 358:615\u2013624. https:\/\/doi.org\/10.1056\/NEJMcp074189","journal-title":"New Engl J Med"},{"key":"841_CR17","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1002\/mds.10473","volume":"18","author":"Movement Disorder Society Task Force on Rating Scales for Parkinson\u2019s Disease","year":"2003","unstructured":"Movement Disorder Society Task Force on Rating Scales for Parkinson\u2019s Disease (2003) The unified Parkinson\u2019s disease rating scale (UPDRS): status and recommendations. Mov Disord 18:738\u2013750. https:\/\/doi.org\/10.1002\/mds.10473","journal-title":"Mov Disord"},{"key":"841_CR18","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3988\/jcn.2012.8.4.276","volume":"8","author":"SB Koh","year":"2012","unstructured":"Koh SB, Kim JW, Ma HI et al (2012) Validation of the Korean-version of the nonmotor symptoms scale for Parkinson\u2019s disease. J Clin Neurol (Seoul, Korea) 8:276\u2013283. https:\/\/doi.org\/10.3988\/jcn.2012.8.4.276","journal-title":"J Clin Neurol (Seoul, Korea)"},{"key":"841_CR19","doi-asserted-by":"publisher","first-page":"77","DOI":"10.12779\/dnd.2019.18.3.77","volume":"18","author":"SH Kang","year":"2019","unstructured":"Kang SH, Park YH, Lee D et al (2019) The cortical neuroanatomy related to specific neuropsychological deficits in Alzheimer\u2019s continuum. Dement Neurocogn Disord 18:77\u201395. https:\/\/doi.org\/10.12779\/dnd.2019.18.3.77","journal-title":"Dement Neurocogn Disord"},{"key":"841_CR20","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","volume":"55","author":"AJ Hughes","year":"1992","unstructured":"Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181\u2013184. https:\/\/doi.org\/10.1136\/jnnp.55.3.181","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"841_CR21","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1037\/1040-3590.3.2.168","volume":"3","author":"KJ Christensen","year":"1991","unstructured":"Christensen KJ, Multhaup KS, Nordstrom S, Voss K (1991) A cognitive battery for dementia: development and measurement characteristics. Psychol Assess 3:168\u2013174. https:\/\/doi.org\/10.1037\/1040-3590.3.2.168","journal-title":"Psychol Assess"},{"key":"841_CR22","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/mds.24893","volume":"27","author":"I Litvan","year":"2012","unstructured":"Litvan I, Goldman JG, Tr\u00f6ster AI et al (2012) Diagnostic criteria for mild cognitive impairment in Parkinson\u2019s disease: movement disorder society task force guidelines. Mov Disord 27:349\u2013356. https:\/\/doi.org\/10.1002\/mds.24893","journal-title":"Mov Disord"},{"key":"841_CR23","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1002\/mds.21740","volume":"22","author":"K Stiasny-Kolster","year":"2007","unstructured":"Stiasny-Kolster K, Mayer G, Sch\u00e4fer S, M\u00f6ller JC, Heinzel-Gutenbrunner M, Oertel WH (2007) The REM sleep behavior disorder screening questionnaire\u2014a new diagnostic instrument. Mov Disord 22:2386\u20132393. https:\/\/doi.org\/10.1002\/mds.21740","journal-title":"Mov Disord"},{"key":"841_CR24","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1007\/s00415-016-8375-x","volume":"264","author":"CH Gibbons","year":"2017","unstructured":"Gibbons CH, Schmidt P, Biaggioni I et al (2017) The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension. J Neurol 264:1567\u20131582. https:\/\/doi.org\/10.1007\/s00415-016-8375-x","journal-title":"J Neurol"},{"key":"841_CR25","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s10286-018-0529-8","volume":"28","author":"A Fanciulli","year":"2018","unstructured":"Fanciulli A, Jordan J, Biaggioni I et al (2018) Consensus statement on the definition of neurogenic supine hypertension in cardiovascular autonomic failure by the American Autonomic Society (AAS) and the European Federation of Autonomic Societies (EFAS): endorsed by the European Academy of Neurology (EAN) and the European Society of Hypertension (ESH). Clin Auton Res 28:355\u2013362. https:\/\/doi.org\/10.1007\/s10286-018-0529-8","journal-title":"Clin Auton Res"},{"key":"841_CR26","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/j.1600-0404.2005.00427.x","volume":"112","author":"H Matsui","year":"2005","unstructured":"Matsui H, Udaka F, Miyoshi T et al (2005) Three-dimensional stereotactic surface projection study of orthostatic hypotension and brain perfusion image in Parkinson\u2019s disease. Acta Neurol Scand 112:36\u201341. https:\/\/doi.org\/10.1111\/j.1600-0404.2005.00427.x","journal-title":"Acta Neurol Scand"},{"key":"841_CR27","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00401-003-0705-2","volume":"106","author":"E K\u00f6vari","year":"2003","unstructured":"K\u00f6vari E, Gold G, Herrmann FR et al (2003) Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson\u2019s disease. Acta Neuropathol 106:83\u201388. https:\/\/doi.org\/10.1007\/s00401-003-0705-2","journal-title":"Acta Neuropathol"},{"key":"841_CR28","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1002\/mds.25109","volume":"27","author":"C Pifl","year":"2012","unstructured":"Pifl C, Kish SJ, Hornykiewicz O (2012) Thalamic noradrenaline in Parkinson\u2019s disease: deficits suggest role in motor and non-motor symptoms. Mov Disord 27:1618\u20131624. https:\/\/doi.org\/10.1002\/mds.25109","journal-title":"Mov Disord"},{"key":"841_CR29","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1093\/brain\/awh067","volume":"127","author":"T Foltynie","year":"2004","unstructured":"Foltynie T, Brayne CE, Robbins TW, Barker RA (2004) The cognitive ability of an incident cohort of Parkinson\u2019s patients in the UK. The CamPaIGN study Brain 127:550\u2013560. https:\/\/doi.org\/10.1093\/brain\/awh067","journal-title":"The CamPaIGN study Brain"},{"key":"841_CR30","doi-asserted-by":"publisher","first-page":"4652","DOI":"10.1002\/hbm.24311","volume":"39","author":"L Wu","year":"2018","unstructured":"Wu L, Liu FT, Ge JJ et al (2018) Clinical characteristics of cognitive impairment in patients with Parkinson\u2019s disease and its related pattern in 18F-FDG PET imaging. Hum Brain Mapp 39:4652\u20134662. https:\/\/doi.org\/10.1002\/hbm.24311","journal-title":"Hum Brain Mapp"},{"key":"841_CR31","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1212\/wnl.0000000000002492","volume":"86","author":"NW Sterling","year":"2016","unstructured":"Sterling NW, Wang M, Zhang L et al (2016) Stage-dependent loss of cortical gyrification as Parkinson disease \u201cunfolds.\u201d Neurology 86:1143\u20131151. https:\/\/doi.org\/10.1212\/wnl.0000000000002492","journal-title":"Neurology"},{"key":"841_CR32","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1007\/s00415-016-8122-3","volume":"263","author":"Y Xu","year":"2016","unstructured":"Xu Y, Yang J, Hu X, Shang H (2016) Voxel-based meta-analysis of gray matter volume reductions associated with cognitive impairment in Parkinson\u2019s disease. J Neurol 263:1178\u20131187. https:\/\/doi.org\/10.1007\/s00415-016-8122-3","journal-title":"J Neurol"},{"key":"841_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.111973","volume":"371","author":"D Zheng","year":"2019","unstructured":"Zheng D, Chen C, Song W et al (2019) Regional gray matter reductions associated with mild cognitive impairment in Parkinson\u2019s disease: a meta-analysis of voxel-based morphometry studies. Behav Brain Res 371:111973. https:\/\/doi.org\/10.1016\/j.bbr.2019.111973","journal-title":"Behav Brain Res"},{"key":"841_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.irn.2018.09.009","volume":"144","author":"JM Hall","year":"2019","unstructured":"Hall JM, Lewis SJG (2019) Neural correlates of cognitive impairment in Parkinson\u2019s disease: a review of structural MRI findings. Int Rev Neurobiol 144:1\u201328. https:\/\/doi.org\/10.1016\/bs.irn.2018.09.009","journal-title":"Int Rev Neurobiol"},{"key":"841_CR35","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/gps.1562","volume":"21","author":"LM Allcock","year":"2006","unstructured":"Allcock LM, Kenny RA, Mosimann UP et al (2006) Orthostatic hypotension in Parkinson\u2019s disease: association with cognitive decline? Int J Geriatr Psychiatry 21:778\u2013783. https:\/\/doi.org\/10.1002\/gps.1562","journal-title":"Int J Geriatr Psychiatry"},{"key":"841_CR36","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s10072-012-1250-3","volume":"34","author":"PL Pan","year":"2013","unstructured":"Pan PL, Shi HC, Zhong JG et al (2013) Gray matter atrophy in Parkinson\u2019s disease with dementia: evidence from meta-analysis of voxel-based morphometry studies. Neurol Sci 34:613\u2013619. https:\/\/doi.org\/10.1007\/s10072-012-1250-3","journal-title":"Neurol Sci"},{"key":"841_CR37","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1212\/wnl.49.6.1570","volume":"49","author":"A Churchyard","year":"1997","unstructured":"Churchyard A, Lees AJ (1997) The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson\u2019s disease. Neurology 49:1570\u20131576. https:\/\/doi.org\/10.1212\/wnl.49.6.1570","journal-title":"Neurology"},{"key":"841_CR38","doi-asserted-by":"publisher","first-page":"102685","DOI":"10.1016\/j.nicl.2021.102685","volume":"30","author":"SH Kang","year":"2021","unstructured":"Kang SH, Park YH, Kim JP et al (2021) Cortical neuroanatomical changes related to specific neuropsychological deficits in subcortical vascular cognitive impairment. Neuroimage Clin 30:102685. https:\/\/doi.org\/10.1016\/j.nicl.2021.102685","journal-title":"Neuroimage Clin"}],"container-title":["Clinical Autonomic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-021-00841-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10286-021-00841-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-021-00841-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:04:04Z","timestamp":1646481844000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10286-021-00841-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,29]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["841"],"URL":"https:\/\/doi.org\/10.1007\/s10286-021-00841-2","relation":{},"ISSN":["0959-9851","1619-1560"],"issn-type":[{"value":"0959-9851","type":"print"},{"value":"1619-1560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,29]]},"assertion":[{"value":"22 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was reviewed and approved by the Institutional Review Boards of the Korea University Guro Hospital and Myongji Hospital. All procedures were performed in accordance with the ethical standards outlined in the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}