{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:28:43Z","timestamp":1740137323650,"version":"3.37.3"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL157584","R01HL159203","R01HL144941","R01HL149386","R01HL142583"],"award-info":[{"award-number":["R01HL157584","R01HL159203","R01HL144941","R01HL149386","R01HL142583"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23CDA1053072"],"award-info":[{"award-number":["23CDA1053072"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007206","name":"Vanderbilt Institute for Clinical and Translational Research","doi-asserted-by":"publisher","award":["5UL1TR002243-03"],"award-info":[{"award-number":["5UL1TR002243-03"]}],"id":[{"id":"10.13039\/100007206","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Auton Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Hypertension is one of the major causes of cardiovascular morbidity and mortality in the USA and disproportionately affects Black women. Endothelial-derived nitric oxide (eNO) substantially regulates blood pressure in humans, and impaired NO-mediated vasodilation has been reported in the Black population. Previous studies using an NO synthase inhibitor, N<jats:sup>G<\/jats:sup>-monomethyl-L-arginine (L-NMMA) did not fully determine the NO contribution to blood pressure because of baroreflex buffering. Therefore, in the present study we used trimethaphan, a ganglionic blocker, to inhibit baroreflex buffering and study NO modulation of blood pressure in Black women during L-NMMA infusion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>L-NMMA at doses of 250\u00a0\u03bcg\/kg per minute was infused in combination with trimethaphan at doses of 4\u00a0mg\/min to eliminate baroreflex mechanisms. Heart rate (HR) was obtained with continuous electrocardiogram monitoring, and continuous blood pressure was measured with the volume clamp method. The increase in systolic blood pressure (SBP) during both infusions was used to estimate the contribution of NO to blood pressure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Ten Black (age range 30\u201350\u00a0years, body mass index [BMI] 30\u201345\u00a0kg\/m<jats:sup>2<\/jats:sup>), and nine White women (age range 30\u201350\u00a0years, body mass index 30\u201345\u00a0kg\/m<jats:sup>2<\/jats:sup>) were enrolled in this study. During autonomic blockade, there was no difference in the decrease in SBP between Black and White women (\u2212\u00a020\u2009\u00b1\u200916.45 vs. \u2212\u00a024\u2009\u00b1\u200915.49\u00a0mm Hg, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.659). When autonomic blockade was combined with L-NMMA, Black women had a significant increase in SBP compared to White women (54\u2009\u00b1\u200913.62 vs. 39\u2009\u00b1\u200909.64\u00a0mm Hg, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.022, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Autonomic blood pressure regulation was similar between Black and White women. However, NO contribution to blood pressure was significantly greater in Black women compared to White women.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Registration<\/jats:title>\n                <jats:p>ClinicalTrials.gov: NCT01122407.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10286-024-01050-3","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T16:02:14Z","timestamp":1722528134000},"page":"427-436","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complete autonomic blockade reveals nitric oxide contribution to blood pressure regulation in obese Black women"],"prefix":"10.1007","volume":"34","clinical-trial-number":[{"clinical-trial-number":"nct01122407","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Sharla","family":"Rahman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Gamboa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surat","family":"Kulapatana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Diedrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Italo","family":"Biaggioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annet","family":"Kirabo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4518-6801","authenticated-orcid":false,"given":"Cyndya A.","family":"Shibao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"1050_CR1","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.2337\/diacare.28.7.1599","volume":"28","author":"PW Sullivan","year":"2005","unstructured":"Sullivan PW, Morrato EH, Ghushchyan V et al (2005) Obesity, inactivity, and the prevalence of diabetes and diabetes-related cardiovascular comorbidities in the U.S., 2000\u20132002. Diabetes Care 28:1599\u20131603. https:\/\/doi.org\/10.2337\/diacare.28.7.1599","journal-title":"Diabetes Care"},{"key":"1050_CR2","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.2337\/diacare.27.10.2444","volume":"27","author":"ES Ford","year":"2004","unstructured":"Ford ES, Giles WH, Mokdad AH (2004) Increasing prevalence of the metabolic syndrome among U.S. adults. Diabetes Care 27:2444\u20132449. https:\/\/doi.org\/10.2337\/diacare.27.10.2444","journal-title":"Diabetes Care"},{"issue":"1","key":"1050_CR3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/endocrines4010003","volume":"4","author":"M Saleem","year":"2023","unstructured":"Saleem M (2023) Obesity is associated with increased F2-isoprostanes and IL-6 in black women. Endocrines 4(1):38\u201354","journal-title":"Endocrines"},{"key":"1050_CR4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1089\/met.2018.0072","volume":"17","author":"YS Choi","year":"2019","unstructured":"Choi YS, Klaric JS, Beltran TH (2019) Prediction of insulin resistance with anthropometric and clinical laboratory measures in nondiabetic teenagers. Metab Syndr Relat Disord 17:37\u201345. https:\/\/doi.org\/10.1089\/met.2018.0072","journal-title":"Metab Syndr Relat Disord"},{"key":"1050_CR5","first-page":"188","volume":"95","author":"ME Reusser","year":"2003","unstructured":"Reusser ME, DiRienzo DB, Miller GD, McCarron DA (2003) Adequate nutrient intake can reduce cardiovascular disease risk in African Americans. J Natl Med Assoc 95:188\u2013195","journal-title":"J Natl Med Assoc"},{"key":"1050_CR6","first-page":"633","volume":"16","author":"RA Williams","year":"2006","unstructured":"Williams RA, Gavin JR, Phillips RA et al (2006) High-risk African Americans with multiple risk factors for cardiovascular disease: challenges in prevention, diagnosis, and treatment. Ethn Dis 16:633\u2013639","journal-title":"Ethn Dis"},{"key":"1050_CR7","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.1161\/CIR.0b013e3182009701","volume":"123","author":"VL Roger","year":"2011","unstructured":"Roger VL, Go AS, Lloyd-Jones DM et al (2011) Heart disease and stroke statistics\u20132011 update: a report from the American Heart Association. Circulation 123:e18\u2013e209. https:\/\/doi.org\/10.1161\/CIR.0b013e3182009701","journal-title":"Circulation"},{"key":"1050_CR8","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1001\/archinte.162.22.2565","volume":"162","author":"DW Jones","year":"2002","unstructured":"Jones DW, Chambless LE, Folsom AR et al (2002) Risk factors for coronary heart disease in African Americans: the atherosclerosis risk in communities study, 1987\u20131997. Arch Intern Med 162:2565\u20132571. https:\/\/doi.org\/10.1001\/archinte.162.22.2565","journal-title":"Arch Intern Med"},{"key":"1050_CR9","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1161\/01.cir.97.20.2037","volume":"97","author":"G Grassi","year":"1998","unstructured":"Grassi G, Seravalle G, Colombo M et al (1998) Body weight reduction, sympathetic nerve traffic, and arterial baroreflex in obese normotensive humans. Circulation 97:2037\u20132042. https:\/\/doi.org\/10.1161\/01.cir.97.20.2037","journal-title":"Circulation"},{"key":"1050_CR10","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1161\/01.hyp.25.4.560","volume":"25","author":"G Grassi","year":"1995","unstructured":"Grassi G, Seravalle G, Cattaneo BM et al (1995) Sympathetic activation in obese normotensive subjects. Hypertension 25:560\u2013563. https:\/\/doi.org\/10.1161\/01.hyp.25.4.560","journal-title":"Hypertension"},{"key":"1050_CR11","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1161\/01.cir.0000041244.79165.25","volume":"106","author":"GE Alvarez","year":"2002","unstructured":"Alvarez GE, Beske SD, Ballard TP, Davy KP (2002) Sympathetic neural activation in visceral obesity. Circulation 106:2533\u20132536. https:\/\/doi.org\/10.1161\/01.cir.0000041244.79165.25","journal-title":"Circulation"},{"key":"1050_CR12","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/978-1-4939-1441-8_5","volume":"1208","author":"D Pierini","year":"2015","unstructured":"Pierini D, Bryan NS (2015) Nitric oxide availability as a marker of oxidative stress. Methods Mol Biol 1208:63\u201371. https:\/\/doi.org\/10.1007\/978-1-4939-1441-8_5","journal-title":"Methods Mol Biol"},{"key":"1050_CR13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.ccc.2019.12.009","volume":"36","author":"AR Cyr","year":"2020","unstructured":"Cyr AR, Huckaby LV, Shiva SS, Zuckerbraun BS (2020) Nitric oxide and endothelial dysfunction. Crit Care Clin 36:307\u2013321. https:\/\/doi.org\/10.1016\/j.ccc.2019.12.009","journal-title":"Crit Care Clin"},{"key":"1050_CR14","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.12688\/f1000research.19998.1","volume":"9","author":"M Tenopoulou","year":"2020","unstructured":"Tenopoulou M, Doulias P-T (2020) Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism. F1000Res 9:1000. https:\/\/doi.org\/10.12688\/f1000research.19998.1","journal-title":"F1000Res"},{"key":"1050_CR15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.4103\/2045-9912.273957","volume":"9","author":"E Goshi","year":"2019","unstructured":"Goshi E, Zhou G, He Q (2019) Nitric oxide detection methods in vitro and in vivo. Med Gas Res 9:192\u2013207. https:\/\/doi.org\/10.4103\/2045-9912.273957","journal-title":"Med Gas Res"},{"key":"1050_CR16","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1161\/CIRCULATIONAHA.110.990317","volume":"123","author":"MA Ozkor","year":"2011","unstructured":"Ozkor MA, Murrow JR, Rahman AM et al (2011) Endothelium-derived hyperpolarizing factor determines resting and stimulated forearm vasodilator tone in health and in disease. Circulation 123:2244\u20132253. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.110.990317","journal-title":"Circulation"},{"key":"1050_CR17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1161\/01.res.88.2.145","volume":"88","author":"MJ Mullen","year":"2001","unstructured":"Mullen MJ, Kharbanda RK, Cross J et al (2001) Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo: relevance to endothelial dysfunction in hypercholesterolemia. Circ Res 88:145\u2013151. https:\/\/doi.org\/10.1161\/01.res.88.2.145","journal-title":"Circ Res"},{"key":"1050_CR18","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1161\/01.hyp.26.2.327","volume":"26","author":"R Joannides","year":"1995","unstructured":"Joannides R, Richard V, Haefeli WE et al (1995) Role of basal and stimulated release of nitric oxide in the regulation of radial artery caliber in humans. Hypertension 26:327\u2013331. https:\/\/doi.org\/10.1161\/01.hyp.26.2.327","journal-title":"Hypertension"},{"key":"1050_CR19","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1161\/01.cir.92.3.320","volume":"92","author":"AA Quyyumi","year":"1995","unstructured":"Quyyumi AA, Dakak N, Andrews NP et al (1995) Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation 92:320\u2013326. https:\/\/doi.org\/10.1161\/01.cir.92.3.320","journal-title":"Circulation"},{"key":"1050_CR20","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1161\/01.cir.90.6.2853","volume":"90","author":"DM Gilligan","year":"1994","unstructured":"Gilligan DM, Panza JA, Kilcoyne CM et al (1994) Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation 90:2853\u20132858. https:\/\/doi.org\/10.1161\/01.cir.90.6.2853","journal-title":"Circulation"},{"key":"1050_CR21","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1161\/01.cir.87.5.1468","volume":"87","author":"JA Panza","year":"1993","unstructured":"Panza JA, Casino PR, Kilcoyne CM, Quyyumi AA (1993) Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation 87:1468\u20131474. https:\/\/doi.org\/10.1161\/01.cir.87.5.1468","journal-title":"Circulation"},{"key":"1050_CR22","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1161\/01.atv.0000017704.45007.1d","volume":"22","author":"DA Rosenbaum","year":"2002","unstructured":"Rosenbaum DA, Pretorius M, Gainer JV et al (2002) Ethnicity affects vasodilation, but not endothelial tissue plasminogen activator release, in response to bradykinin. Arterioscler Thromb Vasc Biol 22:1023\u20131028. https:\/\/doi.org\/10.1161\/01.atv.0000017704.45007.1d","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1050_CR23","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/S0009-9236(99)70135-9","volume":"65","author":"DS Jones","year":"1999","unstructured":"Jones DS, Andrawis NS, Abernethy DR (1999) Impaired endothelial-dependent forearm vascular relaxation in black Americans. Clin Pharmacol Ther 65:408\u2013412. https:\/\/doi.org\/10.1016\/S0009-9236(99)70135-9","journal-title":"Clin Pharmacol Ther"},{"key":"1050_CR24","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1161\/01.hyp.0000024571.69634.ed","volume":"40","author":"DF Kahn","year":"2002","unstructured":"Kahn DF, Duffy SJ, Tomasian D et al (2002) Effects of black race on forearm resistance vessel function. Hypertension 40:195\u2013201. https:\/\/doi.org\/10.1161\/01.hyp.0000024571.69634.ed","journal-title":"Hypertension"},{"key":"1050_CR25","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/S0009-9236(97)90122-3","volume":"62","author":"CM Stein","year":"1997","unstructured":"Stein CM, Lang CC, Nelson R et al (1997) Vasodilation in black Americans: attenuated nitric oxide-mediated responses. Clin Pharmacol Ther 62:436\u2013443. https:\/\/doi.org\/10.1016\/S0009-9236(97)90122-3","journal-title":"Clin Pharmacol Ther"},{"key":"1050_CR26","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1161\/01.hyp.36.6.945","volume":"36","author":"CM Stein","year":"2000","unstructured":"Stein CM, Lang CC, Singh I et al (2000) Increased vascular adrenergic vasoconstriction and decreased vasodilation in blacks. Additive mechanisms leading to enhanced vascular reactivity. Hypertension 36:945\u2013951. https:\/\/doi.org\/10.1161\/01.hyp.36.6.945","journal-title":"Hypertension"},{"key":"1050_CR27","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1056\/NEJM199507203330304","volume":"333","author":"CC Lang","year":"1995","unstructured":"Lang CC, Stein CM, Brown RM et al (1995) Attenuation of isoproterenol-mediated vasodilatation in blacks. N Engl J Med 333:155\u2013160. https:\/\/doi.org\/10.1056\/NEJM199507203330304","journal-title":"N Engl J Med"},{"key":"1050_CR28","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1093\/ajh\/5.11.781","volume":"5","author":"DR Bassett","year":"1992","unstructured":"Bassett DR, Duey WJ, Walker AJ et al (1992) Racial differences in maximal vasodilatory capacity of forearm resistance vessels in normotensive young adults. Am J Hypertens 5:781\u2013786. https:\/\/doi.org\/10.1093\/ajh\/5.11.781","journal-title":"Am J Hypertens"},{"key":"1050_CR29","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1161\/01.hyp.31.6.1235","volume":"31","author":"C Cardillo","year":"1998","unstructured":"Cardillo C, Kilcoyne CM, Cannon RO, Panza JA (1998) Racial differences in nitric oxide-mediated vasodilator response to mental stress in the forearm circulation. Hypertension 31:1235\u20131239. https:\/\/doi.org\/10.1161\/01.hyp.31.6.1235","journal-title":"Hypertension"},{"key":"1050_CR30","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1177\/174182679600300502","volume":"3","author":"V Bond","year":"1996","unstructured":"Bond V, Thompson GD, Franks BD et al (1996) Racial differences in minimum lower leg vascular resistance in normotensive young adults with positive and negative parental histories of hypertension. J Cardiovasc Risk 3:423\u2013426. https:\/\/doi.org\/10.1177\/174182679600300502","journal-title":"J Cardiovasc Risk"},{"key":"1050_CR31","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/s0002-9149(96)90397-5","volume":"78","author":"AL Hinderliter","year":"1996","unstructured":"Hinderliter AL, Sager AR, Sherwood A et al (1996) Ethnic differences in forearm vasodilator capacity. Am J Cardiol 78:208\u2013211. https:\/\/doi.org\/10.1016\/s0002-9149(96)90397-5","journal-title":"Am J Cardiol"},{"key":"1050_CR32","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1161\/01.HYP.0000252425.06216.26","volume":"49","author":"A Gamboa","year":"2007","unstructured":"Gamboa A, Shibao C, Diedrich A et al (2007) Contribution of endothelial nitric oxide to blood pressure in humans. Hypertension 49:170\u2013177. https:\/\/doi.org\/10.1161\/01.HYP.0000252425.06216.26","journal-title":"Hypertension"},{"key":"1050_CR33","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006971","volume":"6","author":"A Marinos","year":"2017","unstructured":"Marinos A, Gamboa A, Celedonio JE et al (2017) Hypertension in obese Black women is not caused by increased sympathetic vascular tone. J Am Heart Assoc 6:e006971. https:\/\/doi.org\/10.1161\/JAHA.117.006971","journal-title":"J Am Heart Assoc"},{"key":"1050_CR34","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/s41440-018-0179-1","volume":"42","author":"JE Middlemiss","year":"2019","unstructured":"Middlemiss JE, Cocks A, Paapstel K et al (2019) Evaluation of inert gas rebreathing for determination of cardiac output: influence of age, gender and body size. Hypertens Res 42:834\u2013844. https:\/\/doi.org\/10.1038\/s41440-018-0179-1","journal-title":"Hypertens Res"},{"key":"1050_CR35","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1097\/00004872-200309000-00017","volume":"21","author":"A Diedrich","year":"2003","unstructured":"Diedrich A, Jordan J, Tank J et al (2003) The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade. J Hypertens 21:1677\u20131686. https:\/\/doi.org\/10.1097\/00004872-200309000-00017","journal-title":"J Hypertens"},{"key":"1050_CR36","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1161\/01.cir.0000012126.56352.fd","volume":"105","author":"J Jordan","year":"2002","unstructured":"Jordan J, Tank J, Shannon JR et al (2002) Baroreflex buffering and susceptibility to vasoactive drugs. Circulation 105:1459\u20131464. https:\/\/doi.org\/10.1161\/01.cir.0000012126.56352.fd","journal-title":"Circulation"},{"key":"1050_CR37","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1109\/TBME.1985.325532","volume":"32","author":"J Pan","year":"1985","unstructured":"Pan J, Tompkins WJ (1985) A real-time QRS detection algorithm. IEEE Trans Biomed Eng 32:230\u2013236. https:\/\/doi.org\/10.1109\/TBME.1985.325532","journal-title":"IEEE Trans Biomed Eng"},{"key":"1050_CR38","doi-asserted-by":"crossref","unstructured":"[No authors listed] (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93:1043\u20131065","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"1050_CR39","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1161\/01.hyp.33.4.937","volume":"33","author":"M Sander","year":"1999","unstructured":"Sander M, Chavoshan B, Victor RG (1999) A large blood pressure-raising effect of nitric oxide synthase inhibition in humans. Hypertension 33:937\u2013942. https:\/\/doi.org\/10.1161\/01.hyp.33.4.937","journal-title":"Hypertension"},{"key":"1050_CR40","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1161\/ATVBAHA.113.303136","volume":"34","author":"MA Ozkor","year":"2014","unstructured":"Ozkor MA, Rahman AM, Murrow JR et al (2014) Differences in vascular nitric oxide and endothelium-derived hyperpolarizing factor bioavailability in Blacks and Whites. Arterioscler Thromb Vasc Biol 34:1320\u20131327. https:\/\/doi.org\/10.1161\/ATVBAHA.113.303136","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1050_CR41","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1161\/01.res.27.1.97","volume":"27","author":"Y Kaneko","year":"1970","unstructured":"Kaneko Y, Takeda T, Ikeda T et al (1970) Effect of ganglion-blocking agents on renin release in hypertensive patients. Circ Res 27:97\u2013103. https:\/\/doi.org\/10.1161\/01.res.27.1.97","journal-title":"Circ Res"},{"key":"1050_CR42","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1161\/CIRCRESAHA.122.320818","volume":"131","author":"A Pitzer","year":"2022","unstructured":"Pitzer A, Elijovich F, Laffer CL et al (2022) DC ENaC-dependent inflammasome activation contributes to salt-sensitive hypertension. Circ Res 131:328\u2013344. https:\/\/doi.org\/10.1161\/CIRCRESAHA.122.320818","journal-title":"Circ Res"},{"key":"1050_CR43","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1089\/ars.2021.0212","volume":"35","author":"M Sahinoz","year":"2021","unstructured":"Sahinoz M, Elijovich F, Ertuglu LA et al (2021) Salt sensitivity of blood pressure in blacks and women: a role of inflammation, oxidative stress, and epithelial Na+ channel. Antioxid Redox Signal 35:1477\u20131493. https:\/\/doi.org\/10.1089\/ars.2021.0212","journal-title":"Antioxid Redox Signal"},{"key":"1050_CR44","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jash.2013.01.003","volume":"7","author":"SI Richardson","year":"2013","unstructured":"Richardson SI, Freedman BI, Ellison DH, Rodriguez CJ (2013) Salt sensitivity: a review with a focus on non-hispanic blacks and hispanics. J Am Soc Hypertens 7:170\u2013179. https:\/\/doi.org\/10.1016\/j.jash.2013.01.003","journal-title":"J Am Soc Hypertens"},{"key":"1050_CR45","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1213\/ANE.0b013e3182312e21","volume":"114","author":"GJ Crystal","year":"2012","unstructured":"Crystal GJ, Salem MR (2012) The Bainbridge and the \u201creverse\u201d Bainbridge reflexes: history, physiology, and clinical relevance. Anesth Analg 114:520\u2013532. https:\/\/doi.org\/10.1213\/ANE.0b013e3182312e21","journal-title":"Anesth Analg"},{"key":"1050_CR46","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1097\/EJA.0000000000001941","volume":"41","author":"S Gelman","year":"2024","unstructured":"Gelman S (2024) Norepinephrine produces two different haemodynamic effects depending on the dose used. Eur J Anaesthesiol 41:157\u2013160. https:\/\/doi.org\/10.1097\/EJA.0000000000001941","journal-title":"Eur J Anaesthesiol"}],"container-title":["Clinical Autonomic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-024-01050-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10286-024-01050-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-024-01050-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T16:05:24Z","timestamp":1724947524000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10286-024-01050-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["1050"],"URL":"https:\/\/doi.org\/10.1007\/s10286-024-01050-3","relation":{},"ISSN":["0959-9851","1619-1560"],"issn-type":[{"type":"print","value":"0959-9851"},{"type":"electronic","value":"1619-1560"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"25 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"CAS is a consultant for Antag Therapeutics, Theravance Biopharma, and Argenx. AK is a consultant for Argenx. All other authors (SR, AG, MS, SK, AD, IB) have nothing to declare.\u00a0The author(s) declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}