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However, the impact of nOH on balance and gait features remains unclear. This cross-sectional study aimed to assess the influence of nOH on postural and gait parameters in a cohort of patients with PD by means of wearable inertial sensors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Gait and balance were assessed using Opal inertial sensors. nOH was defined as sustained systolic blood pressure (BP) drop\u2009\u2265\u200920\u00a0mmHg or diastolic BP drop\u2009\u2265\u200910\u00a0mmHg within 3\u00a0min of standing, with a \u0394HR\/\u0394SBP ratio\u2009\u2264\u20090.5\u00a0bpm\/mmHg. Analysis of covariance was performed to evaluate differences in gait\/balance features between patients with and without nOH, adjusting for age, cognitive status, and motor disability. Moreover, we performed the same analysis considering the presence of hemodynamically relevant nOH (orthostatic mean BP\u2009\u2264\u200975\u00a0mmHg).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 82 patients were enrolled, 26 with nOH (31.7%), of which 13 presented with hemodynamically relevant nOH. After correcting for confounders, nOH was independently associated with lower gait speed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027), shorter stride length (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033), longer time for postural transitions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), and increased postural sway (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019). These differences were even more pronounced in patients with hemodynamically relevant nOH. Higher postural sway was associated with a 7.9-fold higher odds of falls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study presents an objective demonstration of the independent negative impact of nOH on gait and balance in PD, emphasizing the need for careful detection and management of nOH to mitigate gait and balance disturbances in PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10286-024-01071-y","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T15:01:23Z","timestamp":1727881283000},"page":"593-601","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Unraveling the stride: exploring the influence of neurogenic orthostatic hypotension on gait and balance in Parkinson\u2019s disease"],"prefix":"10.1007","volume":"34","author":[{"given":"Gabriele","family":"Imbalzano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ledda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Maria","family":"Tangari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Alberto","family":"Artusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Montanaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Giorgio","family":"Rizzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Zibetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Lopiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1312-1843","authenticated-orcid":false,"given":"Alberto","family":"Romagnolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"1071_CR1","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1002\/mds.21879","volume":"30","author":"LM Shulman","year":"2008","unstructured":"Shulman LM, Gruber-Baldini AL, Anderson KE et\u00a0al (2008) The evolution of disability in Parkinson disease. 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C.L. has received speech honoraria from Lusofarmaco. C.A.A. has received speech honoraria from Zambon, Bial, and Lusofarmaco. M.Z. has received speech honoraria from Medtronic, Bial, and AbbVie. L.L. has received speech honoraria from Medtronic, Bial, and Zambon and AbbVie. A.R. and M.G.R. have received speech honoraria from Zambon.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}