{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:57:38Z","timestamp":1764172658480,"version":"3.40.3"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin. Auton. Res."],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s10286-024-01085-6","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T10:21:14Z","timestamp":1734517274000},"page":"31-43","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sphenopalatine ganglion stimulation for the treatment of cerebrovascular ischemia"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5059-1174","authenticated-orcid":false,"given":"Juan Manuel","family":"Marquez-Romero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2709-7489","authenticated-orcid":false,"given":"Karen Itzel","family":"S\u00e1nchez-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"issue":"6","key":"1085_CR1","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s12975-022-01100-w","volume":"14","author":"IJ Biose","year":"2023","unstructured":"Biose IJ, Oremosu J, Bhatnagar S, Bix GJ (2023) Promising cerebral blood flow enhancers in acute ischemic stroke. Transl Stroke Res 14(6):863\u2013889. https:\/\/doi.org\/10.1007\/s12975-022-01100-w","journal-title":"Transl Stroke Res"},{"key":"1085_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054334","author":"M Haupt","year":"2023","unstructured":"Haupt M, Gerner ST, Bahr M, Doeppner TR (2023) Neuroprotective strategies for ischemic stroke-future perspectives. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24054334","journal-title":"Int J Mol Sci"},{"key":"1085_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2024.04.006","author":"B Franx","year":"2024","unstructured":"Franx B, Dijkhuizen RM, Dippel DWJ (2024) Acute ischemic stroke in the clinic and the laboratory: targets for translational research. Neuroscience. https:\/\/doi.org\/10.1016\/j.neuroscience.2024.04.006","journal-title":"Neuroscience"},{"issue":"3","key":"1085_CR4","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1080\/02688699550041331","volume":"9","author":"NM Branston","year":"1995","unstructured":"Branston NM (1995) The physiology of the cerebrovascular parasympathetic innervation. Br J Neurosurg 9(3):319\u2013329. https:\/\/doi.org\/10.1080\/02688699550041331","journal-title":"Br J Neurosurg"},{"issue":"8","key":"1085_CR5","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1177\/1747493020920739","volume":"15","author":"M Bahr-Hosseini","year":"2020","unstructured":"Bahr-Hosseini M, Saver JL (2020) Mechanisms of action of acute and subacute sphenopalatine ganglion stimulation for ischemic stroke. Int J Stroke 15(8):839\u2013848. https:\/\/doi.org\/10.1177\/1747493020920739","journal-title":"Int J Stroke"},{"issue":"3","key":"1085_CR6","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1002\/cne.10372","volume":"452","author":"K Agassandian","year":"2002","unstructured":"Agassandian K, Fazan VP, Adanina V, Talman WT (2002) Direct projections from the cardiovascular nucleus tractus solitarii to pontine preganglionic parasympathetic neurons: a link to cerebrovascular regulation. J Comp Neurol 452(3):242\u2013254. https:\/\/doi.org\/10.1002\/cne.10372","journal-title":"J Comp Neurol"},{"issue":"1","key":"1085_CR7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12975-022-01019-2","volume":"14","author":"MJ Cipolla","year":"2023","unstructured":"Cipolla MJ (2023) Therapeutic induction of collateral flow. Transl Stroke Res 14(1):53\u201365","journal-title":"Transl Stroke Res"},{"issue":"3","key":"1085_CR8","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1177\/23969873231177766","volume":"8","author":"J Jesser","year":"2023","unstructured":"Jesser J, Awounvo S, Vey JA, Vollherbst DF, Hilgenfeld T, Chen M et al (2023) Prediction and outcomes of cerebral vasospasm in ischemic stroke patients receiving anterior circulation endovascular stroke treatment. Eur Stroke J 8(3):684\u2013691","journal-title":"Eur Stroke J"},{"key":"1085_CR9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fneur.2020.00034","volume":"11","author":"F Pilato","year":"2020","unstructured":"Pilato F, Distefano M, Calandrelli R (2020) Posterior reversible encephalopathy syndrome and reversible cerebral vasoconstriction syndrome: clinical and radiological considerations. Front Neurol 11:34","journal-title":"Front Neurol"},{"issue":"1","key":"1085_CR10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2174\/1574887117666220810121048","volume":"18","author":"T Romenskaya","year":"2023","unstructured":"Romenskaya T, Longhitano Y, Piccolella F, Berger JM, Artico M, Taurone S et al (2023) Cerebral vasospasm: practical review of diagnosis and management. Rev Recent Clin Trials 18(1):12\u201318","journal-title":"Rev Recent Clin Trials"},{"key":"1085_CR11","doi-asserted-by":"publisher","first-page":"1800707","DOI":"10.1109\/JTEHM.2019.2937121","volume":"7","author":"D San-Juan","year":"2019","unstructured":"San-Juan D, Zenteno MA, Trinidad D, Meza F, Borsody MK, Godinez Garcia MM et al (2019) A pilot study of facial nerve stimulation on cerebral artery vasospasm in subarachnoid hemorrhage patients. IEEE J Transl Eng Health Med 7:1800707. https:\/\/doi.org\/10.1109\/JTEHM.2019.2937121","journal-title":"IEEE J Transl Eng Health Med"},{"issue":"4","key":"1085_CR12","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.3171\/2010.6.JNS091525","volume":"114","author":"M Takahashi","year":"2011","unstructured":"Takahashi M, Zhang ZD, Macdonald RL (2011) Sphenopalatine ganglion stimulation for vasospasm after experimental subarachnoid hemorrhage. J Neurosurg 114(4):1104\u20131109. https:\/\/doi.org\/10.3171\/2010.6.JNS091525","journal-title":"J Neurosurg"},{"issue":"1","key":"1085_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.surneu.2004.09.029","volume":"64","author":"D Yarnitsky","year":"2005","unstructured":"Yarnitsky D, Lorian A, Shalev A, Zhang ZD, Takahashi M, Agbaje-Williams M et al (2005) Reversal of cerebral vasospasm by sphenopalatine ganglion stimulation in a dog model of subarachnoid hemorrhage. Surg Neurol 64(1):5\u201311. https:\/\/doi.org\/10.1016\/j.surneu.2004.09.029. (discussion)","journal-title":"Surg Neurol"},{"key":"1085_CR14","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/B978-0-444-53491-0.00016-X","volume":"117","author":"PJ Goadsby","year":"2013","unstructured":"Goadsby PJ (2013) Autonomic nervous system control of the cerebral circulation. Handb Clin Neurol 117:193\u2013201. https:\/\/doi.org\/10.1016\/B978-0-444-53491-0.00016-X","journal-title":"Handb Clin Neurol"},{"issue":"7","key":"1085_CR15","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s11916-014-0432-5","volume":"18","author":"S Narouze","year":"2014","unstructured":"Narouze S (2014) Neurostimulation at pterygopalatine fossa for cluster headaches and cerebrovascular disorders. Curr Pain Headache Rep 18(7):432. https:\/\/doi.org\/10.1007\/s11916-014-0432-5","journal-title":"Curr Pain Headache Rep"},{"issue":"8","key":"1085_CR16","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1002\/ar.23833","volume":"301","author":"M Yamamoto","year":"2018","unstructured":"Yamamoto M, Ho Cho K, Murakami G, Abe S, Rodriguez-Vazquez JF (2018) Early fetal development of the otic and pterygopalatine ganglia with special reference to the topographical relationship with the developing sphenoid bone. Anat Rec (Hoboken) 301(8):1442\u20131453. https:\/\/doi.org\/10.1002\/ar.23833","journal-title":"Anat Rec (Hoboken)"},{"issue":"1","key":"1085_CR17","first-page":"31","volume":"48","author":"T Chyi","year":"2005","unstructured":"Chyi T, Wang SD, Gong CL, Lin SZ, Cheng V, Kuo JS (2005) Preganglionic neurons of the sphenopalatine ganglia reside in the dorsal facial area of the medulla in cats. Chin J Physiol 48(1):31\u201340","journal-title":"Chin J Physiol"},{"issue":"3","key":"1085_CR18","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1161\/01.str.22.3.331","volume":"22","author":"JE Hardebo","year":"1991","unstructured":"Hardebo JE, Arbab M, Suzuki N, Svendgaard NA (1991) Pathways of parasympathetic and sensory cerebrovascular nerves in monkeys. Stroke 22(3):331\u2013342. https:\/\/doi.org\/10.1161\/01.str.22.3.331","journal-title":"Stroke"},{"issue":"1","key":"1085_CR19","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1152\/jn.00295.2009","volume":"103","author":"W Margas","year":"2010","unstructured":"Margas W, Mahmoud S, Ruiz-Velasco V (2010) Muscarinic acetylcholine receptor modulation of mu (mu) opioid receptors in adult rat sphenopalatine ganglion neurons. J Neurophysiol 103(1):172\u2013182. https:\/\/doi.org\/10.1152\/jn.00295.2009","journal-title":"J Neurophysiol"},{"issue":"6","key":"1085_CR20","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1001\/archneurpsyc.1932.02240060016002","volume":"28","author":"J Chorobski","year":"1932","unstructured":"Chorobski J, Penfield W (1932) Cerebral vasodilator nerves and their pathway from the medulla oblongata: with observations on the pial and intracerebral vascular plexus. Arch Neurol Psychiatry 28(6):1257\u20131289. https:\/\/doi.org\/10.1001\/archneurpsyc.1932.02240060016002","journal-title":"Arch Neurol Psychiatry"},{"key":"1085_CR21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1159\/000323049","volume":"24","author":"CO Oluigbo","year":"2011","unstructured":"Oluigbo CO, Makonnen G, Narouze S, Rezai AR (2011) Sphenopalatine ganglion interventions: technical aspects and application. Prog Neurol Surg 24:171\u2013179. https:\/\/doi.org\/10.1159\/000323049","journal-title":"Prog Neurol Surg"},{"issue":"2","key":"1085_CR22","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1007\/s11916-010-0100-3","volume":"14","author":"SN Narouze","year":"2010","unstructured":"Narouze SN (2010) Role of sphenopalatine ganglion neuroablation in the management of cluster headache. Curr Pain Headache Rep 14(2):160\u2013163. https:\/\/doi.org\/10.1007\/s11916-010-0100-3","journal-title":"Curr Pain Headache Rep"},{"issue":"4","key":"1085_CR23","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4103\/2394-8108.195281","volume":"2","author":"MK Borsody","year":"2016","unstructured":"Borsody MK, Sacristan E (2016) Facial nerve stimulation as a future treatment for ischemic stroke. Brain circulation 2(4):164\u2013177","journal-title":"Brain circulation"},{"issue":"1","key":"1085_CR24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12967-018-1398-6","volume":"16","author":"O Sanchez","year":"2018","unstructured":"Sanchez O, Garcia A, Castro-Prado F, Perez M, Lara-Estrada R, Ramirez-Meza M et al (2018) Facial nerve stimulation in normal pigs and healthy human volunteers: transitional development of a medical device for the emergency treatment of ischemic stroke. J Transl Med 16(1):27. https:\/\/doi.org\/10.1186\/s12967-018-1398-6","journal-title":"J Transl Med"},{"issue":"7","key":"1085_CR25","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1161\/STROKEAHA.120.032773","volume":"52","author":"JM Marquez-Romero","year":"2021","unstructured":"Marquez-Romero JM, Huerta-Franco MR, Vargas-Luna M, Madrigal-Gutierrez CA, Esparza-Hernandez JM, Velazquez-Barcena MG (2021) Dose escalation and safety of capsaicin for cerebral perfusion augmentation: a pilot study. Stroke 52(7):2203\u20132209. https:\/\/doi.org\/10.1161\/STROKEAHA.120.032773","journal-title":"Stroke"},{"issue":"4","key":"1085_CR26","doi-asserted-by":"publisher","first-page":"e112","DOI":"10.1161\/STROKEAHA.123.046045","volume":"55","author":"JM Marquez-Romero","year":"2024","unstructured":"Marquez-Romero JM, Garcia-Perales C, Garcia-Arellano M, Ortiz MS, Perez-Malagon CD, Huerta-Franco MR et al (2024) Capsaicin for cerebral perfusion augmentation: a randomized open-label trial. Stroke 55(4):e112\u2013e114. https:\/\/doi.org\/10.1161\/STROKEAHA.123.046045","journal-title":"Stroke"},{"issue":"3","key":"1085_CR27","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1468-2982.2004.00649.x","volume":"24","author":"R Gottselig","year":"2004","unstructured":"Gottselig R, Messlinger K (2004) Noxious chemical stimulation of rat facial mucosa increases intracranial blood flow through a trigemino-parasympathetic reflex\u2013an experimental model for vascular dysfunctions in cluster headache. Cephalalgia 24(3):206\u2013214. https:\/\/doi.org\/10.1111\/j.1468-2982.2004.00649.x","journal-title":"Cephalalgia"},{"issue":"5","key":"1085_CR28","doi-asserted-by":"crossref","first-page":"H1352","DOI":"10.1152\/ajpheart.00950.2008","volume":"296","author":"JJ Iliff","year":"2009","unstructured":"Iliff JJ, Wang R, Zeldin DC, Alkayed NJ (2009) Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels. Am J Physiol-Heart Circul Physiol 296(5):H1352\u2013H1363","journal-title":"Am J Physiol-Heart Circul Physiol"},{"issue":"2","key":"1085_CR29","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1161\/01.str.4.2.213","volume":"4","author":"VD Salanga","year":"1973","unstructured":"Salanga VD, Waltz AG (1973) Regional cerebral blood flow during stimulation of seventh cranial nerve. Stroke 4(2):213\u2013217. https:\/\/doi.org\/10.1161\/01.str.4.2.213","journal-title":"Stroke"},{"issue":"6","key":"1085_CR30","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/jcbfm.1988.145","volume":"8","author":"J Seylaz","year":"1988","unstructured":"Seylaz J, Hara H, Pinard E, Mraovitch S, MacKenzie ET, Edvinsson L (1988) Effect of stimulation of the sphenopalatine ganglion on cortical blood flow in the rat. J Cereb Blood Flow Metab 8(6):875\u2013878. https:\/\/doi.org\/10.1038\/jcbfm.1988.145","journal-title":"J Cereb Blood Flow Metab"},{"issue":"11","key":"1085_CR31","doi-asserted-by":"crossref","first-page":"819","DOI":"10.5692\/clinicalneurol.52.819","volume":"52","author":"N Suzuki","year":"2012","unstructured":"Suzuki N (2012) Roles of cerebrovascular innervations and their neurotransmitters in various pathological conditions of central nervous system. Rinsho Shinkeigaku Clin Neurol 52(11):819\u2013824","journal-title":"Rinsho Shinkeigaku Clin Neurol"},{"issue":"1","key":"1085_CR32","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/BF01826054","volume":"1","author":"N Suzuki","year":"1991","unstructured":"Suzuki N, Gotoh F, Gotoh J, Koto A (1991) Evidence for in vivo cerebrovascular neurogenic vasodilatation in the rat. Clin Auton Res 1(1):23\u201326. https:\/\/doi.org\/10.1007\/BF01826054","journal-title":"Clin Auton Res"},{"issue":"3","key":"1085_CR33","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/jcbfm.1990.68","volume":"10","author":"N Suzuki","year":"1990","unstructured":"Suzuki N, Hardebo JE, Kahrstrom J, Owman C (1990) Selective electrical stimulation of postganglionic cerebrovascular parasympathetic nerve fibers originating from the sphenopalatine ganglion enhances cortical blood flow in the rat. J Cereb Blood Flow Metab 10(3):383\u2013391. https:\/\/doi.org\/10.1038\/jcbfm.1990.68","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"1085_CR34","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0006-8993(90)91211-x","volume":"506","author":"PJ Goadsby","year":"1990","unstructured":"Goadsby PJ (1990) Sphenopalatine ganglion stimulation increases regional cerebral blood flow independent of glucose utilization in the cat. Brain Res 506(1):145\u2013148. https:\/\/doi.org\/10.1016\/0006-8993(90)91211-x","journal-title":"Brain Res"},{"issue":"1 Pt 2","key":"1085_CR35","doi-asserted-by":"publisher","first-page":"R255","DOI":"10.1152\/ajpregu.1991.260.1.R255","volume":"260","author":"PJ Goadsby","year":"1991","unstructured":"Goadsby PJ (1991) Characteristics of facial nerve-elicited cerebral vasodilatation determined using laser Doppler flowmetry. Am J Physiol 260(1 Pt 2):R255\u2013R262. https:\/\/doi.org\/10.1152\/ajpregu.1991.260.1.R255","journal-title":"Am J Physiol"},{"issue":"1","key":"1085_CR36","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/0006-8993(95)01206-0","volume":"707","author":"PJ Goadsby","year":"1996","unstructured":"Goadsby PJ, Uddman R, Edvinsson L (1996) Cerebral vasodilatation in the cat involves nitric oxide from parasympathetic nerves. Brain Res 707(1):110\u2013118. https:\/\/doi.org\/10.1016\/0006-8993(95)01206-0","journal-title":"Brain Res"},{"issue":"4","key":"1085_CR37","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/jcbfm.1991.114","volume":"11","author":"M Kano","year":"1991","unstructured":"Kano M, Moskowitz MA, Yokota M (1991) Parasympathetic denervation of rat pial vessels significantly increases infarction volume following middle cerebral artery occlusion. J Cereb Blood Flow Metab 11(4):628\u2013637. https:\/\/doi.org\/10.1038\/jcbfm.1991.114","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"1085_CR38","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/jcbfm.1993.124","volume":"13","author":"Y Morita-Tsuzuki","year":"1993","unstructured":"Morita-Tsuzuki Y, Hardebo JE, Bouskela E (1993) Inhibition of nitric oxide synthase attenuates the cerebral blood flow response to stimulation of postganglionic parasympathetic nerves in the rat. J Cereb Blood Flow Metab 13(6):993\u2013997. https:\/\/doi.org\/10.1038\/jcbfm.1993.124","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"1085_CR39","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1161\/01.res.72.2.470","volume":"72","author":"M Nakai","year":"1993","unstructured":"Nakai M, Tamaki K, Ogata J, Matsui Y, Maeda M (1993) Parasympathetic cerebrovasodilator center of the facial nerve. Circ Res 72(2):470\u2013475. https:\/\/doi.org\/10.1161\/01.res.72.2.470","journal-title":"Circ Res"},{"key":"1085_CR40","doi-asserted-by":"publisher","unstructured":"Ayajiki K, Fujioka H, Shinozaki K, Okamura T. Effects of capsaicin and nitric oxide synthase inhibitor on increase in cerebral blood flow induced by sensory and parasympathetic nerve stimulation in the rat. J Appl Physiol (1985). 2005;98(5):1792\u20138. https:\/\/doi.org\/10.1152\/japplphysiol.00690.2004.","DOI":"10.1152\/japplphysiol.00690.2004"},{"issue":"4","key":"1085_CR41","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1097\/00004647-200004000-00007","volume":"20","author":"N Toda","year":"2000","unstructured":"Toda N, Ayajiki K, Tanaka T, Okamura T (2000) Preganglionic and postganglionic neurons responsible for cerebral vasodilation mediated by nitric oxide in anesthetized dogs. J Cereb Blood Flow Metab 20(4):700\u2013708. https:\/\/doi.org\/10.1097\/00004647-200004000-00007","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"1085_CR42","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/s0306-4522(99)00557-6","volume":"96","author":"N Toda","year":"2000","unstructured":"Toda N, Tanaka T, Ayajiki K, Okamura T (2000) Cerebral vasodilatation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anesthetized monkeys. Neuroscience 96(2):393\u2013398. https:\/\/doi.org\/10.1016\/s0306-4522(99)00557-6","journal-title":"Neuroscience"},{"key":"1085_CR43","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.brainres.2013.06.022","volume":"1528","author":"MK Borsody","year":"2013","unstructured":"Borsody MK, Yamada C, Bielawski D, Heaton T, Lyeth B, Garcia A et al (2013) Effect of pulsed magnetic stimulation of the facial nerve on cerebral blood flow. Brain Res 1528:58\u201367. https:\/\/doi.org\/10.1016\/j.brainres.2013.06.022","journal-title":"Brain Res"},{"key":"1085_CR44","doi-asserted-by":"publisher","first-page":"6599","DOI":"10.1109\/EMBC.2013.6611068","volume":"2013","author":"A Garcia","year":"2013","unstructured":"Garcia A, Sacristan E, Azpiroz J, Borsody MK (2013) Restored brain perfusion after non-invasive stimulation of the facial nerve in a canine stroke model. Annu Int Conf IEEE Eng Med Biol Soc 2013:6599\u20136602. https:\/\/doi.org\/10.1109\/EMBC.2013.6611068","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"issue":"4","key":"1085_CR45","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s10072-010-0238-0","volume":"31","author":"S Diansan","year":"2010","unstructured":"Diansan S, Shifen Z, Zhen G, Heming W, Xiangrui W (2010) Resection of the nerves bundle from the sphenopalatine ganglia tend to increase the infarction volume following middle cerebral artery occlusion. Neurol Sci 31(4):431\u2013435. https:\/\/doi.org\/10.1007\/s10072-010-0238-0","journal-title":"Neurol Sci"},{"issue":"6","key":"1085_CR46","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1002\/jmri.22110","volume":"31","author":"A Bar-Shir","year":"2010","unstructured":"Bar-Shir A, Shemesh N, Nossin-Manor R, Cohen Y (2010) Late stimulation of the sphenopalatine-ganglion in ischemic rats: improvement in N-acetyl-aspartate levels and diffusion weighted imaging characteristics as seen by MR. J Magn Reson Imaging 31(6):1355\u20131363. https:\/\/doi.org\/10.1002\/jmri.22110","journal-title":"J Magn Reson Imaging"},{"issue":"10","key":"1085_CR47","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1161\/STROKEAHA.107.485581","volume":"38","author":"N Henninger","year":"2007","unstructured":"Henninger N, Fisher M (2007) Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke. Stroke 38(10):2779\u20132786. https:\/\/doi.org\/10.1161\/STROKEAHA.107.485581","journal-title":"Stroke"},{"issue":"4","key":"1085_CR48","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1161\/STROKEAHA.113.003243","volume":"45","author":"MK Borsody","year":"2014","unstructured":"Borsody MK, Yamada C, Bielawski D, Heaton T, Castro Prado F, Garcia A et al (2014) Effects of noninvasive facial nerve stimulation in the dog middle cerebral artery occlusion model of ischemic stroke. Stroke 45(4):1102\u20131107. https:\/\/doi.org\/10.1161\/STROKEAHA.113.003243","journal-title":"Stroke"},{"issue":"10","key":"1085_CR49","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000446","volume":"54","author":"Expression of Concern for","year":"2023","unstructured":"Expression of Concern for (2023) Effects of noninvasive facial nerve stimulation in the dog middle cerebral artery occlusion model of ischemic stroke. Stroke 54(10):e480. https:\/\/doi.org\/10.1161\/STR.0000000000000446","journal-title":"Stroke"},{"issue":"8","key":"1085_CR50","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1161\/STROKEAHA.118.024582","volume":"50","author":"NM Bornstein","year":"2019","unstructured":"Bornstein NM, Saver JL, Diener HC, Gorelick PB, Shuaib A, Solberg Y et al (2019) Sphenopalatine ganglion stimulation to augment cerebral blood flow: a randomized. Sham-Controlled Trial Stroke 50(8):2108\u20132117. https:\/\/doi.org\/10.1161\/STROKEAHA.118.024582","journal-title":"Sham-Controlled Trial Stroke"},{"issue":"10194","key":"1085_CR51","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0140-6736(19)31192-4","volume":"394","author":"NM Bornstein","year":"2019","unstructured":"Bornstein NM, Saver JL, Diener HC, Gorelick PB, Shuaib A, Solberg Y et al (2019) An injectable implant to stimulate the sphenopalatine ganglion for treatment of acute ischaemic stroke up to 24 h from onset (ImpACT-24B): an international, randomised, double-blind, sham-controlled, pivotal trial. Lancet 394(10194):219\u2013229. https:\/\/doi.org\/10.1016\/S0140-6736(19)31192-4","journal-title":"Lancet"},{"issue":"6","key":"1085_CR52","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1111\/j.1747-4949.2009.00385.x","volume":"4","author":"D Khurana","year":"2009","unstructured":"Khurana D, Kaul S, Bornstein NM, Imp ACTSG (2009) Implant for augmentation of cerebral blood flow trial 1: a pilot study evaluating the safety and effectiveness of the Ischaemic Stroke System for treatment of acute ischaemic stroke. Int J Stroke 4(6):480\u2013485. https:\/\/doi.org\/10.1111\/j.1747-4949.2009.00385.x","journal-title":"Int J Stroke"},{"issue":"7","key":"1085_CR53","doi-asserted-by":"publisher","first-page":"e0217472","DOI":"10.1371\/journal.pone.0217472","volume":"14","author":"D Khurana","year":"2019","unstructured":"Khurana D, Kaul S, Schneider D, Csanyi A, Adam I, Ichaporia NR et al (2019) Implant for Augmentation of Cerebral Blood Flow Trial-1 (ImpACT-1). A single-arm feasibility study evaluating the safety and potential benefit of the Ischemic Stroke System for treatment of acute ischemic stroke. PLoS ONE 14(7):e0217472. https:\/\/doi.org\/10.1371\/journal.pone.0217472","journal-title":"PLoS ONE"},{"issue":"12","key":"1085_CR54","doi-asserted-by":"publisher","first-page":"3512","DOI":"10.1161\/STROKEAHA.119.027177","volume":"50","author":"JL Saver","year":"2019","unstructured":"Saver JL, Kharaishvili N, Janelidze T, Beridze M, Zarqua N, Solberg Y et al (2019) Refined Sphenopalatine Ganglion Stimulator Placement and Intensity Setting to Augment Blood Flow and Neurologic Function. Stroke 50(12):3512\u20133518. https:\/\/doi.org\/10.1161\/STROKEAHA.119.027177","journal-title":"Stroke"},{"key":"1085_CR55","doi-asserted-by":"publisher","first-page":"1352145","DOI":"10.3389\/fneur.2024.1352145","volume":"15","author":"L Qin","year":"2024","unstructured":"Qin L, Chen D, Li X, Gao Y, Xia W, Dai H et al (2024) Sphenopalatine ganglion stimulation: a comprehensive evaluation across diseases in randomized controlled trials. Front Neurol 15:1352145. https:\/\/doi.org\/10.3389\/fneur.2024.1352145","journal-title":"Front Neurol"},{"issue":"Supplement","key":"1085_CR56","doi-asserted-by":"publisher","first-page":"S231","DOI":"10.4103\/0028-3886.302477","volume":"68","author":"KF Rajneesh","year":"2020","unstructured":"Rajneesh KF (2020) Occipital nerve stimulation and sphenopalatine ganglion stimulation for treatment of intractable headache syndromes. Neurol India 68(Supplement):S231\u2013S234. https:\/\/doi.org\/10.4103\/0028-3886.302477","journal-title":"Neurol India"},{"issue":"6","key":"1085_CR57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039636","volume":"7","author":"H Levi","year":"2012","unstructured":"Levi H, Schoknecht K, Prager O, Chassidim Y, Weissberg I, Serlin Y et al (2012) Stimulation of the sphenopalatine ganglion induces reperfusion and blood-brain barrier protection in the photothrombotic stroke model. PLoS ONE 7(6):e39636. https:\/\/doi.org\/10.1371\/journal.pone.0039636","journal-title":"PLoS ONE"},{"key":"1085_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.105949","volume":"195","author":"H AlHarfany","year":"2020","unstructured":"AlHarfany H, Haidar L, Cherri S, Malaeb D, Salameh P, Hosseini H (2020) Assessment of acute treatment of hypertension in ischemic stroke patients. Clin Neurol Neurosurg 195:105949. https:\/\/doi.org\/10.1016\/j.clineuro.2020.105949","journal-title":"Clin Neurol Neurosurg"},{"issue":"6","key":"1085_CR59","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1097\/HJH.0000000000001704","volume":"36","author":"D Gasecki","year":"2018","unstructured":"Gasecki D, Coca A, Cunha P, Hering D, Manios E, Lovic D et al (2018) Blood pressure in acute ischemic stroke: challenges in trial interpretation and clinical management: position of the ESH Working Group on Hypertension and the Brain. J Hypertens 36(6):1212\u20131221. https:\/\/doi.org\/10.1097\/HJH.0000000000001704","journal-title":"J Hypertens"},{"issue":"3","key":"1085_CR60","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.neurad.2018.09.008","volume":"46","author":"NS Hartkamp","year":"2019","unstructured":"Hartkamp NS, Hendrikse J, de Borst GJ, Kappelle LJ, Bokkers RPH (2019) Intracerebral steal phenomenon in symptomatic carotid artery disease. J Neuroradiol 46(3):173\u2013178. https:\/\/doi.org\/10.1016\/j.neurad.2018.09.008","journal-title":"J Neuroradiol"},{"issue":"11","key":"1085_CR61","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1161\/STROKEAHA.107.482810","volume":"38","author":"AV Alexandrov","year":"2007","unstructured":"Alexandrov AV, Sharma VK, Lao AY, Tsivgoulis G, Malkoff MD, Alexandrov AW (2007) Reversed Robin Hood syndrome in acute ischemic stroke patients. Stroke 38(11):3045\u20133048. https:\/\/doi.org\/10.1161\/STROKEAHA.107.482810","journal-title":"Stroke"},{"issue":"1","key":"1085_CR62","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1113\/JP281058","volume":"600","author":"JL Koep","year":"2022","unstructured":"Koep JL, Taylor CE, Coombes JS, Bond B, Ainslie PN, Bailey TG (2022) Autonomic control of cerebral blood flow: fundamental comparisons between peripheral and cerebrovascular circulations in humans. J Physiol 600(1):15\u201339. https:\/\/doi.org\/10.1113\/JP281058","journal-title":"J Physiol"},{"key":"1085_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2023.103082","volume":"246","author":"A Mankoo","year":"2023","unstructured":"Mankoo A, Roy S, Davies A, Panerai RB, Robinson TG, Brassard P et al (2023) The role of the autonomic nervous system in cerebral blood flow regulation in stroke: a review. Auton Neurosci 246:103082. https:\/\/doi.org\/10.1016\/j.autneu.2023.103082","journal-title":"Auton Neurosci"},{"issue":"10194","key":"1085_CR64","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0140-6736(19)31412-6","volume":"394","author":"EC Sandset","year":"2019","unstructured":"Sandset EC, Ford GA (2019) Sphenopalatine ganglion stimulation after stroke, promising but not yet ready for adoption. Lancet 394(10194):189\u2013190. https:\/\/doi.org\/10.1016\/S0140-6736(19)31412-6","journal-title":"Lancet"},{"issue":"1","key":"1085_CR65","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/00004647-199701000-00009","volume":"17","author":"RB Buxton","year":"1997","unstructured":"Buxton RB, Frank LR (1997) A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. J Cereb Blood Flow Metab 17(1):64\u201372","journal-title":"J Cereb Blood Flow Metab"},{"issue":"8","key":"1085_CR66","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1161\/STROKEAHA.119.026029","volume":"50","author":"MP Sphenopalatine","year":"2019","unstructured":"Sphenopalatine MP, Stimulation G (2019) Stroke 50(8):1954\u20131955. https:\/\/doi.org\/10.1161\/STROKEAHA.119.026029","journal-title":"Stroke"},{"issue":"3","key":"1085_CR67","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/micc.12177","volume":"22","author":"IR Winship","year":"2015","unstructured":"Winship IR (2015) Cerebral collaterals and collateral therapeutics for acute ischemic stroke. Microcirculation 22(3):228\u2013236. https:\/\/doi.org\/10.1111\/micc.12177","journal-title":"Microcirculation"},{"issue":"01","key":"1085_CR68","doi-asserted-by":"publisher","first-page":"i62","DOI":"10.1136\/neurintsurg-2012-010512","volume":"5 Suppl 1","author":"KN Sheth","year":"2013","unstructured":"Sheth KN, Terry JB, Nogueira RG, Horev A, Nguyen TN, Fong AK et al (2013) Advanced modality imaging evaluation in acute ischemic stroke may lead to delayed endovascular reperfusion therapy without improvement in clinical outcomes. J Neurointerv Surg. 5 Suppl 1(01):i62\u2013i65. https:\/\/doi.org\/10.1136\/neurintsurg-2012-010512","journal-title":"J Neurointerv Surg."},{"issue":"6","key":"1085_CR69","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/s41582-018-0002-2","volume":"14","author":"JC Baron","year":"2018","unstructured":"Baron JC (2018) Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke. Nat Rev Neurol 14(6):325\u2013337. https:\/\/doi.org\/10.1038\/s41582-018-0002-2","journal-title":"Nat Rev Neurol"},{"issue":"9","key":"1085_CR70","doi-asserted-by":"publisher","first-page":"e922","DOI":"10.1212\/WNL.0000000000207536","volume":"101","author":"Q Li","year":"2023","unstructured":"Li Q, Abdalkader M, Siegler JE, Yaghi S, Sarraj A, Campbell BCV et al (2023) Mechanical thrombectomy for large ischemic stroke: a systematic review and meta-analysis. Neurology 101(9):e922\u2013e932. https:\/\/doi.org\/10.1212\/WNL.0000000000207536","journal-title":"Neurology"},{"issue":"8","key":"1085_CR71","doi-asserted-by":"publisher","first-page":"2794","DOI":"10.1111\/ene.14916","volume":"28","author":"JC Baron","year":"2021","unstructured":"Baron JC (2021) The core\/penumbra model: implications for acute stroke treatment and patient selection in 2021. Eur J Neurol 28(8):2794\u20132803. https:\/\/doi.org\/10.1111\/ene.14916","journal-title":"Eur J Neurol"},{"issue":"8","key":"1085_CR72","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1161\/01.str.0000025518.34157.51","volume":"33","author":"DJ Gladstone","year":"2002","unstructured":"Gladstone DJ, Black SE, Hakim AM, Heart, Stroke Foundation of Ontario Centre of Excellence in Stroke R (2002) Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 33(8):2123\u20132136. https:\/\/doi.org\/10.1161\/01.str.0000025518.34157.51","journal-title":"Stroke"},{"issue":"11","key":"1085_CR73","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1161\/STROKEAHA.111.618801","volume":"42","author":"BT Bratane","year":"2011","unstructured":"Bratane BT, Cui H, Cook DJ, Bouley J, Tymianski M, Fisher M (2011) Neuroprotection by freezing ischemic penumbra evolution without cerebral blood flow augmentation with a postsynaptic density-95 protein inhibitor. Stroke 42(11):3265\u20133270. https:\/\/doi.org\/10.1161\/STROKEAHA.111.618801","journal-title":"Stroke"},{"issue":"4","key":"1085_CR74","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1161\/STROKEAHA.118.022815","volume":"50","author":"P Seners","year":"2019","unstructured":"Seners P, Roca P, Legrand L, Turc G, Cottier JP, Cho TH et al (2019) Better Collaterals Are Independently Associated With Post-Thrombolysis Recanalization Before Thrombectomy. Stroke 50(4):867\u2013872. https:\/\/doi.org\/10.1161\/STROKEAHA.118.022815","journal-title":"Stroke"},{"key":"1085_CR75","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.753182","volume":"12","author":"TS Baker","year":"2021","unstructured":"Baker TS, Robeny J, Cruz D, Bruhat A, Iloreta AM, Costa A et al (2021) Stimulating the facial nerve to treat ischemic stroke: a systematic review. Front Neurol 12:753182. https:\/\/doi.org\/10.3389\/fneur.2021.753182","journal-title":"Front Neurol"},{"issue":"3","key":"1085_CR76","first-page":"122","volume":"22","author":"YC Wang","year":"1998","unstructured":"Wang YC, Kuo JS, Lin SZ (1998) The effect of sphenopalatine postganglionic neurotomy on the alteration of local cerebral blood flow of normotensive and hypertensive rats in acute cold stress. Proc Natl Sci Counc Repub China B 22(3):122\u2013128","journal-title":"Proc Natl Sci Counc Repub China B"},{"issue":"3","key":"1085_CR77","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/nimg.1996.0021","volume":"3","author":"H Fukuyama","year":"1996","unstructured":"Fukuyama H, Ouchi Y, Matsuzaki S, Ogawa M, Yamauchi H, Nagahama Y et al (1996) Focal cortical blood flow activation is regulated by intrinsic cortical cholinergic neurons. Neuroimage 3(3):195\u2013201","journal-title":"Neuroimage"},{"issue":"2","key":"1085_CR78","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.autneu.2006.12.002","volume":"133","author":"WT Talman","year":"2007","unstructured":"Talman WT, Corr J, Nitschke Dragon D, Wang D (2007) Parasympathetic stimulation elicits cerebral vasodilatation in rat. Auton Neurosci 133(2):153\u2013157. https:\/\/doi.org\/10.1016\/j.autneu.2006.12.002","journal-title":"Auton Neurosci"},{"issue":"1\u20132","key":"1085_CR79","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.autneu.2009.01.009","volume":"147","author":"NC Boysen","year":"2009","unstructured":"Boysen NC, Dragon DN, Talman WT (2009) Parasympathetic tonic dilatory influences on cerebral vessels. Auton Neurosci 147(1\u20132):101\u2013104. https:\/\/doi.org\/10.1016\/j.autneu.2009.01.009","journal-title":"Auton Neurosci"}],"container-title":["Clinical Autonomic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-024-01085-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10286-024-01085-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-024-01085-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T01:23:07Z","timestamp":1743211387000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10286-024-01085-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["1085"],"URL":"https:\/\/doi.org\/10.1007\/s10286-024-01085-6","relation":{},"ISSN":["0959-9851","1619-1560"],"issn-type":[{"type":"print","value":"0959-9851"},{"type":"electronic","value":"1619-1560"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"8 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study did not involve human participants, their data or biological material.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}