{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T04:13:45Z","timestamp":1749096825693,"version":"3.41.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","award":["96108"],"award-info":[{"award-number":["96108"]}],"id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007753","name":"University of Eastern Finland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007753","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin. Auton. Res."],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Cardiovascular autonomic neuropathy remains underdiagnosed in type\u00a01 diabetes mellitus, posing a risk for severe complications, particularly in patients with lowered V\u0307O<jats:sub>2max<\/jats:sub>, compared to controls. This study aimed to determine whether heart rate variability during cardiovascular autonomic reflex tests reveals early signs of cardiovascular autonomic neuropathy in patients with uncomplicated type\u00a01 diabetes mellitus and normal cardiovascular fitness, compared to healthy controls.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A type\u00a01 diabetes mellitus group (<jats:italic>n<\/jats:italic>\u2009=\u200914) with no other diagnosed diseases (diabetes duration 15\u2009\u00b1\u20097\u00a0years) and a control group (<jats:italic>n<\/jats:italic>\u2009=\u200931) underwent deep breathing test, passive orthostatic test, and cardiopulmonary exercise test. Participants were assessed for heart rate variability, heart rate, blood pressure, and V\u0307O<jats:sub>2max<\/jats:sub> (mL\/min\/kg).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Participant characteristics, including V\u0307O<jats:sub>2max<\/jats:sub> (mL\/min\/kg), showed no significant differences. The type\u00a01 diabetes mellitus group had higher systolic blood pressure during the supine phase of the orthostatic test than healthy controls (131.6\u2009\u00b1\u200914.7\u00a0mmHg vs. 122.4\u2009\u00b1\u200910.8\u00a0mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.022). After 5\u00a0mins in the upright position, systolic blood pressure (132.2\u2009\u00b1\u200920.6\u00a0mmHg vs. 118.7\u2009\u00b1\u200911.7\u00a0mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.036), heart rate (85 (76; 89) bpm vs. 75 (72; 83) bpm, <jats:italic>p<\/jats:italic>\u2009=\u20090.013), and the root mean square of successive RR interval differences (20.22 (11.22; 27.42) vs. 27.11 (19.90; 35.52), <jats:italic>p<\/jats:italic>\u2009=\u20090.033) were significantly different compared to controls.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Patients with uncomplicated type\u00a01 diabetes mellitus, despite having normal cardiorespiratory fitness, exhibited higher systolic pressure and greater sympathetic activation in orthostatic tests, suggesting subclinically altered cardiovascular autonomic function.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10286-024-01094-5","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T01:21:08Z","timestamp":1734398468000},"page":"381-391","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Orthostatic test shows\u00a0higher\u00a0systolic blood pressure and\u00a0sympathetic response in uncomplicated type\u00a01 diabetes\u00a0patients with normal V\u0307O2max\u00a0vs. healthy controls"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8713-7365","authenticated-orcid":false,"given":"Samu","family":"Sorola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4696-2307","authenticated-orcid":false,"given":"Vesa","family":"Hyryl\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2622-3971","authenticated-orcid":false,"given":"Timo","family":"Eronen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9168-8159","authenticated-orcid":false,"given":"Saana","family":"Kupari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-9760","authenticated-orcid":false,"given":"Mika","family":"Venoj\u00e4rvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6067-4101","authenticated-orcid":false,"given":"Heikki","family":"Tikkanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8686-5395","authenticated-orcid":false,"given":"Mika","family":"Tarvainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1565-0909","authenticated-orcid":false,"given":"Harri","family":"Lindholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"issue":"10138","key":"1094_CR1","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1016\/S0140-6736(18)31320-5","volume":"391","author":"LA DiMeglio","year":"2018","unstructured":"DiMeglio LA, Evans-Molina C, Oram RA (2018) Type\u00a01 diabetes. Lancet 391(10138):2449\u20132462. https:\/\/doi.org\/10.1016\/S0140-6736(18)31320-5","journal-title":"Lancet"},{"issue":"3","key":"1094_CR2","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1161\/circulationaha.106.634949","volume":"115","author":"AI Vinik","year":"2007","unstructured":"Vinik AI, Ziegler D (2007) Diabetic cardiovascular autonomic neuropathy. Circulation 115(3):387\u2013397. https:\/\/doi.org\/10.1161\/circulationaha.106.634949","journal-title":"Circulation"},{"issue":"10","key":"1094_CR3","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.2337\/dc10-1303","volume":"33","author":"S Tesfaye","year":"2010","unstructured":"Tesfaye S et al (2010) Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care 33(10):2285\u20132293. https:\/\/doi.org\/10.2337\/dc10-1303","journal-title":"Diabetes Care"},{"issue":"4","key":"1094_CR4","doi-asserted-by":"publisher","first-page":"251","DOI":"10.14797\/mdcj-14-4-251","volume":"14","author":"S Agashe","year":"2018","unstructured":"Agashe S, Petak S (2018) Cardiac autonomic neuropathy in diabetes mellitus. Methodist Debakey Cardiovasc J 14(4):251\u2013256. https:\/\/doi.org\/10.14797\/mdcj-14-4-251","journal-title":"Methodist Debakey Cardiovasc J"},{"issue":"4","key":"1094_CR5","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/dmr.5610100403","volume":"10","author":"D Ziegler","year":"1994","unstructured":"Ziegler D (1994) Diabetic cardiovascular autonomic neuropathy: prognosis, diagnosis and treatment. Diabetes Metab Rev 10(4):339\u2013383. https:\/\/doi.org\/10.1002\/dmr.5610100403","journal-title":"Diabetes Metab Rev"},{"key":"1094_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.937701","author":"P Castiglioni","year":"2022","unstructured":"Castiglioni P et al (2022) Heart rate variability for the early detection of cardiac autonomic dysfunction in type\u00a01 diabetes. Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2022.937701","journal-title":"Front Physiol"},{"issue":"2","key":"1094_CR7","doi-asserted-by":"publisher","first-page":"434","DOI":"10.2337\/dc09-1294","volume":"33","author":"R Pop-Busui","year":"2010","unstructured":"Pop-Busui R (2010) Cardiac autonomic neuropathy in diabetes. Diabetes Care 33(2):434\u2013441. https:\/\/doi.org\/10.2337\/dc09-1294","journal-title":"Diabetes Care"},{"issue":"2","key":"1094_CR8","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1249\/MSS.0000000000000424","volume":"47","author":"S Tagougui","year":"2015","unstructured":"Tagougui S et al (2015) Muscle oxygen supply impairment during exercise in poorly controlled type\u00a01 diabetes. Med Sci Sports Exerc 47(2):231\u2013239. https:\/\/doi.org\/10.1249\/MSS.0000000000000424","journal-title":"Med Sci Sports Exerc"},{"issue":"6S","key":"1094_CR9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1249\/01.mss.0000560580.17144.a0","volume":"51","author":"CJ Cruz","year":"2019","unstructured":"Cruz CJ, Porto LG, Costa GA, Molina GE (2019) Relationship between heart rate variability threshold and 5-km outdoor running performance in non-athletes. Med Sci Sports Exerc 51(6S):30\u201330. https:\/\/doi.org\/10.1249\/01.mss.0000560580.17144.a0","journal-title":"Med Sci Sports Exerc"},{"key":"1094_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00337","author":"CC Grant","year":"2013","unstructured":"Grant CC, Murray C, Janse van Rensburg DC, Fletcher L (2013) A comparison between heart rate and heart rate variability as indicators of cardiac health and fitness. Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2013.00337","journal-title":"Front Physiol"},{"key":"1094_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2017.00258","author":"F Shaffer","year":"2017","unstructured":"Shaffer F, Ginsberg JP (2017) An overview of heart rate variability metrics and norms. Front Public Health. https:\/\/doi.org\/10.3389\/fpubh.2017.00258","journal-title":"Front Public Health"},{"key":"1094_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1430458","author":"S Sammito","year":"2024","unstructured":"Sammito S, Thielmann B, B\u00f6ckelmann I (2024) Update: factors influencing heart rate variability\u2013a narrative review. Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2024.1430458","journal-title":"Front Physiol"},{"issue":"8","key":"1094_CR13","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13248","volume":"5","author":"LC Wilson","year":"2017","unstructured":"Wilson LC et al (2017) Resting heart rate variability and exercise capacity in type\u00a01 diabetes. Physiol Rep 5(8):e13248. https:\/\/doi.org\/10.14814\/phy2.13248","journal-title":"Physiol Rep"},{"issue":"11","key":"1094_CR14","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.2337\/dc16-1728","volume":"39","author":"SR Colberg","year":"2016","unstructured":"Colberg SR et al (2016) Physical activity\/exercise and diabetes: a position statement of the American Diabetes Association. Diabetes Care 39(11):2065\u20132079. https:\/\/doi.org\/10.2337\/dc16-1728","journal-title":"Diabetes Care"},{"issue":"5","key":"1094_CR15","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1152\/jappl.1993.75.5.2310","volume":"75","author":"TE Brown","year":"1993","unstructured":"Brown TE, Beightol LA, Koh J, Eckberg DL (1993) Important influence of respiration on human R-R interval power spectra is largely ignored. J Appl Physiol 75(5):2310\u20132317. https:\/\/doi.org\/10.1152\/jappl.1993.75.5.2310","journal-title":"J Appl Physiol"},{"issue":"4","key":"1094_CR16","doi-asserted-by":"publisher","first-page":"H967","DOI":"10.1152\/ajpheart.1990.258.4.H967","volume":"258","author":"O Rimoldi","year":"1990","unstructured":"Rimoldi O, Pierini S, Ferrari A, Cerutti S, Pagani M, Malliani A (1990) Analysis of short-term oscillations of R-R and arterial pressure in conscious dogs. Am J Physiol 258(4):H967\u2013H976. https:\/\/doi.org\/10.1152\/ajpheart.1990.258.4.H967","journal-title":"Am J Physiol"},{"issue":"4","key":"1094_CR17","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1161\/01.CIR.90.4.1826","volume":"90","author":"N Montano","year":"1994","unstructured":"Montano N, Ruscone TG, Porta A, Lombardi F, Pagani M, Malliani A (1994) Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt. Circulation 90(4):1826\u20131831. https:\/\/doi.org\/10.1161\/01.CIR.90.4.1826","journal-title":"Circulation"},{"issue":"3","key":"1094_CR18","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1093\/oxfordjournals.eurheartj.a014868","volume":"17","author":"M Malik","year":"1996","unstructured":"Malik M et al (1996) Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Eur Heart J 17(3):354\u2013381. https:\/\/doi.org\/10.1093\/oxfordjournals.eurheartj.a014868","journal-title":"Eur Heart J"},{"issue":"12","key":"1094_CR19","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1113\/expphysiol.2010.056259","volume":"96","author":"DS Goldstein","year":"2011","unstructured":"Goldstein DS, Bentho O, Park M-Y, Sharabi Y (2011) Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes. Exp Physiol 96(12):1255\u20131261. https:\/\/doi.org\/10.1113\/expphysiol.2010.056259","journal-title":"Exp Physiol"},{"key":"1094_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.01040","author":"F Shaffer","year":"2014","unstructured":"Shaffer F, McCraty R, Zerr CL (2014) A healthy heart is not a metronome: an integrative review of the heart\u2019s anatomy and heart rate variability. Front Psychol. https:\/\/doi.org\/10.3389\/fpsyg.2014.01040","journal-title":"Front Psychol"},{"issue":"1","key":"1094_CR21","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1042\/cs0880103","volume":"88","author":"P Sleight","year":"1995","unstructured":"Sleight P et al (1995) Physiology and pathophysiology of heart rate and blood pressure variability in humans: is power spectral analysis largely an index of baroreflex gain? Clin Sci 88(1):103\u2013109. https:\/\/doi.org\/10.1042\/cs0880103","journal-title":"Clin Sci"},{"issue":"4","key":"1094_CR22","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/cpf.12096","volume":"34","author":"S Sepp\u00e4l\u00e4","year":"2014","unstructured":"Sepp\u00e4l\u00e4 S et al (2014) Normal values for heart rate variability parameters in children 6\u20138\u00a0years of age: the PANIC Study. Clin Physiol Funct Imaging 34(4):290\u2013296. https:\/\/doi.org\/10.1111\/cpf.12096","journal-title":"Clin Physiol Funct Imaging"},{"issue":"4","key":"1094_CR23","doi-asserted-by":"publisher","first-page":"H620","DOI":"10.1152\/ajpheart.1981.241.4.H620","volume":"241","author":"JA Hirsch","year":"1981","unstructured":"Hirsch JA, Bishop B (1981) Respiratory sinus arrhythmia in humans: how breathing pattern modulates heart rate. Am J Physiol 241(4):H620\u2013H629. https:\/\/doi.org\/10.1152\/ajpheart.1981.241.4.H620","journal-title":"Am J Physiol"},{"issue":"6","key":"1094_CR24","doi-asserted-by":"publisher","first-page":"H838","DOI":"10.1152\/ajpheart.1984.246.6.H838","volume":"246","author":"FM Fouad","year":"1984","unstructured":"Fouad FM, Tarazi RC, Ferrario CM, Fighaly S, Alicandri C (1984) Assessment of parasympathetic control of heart rate by a noninvasive method. Am J Physiol 246(6):H838\u2013H842. https:\/\/doi.org\/10.1152\/ajpheart.1984.246.6.H838","journal-title":"Am J Physiol"},{"issue":"6","key":"1094_CR25","doi-asserted-by":"publisher","first-page":"648","DOI":"10.2337\/diacare.9.6.648","volume":"9","author":"DJ Ewing","year":"1986","unstructured":"Ewing DJ, Clarke BF (1986) Diabetic autonomic neuropathy: present insights and future prospects. Diabetes Care 9(6):648\u2013665. https:\/\/doi.org\/10.2337\/diacare.9.6.648","journal-title":"Diabetes Care"},{"issue":"2","key":"1094_CR26","first-page":"243","volume":"45","author":"AP Gauer","year":"1965","unstructured":"Gauer AP, Tiron Otto H (1965) Postural changes in blood volume and pressure in humans. Physiol Rev. 45(2):243\u2013269","journal-title":"Physiol Rev"},{"issue":"11","key":"1094_CR27","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.jacc.2018.05.079","volume":"72","author":"R Freeman","year":"2018","unstructured":"Freeman R, Abuzinadah AR, Gibbons C, Jones P, Miglis MG, Sinn DI (2018) Orthostatic hypotension. J Am Coll Cardiol 72(11):1294\u20131309. https:\/\/doi.org\/10.1016\/j.jacc.2018.05.079","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"1094_CR28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1475-2840-13-28","volume":"13","author":"DZ Cherney","year":"2014","unstructured":"Cherney DZ et al (2014) The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type\u00a01 diabetes mellitus. Cardiovasc Diabetol 13(1):28. https:\/\/doi.org\/10.1186\/1475-2840-13-28","journal-title":"Cardiovasc Diabetol"},{"issue":"3","key":"1094_CR29","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1161\/hypertensionaha.109.142190","volume":"55","author":"J Bellien","year":"2010","unstructured":"Bellien J et al (2010) Arterial stiffness is regulated by nitric oxide and endothelium-derived hyperpolarizing factor during changes in blood flow in humans. Hypertension 55(3):674\u2013680. https:\/\/doi.org\/10.1161\/hypertensionaha.109.142190","journal-title":"Hypertension"},{"issue":"1","key":"1094_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4239\/wjd.v3.i1.1","volume":"3","author":"AN Sasson","year":"2012","unstructured":"Sasson AN (2012) Renal hyperfiltration related to diabetes mellitus and obesity in human disease. World J Diabetes 3(1):1. https:\/\/doi.org\/10.4239\/wjd.v3.i1.1","journal-title":"World J Diabetes"},{"issue":"11","key":"1094_CR31","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/sj.jhh.1001751","volume":"18","author":"FJ van Ittersum","year":"2004","unstructured":"van Ittersum FJ et al (2004) Autonomic nervous function, arterial stiffness and blood pressure in patients with type\u00a0I diabetes mellitus and normal urinary albumin excretion. J Hum Hypertens 18(11):761\u2013768. https:\/\/doi.org\/10.1038\/sj.jhh.1001751","journal-title":"J Hum Hypertens"},{"issue":"11","key":"1094_CR32","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1111\/j.1440-1681.2004.04074.x","volume":"31","author":"IB Wilkinson","year":"2004","unstructured":"Wilkinson IB, McEniery CM (2004) Arterial stiffness, endothelial function and novel pharmacological approaches. Clin Exp Pharmacol Physiol 31(11):795\u2013799. https:\/\/doi.org\/10.1111\/j.1440-1681.2004.04074.x","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"1\u20132","key":"1094_CR33","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1081\/CEH-100001196","volume":"23","author":"PC Perin","year":"2001","unstructured":"Perin PC, Maule S, Quadri R (2001) Sympathetic nervous system, diabetes, and hypertension. Clin Exp Hypertens 23(1\u20132):45\u201355. https:\/\/doi.org\/10.1081\/CEH-100001196","journal-title":"Clin Exp Hypertens"},{"issue":"6","key":"1094_CR34","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1080\/08037051.2018.1527177","volume":"27","author":"B Williams","year":"2018","unstructured":"Williams B et al (2018) 2018 Practice guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. Blood Press 27(6):314\u2013340. https:\/\/doi.org\/10.1080\/08037051.2018.1527177","journal-title":"Blood Press"},{"issue":"3","key":"1094_CR35","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0002-9149(00)00920-6","volume":"86","author":"JP Singh","year":"2000","unstructured":"Singh JP et al (2000) Association of hyperglycemia with reduced heart rate variability (The Framingham Heart Study). Am J Cardiol 86(3):309\u2013312. https:\/\/doi.org\/10.1016\/S0002-9149(00)00920-6","journal-title":"Am J Cardiol"},{"issue":"4","key":"1094_CR36","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1097\/00000441-198804000-00019","volume":"295","author":"MW Chapleau","year":"1988","unstructured":"Chapleau MW, Hajduczok G, Abboud FM (1988) Mechanisms of resetting of arterial baroreceptors: an overview. Am J Med Sci 295(4):327\u2013334. https:\/\/doi.org\/10.1097\/00000441-198804000-00019","journal-title":"Am J Med Sci"},{"issue":"5","key":"1094_CR37","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1152\/japplphysiol.91107.2008a","volume":"106","author":"JM Karemaker","year":"2009","unstructured":"Karemaker JM (2009) Counterpoint: respiratory sinus arrhythmia is due to the baroreflex mechanism. J Appl Physiol 106(5):1742\u20131743. https:\/\/doi.org\/10.1152\/japplphysiol.91107.2008a","journal-title":"J Appl Physiol"}],"container-title":["Clinical Autonomic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-024-01094-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10286-024-01094-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-024-01094-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T14:54:00Z","timestamp":1749048840000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10286-024-01094-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["1094"],"URL":"https:\/\/doi.org\/10.1007\/s10286-024-01094-5","relation":{},"ISSN":["0959-9851","1619-1560"],"issn-type":[{"type":"print","value":"0959-9851"},{"type":"electronic","value":"1619-1560"}],"subject":[],"published":{"date-parts":[[2024,12,17]]},"assertion":[{"value":"21 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}