{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T02:53:25Z","timestamp":1781492005183,"version":"3.54.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1OT2HL156812-01"],"award-info":[{"award-number":["1OT2HL156812-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FBRI","award":["2022A018462"],"award-info":[{"award-number":["2022A018462"]}]},{"name":"Mona Taliaferro\/Bay Shore Recycling"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin. Auton. Res."],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10286-026-01193-5","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T18:24:50Z","timestamp":1772475890000},"page":"367-372","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utilization of machine learning in diagnosis of postural tachycardia syndrome (POTS)"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5971-1208","authenticated-orcid":false,"given":"Seiji","family":"Akera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2501-7397","authenticated-orcid":false,"given":"Peter","family":"Novak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"1193_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2021.102828","volume":"235","author":"S Vernino","year":"2021","unstructured":"Vernino S, Bourne KM, Stiles LE et al (2021) Postural orthostatic tachycardia syndrome (POTS): state of the science and clinical care from a 2019 National Institutes of Health expert consensus meeting - Part 1. Auton Neurosci 235:102828. https:\/\/doi.org\/10.1016\/j.autneu.2021.102828","journal-title":"Auton Neurosci"},{"key":"1193_CR2","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/joim.12852","volume":"285","author":"A Fedorowski","year":"2019","unstructured":"Fedorowski A (2019) Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management. J Intern Med 285:352\u2013366. https:\/\/doi.org\/10.1111\/joim.12852","journal-title":"J Intern Med"},{"key":"1193_CR3","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1016\/j.hrthm.2015.03.029","volume":"12","author":"RS Sheldon","year":"2015","unstructured":"Sheldon RS, Grubb BP, Olshansky B et al (2015) 2015\u00a0heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm 12:e41-63. https:\/\/doi.org\/10.1016\/j.hrthm.2015.03.029","journal-title":"Heart Rhythm"},{"key":"1193_CR4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.pcad.2020.03.010","volume":"63","author":"B Olshansky","year":"2020","unstructured":"Olshansky B, Cannom D, Fedorowski A et al (2020) Postural orthostatic tachycardia syndrome (POTS): a critical assessment. Prog Cardiovasc Dis 63:263\u2013270. https:\/\/doi.org\/10.1016\/j.pcad.2020.03.010","journal-title":"Prog Cardiovasc Dis"},{"key":"1193_CR5","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1007\/s11910-023-01307-w","volume":"23","author":"S Blitshteyn","year":"2023","unstructured":"Blitshteyn S (2023) Dysautonomia, hypermobility spectrum disorders and mast cell activation syndrome as migraine comorbidities. Curr Neurol Neurosci Rep 23:769\u2013776. https:\/\/doi.org\/10.1007\/s11910-023-01307-w","journal-title":"Curr Neurol Neurosci Rep"},{"key":"1193_CR6","volume-title":"Deep learning","author":"I Goodfellow","year":"2016","unstructured":"Goodfellow I, Bengio Y, Courville A (2016) Deep learning. MIT Press, Cambridge"},{"key":"1193_CR7","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/j.mayocp.2012.10.013","volume":"87","author":"DM Sletten","year":"2012","unstructured":"Sletten DM, Suarez GA, Low PA et al (2012) COMPASS 31: a refined and abbreviated composite autonomic symptom score. Mayo Clin Proc 87:1196\u20131201. https:\/\/doi.org\/10.1016\/j.mayocp.2012.10.013","journal-title":"Mayo Clin Proc"},{"key":"1193_CR8","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1212\/WNL.0b013e3182120147","volume":"76","author":"L Zilliox","year":"2011","unstructured":"Zilliox L, Peltier AC, Wren PA et al (2011) Assessing autonomic dysfunction in early diabetic neuropathy: the survey of autonomic symptoms. Neurology 76:1099\u20131105. https:\/\/doi.org\/10.1212\/WNL.0b013e3182120147","journal-title":"Neurology"},{"key":"1193_CR9","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780190889227.001.0001","volume-title":"Autonomic testing","author":"P Novak","year":"2019","unstructured":"Novak P (2019) Autonomic testing, 1st edn. Oxford University Press, New York","edition":"1"},{"key":"1193_CR10","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.1007\/s10072-022-06007-w","volume":"43","author":"P Novak","year":"2022","unstructured":"Novak P (2022) Qpack-a python package for QASAT-quantitative scale for grading cerebral blood flow, autonomic testing, and skin biopsies. Neurol Sci 43:4821\u20134828. https:\/\/doi.org\/10.1007\/s10072-022-06007-w","journal-title":"Neurol Sci"},{"key":"1193_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad481","volume":"25","author":"X Feng","year":"2023","unstructured":"Feng X, Xiu Y-H, Long H-X et al (2023) Advancing single-cell RNA-seq data analysis through the fusion of multi-layer perceptron and graph neural network. Brief Bioinform 25:bbad481. https:\/\/doi.org\/10.1093\/bib\/bbad481","journal-title":"Brief Bioinform"},{"key":"1193_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2022.102381","volume":"132","author":"K Rjoob","year":"2022","unstructured":"Rjoob K, Bond R, Finlay D et al (2022) Machine learning and the electrocardiogram over two decades: time series and meta-analysis of the algorithms, evaluation metrics and applications. Artif Intell Med 132:102381. https:\/\/doi.org\/10.1016\/j.artmed.2022.102381","journal-title":"Artif Intell Med"},{"key":"1193_CR13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jns.2017.03.032","volume":"377","author":"NA Rea","year":"2017","unstructured":"Rea NA, Campbell CL, Cortez MM (2017) Quantitative assessment of autonomic symptom burden in postural tachycardia syndrome (POTS). J Neurol Sci 377:35\u201341. https:\/\/doi.org\/10.1016\/j.jns.2017.03.032","journal-title":"J Neurol Sci"},{"key":"1193_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2025.103281","volume":"260","author":"J Uppal","year":"2025","unstructured":"Uppal J, Baker JR, Hira R et al (2025) Physiological and clinical comparison of active stand and head-up tilt tests in postural orthostatic tachycardia syndrome (POTS). Auton Neurosci 260:103281. https:\/\/doi.org\/10.1016\/j.autneu.2025.103281","journal-title":"Auton Neurosci"}],"container-title":["Clinical Autonomic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-026-01193-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10286-026-01193-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-026-01193-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T02:42:26Z","timestamp":1781491346000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10286-026-01193-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["1193"],"URL":"https:\/\/doi.org\/10.1007\/s10286-026-01193-5","relation":{},"ISSN":["0959-9851","1619-1560"],"issn-type":[{"value":"0959-9851","type":"print"},{"value":"1619-1560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]},"assertion":[{"value":"30 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"PN is a current or previous shareholder of Moderna, Editas Medicine, Novavax, and Pfizer. PN received royalties from Oxford University Press and he is an advisor\/independent contractor for the Dysimmune Diseases Foundation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}