{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:45:42Z","timestamp":1781541942539,"version":"3.54.5"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR002381"],"award-info":[{"award-number":["KL2TR002381"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin. Auton. Res."],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10286-026-01198-0","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T17:18:54Z","timestamp":1772299134000},"page":"405-408","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Autonomic debate: symptoms are an optimal target for orthostatic hypotension screening and management. An argument in opposition"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3657-7106","authenticated-orcid":false,"given":"Paul A.","family":"Beach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"1198_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","volume":"21","author":"R Freeman","year":"2011","unstructured":"Freeman R et al (2011) Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res 21:69\u201372","journal-title":"Clin Auton Res"},{"key":"1198_CR2","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1093\/gerona\/gly188","volume":"75","author":"NI Saedon","year":"2020","unstructured":"Saedon NI, Pin Tan M, Frith J (2020) The prevalence of orthostatic hypotension: a systematic review and meta-analysis. J Gerontol A Biol Sci Med Sci 75:117\u2013122","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"1198_CR3","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.archger.2015.05.005","volume":"61","author":"LC Hartog","year":"2015","unstructured":"Hartog LC et al (2015) The association between orthostatic hypotension, falling and successful rehabilitation in a nursing home population. Arch Gerontol Geriatr 61:190\u2013196","journal-title":"Arch Gerontol Geriatr"},{"key":"1198_CR4","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.jacc.2018.05.079","volume":"72","author":"R Freeman","year":"2018","unstructured":"Freeman R et al (2018) Orthostatic hypotension: JACC state-of-the-art review. J Am Coll Cardiol 72:1294\u20131309","journal-title":"J Am Coll Cardiol"},{"key":"1198_CR5","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s10286-025-01146-4","volume":"35","author":"H Wang","year":"2025","unstructured":"Wang H, Zhang C, Xu D (2025) Prevalence and impact of orthostatic hypotension in Parkinson\u2019s disease: a systematic review and meta-analysis. Clin Auton Res 35:697\u2013710","journal-title":"Clin Auton Res"},{"key":"1198_CR6","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1055\/s-0040-1713844","volume":"40","author":"EA Coon","year":"2020","unstructured":"Coon EA (2020) Autonomic dysfunction in the synucleinopathies. Semin Neurol 40:492\u2013501","journal-title":"Semin Neurol"},{"key":"1198_CR7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s10286-011-0146-2","volume":"22","author":"H Kaufmann","year":"2012","unstructured":"Kaufmann H, Malamut R, Norcliffe-Kaufmann L, Rosa K, Freeman R (2012) The orthostatic hypotension questionnaire (OHQ): validation of a novel symptom assessment scale. Clin Auton Res 22:79\u201390","journal-title":"Clin Auton Res"},{"key":"1198_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-025-01168-y","author":"H Kaufmann","year":"2025","unstructured":"Kaufmann H et al (2025) Establishing minimally clinically important differences for the orthostatic hypotension questionnaire (OHQ). Clin Auton Res. https:\/\/doi.org\/10.1007\/s10286-025-01168-y","journal-title":"Clin Auton Res"},{"key":"1198_CR9","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1007\/s00415-016-8375-x","volume":"264","author":"CH Gibbons","year":"2017","unstructured":"Gibbons CH et al (2017) The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension. J Neurol 264:1567\u20131582","journal-title":"J Neurol"},{"key":"1198_CR10","unstructured":"Theravance Biopharma (2024) A phase\u00a03, multi-center, randomized withdrawal and long term extension study of ampreloxetine for the treatment of symptomatic neurogenic orthostatic hypotension in participants with multiple system atrophy. https:\/\/clinicaltrials.gov\/study\/NCT05696717. Accessed 31 Dec 2023"},{"key":"1198_CR11","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.amjmed.2008.10.040","volume":"122","author":"SD Arbogast","year":"2009","unstructured":"Arbogast SD, Alshekhlee A, Hussain Z, McNeeley K, Chelimsky TC (2009) Hypotension unawareness in profound orthostatic hypotension. Am J Med 122:574\u2013580","journal-title":"Am J Med"},{"key":"1198_CR12","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/mds.26079","volume":"30","author":"J-A Palma","year":"2015","unstructured":"Palma J-A et al (2015) Orthostatic hypotension in Parkinson disease: how much you fall or how low you go? Mov Disord 30:639\u2013645","journal-title":"Mov Disord"},{"key":"1198_CR13","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1161\/HYPERTENSIONAHA.119.13619","volume":"75","author":"R Freeman","year":"2020","unstructured":"Freeman R et al (2020) Symptom recognition is impaired in patients with orthostatic hypotension. Hypertension 75:1325\u20131332","journal-title":"Hypertension"},{"key":"1198_CR14","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s10286-020-00679-0","volume":"30","author":"PW Tipton","year":"2020","unstructured":"Tipton PW, Cheshire WP (2020) Mechanisms underlying unawareness of neurogenic orthostatic hypotension. Clin Auton Res 30:279\u2013281","journal-title":"Clin Auton Res"},{"key":"1198_CR15","doi-asserted-by":"publisher","first-page":"afac295","DOI":"10.1093\/ageing\/afac295","volume":"51","author":"P Claffey","year":"2022","unstructured":"Claffey P et al (2022) Asymptomatic orthostatic hypotension and risk of falls in community-dwelling older people. Age Ageing 51:afac295","journal-title":"Age Ageing"},{"key":"1198_CR16","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.parkreldis.2016.09.013","volume":"33","author":"A Merola","year":"2016","unstructured":"Merola A et al (2016) Orthostatic hypotension in Parkinson\u2019s disease: does it matter if asymptomatic? Parkinsonism Relat Disord 33:65\u201371","journal-title":"Parkinsonism Relat Disord"},{"key":"1198_CR17","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1007\/s00415-020-10240-8","volume":"268","author":"A Sturchio","year":"2021","unstructured":"Sturchio A et al (2021) Kinematic but not clinical measures predict falls in Parkinson-related orthostatic hypotension. J Neurol 268:1006\u20131015","journal-title":"J Neurol"},{"key":"1198_CR18","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1136\/jnnp.63.5.584","volume":"63","author":"JM Senard","year":"1997","unstructured":"Senard JM et al (1997) Prevalence of orthostatic hypotension in Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 63:584\u2013589","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1198_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2024.106980","volume":"123","author":"KB Lim","year":"2024","unstructured":"Lim KB et al (2024) Orthostatic hypotension in Parkinson\u2019s disease: sit-to-stand vs. supine-to-stand protocol and clinical correlates. Parkinsonism Relat Disord 123:106980","journal-title":"Parkinsonism Relat Disord"},{"key":"1198_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-025-01149-1","author":"T Virmani","year":"2025","unstructured":"Virmani T, Jones RD, Pillai L (2025) Exploring the relationship between orthostatic hypotension and gait in people with Parkinson\u2019s disease. Clin Auton Res. https:\/\/doi.org\/10.1007\/s10286-025-01149-1","journal-title":"Clin Auton Res"},{"key":"1198_CR21","doi-asserted-by":"publisher","first-page":"e998","DOI":"10.1212\/WNL.0000000000201659","volume":"100","author":"I Ruiz Barrio","year":"2023","unstructured":"Ruiz Barrio I, Miki Y, Jaunmuktane ZT, Warner T, De Pablo-Fernandez E (2023) Association between orthostatic hypotension and dementia in patients with Parkinson disease and multiple system atrophy. Neurology 100:e998\u2013e1008","journal-title":"Neurology"},{"key":"1198_CR22","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3389\/fneur.2020.00897","volume":"11","author":"K Longardner","year":"2020","unstructured":"Longardner K, Bayram E, Litvan I (2020) Orthostatic hypotension is associated with cognitive decline in Parkinson disease. Front Neurol 11:897","journal-title":"Front Neurol"},{"key":"1198_CR23","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.124.23188","author":"JR Baker","year":"2024","unstructured":"Baker JR et al (2024) Cerebral blood flow dynamics in neurogenic orthostatic hypotension: a systematic review and meta-analysis. Hypertens Dallas Tex 1979. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.124.23188","journal-title":"Hypertens. Dallas Tex 1979"},{"key":"1198_CR24","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1161\/01.STR.29.1.104","volume":"29","author":"V Novak","year":"1998","unstructured":"Novak V, Novak P, Spies JM, Low PA (1998) Autoregulation of cerebral blood flow in orthostatic hypotension. Stroke 29:104\u2013111","journal-title":"Stroke"},{"key":"1198_CR25","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/BF02292768","volume":"11","author":"DR Horowitz","year":"2001","unstructured":"Horowitz DR, Kaufmann H (2001) Autoregulatory cerebral vasodilation occurs during orthostatic hypotension in patients with primary autonomic failure. Clin Auton Res 11:363\u2013367","journal-title":"Clin Auton Res"},{"key":"1198_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.70268","author":"A Lenka","year":"2025","unstructured":"Lenka A, Beach P (2025) Approach to cardiovascular autonomic dysfunction in patients with synucleinopathies. Mov Disord Clin Pract. https:\/\/doi.org\/10.1002\/mdc3.70268","journal-title":"Mov Disord Clin Pract"},{"key":"1198_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2025.103258","volume":"259","author":"K Longardner","year":"2025","unstructured":"Longardner K et al (2025) Interoception in Parkinson\u2019s disease: a narrative review and framework for translational research. Auton Neurosci 259:103258","journal-title":"Auton Neurosci"},{"key":"1198_CR28","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.2337\/diab.41.10.1335","volume":"41","author":"MR Davis","year":"1992","unstructured":"Davis MR, Mellman M, Shamoon H (1992) Further defects in counterregulatory responses induced by recurrent hypoglycemia in IDDM. Diabetes 41:1335\u20131340","journal-title":"Diabetes"},{"key":"1198_CR29","doi-asserted-by":"publisher","first-page":"e768","DOI":"10.3399\/BJGP.2024.0695","volume":"75","author":"R Cross","year":"2025","unstructured":"Cross R et al (2025) Practitioners\u2019 views on the measurement and management of postural hypotension in general practice: a qualitative inquiry. Br J Gen Pract 75:e768\u2013e776","journal-title":"Br J Gen Pract"},{"key":"1198_CR30","doi-asserted-by":"publisher","DOI":"10.3399\/BJGP.2025.0025","author":"ST McDonagh","year":"2025","unstructured":"McDonagh ST et al (2025) Understanding measurement of postural hypotension: a nationwide survey of general practice in England. Br J Gen Pract. https:\/\/doi.org\/10.3399\/BJGP.2025.0025","journal-title":"Br J Gen Pract"},{"key":"1198_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-52368-x","volume":"14","author":"P Novak","year":"2024","unstructured":"Novak P et al (2024) Mismatch between subjective and objective dysautonomia. Sci Rep 14:2513","journal-title":"Sci Rep"},{"key":"1198_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1129-x","volume":"18","author":"DO Claassen","year":"2018","unstructured":"Claassen DO, Adler CH, Hewitt LA, Gibbons C (2018) Characterization of the symptoms of neurogenic orthostatic hypotension and their impact from a survey of patients and caregivers. BMC Neurol 18:125","journal-title":"BMC Neurol"},{"key":"1198_CR33","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.parkreldis.2020.06.029","volume":"77","author":"C Raccagni","year":"2020","unstructured":"Raccagni C et al (2020) The footprint of orthostatic hypotension in parkinsonian syndromes. Parkinsonism Relat Disord 77:107\u2013109","journal-title":"Parkinsonism Relat Disord"},{"key":"1198_CR34","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s10286-024-01071-y","volume":"34","author":"G Imbalzano","year":"2024","unstructured":"Imbalzano G et al (2024) Unraveling the stride: exploring the influence of neurogenic orthostatic hypotension on gait and balance in Parkinson\u2019s disease. Clin Auton Res 34:593\u2013601","journal-title":"Clin Auton Res"},{"key":"1198_CR35","doi-asserted-by":"publisher","first-page":"e759","DOI":"10.1212\/WNL.0000000000006027","volume":"91","author":"AM Rawlings","year":"2018","unstructured":"Rawlings AM et al (2018) Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline. Neurology 91:e759\u2013e768","journal-title":"Neurology"},{"key":"1198_CR36","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1210\/clinem\/dgad764","volume":"109","author":"Q Xiong","year":"2024","unstructured":"Xiong Q et al (2024) Orthostatic hypotension promotes the progression from mild cognitive impairment to dementia in type\u00a02 diabetes mellitus. J Clin Endocrinol Metab 109:1454\u20131463","journal-title":"J Clin Endocrinol Metab"},{"key":"1198_CR37","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s10072-022-06537-3","volume":"44","author":"D Loureiro","year":"2023","unstructured":"Loureiro D et al (2023) A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson\u2019s disease. Neurol Sci 44:1211\u20131222","journal-title":"Neurol Sci"},{"key":"1198_CR38","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012342","author":"A Pilotto","year":"2021","unstructured":"Pilotto A et al (2021) Association of orthostatic hypotension with cerebral atrophy in patients with Lewy body disorders. Neurology. https:\/\/doi.org\/10.1212\/WNL.0000000000012342","journal-title":"Neurology"},{"key":"1198_CR39","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s10072-011-0746-6","volume":"33","author":"R Poda","year":"2012","unstructured":"Poda R et al (2012) Standing worsens cognitive functions in patients with neurogenic orthostatic hypotension. Neurol Sci 33:469\u2013473","journal-title":"Neurol Sci"},{"key":"1198_CR40","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1212\/WNL.0000000000003452","volume":"88","author":"J Centi","year":"2017","unstructured":"Centi J et al (2017) Effects of orthostatic hypotension on cognition in Parkinson disease. Neurology 88:17\u201324","journal-title":"Neurology"},{"key":"1198_CR41","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1007\/s10072-018-3394-2","volume":"39","author":"M Sforza","year":"2018","unstructured":"Sforza M et al (2018) Orthostatic hypotension acutely impairs executive functions in Parkinson\u2019s disease. Neurol Sci 39:1459\u20131462","journal-title":"Neurol Sci"},{"key":"1198_CR42","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1055\/s-0040-1713846","volume":"40","author":"J-A Palma","year":"2020","unstructured":"Palma J-A, Kaufmann H (2020) Clinical trials for neurogenic orthostatic hypotension: a comprehensive review of endpoints, pitfalls, and challenges. Semin Neurol 40:523\u2013539","journal-title":"Semin Neurol"},{"key":"1198_CR43","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1212\/WNL.0000000000206803","volume":"100","author":"J-A Palma","year":"2023","unstructured":"Palma J-A, Cortelli P (2023) Blood pressure and risk of dementia in Parkinson disease and multiple system atrophy: should you buy the dip in such a volatile market? Neurology 100:451\u2013453","journal-title":"Neurology"},{"key":"1198_CR44","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10286-023-01006-z","volume":"34","author":"A Lenka","year":"2024","unstructured":"Lenka A, Lamotte G, Beach P (2024) Asymptomatic orthostatic hypotension in synucleinopathies: to treat or not to treat? Clin Auton Res 34:25\u201329","journal-title":"Clin Auton Res"}],"container-title":["Clinical Autonomic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-026-01198-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10286-026-01198-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-026-01198-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T02:43:06Z","timestamp":1781491386000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10286-026-01198-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["1198"],"URL":"https:\/\/doi.org\/10.1007\/s10286-026-01198-0","relation":{},"ISSN":["0959-9851","1619-1560"],"issn-type":[{"value":"0959-9851","type":"print"},{"value":"1619-1560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"assertion":[{"value":"29 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None. Dr. Beach has served as a consultant for Theravance Biopharma and Lundbeck. Dr. Beach has received honoraria from the American Academy of Neurology.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}