{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:37:11Z","timestamp":1791286631832,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2010,11,18]],"date-time":"2010-11-18T00:00:00Z","timestamp":1290038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Ind Microbiol Biotechnol"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s10295-010-0849-8","type":"journal-article","created":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T11:26:21Z","timestamp":1289993181000},"page":"1241-1248","source":"Crossref","is-referenced-by-count":57,"title":["Do we need new antibiotics? The search for new targets and new compounds"],"prefix":"10.1093","volume":"37","author":[{"given":"Jaroslav","family":"Sp\u00ed\u017eek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitka","family":"Novotn\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"\u0158ezanka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold L.","family":"Demain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,11,18]]},"reference":[{"key":"849_CR1","first-page":"607","volume":"35","author":"AJ Alanis","year":"2005","unstructured":"Alanis AJ (2005) Resistance to antibiotics: are we in the post-antibiotic era? Arch Med Res 35:607\u2013705","journal-title":"Arch Med Res"},{"key":"849_CR2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrmicro2312","volume":"8","author":"HK Allen","year":"2010","unstructured":"Allen HK, Donato J, Wang HH, Cloud-Hansen KA, Davies J, Handelsman J (2010) Call of the wild: antibiotic resistance genes in natural environment. Nat Rev Microbiol 8:251\u2013259","journal-title":"Nat Rev Microbiol"},{"key":"849_CR3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrmicro2319","volume":"8","author":"DI Andersson","year":"2010","unstructured":"Andersson DI, Hughes D (2010) Antibiotic resistance and its cost: is it possible to reverse resistance? Nat Rev Microbiol 8:260\u2013271","journal-title":"Nat Rev Microbiol"},{"key":"849_CR4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.nbt.2008.12.009","volume":"25","author":"WJ Ansorge","year":"2009","unstructured":"Ansorge WJ (2009) Next-generation DNA sequencing techniques. New Biotechnol 25:195\u2013203","journal-title":"New Biotechnol"},{"key":"849_CR5","first-page":"125","volume":"2","author":"RH Baltz","year":"2007","unstructured":"Baltz RH (2007) Antimicrobials from actinomycetes: back to the future. Microbe 2:125\u2013131","journal-title":"Microbe"},{"key":"849_CR6","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.coph.2008.04.008","volume":"8","author":"RH Baltz","year":"2008","unstructured":"Baltz RH (2008) Renaissance in antibacterial discovery from actinomycetes. Curr Opinion Pharmacol 8:557\u2013563","journal-title":"Curr Opinion Pharmacol"},{"key":"849_CR7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/417141a","volume":"417","author":"SD Bentley","year":"2002","unstructured":"Bentley SD, Chater KF, Cerde\u00f1o-T\u00e1rraga AM, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, Bateman A, Brown S, Chandra CW, Chen CW, Cronin A, Fraser A, Goble A, Hidalgo J, Hornsby T, Howarth S, Huang CH, Kieser T, Larke L, Murphy L, Oliver K, O\u2019Neil S, Rabbinowitsch E, Rajandream MA, Rutherford K, Rutter S, Server K, Saunders D, Sharp S, Squares R, Squares S, Taylor K, Warren T, Wietzorek A, Woodward J, Barrell BG, Parkhill J, Hopwood DA (2002) Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417:141\u2013147","journal-title":"Nature"},{"key":"849_CR8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nchembio869","volume":"3","author":"S Bergmann","year":"2007","unstructured":"Bergmann S, Sch\u00fcmann J, Scherlach K, Lange C, Brakhage AA, Hertweck C (2007) Genomics driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol 3:213\u2013217","journal-title":"Nat Chem Biol"},{"issue":"2","key":"849_CR9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1021\/cen-v080n002.p023","volume":"80","author":"S Borman","year":"2002","unstructured":"Borman S (2002) Organic lab sparks drug discovery. Chem Eng News 80(2):23\u201324","journal-title":"Chem Eng News"},{"key":"849_CR10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1371\/journal.ppat.0030018","volume":"3","author":"J Breger","year":"2007","unstructured":"Breger J, Fuchs BB, Aperis G, Moy TI, Ausubel FM, Mylonakis E (2007) Antifungal chemical compounds identified using a C. elegans pathogenicity assay. PloS Pathog 3:168\u2013178","journal-title":"PloS Pathog"},{"key":"849_CR11","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.2174\/0929867023368773","volume":"9","author":"R Breinbauer","year":"2002","unstructured":"Breinbauer R, Manger M, Scheck M, Waldmann H (2002) Natural product guided compound library development. Curr Med Chem 9:2129\u20132145","journal-title":"Curr Med Chem"},{"key":"849_CR12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0076-6879(09)04804-6","volume":"458","author":"M Bibb","year":"2009","unstructured":"Bibb M, Hesketh A (2009) Analyzing the regulation of antibiotic production in streptomycetes. Methods Enzymol 458:93\u2013116","journal-title":"Methods Enzymol"},{"key":"849_CR13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1021\/cr030116o","volume":"105","author":"ED Brown","year":"2005","unstructured":"Brown ED, Wright DW (2005) New targets and screening approaches in antimicrobial drug discovery. Chem Rev 105:759\u2013774","journal-title":"Chem Rev"},{"key":"849_CR14","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-59745-246-5","volume-title":"New antibiotic targets (methods in molecular biology)","author":"WS Champney","year":"2008","unstructured":"Champney WS (2008) New antibiotic targets (methods in molecular biology). Humana, Totowa, New Jersey, USA"},{"key":"849_CR15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.copbio.2004.04.005","volume":"15","author":"R Daniel","year":"2005","unstructured":"Daniel R (2005) The soil metagenome\u2014a rich resource for the discovery of novel natural products. Curr Opin Biotechnol 15:199\u2013204","journal-title":"Curr Opin Biotechnol"},{"key":"849_CR16","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/sj.embor.7401022","volume":"8","author":"J Davies","year":"2007","unstructured":"Davies J (2007) Microbes have the last word. A drastic re-evaluation of antimicrobial treatment is needed to overcome the threat of antibiotic resistant bacteria. EMBO Rep 8:616\u2013621","journal-title":"EMBO Rep"},{"key":"849_CR17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/ja.2008.16","volume":"62","author":"AL Demain","year":"2009","unstructured":"Demain AL, Sanchez S (2009) Microbial drug discovery: 80\u00a0years of progress. J Antibiot 62:5\u201316","journal-title":"J Antibiot"},{"key":"849_CR18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1021\/ci0200467","volume":"43","author":"M Feher","year":"2003","unstructured":"Feher M, Schmidt JM (2003) Property distributions: differences between drug, natural products, and molecules from combinatorial chemistry. J Chem Inf Comput Sci 43:218\u2013227","journal-title":"J Chem Inf Comput Sci"},{"key":"849_CR19","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nchembio841","volume":"2","author":"W Fenical","year":"2006","unstructured":"Fenical W, Jensen PR (2006) Developing a new resource for drug discovery: marine actinomycete bacteria. Nat Chem Biol 2:666\u2013673","journal-title":"Nat Chem Biol"},{"key":"849_CR20","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1038\/nmeth.1376","volume":"6","author":"P Flicek","year":"2009","unstructured":"Flicek P, Birney E (2009) Sense from sequence reads: methods for aligment and assembly. Nat Methods 6:S6\u2013S12","journal-title":"Nat Methods"},{"key":"849_CR21","first-page":"489","volume":"6","author":"REW Hancock","year":"2007","unstructured":"Hancock REW (2007) The end of an era. Nat Rev Drug Discov 6:489\u2013497","journal-title":"Nat Rev Drug Discov"},{"key":"849_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.genet.40.110405.090639","volume":"40","author":"DA Hopwood","year":"2006","unstructured":"Hopwood DA (2006) Soil to genomics: the Streptomyces chromosome. Ann Rev Genet 40:1\u201323","journal-title":"Ann Rev Genet"},{"key":"849_CR23","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1365-2958.2006.05584.x","volume":"63","author":"DA Hopwood","year":"2007","unstructured":"Hopwood DA (2007) How do antibiotic-producing bacteria ensure their self-resistance before antibiotic biosynthesis incapacitates them. Mol Microbiol 63:937\u2013940","journal-title":"Mol Microbiol"},{"key":"849_CR24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nchembio0807-457","volume":"3","author":"DA Hopwood","year":"2007","unstructured":"Hopwood DA (2007) Therapeutic treasures from the deep. Nat Chem Biol 3:457\u2013458","journal-title":"Nat Chem Biol"},{"key":"849_CR25","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nbt820","volume":"21","author":"H Ikeda","year":"2003","unstructured":"Ikeda H, Ishikawa J, Hanamoto A, Shinose M, Kikuchi H, Shiba T, Sakaki Y, Hattori M, \u00d5mura S (2003) Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol 21:526\u2013531","journal-title":"Nat Biotechnol"},{"key":"849_CR26","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.2105\/AJPH.94.11.1931","volume":"94","author":"MP Kieny","year":"2004","unstructured":"Kieny MP, Excler JL, Girard M (2004) Research and development of new vaccines against infectious diseases. Am J Public Health 94:1931\u20131935","journal-title":"Am J Public Health"},{"key":"849_CR27","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.mib.2008.09.009","volume":"11","author":"CH Kraus","year":"2008","unstructured":"Kraus CH (2008) Low hanging fruit in infectious disease drug development. Curr Opin Microbiol 11:434\u2013438","journal-title":"Curr Opin Microbiol"},{"key":"849_CR28","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nbt.1552","volume":"27","author":"NC Kyrpides","year":"2009","unstructured":"Kyrpides NC (2009) Fifteen years of microbial genomics: meeting the challenges and fulfilling the dream. Nat Biotechnol 27:627\u2013632","journal-title":"Nat Biotechnol"},{"key":"849_CR29","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1099\/mic.0.038257-0","volume":"156","author":"KW Lagesen","year":"2010","unstructured":"Lagesen KW, Ussery DW, Wassenaar TM (2010) Genome update: the 1000th genome\u2013cautionary tale. Microbiology 156:603\u2013608","journal-title":"Microbiology"},{"key":"849_CR30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.resmic.2007.12.011","volume":"159","author":"F Lefevre","year":"2008","unstructured":"Lefevre F, Robe P, Jarrin C, Ginolhac A, Zago C, Auriol D, Vogel TM, Simonet P, Nalin R (2008) Drugs from hidden bugs: their discovery via untapped resources. Res Microbiol 159:153\u2013161","journal-title":"Res Microbiol"},{"key":"849_CR31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev.med.59.110106.132000","volume":"59","author":"AS Lynch","year":"2008","unstructured":"Lynch AS, Robertson GT (2008) Bacterial and fungal biofilm infections. Ann Rev Med 59:415\u2013428","journal-title":"Ann Rev Med"},{"key":"849_CR32","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1128\/MMBR.44.2.230-251.1980","volume":"44","author":"JF Martin","year":"1980","unstructured":"Martin JF, Demain AL (1980) Control of antibiotic biosynthesis. Microbiol Rev 44:230\u2013251","journal-title":"Microbiol Rev"},{"key":"849_CR33","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nbt1128","volume":"23","author":"HG Menzella","year":"2005","unstructured":"Menzella HG, Ralph RR, Carney JR, Chandran SS, Reisinger SJ, Patel KD, Hopwood DA, Santi D (2005) Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes. Nat Biotechnol 23:1171\u20131176","journal-title":"Nat Biotechnol"},{"key":"849_CR34","doi-asserted-by":"crossref","first-page":"10414","DOI":"10.1073\/pnas.0604055103","volume":"103","author":"TI Moy","year":"2006","unstructured":"Moy TI, Ball AR, Anklesaria G, Lewis K, Ausubel FM (2006) Identification of novel antimicrobials using a live-animal infection model. Proc Natl Acad Sci U S A 103:10414\u201310419","journal-title":"Proc Natl Acad Sci U S A"},{"key":"849_CR35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.biochem.78.082907.145923","volume":"78","author":"H Nikaido","year":"2009","unstructured":"Nikaido H (2009) Multidrug resistance in bacteria. Ann Rev Biochem 78:119\u2013146","journal-title":"Ann Rev Biochem"},{"key":"849_CR36","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1128\/JB.00204-08","volume":"190","author":"Y Ohnisi","year":"2008","unstructured":"Ohnisi Y, Ishikawa J, Hara H, Suzuki H, Ikenoya M, Ikeda H, Yamashita A, Hattori M, Horinouchi S (2008) Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350. J Bacteriol 190:4050\u20134060","journal-title":"J Bacteriol"},{"key":"849_CR37","first-page":"1909","volume":"17","author":"T-J Oh","year":"2007","unstructured":"Oh T-J, Mo SJ, Yoon YJ, Sohng JK (2007) Discovery and molecular engineering of sugar-containing natural product biosynthetic pathways in actinomycetes. J Microbiol Biotechnol 17:1909\u20131921","journal-title":"J Microbiol Biotechnol"},{"key":"849_CR38","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.bcp.2005.10.010","volume":"71","author":"F Pel\u00e1ez","year":"2006","unstructured":"Pel\u00e1ez F (2006) The historical delivery of antibiotics from microbial natural products\u2014can history repeat? Biochem Pharmacol 71:981\u2013990","journal-title":"Biochem Pharmacol"},{"key":"849_CR39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/092986706775197944","volume":"13","author":"J Piel","year":"2006","unstructured":"Piel J (2006) Bacterial symbionts: prospects for the sustainable production of invertebrate-derived pharmaceuticals. Curr Med Chem 13:39\u201350","journal-title":"Curr Med Chem"},{"key":"849_CR40","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1098\/rsif.2008.0341","volume":"6","author":"GA Reeves","year":"2009","unstructured":"Reeves GA, Talavera D, Thornton JM (2009) Genome and proteome annotation: organization, interpretation and integration. J R Soc Interface 6:129\u2013147","journal-title":"J R Soc Interface"},{"key":"849_CR41","unstructured":"Report from the American Academy of Microbiology, 2009"},{"key":"849_CR42","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/embor.2008.83","volume":"9","author":"S Rigali","year":"2008","unstructured":"Rigali S, Titgemeyer F, Barends S, Mulder S, Thomae AW, Hopwood DA, van Wezel GP (2008) Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces. EMBO Rep 9:670\u2013675","journal-title":"EMBO Rep"},{"key":"849_CR43","first-page":"1","volume-title":"New antibiotic targets","author":"KR Sakharkar","year":"2008","unstructured":"Sakharkar KR, Sakharkar MK, Chow VTK (2008) Biocomputational strategies for microbial drug target identification. In: Champney WS (ed) New antibiotic targets. Humana, Totowa, New Jersey, USA, pp 1\u20139"},{"key":"849_CR44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF02816527","volume":"40","author":"J Sp\u00ed\u017eek","year":"1995","unstructured":"Sp\u00ed\u017eek J, Tich\u00fd P (1995) Some aspects of overproduction of secondary metabolites. Folia Microbiol 40:43\u201350","journal-title":"Folia Microbiol"},{"key":"849_CR45","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1365-2958.2006.05559.x","volume":"63","author":"K Tahlan","year":"2007","unstructured":"Tahlan K, Ahn SA, Sing A, Bodnaruk TD, Willems AR, Davidson AR, Nodwell JR (2007) Initiation of actinorhodin export in Streptomyces coelicolor. Mol Microbiol 63:951\u2013961","journal-title":"Mol Microbiol"},{"key":"849_CR46","doi-asserted-by":"crossref","first-page":"10376","DOI":"10.1073\/pnas.0700962104","volume":"104","author":"DW Udwary","year":"2007","unstructured":"Udwary DW, Zeigler L, Asokar RN, Singan V, Lapidus A, Fenical W, Jensen PR, Moore BS (2007) Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinospora tropica. Proc Natl Acad Sci U S A 104:10376\u201310381","journal-title":"Proc Natl Acad Sci U S A"},{"key":"849_CR47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0734-9750(90)90003-T","volume":"8","author":"Z Van\u011bk","year":"1990","unstructured":"Van\u011bk Z, Ho\u0161\u0165\u00e1lek Z, Sp\u00ed\u017eek J (1990) Overproduction of microbial products\u2014facts and ideas. Biotechnol Adv 8:1\u201327","journal-title":"Biotechnol Adv"},{"key":"849_CR48","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1021\/cr030100y","volume":"105","author":"CF Walsh","year":"2005","unstructured":"Walsh CF, Wright G (2005) Introduction: antibiotic resistance. Chem Rev 105:391\u2013393","journal-title":"Chem Rev"},{"issue":"1","key":"849_CR49","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/scientificamerican0709-44","volume":"301","author":"CT Walsh","year":"2009","unstructured":"Walsh CT, Fischbach MA (2009) Squashing superbugs\u2014the race for new antibiotics. Sci Amer Mag 301(1):44\u201351","journal-title":"Sci Amer Mag"},{"key":"849_CR50","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s002030100345","volume":"176","author":"MG Watve","year":"2001","unstructured":"Watve MG, Tickoo R, Jog MM, Rhole BD (2001) How many antibiotics are produced by the genus Streptomyces? Arch Microbiol 176:386\u2013390","journal-title":"Arch Microbiol"}],"container-title":["Journal of Industrial Microbiology &amp; Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10295-010-0849-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10295-010-0849-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10295-010-0849-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:40:08Z","timestamp":1676374808000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimb\/article\/37\/12\/1241\/5993919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,18]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["849"],"URL":"https:\/\/doi.org\/10.1007\/s10295-010-0849-8","relation":{},"ISSN":["1367-5435","1476-5535"],"issn-type":[{"value":"1367-5435","type":"print"},{"value":"1476-5535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,18]]}}}