{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:14:13Z","timestamp":1778552053104,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015M3D3A1A01064882"],"award-info":[{"award-number":["2015M3D3A1A01064882"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Propane is the major component of liquefied petroleum gas (LPG). Nowadays, the use of LPG is decreasing, and thus utilization of propane as a chemical feedstock is in need of development. An efficient biological conversion of propane to acetone using a methanotrophic whole cell as the biocatalyst was proposed and investigated. A bio-oxidation pathway of propane to acetone in Methylomonas sp. DH-1 was analyzed by gene expression profiling via RNA sequencing. Propane was oxidized to 2-propanol by particulate methane monooxygenase and subsequently to acetone by methanol dehydrogenases. Methylomonas sp. DH-1 was deficient in acetone-converting enzymes and thus accumulated acetone in the absence of any enzyme inhibition. The maximum accumulation, average productivity and specific productivity of acetone were 16.62\u00a0mM, 0.678\u00a0mM\/h and 0.141\u00a0mmol\/g cell\/h, respectively, under the optimized conditions. Our study demonstrates a novel method for the bioconversion of propane to acetone using methanotrophs under mild reaction condition.<\/jats:p>","DOI":"10.1007\/s10295-017-1936-x","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T09:55:28Z","timestamp":1490003728000},"page":"1097-1105","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Selective bio-oxidation of propane to acetone using methane-oxidizing <i>Methylomonas<\/i> sp.\u00a0DH-1"],"prefix":"10.1093","volume":"44","author":[{"given":"Dong Hoon","family":"Hur","sequence":"first","affiliation":[{"name":"0000 0001 2171 7818 grid.289247.2 Department of Chemical Engineering Kyung Hee University 446-701 Yongin-si Gyeonggi-do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thu Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"0000 0001 2171 7818 grid.289247.2 Department of Chemical Engineering Kyung Hee University 446-701 Yongin-si Gyeonggi-do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghyuk","family":"Kim","sequence":"additional","affiliation":[{"name":"0000 0001 2171 7818 grid.289247.2 Department of Genetic Engineering Kyung Hee University 446-701 Yongin-si Gyeonggi-do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Yeol","family":"Lee","sequence":"additional","affiliation":[{"name":"0000 0001 2171 7818 grid.289247.2 Department of Chemical Engineering Kyung Hee University 446-701 Yongin-si Gyeonggi-do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,7,1]]},"reference":[{"key":"2021033104402563100_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.supflu.2014.02.006","article-title":"Removal of small hydrocarbons (ethane, propane, butane) from natural gas streams using the ionic liquid 1-ethyl-3-methylimidazolium tris (pentafluoroethyl) trifluorophosphate","volume":"90","author":"Althuluth","year":"2014","journal-title":"J Supercrit Fluids"},{"key":"2021033104402563100_CR2","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1021\/ie071083w","article-title":"Natural gas processing with membranes: an overview","volume":"47","author":"Baker","year":"2008","journal-title":"Ind Eng Chem Res"},{"key":"2021033104402563100_CR3","doi-asserted-by":"publisher","first-page":"3327","DOI":"10.1099\/00221287-130-12-3327","article-title":"Substrate specificities of the soluble and particulate methane mono-oxygenases of Methylosinus trichosporium OB3b","volume":"130","author":"Burrows","year":"1984","journal-title":"Microbiol"},{"key":"2021033104402563100_CR4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/nature13192","article-title":"Trace-gas metabolic versatility of the facultative methanotroph Methylocella silvestris","volume":"510","author":"Crombie","year":"2014","journal-title":"Nat"},{"key":"2021033104402563100_CR5","doi-asserted-by":"publisher","first-page":"9949","DOI":"10.1021\/ja971049g","article-title":"Regio-and stereoselectivity of particulate methane monooxygenase from Methylococcus capsulatus (Bath)","volume":"119","author":"Elliott","year":"1997","journal-title":"J Am Chem Soc"},{"key":"2021033104402563100_CR6","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1023\/A:1025103011923","article-title":"Production of acetone, butanol and ethanol by Clostridium beijerinckii BA101 and in situ recovery by gas stripping","volume":"19","author":"Ezeji","year":"2003","journal-title":"World J Microbiol Biotechnol"},{"key":"2021033104402563100_CR7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1128\/MR.60.2.439-471.1996","article-title":"Methanotrophic bacteria","volume":"60","author":"Hanson","year":"1996","journal-title":"Microbiol Rev"},{"key":"2021033104402563100_CR8","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0014-5793(79)81321-6","article-title":"Identification and purification of a nicotinamide adenine dinucleotide-dependent secondary alcohol dehydrogenase from C1-utilizing microbes","volume":"101","author":"Hou","year":"1979","journal-title":"FEBS Lett"},{"key":"2021033104402563100_CR9","article-title":"Highly efficient bioconversion of methane to methanol using a novel type I Methylomonas sp. 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