{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:25:59Z","timestamp":1791919559252,"version":"4.3.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"3-4","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM114353"],"award-info":[{"award-number":["GM114353"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM115575"],"award-info":[{"award-number":["GM115575"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["NCI106150"],"award-info":[{"award-number":["NCI106150"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recent advances and emerging technologies for metabolic pathway engineering and synthetic biology have transformed the field of natural product discovery, production, and engineering. Despite these advancements, there remain many challenges in understanding how biosynthetic gene clusters are silenced or activated, including changes in the transcription of key biosynthetic and regulatory genes. This knowledge gap is highlighted by the success and failed attempts of manipulating regulatory genes within biosynthetic gene clusters in both native producers and heterologous hosts. These complexities make the choice of native producers versus heterologous hosts, fermentation medium, and supply of precursors crucial factors in achieving the production of the target natural products and engineering designer analogs. Nature continues to serve as inspiration for filling the knowledge gaps and developing new research strategies. By exploiting the evolutionary power of nature, alternative producers, with the desired genetic amenability and higher titers of the target natural products, and new strains, harboring gene clusters that encode evolutionary optimized congeners of the targeted natural product scaffolds, can be discovered. These newly identified strains can serve as an outstanding biotechnology platform for the engineered production of sufficient quantities of the target natural products and their analogs, enabling biosynthetic studies and potential therapeutic applications. These challenges and opportunities are showcased herein using fredericamycin, iso-migrastatin, platencin and platensimycin, the enediynes of C-1027, tiancimycin, and yangpumicin, and the leinamycin family of natural products.<\/jats:p>","DOI":"10.1007\/s10295-018-2094-5","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T05:08:39Z","timestamp":1542085719000},"page":"433-444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts"],"prefix":"10.1093","volume":"46","author":[{"given":"Christiana N","family":"Teijaro","sequence":"first","affiliation":[{"name":"0000000122199231 grid.214007.0 Department of Chemistry The Scripps Research Institute 33458 Jupiter FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajeeth","family":"Adhikari","sequence":"additional","affiliation":[{"name":"0000000122199231 grid.214007.0 Department of Chemistry The Scripps Research Institute 33458 Jupiter FL USA"},{"name":"0000000122199231 grid.214007.0 Department of Molecular Medicine The Scripps Research Institute 33458 Jupiter FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Shen","sequence":"additional","affiliation":[{"name":"0000000122199231 grid.214007.0 Department of Chemistry The Scripps Research Institute 33458 Jupiter FL USA"},{"name":"0000000122199231 grid.214007.0 Department of Molecular Medicine The Scripps Research Institute 33458 Jupiter FL USA"},{"name":"0000000122199231 grid.214007.0 Natural Products Library Initiative at The Scripps Research Institute, The Scripps Research Institute 33458 Jupiter FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,1]]},"reference":[{"key":"2023072013283161800_CR1","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1128\/JB.186.9.2567-2575.2004","article-title":"Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis","volume":"186","author":"Anton","year":"2004","journal-title":"J Bacteriol"},{"key":"2023072013283161800_CR2","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1021\/bi00323a035","article-title":"Biosynthesis of fredericamycin A, a new antitumor antibiotic","volume":"24","author":"Byrne","year":"1985","journal-title":"Biochemistry"},{"key":"2023072013283161800_CR3","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1021\/jacs.7b13292","article-title":"A pressure test to make 10 molecules in 90\u00a0days: external evaluation of methods to engineer biology","volume":"140","author":"Casini","year":"2018","journal-title":"J Am Chem Soc"},{"key":"2023072013283161800_CR4","doi-asserted-by":"publisher","first-page":"5587","DOI":"10.1128\/JB.00592-08","article-title":"Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts","volume":"190","author":"Chen","year":"2008","journal-title":"J Bacteriol"},{"key":"2023072013283161800_CR5","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/ja.2010.55","article-title":"Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027","volume":"63","author":"Chen","year":"2010","journal-title":"J Antibiot"},{"key":"2023072013283161800_CR6","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1021\/np100825y","article-title":"Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus","volume":"74","author":"Chen","year":"2011","journal-title":"J Nat Prod"},{"key":"2023072013283161800_CR7","doi-asserted-by":"publisher","first-page":"7013","DOI":"10.1128\/JB.184.24.7013-7024.2002","article-title":"Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140","volume":"184","author":"Cheng","year":"2002","journal-title":"J Bacteriol"},{"key":"2023072013283161800_CR8","doi-asserted-by":"publisher","first-page":"5233","DOI":"10.1021\/ol052081f","article-title":"Uncialamycin, a new enediyne antibiotic","volume":"7","author":"Davies","year":"2005","journal-title":"Org Lett"},{"key":"2023072013283161800_CR9","doi-asserted-by":"publisher","first-page":"4606","DOI":"10.1021\/acs.orglett.6b02248","article-title":"A mutasynthetic library of platensimycin and platencin analogues","volume":"18","author":"Dong","year":"2016","journal-title":"Org Lett"},{"key":"2023072013283161800_CR10","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/S0040-4039(01)80810-8","article-title":"The structure of neocarzinostatin chromophore possessing a novel bicylco-[7,3,0]dodecadiyne system","volume":"26","author":"Edo","year":"1985","journal-title":"Tetrahedron Lett"},{"key":"2023072013283161800_CR11","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1016\/j.bmc.2008.10.074","article-title":"Engineered production of iso-migrastatin in heterologous Streptomyces hosts","volume":"17","author":"Feng","year":"2009","journal-title":"Bioorg Med Chem"},{"key":"2023072013283161800_CR12","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.7164\/antibiotics.42.333","article-title":"Leinamycin, a new antitumor antibiotic form Streptomyces: producing organism, fermentation, and isolation","volume":"42","author":"Hara","year":"1989","journal-title":"J Antibiot"},{"key":"2023072013283161800_CR13","doi-asserted-by":"publisher","first-page":"5676","DOI":"10.1021\/bi00476a005","article-title":"DNA strand scission by the novel antitumor antibiotic leinamycin","volume":"29","author":"Hara","year":"1990","journal-title":"Biochemistry"},{"key":"2023072013283161800_CR14","doi-asserted-by":"publisher","first-page":"333","DOI":"10.7164\/antibiotics.42.333","article-title":"DC 107, a novel antitumor antibiotic produced by a Streptomyces sp","volume":"42","author":"Hara","year":"1989","journal-title":"J Antibiot"},{"key":"2023072013283161800_CR15","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1021\/ol800251v","article-title":"Structure and semisynthesis of platensimide A produced by Streptomyces platensis","volume":"10","author":"Herath","year":"2008","journal-title":"Org Lett"},{"key":"2023072013283161800_CR16","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1021\/np5006168","article-title":"Strain prioritization for natural product discovery by a high-throughput real-time PCR method","volume":"77","author":"Hindra","year":"2014","journal-title":"J Nat Prod"},{"key":"2023072013283161800_CR17","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1246\/cl.1993.1957","article-title":"Molecular structure of a novel antitumor antibiotic leinamycin","volume":"22","author":"Hirayama","year":"1993","journal-title":"Chem Lett"},{"key":"2023072013283161800_CR18","doi-asserted-by":"publisher","first-page":"870","DOI":"10.7164\/antibiotics.47.870","article-title":"Dorrigocins: novel antifungal antibiotics that change the morphology or ras-transformed NIH\/3T3 cells to that of normal cells II isolation and elucidation of structures","volume":"47","author":"Hochlowski","year":"1994","journal-title":"J Antibiot"},{"key":"2023072013283161800_CR19","doi-asserted-by":"publisher","first-page":"5868","DOI":"10.1021\/ol062470p","article-title":"Thermolysis of iso-migrastatin and its congeners via [3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues","volume":"8","author":"Ju","year":"2006","journal-title":"Org Lett"},{"key":"2023072013283161800_CR20","doi-asserted-by":"publisher","first-page":"11930","DOI":"10.1021\/ja053118u","article-title":"Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and nk30424 scaffolds","volume":"127","author":"Ju","year":"2005","journal-title":"J Am Chem Soc"},{"key":"2023072013283161800_CR21","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1021\/ja043808i","article-title":"Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin","volume":"127","author":"Ju","year":"2005","journal-title":"J Am Chem Soc"},{"key":"2023072013283161800_CR22","doi-asserted-by":"publisher","first-page":"862","DOI":"10.7164\/antibiotics.47.862","article-title":"Dorrigocins: novel antifungal antibiotics that change the morphology or ras-transformed NIH\/3T3 cells to that of normal cells I taxonomy of the producing organism, fermentation and biological activity","volume":"47","author":"Karwowski","year":"1994","journal-title":"J Antibiot"},{"key":"2023072013283161800_CR23","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.7164\/antibiotics.42.1449","article-title":"Dynemicin A, a novel antibiotic with the anthraquinone and 1,5-diyn-3-ene subunit","volume":"42","author":"Konishi","year":"1989","journal-title":"J Antibiot"},{"key":"2023072013283161800_CR24","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1039\/b908165h","article-title":"Complexity and simplicity in the biosynthesis of enediyne natural products","volume":"27","author":"Liang","year":"2010","journal-title":"Nat Prod Rep"},{"key":"2023072013283161800_CR25","doi-asserted-by":"publisher","first-page":"29746","DOI":"10.1074\/jbc.M109.046805","article-title":"iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase","volume":"284","author":"Lim","year":"2009","journal-title":"J Biol Chem"},{"key":"2023072013283161800_CR26","doi-asserted-by":"publisher","first-page":"10359","DOI":"10.1073\/pnas.1508437112","article-title":"C-S bon cleavage by a polyketide synthase domain","volume":"112","author":"Ma","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072013283161800_CR27","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1093\/gbe\/evq013","article-title":"The sequence of a 1.8-Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways","volume":"2","author":"Medema","year":"2010","journal-title":"Genome Biol Evol"},{"key":"2023072013283161800_CR28","doi-asserted-by":"publisher","first-page":"4478","DOI":"10.1021\/ja00380a025","article-title":"Fredericamycin A, an antitumor antibiotic of novel skeletal type","volume":"104","author":"Misra","year":"1982","journal-title":"J Am Chem Soc"},{"key":"2023072013283161800_CR29","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.7164\/antibiotics.53.1130","article-title":"Migrastatin, a new inhibitor of tumor cell migration from Streptomyces s. MK929-43F1. Taxonomy, fermentation, isolation and biological activites","volume":"53","author":"Nakae","year":"2000","journal-title":"J Antibiot"},{"key":"2023072013283161800_CR30","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural products as sources of new drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J Nat Prod"},{"key":"2023072013283161800_CR31","doi-asserted-by":"publisher","first-page":"E11131","DOI":"10.1073\/pnas.1716245115","article-title":"Discovery of the leinamycin family of natural products by mining actinobacterial genomes","volume":"114","author":"Pan","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072013283161800_CR32","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.7164\/antibiotics.34.1389","article-title":"Fredericamycin A, a new antitumor antibiotic I. production, isolation and physicochemical properties","volume":"34","author":"Pandey","year":"1981","journal-title":"J Antibiot"},{"key":"2023072013283161800_CR33","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.bbagrm.2015.06.007","article-title":"An overview on transcriptional regulators in Streptomyces","volume":"1849","author":"Romero-Rodriguez","year":"2015","journal-title":"Biochimica et Biophysica Acta"},{"key":"2023072013283161800_CR34","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1039\/C5MB00303B","article-title":"A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4. A long-chain acyl-CoA dehydrogenase","volume":"11","author":"Rudolf","year":"2015","journal-title":"Mol Biosyst"},{"key":"2023072013283161800_CR35","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s10295-015-1671-0","article-title":"Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery","volume":"43","author":"Rudolf","year":"2016","journal-title":"J Ind Microbiol Biotechnol"},{"key":"2023072013283161800_CR36","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.cell.2015.11.031","article-title":"A new golden age of natural products drug discovery","volume":"163","author":"Shen","year":"2015","journal-title":"Cell"},{"key":"2023072013283161800_CR37","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1007\/s10295-016-1769-z","article-title":"Titer improvement and pilot-scale production of platensimycin from Streptomyces platensis SB12026","volume":"43","author":"Shi","year":"2016","journal-title":"J Ind Microbiol Biotechnol"},{"key":"2023072013283161800_CR38","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1021\/np3005985","article-title":"Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners","volume":"75","author":"Smanski","year":"2012","journal-title":"J Nat Prod"},{"key":"2023072013283161800_CR39","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1128\/AAC.01358-08","article-title":"Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin","volume":"53","author":"Smanski","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"2023072013283161800_CR40","doi-asserted-by":"publisher","first-page":"13498","DOI":"10.1073\/pnas.1106919108","article-title":"Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis","volume":"108","author":"Smanski","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072013283161800_CR41","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/nrmicro.2015.24","article-title":"Synthetic biology to access and expand nature\u2019s chemical diversity","volume":"14","author":"Smanski","year":"2016","journal-title":"Nat Rev Micobiol"},{"key":"2023072013283161800_CR42","doi-asserted-by":"publisher","first-page":"823","DOI":"10.7164\/antibiotics.57.823","article-title":"Fredericamycin B and C from Streptomyces griseus: structure elucidation after 23 years","volume":"57","author":"Stontag","year":"2004","journal-title":"J Antibiot"},{"key":"2023072013283161800_CR43","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.chembiol.2003.12.014","article-title":"Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase","volume":"11","author":"Tang","year":"2004","journal-title":"Chem Biol"},{"key":"2023072013283161800_CR44","doi-asserted-by":"publisher","first-page":"448","DOI":"10.2174\/156802608783955656","article-title":"Biosynthesis of enediyne antitumor antibiotics","volume":"8","author":"Van Lanen","year":"2008","journal-title":"Curr Top Med Chem"},{"key":"2023072013283161800_CR45","doi-asserted-by":"publisher","first-page":"7612","DOI":"10.1073\/pnas.0700746104","article-title":"Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties","volume":"104","author":"Wang","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072013283161800_CR46","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/nature04784","article-title":"Platensimycin is a selective FabF inhibitor with potent antibiotic properties","volume":"441","author":"Wang","year":"2006","journal-title":"Nature"},{"key":"2023072013283161800_CR47","doi-asserted-by":"publisher","first-page":"4144","DOI":"10.1128\/JB.00797-12","article-title":"Draft genome sequence of Streptomyces globisporus C-1027, which produces an antitumor antibiotic consisting of a nine-membered enediyne with a chromoprotein","volume":"194","author":"Wang","year":"2012","journal-title":"J Bacteriol"},{"key":"2023072013283161800_CR48","doi-asserted-by":"publisher","first-page":"16442","DOI":"10.1021\/ja054376u","article-title":"Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus","volume":"127","author":"Wendt-Pienkowski","year":"2005","journal-title":"J Am Chem Soc"},{"key":"2023072013283161800_CR49","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.copbio.2005.10.001","article-title":"Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways","volume":"16","author":"Wenzel","year":"2005","journal-title":"Curr Opin Biotechnol"},{"key":"2023072013283161800_CR50","doi-asserted-by":"publisher","first-page":"141","DOI":"10.7164\/antibiotics.55.141","article-title":"Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis","volume":"55","author":"Woo","year":"2002","journal-title":"J Antibiot"},{"key":"2023072013283161800_CR51","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1007\/s12257-009-3129-6","article-title":"Iso-migrastatin titer improvement in the engineered Streptomyces lividans SB11002 strain by optimization of fermentation conditions","volume":"15","author":"Wu","year":"2010","journal-title":"Biotechnol Bioprocess Eng"},{"key":"2023072013283161800_CR52","doi-asserted-by":"publisher","first-page":"6192","DOI":"10.1021\/acs.orglett.7b03120","article-title":"Genome mining of Micromonospora yangpuensis DSM 45577 as a producer of an anthraquinone-fused enediyne","volume":"19","author":"Yan","year":"2017","journal-title":"Org Lett"},{"key":"2023072013283161800_CR53","doi-asserted-by":"publisher","first-page":"e02104","DOI":"10.1128\/mBio.02104-16","article-title":"Strain prioritization and genome mining for enediyne natural products","volume":"7","author":"Yan","year":"2016","journal-title":"mBio"},{"key":"2023072013283161800_CR54","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1021\/acs.jnatprod.7b01013","article-title":"Discovery of alternative producers of the enediyne antitumor antibiotic C-1027 with high titers","volume":"81","author":"Yan","year":"2018","journal-title":"J Nat Prod"},{"key":"2023072013283161800_CR55","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1007\/s00253-010-3025-1","article-title":"Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR","volume":"89","author":"Yang","year":"2011","journal-title":"Appl Microbial Biotechnol"},{"key":"2023072013283161800_CR56","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1021\/ol100342m","article-title":"Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners","volume":"12","author":"Yu","year":"2011","journal-title":"Org Lett"},{"key":"2023072013283161800_CR57","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1007\/s00253-015-7119-7","article-title":"Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins","volume":"100","author":"Zhang","year":"2016","journal-title":"Appl Microbiol Biotechnol"},{"key":"2023072013283161800_CR58","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1021\/mp7001329","article-title":"Bacterial hosts for natural product production","volume":"5","author":"Zhang","year":"2008","journal-title":"Mol Pharm"}],"container-title":["Journal of Industrial Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10295-018-2094-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10295-018-2094-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jimb\/article-pdf\/46\/3-4\/433\/50915838\/jimb0433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10295-018-2094-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/academic.oup.com\/jimb\/article-pdf\/46\/3-4\/433\/50915838\/jimb0433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T16:19:21Z","timestamp":1689869961000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimb\/article\/46\/3-4\/433\/5997200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,1]]},"references-count":58,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2019,3,1]]},"published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1007\/s10295-018-2094-5","relation":{},"ISSN":["1476-5535","1367-5435"],"issn-type":[{"value":"1476-5535","type":"electronic"},{"value":"1367-5435","type":"print"}],"subject":[],"published-other":{"date-parts":[[2019,3,1]]},"published":{"date-parts":[[2019,3,1]]},"assertion":[{"value":"27 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}