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Methanotrophic bacteria can convert various alkanes using methane monooxygenase enzyme to primary alcohols. These are further oxidized to various aldehydes by alcohol dehydrogenases or methanol dehydrogenases. In this study, 2-propanol was produced from propane using the whole cells of Methylosinus trichosporium OB3b, Methylomicrobium alcaliphilum 20Z, and Methylomonas sp. DH-1 as the biocatalysts. The biocatalytic process of converting propane to 2-propanol was optimized by the use of several inhibitors and additives, such as EDTA, sodium phosphate, and sodium formate to prevent oxidation of 2-propanol to acetone and to enhance conversion of propane to propanol. The maximum titer of 2-propanol was 0.424\u00a0g\/L, 0.311\u00a0g\/L, and 0.610\u00a0g\/L for Methylomonas sp. DH-1, M. alcaliphilum 20Z, and M. trichosporium OB3b whole cells, respectively. These results showed that type I and type II methanotrophs could be used as the potent biocatalyst for conversion of propane to propanol.<\/jats:p>","DOI":"10.1007\/s10295-019-02141-1","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T14:57:02Z","timestamp":1548946622000},"page":"675-685","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Biological conversion of propane to 2-propanol using group I and II methanotrophs as biocatalysts"],"prefix":"10.1093","volume":"46","author":[{"given":"Thu Thi","family":"Nguyen","sequence":"first","affiliation":[{"name":"0000 0001 2171 7818 grid.289247.2 Department of Chemical Engineering Kyung Hee University 17104 Yongin Gyeonggi Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Yeub","family":"Hwang","sequence":"additional","affiliation":[{"name":"0000 0001 2171 7818 grid.289247.2 Department of Chemical Engineering Kyung Hee University 17104 Yongin Gyeonggi Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Geol","family":"Na","sequence":"additional","affiliation":[{"name":"0000 0001 0286 5954 grid.263736.5 Department of Chemical and Biomolecular Engineering Sogang University 04107 Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Yeol","family":"Lee","sequence":"additional","affiliation":[{"name":"0000 0001 2171 7818 grid.289247.2 Department of Chemical Engineering Kyung Hee University 17104 Yongin Gyeonggi Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,1]]},"reference":[{"key":"2021033103501698500_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3934\/bioeng.2018.1.1","article-title":"Biotechnological conversion of methane to methanol: evaluation of progress and potential","volume":"5","author":"Bjorck","year":"2018","journal-title":"AIMS Bioeng"},{"key":"2021033103501698500_CR2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/jps.3030360105","article-title":"Pharmaceutical applications of isopropyl alcohol II. 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