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Analysis was performed for 81 disc tissue samples (control samples<jats:italic>n<\/jats:italic>\u00a0=\u00a021, degenerated disc tissue samples<jats:italic>n<\/jats:italic>\u00a0=\u00a060). Twenty six metabolites (amino acids, carbohydrates, and alcohols) were identified and quantified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results indicate that the metabolic profile of degenerated discs is characterized by the presence of 2-propanol and the absence of<jats:italic>scyllo<\/jats:italic>-inositol and taurine. The concentrations of 2-propanol and lactate increase with age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PCA analysis of ex vivo<jats:sup>1<\/jats:sup>H HR MAS NMR data revealed the occurrence of two groups: healthy and degenerative disc tissues. The effects of insufficient nutrient supply of discs, leading to their degeneration and back pain, are discussed.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s10334-014-0457-0","type":"journal-article","created":{"date-parts":[[2014,8,9]],"date-time":"2014-08-09T06:14:14Z","timestamp":1407564854000},"page":"173-183","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Characterization of metabolites determined by means of 1H HR MAS NMR in intervertebral disc degeneration"],"prefix":"10.1007","volume":"28","author":[{"given":"Barbara","family":"Pacholczyk-Sienicka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Radek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Radek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Jankowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,8,10]]},"reference":[{"key":"457_CR1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/BRS.0b013e31816201c3","volume":"33","author":"KR Keshari","year":"2008","unstructured":"Keshari KR, Lotz JC, Link TM, Hu S, Majumdar S, Kurhanewicz J (2008) Lactic acid and proteoglycans as metabolic markers for discogenic back pain. 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