{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T23:03:50Z","timestamp":1772147030330,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:00:00Z","timestamp":1483660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:00:00Z","timestamp":1483660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26249057"],"award-info":[{"award-number":["26249057"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Magn Reson Mater Phy"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s10334-016-0606-8","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T06:06:05Z","timestamp":1483682765000},"page":"291-298","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Feasibility of in vivo three-dimensional T*2 mapping using dicarboxy-PROXYL and CW-EPR-based single-point imaging"],"prefix":"10.1007","volume":"30","author":[{"given":"Harue","family":"Kubota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis A.","family":"Komarov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Inanami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor A.","family":"Kirilyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valery V.","family":"Khramtsov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6906-1608","authenticated-orcid":false,"given":"Hiroshi","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,1,6]]},"reference":[{"key":"606_CR1","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1111\/j.1582-4934.2011.01258.x","volume":"15","author":"A Carreau","year":"2011","unstructured":"Carreau A, Hafny-Rahbi BE, Matejuk A, Grillon C, Kieda C (2011) Why is the partial oxygen pressure of human tissues a critical parameter? Small molecules and hypoxia. J Cell Mol Med 15:1239\u20131253","journal-title":"J Cell Mol Med"},{"key":"606_CR2","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/S0360-3016(98)00332-0","volume":"42","author":"MR Horsman","year":"1998","unstructured":"Horsman MR (1998) Measurement of tumor oxygenation. Int J Radiat Oncol Biol Phys 42:701\u2013704","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"606_CR3","first-page":"4509","volume":"56","author":"M H\u00f6ckel","year":"1996","unstructured":"H\u00f6ckel M, Schlenger K, Aral B, Mitze M, Sch\u00e4ffer U, Vaupel P (1996) Association between tumor hypoxia and malignant progress in advanced cancer of the uterine cervix. Cancer Res 56:4509\u20134515","journal-title":"Cancer Res"},{"key":"606_CR4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/jappl.1953.6.3.189","volume":"6","author":"LC Clark Jr","year":"1953","unstructured":"Clark LC Jr, Wolf R, Granger D, Taylor Z (1953) Continuous recording of blood oxygen tensions by polarography. J Appl Physiol 6:189\u2013193","journal-title":"J Appl Physiol"},{"key":"606_CR5","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1021\/ac00265a017","volume":"56","author":"JI Peterson","year":"1984","unstructured":"Peterson JI, Fitzgerald R, Buckhold DK (1984) Fiber-optic probe for in vivo measurement of oxygen partial pressure. Anal Chem 56:62\u201367","journal-title":"Anal Chem"},{"key":"606_CR6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/(SICI)1099-1492(199605)9:3<125::AID-NBM405>3.0.CO;2-F","volume":"9","author":"RP Mason","year":"1996","unstructured":"Mason RP, Rodbumrung W, Anticj PP (1996) Hexafluorobenzene: a sensitive 19F NMR indicator of tumor oxygenation. NMR Biomed 9:125\u2013134","journal-title":"NMR Biomed"},{"key":"606_CR7","doi-asserted-by":"publisher","first-page":"5438","DOI":"10.1073\/pnas.90.12.5438","volume":"90","author":"KJ Liu","year":"1993","unstructured":"Liu KJ, Gast P, Moussavi M, Norby SW, Vahidi N, Walczak T, Wu M, Swartz HM (1993) Lithium phthalocyanine: a probe for electron paramagnetic resonance oximetry in viable biological systems. Proc Natl Acad Sci USA 90:5438\u20135442","journal-title":"Proc Natl Acad Sci USA"},{"key":"606_CR8","doi-asserted-by":"publisher","first-page":"13047","DOI":"10.1073\/pnas.91.26.13047","volume":"91","author":"HJ Halpern","year":"1994","unstructured":"Halpern HJ, Yu C, Peric M, Barth E, Grdina DJ, Teicher BA (1994) Oxymetry deep in tissues with low-frequency electron paramagnetic resonance. Proc Natl Acad Sci USA 91:13047\u201313051","journal-title":"Proc Natl Acad Sci USA"},{"key":"606_CR9","doi-asserted-by":"publisher","first-page":"5703","DOI":"10.1073\/pnas.85.15.5703","volume":"85","author":"JL Zweier","year":"1988","unstructured":"Zweier JL, Kuppusamy P (1988) Electron paramagnetic resonance measurements of free radicals in the intact beating heart: a technique for detection and characterization of free radicals in whole biological tissues. Proc Natl Acad Sci USA 85:5703\u20135707","journal-title":"Proc Natl Acad Sci USA"},{"key":"606_CR10","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/S0891-5849(03)00496-9","volume":"35","author":"RP Pandian","year":"2003","unstructured":"Pandian RP, Parinandi NL, Ilangovan G, Zweier JL, Kuppusamy P (2003) Novel particulate spin probe for targeted determination of oxygen in cells and tissues. Free Radic Biol Med 35:1138\u20131148","journal-title":"Free Radic Biol Med"},{"key":"606_CR11","first-page":"499","volume":"19","author":"J Hoff","year":"1971","unstructured":"Hoff J, Deen R (1971) The influence of oxygen on the E.R.S. spectrum of a radiosensitizing nitroxide. Int J Radiat Biol 19:499\u2013501","journal-title":"Int J Radiat Biol"},{"key":"606_CR12","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/0005-2728(77)90161-X","volume":"460","author":"JM Backer","year":"1977","unstructured":"Backer JM, Budker VG, Eremenko SI, Molin YN (1977) Detection of the kinetics of biochemical reactions with oxygen using exchange broadening in the ESR spectra of nitroxide radicals. Biochim Biophys Acta 460:152\u2013156","journal-title":"Biochim Biophys Acta"},{"key":"606_CR13","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/0003-9861(80)90340-9","volume":"200","author":"T Sarna","year":"1980","unstructured":"Sarna T, Duleba A, Korytowski W, Swartz H (1980) Interaction of melanin with oxygen. Arch Biochem Biophys 200:140\u2013148","journal-title":"Arch Biochem Biophys"},{"key":"606_CR14","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1073\/pnas.79.4.1166","volume":"79","author":"C-S Lai","year":"1982","unstructured":"Lai C-S, Hopwood LE, Hyde JS, Lukiewicz S (1982) ESR studies of O2 uptake by Chinese hamster ovary cells during the cell cycle. Proc Natl Acad Sci USA 79:1166\u20131170","journal-title":"Proc Natl Acad Sci USA"},{"key":"606_CR15","first-page":"40","volume":"90","author":"HJ Halpern","year":"1990","unstructured":"Halpern HJ, Peric M, Nguyen TD, Spencer DP, Teicher BA, Lin YJ (1990) Selective isotopic labeling of a nitroxide spin label to enhance sensitivity for T2 oxymetry. J Magn Reson 90:40\u201351","journal-title":"J Magn Reson"},{"key":"606_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/jmre.1998.1438","volume":"133","author":"JH Ardenkj\u00e6r-Larsen","year":"1998","unstructured":"Ardenkj\u00e6r-Larsen JH, Laursen I, Leunbach I, Ehnholm G, Wistrand LG, Petersson JS, Golman K (1998) EPR and DNP properties of certain novel single electron contrast agents intended for oximetric imaging. J Magn Reson 133:1\u201312","journal-title":"J Magn Reson"},{"key":"606_CR17","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1002\/ejoc.201300176","volume":"2013","author":"OY Rogozhnikova","year":"2013","unstructured":"Rogozhnikova OY, Vasiliev VG, Troitskaya TI, Trukhin DV, Mikhalina TV, Halpern HJ, Tormysheva VM (2013) Generation of trityl radicals by nucleophilic quenching of tris(2,3,5,6-tetrathiaaryl)methyl cations and practical and convenient large-scale synthesis of persistent tris(4-carboxy-2,3,5,6-tetrathiaaryl)methyl radical. Eur J Org Chem 2013:3347\u20133355","journal-title":"Eur J Org Chem"},{"key":"606_CR18","doi-asserted-by":"publisher","first-page":"6801","DOI":"10.1016\/j.bmcl.2007.10.030","volume":"17","author":"I Dhimitruka","year":"2007","unstructured":"Dhimitruka I, Velayutham M, Bobko AA, Khramtsov VV, Villamena FA, Hadad CF, Zweier JL (2007) Large scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging. Bioorg Med Chem Lett 17:6801\u20136805","journal-title":"Bioorg Med Chem Lett"},{"key":"606_CR19","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/978-1-4615-0061-2_8","volume-title":"In vivo EPR (ESR): theory and applications","author":"HJ Halpern","year":"2003","unstructured":"Halpern HJ (2003) Stable soluble paramagnetic compounds. In: Berliner LJ (ed) In vivo EPR (ESR): theory and applications. Kluwer Academic\/Plenum Publishers, New York, pp 201\u2013232"},{"key":"606_CR20","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jmr.2006.12.007","volume":"185","author":"KH Ahn","year":"2007","unstructured":"Ahn KH, Halpern HJ (2007) Spatially uniform sampling in 4-D EPR spectral-spatial imaging. J Magn Reson 185:152\u2013158","journal-title":"J Magn Reson"},{"key":"606_CR21","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1002\/mrm.10594","volume":"50","author":"K Matsumoto","year":"2003","unstructured":"Matsumoto K, Chandrika B, Lohman JAB, Mitchell JB, Krishna MC, Subramanian S (2003) Application of continuous-wave EPR spectral-spatial image reconstruction techniques for in vivo oxymetry: comparison of projection reconstruction and constant-time modalities. Magn Reson Med 50:865\u2013874","journal-title":"Magn Reson Med"},{"key":"606_CR22","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1002\/mrm.10199","volume":"48","author":"S Subramanian","year":"2002","unstructured":"Subramanian S, Devasahayam N, Murugesan R, Yamada K, Cook J, Taube A, Mitchell JB, Lohman JAB, Krishna MC (2002) Single-point (constant-time) imaging in radiofrequency Fourier transform electron paramagnetic resonance. Magn Reson Med 48:370\u2013379","journal-title":"Magn Reson Med"},{"key":"606_CR23","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/mrm.24926","volume":"72","author":"B Epel","year":"2014","unstructured":"Epel B, Bowman MK, Mailer C, Halpern HJ (2014) Absolute oxygen R1e imaging in vivo with pulse electron paramagnetic resonance. Magn Reson Med 72:362\u2013368","journal-title":"Magn Reson Med"},{"key":"606_CR24","first-page":"1965","volume":"118","author":"S Matsumoto","year":"2008","unstructured":"Matsumoto S, Hyodo F, Subramanian S, Devasahayam N, Munasinghe J, Hyodo E, Gadisetti C, Cook JA, Mitchell JB, Krishna MC (2008) Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice. J Clin Invest 118:1965\u20131973","journal-title":"J Clin Invest"},{"key":"606_CR25","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1118\/1.3555297","volume":"38","author":"B Epel","year":"2011","unstructured":"Epel B, Sundramoorthy SV, Barth ED, Mailer C, Halpern HJ (2011) Comparison of 250\u00a0MHz electron spin echo and continuous wave oxygen EPR imaging methods for in vivo applications. Med Phys 38:2045\u20132052","journal-title":"Med Phys"},{"key":"606_CR26","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jmr.2008.12.018","volume":"197","author":"F Hyodo","year":"2009","unstructured":"Hyodo F, Matsumoto S, Devasahayam N, Dharmaraj C, Subramanian S, Mitchell JB, Krishna MC (2009) Pulsed EPR imaging of nitroxides in mice. J Magn Reson 197:181\u2013185","journal-title":"J Magn Reson"},{"key":"606_CR27","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/mrm.10408","volume":"49","author":"M Elas","year":"2003","unstructured":"Elas M, Williams BB, Parasca A, Malier C, Pelizzari CA, Lewis MA, River JN, Karczmar GS, Barth ED, Halpern HJ (2003) Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): methodology and comparison with blood oxygen level-dependent (BOLD) MRI. Magn Reson Med 49:682\u2013691","journal-title":"Magn Reson Med"},{"key":"606_CR28","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1006\/jmrb.1995.1067","volume":"107","author":"P Kuppusamy","year":"1995","unstructured":"Kuppusamy P, Chzhan M, Samouilov A, Wang P, Zweier JL (1995) Mapping the spin-density and lineshape distribution of free radicals using 4D spectral-spatial EPR imaging. J Magn Reson, Ser B 107:116\u2013125","journal-title":"J Magn Reson, Ser B"},{"key":"606_CR29","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/mrm.25867","volume":"76","author":"AA Gorodetsky","year":"2016","unstructured":"Gorodetsky AA, Kirilyuk IA, Khramtsov VV, Komarov DA (2016) Functional electron paramagnetic resonance imaging of ischemic rat heart: monitoring of tissue oxygenation and pH. Magn Reson Med 76:350\u2013358","journal-title":"Magn Reson Med"},{"key":"606_CR30","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1002\/mrm.24813","volume":"71","author":"G Redler","year":"2014","unstructured":"Redler G, Barth ED, Bauer KS Jr, Kao JPY, Rosen GM, Halpern HJ (2014) In vivo electron paramagnetic resonance imaging of differential tumor targeting using cis-3,4-di(acetoxymethoxycarbonyl)-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl. Magn Reson Med 71:1650\u20131656","journal-title":"Magn Reson Med"},{"key":"606_CR31","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jmr.2012.03.022","volume":"218","author":"S Subramanian","year":"2012","unstructured":"Subramanian S, Devasahayam N, Matsumoto S, Saito K, Mitchell JB, Krishna MC (2012) Echo-based single-point imaging (ESPI): a novel pulsed EPR imaging modality for high spatial resolution and quantitative oximetry. J Magn Reson 218:105\u2013114","journal-title":"J Magn Reson"},{"key":"606_CR32","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1038\/nprot.2006.339","volume":"1","author":"NAP Franken","year":"2006","unstructured":"Franken NAP, Rodermond HM, Stap J, Haveman J, van Bree C (2006) Clonogenic assay of cells in vitro. Nat Protoc 1:2315\u20132319","journal-title":"Nat Protoc"},{"key":"606_CR33","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1148\/89.4.713","volume":"89","author":"HD Suit","year":"1967","unstructured":"Suit HD, Suchato C (1967) Hyperbaric oxygen and radiotherapy of a fibrosarcoma and of a squamous-cell carcinoma of C3H mice. Radiology 89:713\u2013719","journal-title":"Radiology"},{"key":"606_CR34","doi-asserted-by":"publisher","first-page":"123701","DOI":"10.1063\/1.3033161","volume":"79","author":"H Sato-Akaba","year":"2008","unstructured":"Sato-Akaba H, Fujii H, Hirata H (2008) Improvement of temporal resolution for three-dimensional continuous-wave electron paramagnetic resonance imaging. Rev Sci Instrum 79:123701","journal-title":"Rev Sci Instrum"},{"key":"606_CR35","doi-asserted-by":"publisher","first-page":"7501","DOI":"10.1021\/ac901169g","volume":"81","author":"H Sato-Akaba","year":"2009","unstructured":"Sato-Akaba H, Kuwahara Y, Fujii H, Hirata H (2009) Half-life mapping of nitroxyl radicals with three-dimensional electron paramagnetic resonance imaging at an interval of 3.6\u00a0seconds. Anal Chem 81:7501\u20137506","journal-title":"Anal Chem"},{"key":"606_CR36","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jmr.2006.09.014","volume":"184","author":"Y Kawada","year":"2007","unstructured":"Kawada Y, Hirata H, Fujii H (2007) Use of multi-coil parallel-gap resonators for co-registration EPR\/NMR imaging. J Magn Reson 184:29\u201338","journal-title":"J Magn Reson"},{"key":"606_CR37","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1002\/mrm.24886","volume":"70","author":"H Jang","year":"2013","unstructured":"Jang H, Subramanian S, Devasahayam N, Saito K, Matsumoto S, Krishna MC, McMillan AB (2013) Single acquisition quantitative single-point electron paramagnetic resonance imaging. Magn Reson Med 70:1173\u20131181","journal-title":"Magn Reson Med"},{"key":"606_CR38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/jmri.1880070113","volume":"7","author":"PS Tofts","year":"1997","unstructured":"Tofts PS (1997) Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. J Magn Reson Imaging 7:91\u2013101","journal-title":"J Magn Reson Imaging"},{"key":"606_CR39","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1139\/v82-209","volume":"60","author":"JFW Keana","year":"1982","unstructured":"Keana JFW, Hideg K, Birrell GB, Hankovszky OH, Ferguson G, Parvez M (1982) New mono- and difunctionalized 2,2,5,5-tetramethylpyrrolidine- and \u03943-pyrroline-1-oxyl nitroxide spin labels. Can J Chem 60:1439\u20131447","journal-title":"Can J Chem"},{"key":"606_CR40","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1002\/mrm.1910050603","volume":"5","author":"JFW Keana","year":"1987","unstructured":"Keana JFW, Pou S, Rosen GM (1987) Nitroxides as potential contrast enhancing agents for MRI application: influence of structure on the rate of reduction by rat hepatocytes, whole liver homogenate, subcellular fractions, and ascorbate. Magn Reson Med 5:525\u2013536","journal-title":"Magn Reson Med"},{"key":"606_CR41","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1124\/jpet.106.106245","volume":"318","author":"M Miyake","year":"2006","unstructured":"Miyake M, Shen J, Liu S, Shi H, Liu W, Yuan Z, Pritchard A, Kao JPY, Liu KJ, Rosen GM (2006) Acetoxymethoxycarbonyl nitroxides as electron paramagnetic resonance proimaging agents to measure O2 levels in mouse brain: a pharmacokinetic and pharmacodynamic study. J Pharmacol Exp Ther 318:1187\u20131193","journal-title":"J Pharmacol Exp Ther"},{"key":"606_CR42","doi-asserted-by":"publisher","first-page":"6463","DOI":"10.1021\/jo1011619","volume":"75","author":"SR Burks","year":"2010","unstructured":"Burks SR, Bakhshai J, Makowsky MA, Muralidharan S, Tsai P, Rosen GM, Kao JPY (2010) 2H,15N-substituted nitroxides as sensitive probes for electron paramagnetic resonance imaging. J Org Chem 75:6463\u20136467","journal-title":"J Org Chem"}],"container-title":["Magnetic Resonance Materials in Physics, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10334-016-0606-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10334-016-0606-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10334-016-0606-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T19:24:51Z","timestamp":1589657091000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10334-016-0606-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,6]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["606"],"URL":"https:\/\/doi.org\/10.1007\/s10334-016-0606-8","relation":{},"ISSN":["0968-5243","1352-8661"],"issn-type":[{"value":"0968-5243","type":"print"},{"value":"1352-8661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,6]]},"assertion":[{"value":"17 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal experiments were in accordance with the Law for The Care and Welfare of Animals in Japan and with protocols approved by the Animal Experiment Committee of Hokkaido University. This article does not contain any studies with human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}