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Six and one of those healthy subjects further underwent a commonly used multi-echo spin-echo (MESE) sequence and magnetic resonance spectroscopy (MRS), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T2 values derived from the T2-prepared TSE sequence were 44.6\u2009\u00b1\u20093.0\u00a0ms (left) and 44.5\u2009\u00b1\u20092.6\u00a0ms (right) in healthy subjects and showed good inter-reader reliability. In patients, T2 values of 61.5\u2009\u00b1\u20096.2\u00a0ms (affected side) versus 43.3\u2009\u00b1\u20092.4\u00a0ms (unaffected side) were obtained. T2 values of MRS were in good agreement with measurements from the T2-prepared TSE, but not with those of the MESE sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>A T2-prepared TSE sequence enables precise determination of T2 values of the distal sciatic nerve in agreement with MRS. A MESE sequence tends to overestimate nerve T2 compared to T2 from MRS due to the influence of residual fat on T2 quantification. 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Kirschke received speaker honoraria from Philips Healthcare. Dimitrios C. Karampinos received grant support from Philips Healthcare. Nico Sollmann, Dominik Weidlich, Elisabeth Klupp, Barbara Cervantes, Carl Ganter, Claus Zimmer, Ernst J. Rummeny, and Thomas Baum declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all subjects included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}