{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:34:31Z","timestamp":1740141271887,"version":"3.37.3"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Institute for Clinical and Experimental Medicine","award":["IN 00023001"],"award-info":[{"award-number":["IN 00023001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Magn Reson Mater Phy"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s10334-020-00864-2","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T13:03:27Z","timestamp":1593263007000},"page":"141-151","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic resonance markers of bilateral neuronal metabolic dysfunction in patients with unilateral internal carotid artery occlusion"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2707-1135","authenticated-orcid":false,"given":"Alberto","family":"Malucelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonin","family":"Skoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svapotluk","family":"Ostry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ales","family":"Tomek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbora","family":"Urbanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Martinkovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Buksakowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Mohapl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Netuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Hort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sroubek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Vrana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Moravec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Bartos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Sames","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Hajek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Horinek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,27]]},"reference":[{"key":"864_CR1","first-page":"e85","volume":"113","author":"T Thom","year":"2006","unstructured":"Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, Zheng Z-J, Flegal K, O\u2019Donnell C, Kittner S, Lloyd-Jones D, Goff DC, Hong Y, Adams R, Friday G, Furie K, Gorelick P, Kissela B, Marler J, Meigs J, Roger V, Sidney S, Sorlie P, Steinberger J, Wasserthiel-Smoller S, Wilson M, Wolf P, American Heart Association Statistics Committee, and Stroke Statistics Subcommittee (2006) Heart disease and stroke statistics\u20132006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 113:e85\u2013e151","journal-title":"Circulation"},{"key":"864_CR2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.amjmed.2004.03.017","volume":"117","author":"A Ergin","year":"2004","unstructured":"Ergin A, Muntner P, Sherwin R, He J (2004) Secular trends in cardiovascular disease mortality, incidence, and case fatality rates in adults in the United States. Am J Med 117:219\u2013227","journal-title":"Am J Med"},{"key":"864_CR3","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1161\/01.STR.30.12.2513","volume":"30","author":"GW Petty","year":"1999","unstructured":"Petty GW, Brown RD, Whisnant JP, Sicks JD, O\u2019Fallon WM, Wiebers DO (1999) Ischemic stroke subtypes: a population-based study of incidence and risk factors. Stroke 30:2513\u20132516","journal-title":"Stroke"},{"key":"864_CR4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0022-510X(90)90262-L","volume":"98","author":"W Rautenberg","year":"1990","unstructured":"Rautenberg W, Mess W, Hennerici M (1990) Prognosis of asymptomatic carotid occlusion. J Neurol Sci 98:213\u2013220","journal-title":"J Neurol Sci"},{"key":"864_CR5","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1161\/01.STR.28.10.2084","volume":"28","author":"CJ Klijn","year":"1997","unstructured":"Klijn CJ, Kappelle LJ, Tulleken CA, van Gijn J (1997) Symptomatic carotid artery occlusion. A reappraisal of hemodynamic factors. Stroke 28:2084\u20132093","journal-title":"Stroke"},{"key":"864_CR6","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/01.STR.29.4.754","volume":"29","author":"CP Derdeyn","year":"1998","unstructured":"Derdeyn CP, Yundt KD, Videen TO, Carpenter DA, Grubb RL, Powers WJ (1998) Increased oxygen extraction fraction is associated with prior ischemic events in patients with carotid occlusion. Stroke 29:754\u2013758","journal-title":"Stroke"},{"key":"864_CR7","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1001\/jama.280.12.1055","volume":"280","author":"RL Grubb","year":"1998","unstructured":"Grubb RL, Derdeyn CP, Fritsch SM, Carpenter DA, Yundt KD, Videen TO, Spitznagel EL, Powers WJ (1998) Importance of hemodynamic factors in the prognosis of symptomatic carotid occlusion. JAMA 280:1055\u20131060","journal-title":"JAMA"},{"key":"864_CR8","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1161\/hs0901.095692","volume":"32","author":"S Kuroda","year":"2001","unstructured":"Kuroda S, Houkin K, Kamiyama H, Mitsumori K, Iwasaki Y, Abe H (2001) Long-term prognosis of medically treated patients with internal carotid or middle cerebral artery occlusion: can acetazolamide test predict it? Stroke 32:2110\u20132116","journal-title":"Stroke"},{"key":"864_CR9","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1161\/STROKEAHA.108.535245","volume":"40","author":"JR Romero","year":"2009","unstructured":"Romero JR, Beiser A, Seshadri S, Benjamin EJ, Polak JF, Vasan RS, Au R, DeCarli C, Wolf PA (2009) Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study. Stroke 40:1590\u20131596","journal-title":"Stroke"},{"key":"864_CR10","doi-asserted-by":"crossref","first-page":"e0207336","DOI":"10.1371\/journal.pone.0207336","volume":"13","author":"J Hellstr\u00f6m","year":"2018","unstructured":"Hellstr\u00f6m J, Romanos Zapata R, Libard S, Wikstr\u00f6m J, Ortiz-Nieto F, Alafuzoff I, Raininko R (2018) The value of magnetic resonance spectroscopy as a supplement to MRI of the brain in a clinical setting. PLoS ONE 13:e0207336","journal-title":"PLoS ONE"},{"key":"864_CR11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/01616412.1999.11740976","volume":"21","author":"M Giroud","year":"1999","unstructured":"Giroud M, Walker P, Guy F, Lemesle M, Lalande A, Baudouin N, Martin D, Couveur G, Brunotte F (1999) Cerebral metabolism after transient ischemic attack. A 1H MR spectroscopy study. Neurol Res 21:563\u2013565","journal-title":"Neurol Res"},{"key":"864_CR12","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/01.STR.26.5.822","volume":"26","author":"J van der Grond","year":"1995","unstructured":"van der Grond J, Balm R, Kappelle LJ, Eikelboom BC, Mali WP (1995) Cerebral metabolism of patients with stenosis or occlusion of the internal carotid artery. A 1H-MR spectroscopic imaging study. Stroke 26:822\u2013828","journal-title":"Stroke"},{"key":"864_CR13","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1212\/01.wnl.0000336970.85817.4a","volume":"71","author":"S Mu\u00f1oz Maniega","year":"2008","unstructured":"Mu\u00f1oz Maniega S, Cvoro V, Chappell FM, Armitage PA, Marshall I, Bastin ME, Wardlaw JM (2008) Changes in NAA and lactate following ischemic stroke: a serial MR spectroscopic imaging study. Neurology 71:1993\u20131999","journal-title":"Neurology"},{"key":"864_CR14","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/01.STR.23.5.668","volume":"23","author":"HS Markus","year":"1992","unstructured":"Markus HS, Harrison MJ (1992) Estimation of cerebrovascular reactivity using transcranial Doppler, including the use of breath-holding as the vasodilatory stimulus. Stroke 23:668\u2013673","journal-title":"Stroke"},{"key":"864_CR15","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","volume":"33","author":"B Fischl","year":"2002","unstructured":"Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33:341\u2013355","journal-title":"Neuron"},{"key":"864_CR16","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","volume":"31","author":"PA Yushkevich","year":"2006","unstructured":"Yushkevich PA, Piven J, Hazlett HC, Smith RG, Ho S, Gee JC, Gerig G (2006) User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. NeuroImage 31:1116\u20131128","journal-title":"NeuroImage"},{"key":"864_CR17","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/1098-1063(2000)10:6<752::AID-HIPO1012>3.0.CO;2-Y","volume":"10","author":"J Pantel","year":"2000","unstructured":"Pantel J, O\u2019Leary DS, Cretsinger K, Bockholt HJ, Keefe H, Magnotta VA, Andreasen NC (2000) A new method for the in vivo volumetric measurement of the human hippocampus with high neuroanatomical accuracy. Hippocampus 10:752\u2013758","journal-title":"Hippocampus"},{"key":"864_CR18","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.neuroimage.2009.05.019","volume":"47","author":"C Konrad","year":"2009","unstructured":"Konrad C, Ukas T, Nebel C, Arolt V, Toga AW, Narr KL (2009) Defining the human hippocampus in cerebral magnetic resonance images\u2014an overview of current segmentation protocols. Neuroimage 47:1185\u20131195","journal-title":"Neuroimage"},{"key":"864_CR19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1088\/0031-9155\/30\/4\/008","volume":"30","author":"A Haase","year":"1985","unstructured":"Haase A, Frahm J, Hanicke W, Matthaei D (1985) 1 H NMR chemical shift selective (CHESS) imaging. Phys Med Biol 30:341\u2013344","journal-title":"Phys Med Biol"},{"key":"864_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jmrb.1994.1048","volume":"104","author":"RJ Ogg","year":"1994","unstructured":"Ogg RJ, Kingsley RB, Taylor JS (1994) WET, a T1- and B1-insensitive water-suppression method for in vivo localized 1H NMR spectroscopy. J Magn Reson Ser B 104:1\u201310","journal-title":"J Magn Reson Ser B"},{"key":"864_CR21","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","volume":"30","author":"SW Provencher","year":"1993","unstructured":"Provencher SW (1993) Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30:672\u2013679","journal-title":"Magn Reson Med"},{"key":"864_CR22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/mrm.1910140104","volume":"14","author":"U Klose","year":"1990","unstructured":"Klose U (1990) In vivo proton spectroscopy in presence of eddy currents. Magn Reson Med 14:26\u201330","journal-title":"Magn Reson Med"},{"key":"864_CR23","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/jmre.2000.2179","volume":"147","author":"M Bak","year":"2000","unstructured":"Bak M, Rasmussen JT, Nielsen NC (2000) SIMPSON: a general simulation program for solid-state NMR spectroscopy. J Magn Reson 147:296\u2013330","journal-title":"J Magn Reson"},{"key":"864_CR24","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/mrm.20901","volume":"55","author":"C Gasparovic","year":"2006","unstructured":"Gasparovic C, Song T, Devier D, Bockholt HJ, Caprihan A, Mullins PG, Posse S, Jung RE, Morrison LA (2006) Use of tissue water as a concentration reference for proton spectroscopic imaging. Magn Reson Med 55:1219\u20131226","journal-title":"Magn Reson Med"},{"key":"864_CR25","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/mrm.21287","volume":"58","author":"S Posse","year":"2007","unstructured":"Posse S, Otazo R, Caprihan A, Bustillo J, Chen H, Henry P-G, Marjanska M, Gasparovic C, Zuo C, Magnotta V, Mueller B, Mullins P, Renshaw P, Ugurbil K, Lim KO, Alger JR (2007) Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla. Magn Reson Med 58:236\u2013244","journal-title":"Magn Reson Med"},{"key":"864_CR26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/(SICI)1522-2586(199904)9:4<531::AID-JMRI4>3.0.CO;2-L","volume":"9","author":"JP Wansapura","year":"1999","unstructured":"Wansapura JP, Holland SK, Dunn RS, Ball WS (1999) NMR relaxation times in the human brain at 3.0 tesla. J Magn Reson Imaging 9:531\u2013538","journal-title":"J Magn Reson Imaging"},{"key":"864_CR27","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/mrm.10640","volume":"50","author":"T Ethofer","year":"2003","unstructured":"Ethofer T, Mader I, Seeger U, Helms G, Erb M, Grodd W, Ludolph A, Klose U (2003) Comparison of longitudinal metabolite relaxation times in different regions of the human brain at 1.5 and 3 Tesla. Magn Reson Med 50:1296\u20131301","journal-title":"Magn Reson Med"},{"key":"864_CR28","volume-title":"Statistical parametric mapping: the analysis of funtional brain images","author":"KJ Friston","year":"2007","unstructured":"Friston KJ (2007) Statistical parametric mapping: the analysis of funtional brain images, 1st edn. Elsevier\/Academic Press, Amsterdam, Boston","edition":"1"},{"key":"864_CR29","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1440-1673.2007.01745.x","volume":"51","author":"T Isobe","year":"2007","unstructured":"Isobe T, Matsumura A, Anno I, Kawamura H, Shibata Y, Muraishi H, Minami M (2007) Lactate quantification by proton magnetic resonance spectroscopy using a clinical MRI machine: a basic study. Australas Radiol 51:330\u2013333","journal-title":"Australas Radiol"},{"key":"864_CR30","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/jmri.20053","volume":"19","author":"F Tr\u00e4ber","year":"2004","unstructured":"Tr\u00e4ber F, Block W, Lamerichs R, Gieseke J, Schild HH (2004) 1H metabolite relaxation times at 3.0 tesla: Measurements of T1 and T2 values in normal brain and determination of regional differences in transverse relaxation. J Magn Reson Imaging 19:537\u2013545","journal-title":"J Magn Reson Imaging"},{"key":"864_CR31","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/mrm.1910210111","volume":"21","author":"T Ernst","year":"1991","unstructured":"Ernst T, Hennig J (1991) Coupling effects in volume selective 1H spectroscopy of major brain metabolites. Magn Reson Med 21:82\u201396","journal-title":"Magn Reson Med"},{"key":"864_CR32","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/jmri.22706","volume":"34","author":"M Zhang","year":"2011","unstructured":"Zhang M, Lu J, Jiao L, Ma Q, Li K (2011) Proton magnetic resonance spectroscopy in patients with symptomatic unilateral internal carotid artery\/middle cerebral artery stenosis or occlusion. J Magn Reson Imaging 34:910\u2013916","journal-title":"J Magn Reson Imaging"},{"key":"864_CR33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/(SICI)1522-2586(200003)11:3<279::AID-JMRI6>3.0.CO;2-0","volume":"11","author":"DR Rutgers","year":"2000","unstructured":"Rutgers DR, Klijn CJ, Kappelle LJ, van der Grond J (2000) Cerebral metabolic changes in patients with a symptomatic occlusion of the internal carotid artery: a longitudinal 1H magnetic resonance spectroscopy study. J Magn Reson Imaging 11:279\u2013286","journal-title":"J Magn Reson Imaging"},{"key":"864_CR34","first-page":"96","volume":"1","author":"VK Sharma","year":"2008","unstructured":"Sharma VK, Tsivgoulis G, Ning C, Teoh HL, Bairaktaris C, Chong VF, Ong BK, Chan BP, Sinha AK (2008) Role of multimodal evaluation of cerebral hemodynamics in selecting patients with symptomatic carotid or middle cerebral artery steno-occlusive disease for revascularization. J Vasc Interv Neurol 1:96\u2013101","journal-title":"J Vasc Interv Neurol"},{"key":"864_CR35","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1136\/jnnp.2005.078238","volume":"77","author":"PM Walker","year":"2006","unstructured":"Walker PM, Ben Salem D, Giroud M, Brunotte F (2006) Is NAA reduction in normal contralateral cerebral tissue in stroke patients dependent on underlying risk factors? J Neurol Neurosurg Psychiatry 77:596\u2013600","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"864_CR36","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3174\/ajnr.A3344","volume":"34","author":"H Saito","year":"2013","unstructured":"Saito H, Ogasawara K, Nishimoto H, Yoshioka Y, Murakami T, Fujiwara S, Sasaki M, Kobayashi M, Yoshida K, Kubo Y, Beppu T, Ogawa A (2013) Postoperative changes in cerebral metabolites associated with cognitive improvement and impairment after carotid endarterectomy: a 3T proton MR spectroscopy study. AJNR Am J Neuroradiol 34:976\u2013982","journal-title":"AJNR Am J Neuroradiol"},{"key":"864_CR37","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1161\/01.STR.0000058158.41581.41","volume":"34","author":"DR Rutgers","year":"2003","unstructured":"Rutgers DR, van Osch MJP, Kappelle LJ, Mali WPTM, van der Grond J (2003) Cerebral hemodynamics and metabolism in patients with symptomatic occlusion of the internal carotid artery. Stroke 34:648\u2013652","journal-title":"Stroke"},{"key":"864_CR38","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1006\/nimg.2000.0629","volume":"12","author":"MJ Valenzuela","year":"2000","unstructured":"Valenzuela MJ, Sachdev PS, Wen W, Shnier R, Brodaty H, Gillies D (2000) Dual voxel proton magnetic resonance spectroscopy in the healthy elderly: subcortical-frontal axonal N-acetylaspartate levels are correlated with fluid cognitive abilities independent of structural brain changes. Neuroimage 12:747\u2013756","journal-title":"Neuroimage"},{"key":"864_CR39","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s004150070108","volume":"247","author":"FC Bakker","year":"2000","unstructured":"Bakker FC, Klijn CJ, Jennekens-Schinkel A, Kappelle LJ (2000) Cognitive disorders in patients with occlusive disease of the carotid artery: a systematic review of the literature. J Neurol 247:669\u2013676","journal-title":"J Neurol"},{"key":"864_CR40","doi-asserted-by":"crossref","first-page":"689","DOI":"10.2174\/156720511796717212","volume":"8","author":"W Lojkowska","year":"2011","unstructured":"Lojkowska W, Sawicka B, Gugala M, Sienkiewicz-Jarosz H, Bochynska A, Scinska A, Korkosz A, Lojek E, Ryglewicz D (2011) Follow-up study of olfactory deficits, cognitive functions, and volume loss of medial temporal lobe structures in patients with mild cognitive impairment. Curr Alzheimer Res 8:689\u2013698","journal-title":"Curr Alzheimer Res"},{"key":"864_CR41","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1093\/cercor\/bhr306","volume":"22","author":"J Persson","year":"2012","unstructured":"Persson J, Pudas S, Lind J, Kauppi K, Nilsson L-G, Nyberg L (2012) Longitudinal structure-function correlates in elderly reveal MTL dysfunction with cognitive decline. Cereb Cortex 22:2297\u20132304","journal-title":"Cereb Cortex"},{"key":"864_CR42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.brainresbull.2011.10.006","volume":"87","author":"F Cechetti","year":"2012","unstructured":"Cechetti F, Pagnussat AS, Worm PV, Elsner VR, Ben J, da Costa MS, Mestriner R, Weis SN, Netto CA (2012) Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment. Brain Res Bull 87:109\u2013116","journal-title":"Brain Res Bull"},{"key":"864_CR43","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1111\/ijs.12574","volume":"10","author":"WM Avelar","year":"2015","unstructured":"Avelar WM, D\u2019Abreu A, Coan AC, Lima FO, Guimar\u00e3es R, Yassuda CL, Oliveira GP, Guillaumon AT, Filho AA, Min LL, Cendes F (2015) Asymptomatic carotid stenosis is associated with gray and white matter damage. Int J Stroke 10:1197\u20131203","journal-title":"Int J Stroke"},{"key":"864_CR44","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1136\/jnnp.71.1.58","volume":"71","author":"D Lythgoe","year":"2001","unstructured":"Lythgoe D, Simmons A, Pereira A, Cullinane M, Williams S, Markus HS (2001) Magnetic resonance markers of ischaemia: their correlation with vasodilatory reserve in patients with carotid artery stenosis and occlusion. J Neurol Neurosurg Psychiatry 71:58\u201362","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"864_CR45","first-page":"1357","volume":"41","author":"C Tsuchida","year":"2000","unstructured":"Tsuchida C, Kimura H, Sadato N, Tsuchida T, Tokuriki Y, Yonekura Y (2000) Evaluation of brain metabolism in steno-occlusive carotid artery disease by proton MR spectroscopy: a correlative study with oxygen metabolism by PET. J Nucl Med 41:1357\u20131362","journal-title":"J Nucl Med"},{"key":"864_CR46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/mrm.1910390202","volume":"39","author":"DA Yablonskiy","year":"1998","unstructured":"Yablonskiy DA, Neil JJ, Raichle ME, Ackerman JJH (1998) Homonuclear J coupling effects in volume localized NMR spectroscopy: Pitfalls and solutions. Magn Reson Med 39:169\u2013178","journal-title":"Magn Reson Med"},{"key":"864_CR47","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1161\/01.STR.0000069725.09499.14","volume":"34","author":"FC Bakker","year":"2003","unstructured":"Bakker FC, Klijn CJM, Jennekens-Schinkel A, van der Tweel I, van der Grond J, van Huffelen AC, Tulleken CAF, Kappelle LJ (2003) Cognitive impairment is related to cerebral lactate in patients with carotid artery occlusion and ipsilateral transient ischemic attacks. Stroke 34:1419\u20131424","journal-title":"Stroke"},{"key":"864_CR48","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1212\/WNL.44.6.1046","volume":"44","author":"JS Fine-Edelstein","year":"1994","unstructured":"Fine-Edelstein JS, Wolf PA, O\u2019Leary DH, Poehlman H, Belanger AJ, Kase CS, D\u2019Agostino RB (1994) Precursors of extracranial carotid atherosclerosis in the Framingham study. Neurology 44:1046\u20131046","journal-title":"Neurology"}],"container-title":["Magnetic Resonance Materials in Physics, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10334-020-00864-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10334-020-00864-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10334-020-00864-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T23:51:24Z","timestamp":1624751484000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10334-020-00864-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,27]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["864"],"URL":"https:\/\/doi.org\/10.1007\/s10334-020-00864-2","relation":{},"ISSN":["0968-5243","1352-8661"],"issn-type":[{"type":"print","value":"0968-5243"},{"type":"electronic","value":"1352-8661"}],"subject":[],"published":{"date-parts":[[2020,6,27]]},"assertion":[{"value":"9 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Joint Ethics Committee of the Institute for Clinical and Experimental Medicine and Thomayer Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}