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V."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Magn Reson Mater Phy"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Brain atrophy has the potential to become a biomarker for severity of radiation-induced side-effects. Particularly brain tumour patients can show great MRI signal changes over time caused by e.g. oedema, tumour progress or necrosis. The goal of this study was to investigate if such changes affect the segmentation accuracy of normal appearing brain and thus influence longitudinal volumetric measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>T1-weighted MR images of 52 glioblastoma patients with unilateral tumours acquired before and three months after the end of radio(chemo)therapy were analysed. GM and WM volumes in the contralateral hemisphere were compared between segmenting the whole brain (full) and the contralateral hemisphere only (cl) with SPM and FSL. Relative GM and WM volumes were compared using paired t tests and correlated with the corresponding mean dose in GM and WM, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean GM atrophy was significantly higher for full segmentation compared to cl segmentation when using SPM (mean\u2009\u00b1\u2009std: \u0394\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>GM,full<\/jats:sub>\n                      \u2009=\u2009\u2212\u20093.1%\u2009\u00b1\u20093.7%, \u0394\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>GM,cl<\/jats:sub>\n                      \u2009=\u2009\u2212\u20091.6%\u2009\u00b1\u20092.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001,\n                      <jats:italic>d<\/jats:italic>\n                      \u2009=\u20090.62). GM atrophy was significantly correlated with the mean GM dose with the SPM cl segmentation (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2212\u20090.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), FSL full segmentation (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2212\u20090.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and FSL cl segmentation (r\u2009=\u2009-0.35, p\u2009=\u20090.012) but not with the SPM full segmentation (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2212\u20090.23,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For accurate normal tissue volume measurements in brain tumour patients using SPM, abnormal tissue needs to be masked prior to segmentation, however, this is not necessary when using FSL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10334-021-00922-3","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T23:53:31Z","timestamp":1617148411000},"page":"145-152","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Overestimation of grey matter atrophy in glioblastoma patients following radio(chemo)therapy"],"prefix":"10.1007","volume":"35","author":[{"given":"A.","family":"Gommlich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1054-9609","authenticated-orcid":false,"given":"F.","family":"Raschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Petr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Seidlitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Jentsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Platzek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"van den Hoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kotzerke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Beuthien-Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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Neuroinformatics 9:381\u2013400","journal-title":"Neuroinformatics"}],"container-title":["Magnetic Resonance Materials in Physics, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10334-021-00922-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10334-021-00922-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10334-021-00922-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T06:21:44Z","timestamp":1646634104000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10334-021-00922-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,31]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["922"],"URL":"https:\/\/doi.org\/10.1007\/s10334-021-00922-3","relation":{},"ISSN":["0968-5243","1352-8661"],"issn-type":[{"value":"0968-5243","type":"print"},{"value":"1352-8661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,31]]},"assertion":[{"value":"12 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In the past 5\u00a0years, Dr. Michael Baumann received funding for his research projects and for educational grants to the University of Dresden by Bayer AG (2016\u20132018), Merck KGaA (2014-open) and Medipan GmbH (2014\u20132018). He is on the supervisory board of HI-STEM gGmbH (Heidelberg) for the German Cancer Research Center (DKFZ, Heidelberg) and also member of the supervisory body of the Charit\u00e9 University Hospital, Berlin. As former chair of OncoRay (Dresden) and present CEO and Scientific Chair of the German Cancer Research Center (DKFZ, Heidelberg), he has been or is responsible for collaborations with a multitude of companies and institutions, worldwide. In this capacity, he has discussed potential projects and signed contracts for research funding and\/or collaborations with industry and academia for his institute(s) and staff, including but not limited to pharmaceutical companies such as Bayer, Boehringer Ingelheim, Bosch, Roche and other companies such as Siemens, IBA, Varian, Elekta, Bruker, etc. In this role, he was\/is also responsible for the commercial technology transfer activities of his institute(s), including the creation of start-ups and licensing. This includes the DKFZ-PSMA617 related patent portfolio [WO2015055318 (A1), ANTIGEN (PSMA)] and similar IP portfolios. Dr. Baumann confirms that, to the best of his knowledge, none of the above funding sources were involved in the preparation of this paper. Within the past years, Dr. Krause received funding for her research projects by IBA (2016), Merck KGaA (2014\u20132018 for preclinical study; 2018\u20132020 for clinical study), Medipan GmbH (2014\u20132018), Attomol GmbH (2019\u20132021), GA Generic Assays GmbH (2019\u20132021), BTU Cottbus-Senftenberg (2019\u20132021), Gesellschaft f\u00fcr medizinische und wissenschaftliche genetische Analysen (2019\u20132021), Lipotype GmbH (2019\u20132021), PolyAn GmbH (2019\u20132021). In the past 5\u00a0years, Dr. Troost has been involved in an ongoing publicly funded (German Federal Ministry of Education and Research) project with the companies Medipan, Attomol GmbH, GA Generic Assays GmbH, Gesellschaft f\u00fcr medizinische und wissenschaftliche genetische Analysen, Lipotype GmbH and PolyAn GmbH (2019\u20132021). Dr. Baumann, Dr. Krause and Dr. Troost confirm that to the best of their knowledge none of the above funding sources were involved in the preparation of this paper. The other authors have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}