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Mean <jats:italic>T<\/jats:italic>\n              <jats:sub>1<\/jats:sub>\/<jats:italic>T<\/jats:italic>\n              <jats:sub>2<\/jats:sub>-values were computed for: normal and normal appearing grey matter (NGM\/NAGM)\/white matter (NWM\/NAWM)\/thalamus\/putamen\/caudate nucleus (CN)\/globus pallidus (GP). Differences between sex, brain lobes, and left\/right were assessed. The age-dependency of <jats:italic>T<\/jats:italic>\n              <jats:sub>1<\/jats:sub>\/<jats:italic>T<\/jats:italic>\n              <jats:sub>2<\/jats:sub>-values in N(A)BTs was investigated. Relaxometry analysis was performed in two clinical case examples.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Mean (standard deviation) <jats:italic>T<\/jats:italic>\n              <jats:sub>1<\/jats:sub>\/<jats:italic>T<\/jats:italic>\n              <jats:sub>2<\/jats:sub>-values were measured in N(A)GM\u2009=\u20091086(73)\/74(9) ms; N(A)WM\u2009=\u2009658(24)\/48(3) ms; thalamus\u2009=\u2009783(51)\/42(4) ms; putamen\u2009=\u2009863(40)\/46(3) ms; CN\u2009=\u20091042(97)\/63(9) ms; GP\u2009=\u2009652(36)\/36(3) ms. Differences between sex were not significant. <jats:italic>T<\/jats:italic>\n              <jats:sub>1<\/jats:sub>\/<jats:italic>T<\/jats:italic>\n              <jats:sub>2<\/jats:sub>-values between the left\/right parietal lobe and the left\/right temporal lobe were significantly different. The quadratic age-dependency of <jats:italic>T<\/jats:italic>\n              <jats:sub>1<\/jats:sub>-values in the CN (<jats:italic>p<\/jats:italic>\u2009=\u20090.00039) and GP (<jats:italic>p<\/jats:italic>\u2009=\u20090.00037), and of <jats:italic>T<\/jats:italic>\n              <jats:sub>2<\/jats:sub>-values in the thalamus (<jats:italic>p<\/jats:italic>\u2009=\u20090.00044) and GP (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) were significant. Pathological tissues could be discerned from NABTs using <jats:italic>T<\/jats:italic>\n              <jats:sub>1<\/jats:sub>\/<jats:italic>T<\/jats:italic>\n              <jats:sub>2<\/jats:sub>-values.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Discussion<\/jats:title>\n            <jats:p>\n              <jats:italic>T<\/jats:italic>\n              <jats:sub>1<\/jats:sub>\/<jats:italic>T<\/jats:italic>\n              <jats:sub>2<\/jats:sub>-values and data trends agree with literature, supporting the validity of MR-STAT as a clinical option for fast relaxometry despite the relatively low number of subjects in the study. Future work should aim to include healthy participants of a wider age-range and to include B<jats:sub>1<\/jats:sub>-field corrections.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10334-025-01237-3","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T10:12:51Z","timestamp":1741083171000},"page":"333-345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fast whole brain relaxometry with Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) at 3\u00a0T: a retrospective cohort study"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4058-4928","authenticated-orcid":false,"given":"Martin B.","family":"Schilder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Mandija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi P. 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