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However, an inadequate fat signal suppression may introduce artifacts and is particularly challenging with non-Cartesian readouts. The aim of this study was to evaluate different fat-signal suppression methods for whole-heart free-running MRI at 1.5\u00a0T using numerical simulations, phantom, and cardiac MRI experiments without the use of contrast agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Binomial off-resonant rectangular (BORR), lipid insensitive binomial off-resonant RF excitation (LIBRE), and lipid insensitive binomial off-resonant (LIBOR) pulses were implemented within a 3D radial bSSFP sequence. Their pulse parameters were optimized for fat signal suppression at 1.5\u00a0T using simulations and phantom experiments. Optimized protocols, along with a free-running fast interrupted steady-state (FISS) and non-fat suppressed bSSFP sequence, were used to acquire phantom and cardiac data in five volunteers. SAR values were recorded. The SNR and CNR\n                      <jats:sub>Water-Fat<\/jats:sub>\n                      were measured in phantom data, while SNR and CNR\n                      <jats:sub>Blood-Myocardium<\/jats:sub>\n                      were quantified in volunteers using reconstruction without motion correction. Motion-resolved reconstructions were used for qualitative assessments. Statistical differences were analyzed using one-way ANOVA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LIBOR had the highest CNR\n                      <jats:sub>Water-Fat<\/jats:sub>\n                      (276.8\u2009\u00b1\u20092.5) in phantoms, followed by LIBRE (268.1\u2009\u00b1\u20092.6), BORR (249.9\u2009\u00b1\u20092.2), and FISS (212.7\u2009\u00b1\u20092.7), though these differences were not statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). In volunteers, BORR had the highest SNR in the ventricular blood pool (17.0\u2009\u00b1\u20091.5), and LIBRE had the highest CNR\n                      <jats:sub>Blood-Fat<\/jats:sub>\n                      (29.4\u2009\u00b1\u20099.3). FISS had the highest CNR\n                      <jats:sub>Blood-Myocardium<\/jats:sub>\n                      (29.0\u2009\u00b1\u20098.9), but the differences were not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Motion-resolved cardiac imaging showed comparable quality across all fat-suppressed sequences, with no significant streaking artifacts observed. Free-running bSSFP with LIBOR required the lowest SAR, up to a sixfold decrease compared with FISS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The tested sequences performed similarly in SNR and CNR but LIBOR offered the lowest SAR, making it a promising candidate for applications where RF energy deposition is a concern.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10334-025-01273-z","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T06:58:35Z","timestamp":1750661915000},"page":"1023-1038","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison between fast-interrupted steady-state (FISS) and rapid water-excitation pulses for fat signal suppression in free-running whole-heart MRI at 1.5\u00a0T"],"prefix":"10.1007","volume":"38","author":[{"given":"Yasaman","family":"Safarkhanlo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Yerly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana B. 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All other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study involved scans of human volunteers, which were conducted in compliance with the ethical guidelines outlined in the Declaration of Helsinki. Ethical approval was obtained from the Commission \u00c9thique Recherche-Vaud (CER-VD) under protocol number CER-VD 2021\u201300708. Written informed consent was obtained from all volunteers prior to participation in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}