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Reliable concentration estimation depends on knowledge of tissue specific relaxation times. This study reports\n                      <jats:italic>T<\/jats:italic>\n                      \u2081 and\n                      <jats:italic>T<\/jats:italic>\n                      \u2082 relaxation time constants of deuterium-labeled water (HDO) and glucose (Glc) from the human liver and kidney at 7T.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Twelve healthy volunteers (6f\/6\u00a0m) were examined using\n                      <jats:italic>k<\/jats:italic>\n                      -space-reordered inversion-recovery and spin-echo DMI with non-Cartesian concentric-ring trajectory (CRT) sampling. Seven volunteers underwent oral\n                      <jats:sup>2<\/jats:sup>\n                      H-Glc (0.8\u00a0g\/kg body weight) administration. Data were averaged over organ-specific masks before spectral fitting. One volunteer was measured after oral D\u2082O (0.5\u00a0ml\/kg body weight) administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Faster longitudinal relaxation but similar transversal relaxation were observed for\n                      <jats:sup>2<\/jats:sup>\n                      H-labeled Glc in the liver compared to kidney tissue (\n                      <jats:italic>T<\/jats:italic>\n                      \u2081\n                      <jats:sup>liver\/kidney<\/jats:sup>\n                      \u2009=\u200960\u2009\u00b1\u20094\u00a0ms\/85\u2009\u00b1\u200918\u00a0ms,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016;\n                      <jats:italic>T<\/jats:italic>\n                      \u2082\n                      <jats:sup>liver\/kidney<\/jats:sup>\n                      \u2009=\u200931\u2009\u00b1\u20096\u00a0ms\/35\u2009\u00b1\u20092\u00a0ms,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.283). HDO exhibited significantly shorter liver relaxation times (\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      <jats:sup>liver\/kidney<\/jats:sup>\n                      \u2009=\u2009218\u2009\u00b1\u200924\u00a0ms\/324\u2009\u00b1\u200934\u00a0ms,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>T<\/jats:italic>\n                      \u2082\n                      <jats:sup>liver\/kidney<\/jats:sup>\n                      \u2009=\u200928\u2009\u00b1\u20094\u00a0ms\/39\u2009\u00b1\u20096\u00a0ms,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). D\u2082O loading improved voxelwise SNR enabling renal\n                      <jats:italic>T<\/jats:italic>\n                      \u2081\/\n                      <jats:italic>T<\/jats:italic>\n                      \u2082 mapping of HDO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Hepatic and renal glucose homeostasis is often impaired in several pathophysiological conditions such as tumors, diabetes and metabolic dysfunction-associated steatotic liver disease. Using organ-specific\n                      <jats:sup>2<\/jats:sup>\n                      H relaxation times increases the accuracy of concentration estimation and can help to improve the understanding of underlying metabolic processes in future abdominal DMI studies, which can help to push abdominal DMI towards clinical application.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10334-025-01320-9","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:04:37Z","timestamp":1768550677000},"page":"499-512","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of T1 and T2 relaxation times of deuterium (2H) labeled resonances in the human liver and kidney using k-space reordered 3D concentric ring trajectory sampling at 7T"],"prefix":"10.1007","volume":"39","author":[{"given":"Viola","family":"Bader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Strasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Hingerl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes J.","family":"Kovarik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Frese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Pfleger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Duguid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Osburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kr\u0161\u0161\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Bogner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-7595","authenticated-orcid":false,"given":"Fabian","family":"Niess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"1320_CR1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat7314","volume":"4","author":"HM De Feyter","year":"2018","unstructured":"De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA (2018) Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. 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