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In this work, we investigate the feasibility of acquiring arterial spin labeling (ASL) perfusion images on a 0.35\u00a0T MR-Linac.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A signal model for the flow-sensitive alternating inversion recovery (FAIR) balanced steady-state free precession (bSSFP) ASL sequence was introduced and an optimized set of sequence parameters for 0.35\u00a0T was determined. The signal dependence on the sequence parameters using the MR-Linac was examined in the brain of two healthy volunteers. Repeatability of cerebral blood flow (CBF) measurements with an adjusted MR-Linac protocol were compared to ASL images from a clinical 3\u00a0T scanner in six healthy volunteers that were scanned twice on each device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The signal model described the observed measurements well, except for the dependence on inversion time. CBF values in gray and white matter in the six volunteers were systematically higher than at the 3\u00a0T scanner, but they had a similar percentage repeatability coefficient of 16\u201317%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An adjusted 10-min FAIR bSSFP ASL protocol on a 0.35\u00a0T MR-Linac yielded repeatable CBF measurements. (glinicaltrials.gov NCT05565326, submitted 2022-09-29).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10334-026-01326-x","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:14:58Z","timestamp":1770884098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adaptation of an arterial spin labeling sequence for the assessment of brain perfusion on a 0.35\u00a0T MR-Linac"],"prefix":"10.1007","clinical-trial-number":[{"clinical-trial-number":"nct05565326","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7110-6617","authenticated-orcid":false,"given":"Philipp","family":"Wallimann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Wild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Martirosian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Schick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mayinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Boss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Guckenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Tanadini-Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaus","family":"Andratschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Pouymayou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"1326_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.615643","volume":"10","author":"PJ Van Houdt","year":"2021","unstructured":"Van Houdt PJ, Yang Y, Van Der Heide UA (2021) Quantitative magnetic resonance imaging for biological image-guided adaptive radiotherapy. 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