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However, unlike the results obtained on placental histology, no perfusion impairment was observed. We used the Two-perfusion IVIM model to investigate the placenta's perfusion compartments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      DWIs of\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912 patients affected by SARS-CoV-2 and\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920 gestational age-matched pre-pandemic healthy subjects were acquired at 1.5\u00a0T scanner with 10\n                      <jats:italic>b<\/jats:italic>\n                      values. The maternal and fetal placentae were investigated. Differences in the two groups were evaluated using Welch\u2019s\n                      <jats:italic>t<\/jats:italic>\n                      test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The placental fetal side showed higher values of D and lower values of f2 (relative to the trophoblast compartment) in SARS-CoV-2 patients. D2* was higher on the maternal side of SARS-CoV-2 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Higher values of D reflect damage to the tissue, while the lower f2 parameter suggested an impairment of the exchange between mother and fetus. The higher values of D2* in the maternal side of SARS-CoV-2 placentas may be due to a decreased capillaries\u2019 size caused by the infiltration of lymphocytes in the decidua basalis. These results further confirm the potential of the two-perfusion IVIM model in detecting placental dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10334-026-01342-x","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:49:41Z","timestamp":1778320181000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The MRI two-perfusion IVIM model improves understanding of SARS-CoV-2 virus impact on placental tissue"],"prefix":"10.1007","author":[{"given":"Alessandra","family":"Maiuro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Cutonilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giada","family":"Ercolani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gennarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Di Mascio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Porpora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Giancotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Manganaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7863-1801","authenticated-orcid":false,"given":"Silvia","family":"Capuani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"1342_CR1","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/978-3-642-23941-0_19","volume-title":"Pathology of the human placenta","author":"K Benirschke","year":"2012","unstructured":"Benirschke K, Burton GJ, Baergen RN (2012) Maternal diseases complicating pregnancy: diabetes, tumors, preeclampsia, Lupus anticoagulant. 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