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D Pareto: has received research support from Fondo de Investigaciones Sanitarias (PI18\/00823, PI22\/01709), co-funded by the European Union. P Ajdinaj: has nothing to disclose M Alberich: has nothing to disclose. M Tintor\u00e9: has received compensation for consulting services, speaking honoraria and research support from Almirall, Bayer Schering Pharma, Biogen-Idec, Genzyme, Janssen, Merck-Serono, Novartis, Roche, Sanofi-Aventis, Viela Bio and Teva Pharmaceuticals. Data Safety Monitoring Board for Parexel and UCB Biopharma X Montalb\u00e1n: has received speaking honoraria and travel expenses for participation in scientific meetings, has been a steering committee member of clinical trials or participated in advisory boards of clinical trials in the past years with Abbvie, Actelion, Alexion, Biogen, Bristol-Myers Squibb\/Celgene, EMD Serono, Genzyme, Hoffmann-La Roche, Immunic, Janssen Pharmaceuticals, Medday, Merck, Mylan, Nervgen, Novartis, Sandoz, Sanofi-Genzyme, Teva Pharmaceutical, TG Therapeutics, Excemed, MSIF and NMSS. \u00c0 Rovira: serves\/ed on scientific advisory boards for Novartis, Sanofi, Synthetic MR, Roche, and Biogen, and has received speaker honoraria from Bayer, Sanofi, Merck-Serono, Teva Pharmaceutical Industries Ltd, Novartis, Roche, Bristol-Myers and Biogen, is CMO and co-founder of TensorMedical. J Sastre-Garriga: serves as co-Editor for Europe & Africa on the editorial board of Multiple Sclerosis Journal and as Editor-in-Chief in Revista de Neurolog\u00eda, receives research support from Fondo de Investigaciones Sanitarias (19\/950-22\/750) and has served in the last 24 months as a consultant\/speaker for BMS, Genzyme, Roche, Sanofi and Merck.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and was approved by the Local Ethics Committee, with the need for written informed consent waived.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}