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In this work, a high-resolution UTE pulse sequence with 1\u20131 binomial water excitation pulses was combined with interleaved multi-echo UTE acquisitions at lower resolution, enabling simultaneous acquisition of quantitative, water-excited, high-resolution T1-weighted structural images. The study included two ex vivo sheep brains, five healthy volunteers, and three patients with multiple sclerosis (MS) were measured. MF maps were calculated using multi-UTE and compared to histology. Magnetization transfer ratio using routine sequences was also calculated as a reference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multi-UTE facilitates the simultaneous acquisition of quantitative and structural images in 20\u00a0min. Myelin fraction values tested in five healthy volunteers agreed well with the literature. The MF estimated using multi-UTE showed a high correlation with histology (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.86) across 120 samples from different brain regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multi-UTE showed the strongest correlations with electron microscopy (EM) histology, and the MF maps overlapped with the lesions in MS patients. Multi-UTE may provide complementary insights for myelin quantification in various inflammatory and neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10334-026-01362-7","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:47:30Z","timestamp":1776779250000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-contrast dual-resolution UTE for myelin fraction mapping and structural imaging"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9690-7390","authenticated-orcid":false,"given":"Nan","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Rau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Reisert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serhat","family":"Ilbey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kian Tadjalli","family":"Mehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Helmst\u00e4dter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Schwabenland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uzay","family":"Emir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"Demerath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Urbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Caglar","family":"\u00d6zen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"1362_CR1","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1097\/WCO.0000000000000481","volume":"30","author":"RA Lewis","year":"2017","unstructured":"Lewis RA (2017) Chronic inflammatory demyelinating polyneuropathy. 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