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First, a healthy volunteer underwent MR-STAT with selective and non-selective excitation to investigate the origin of elevated effective proton density in arteries. Second, ten patients with intracranial aneurysms underwent 3D MR-STAT and time-of-flight MR angiography (TOF MRA). Two neuroradiologists independently assessed vessel visibility, image quality, and aneurysm size. Intraclass correlation coefficients (ICC) were computed for aneurysm size measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Selective excitation amplified inflow effects and yielded increased artery-tissue contrast in PD maps. Major intracranial arteries were visible in all clinical MR-STAT angiographic datasets. Nine out of ten MR-STAT angiographies were rated as at least diagnostically acceptable. Aneurysm measurements showed strong agreement between conventional and MR-STAT angiographic modalities (ICC=0.86\/ICC=0.71) and high inter-rater reliability (ICC=0.90\/ICC=0.92).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>MR-STAT PD maps enable angiographic visualization as an intrinsic component of a single fast quantitative acquisition, demonstrating technical feasibility for vessel depiction. Future work should focus on optimizing MR-STAT acquisition strategies to improve vessel conspicuity and broader clinical validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10334-026-01425-9","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:51:53Z","timestamp":1791280313000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of angiographic imaging using fast 3D Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT)"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4058-4928","authenticated-orcid":false,"given":"Martin Bastiaan","family":"Schilder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Versteeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Mandija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"van der Heide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem","family":"Dankbaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervyn Driek Ingmar","family":"Vergouwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ynte Marije","family":"Ruigrok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"van der Schaaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis Antonius Theodorus","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sbrizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"1425_CR1","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1002\/jmri.28425","volume":"57","author":"JPD Kleinloog","year":"2023","unstructured":"Kleinloog JPD, Mandija S, D\u2019Agata F, Liu H, van der Heide O, Koktas B, Dankbaar JW, Keil VC, Vonken E-J, Jacobs SM, van den Berg CAT, Hendrikse J, van der Kolk AG, Sbrizzi A (2023) Synthetic MRI with magnetic resonance spin tomography in time-domain (MR-STAT): results from a prospective cross-sectional clinical trial. 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