{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:08:02Z","timestamp":1786118882900,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1007\/s10350-007-9077-3","type":"journal-article","created":{"date-parts":[[2007,9,26]],"date-time":"2007-09-26T16:19:51Z","timestamp":1190823591000},"page":"1754-1760","source":"Crossref","is-referenced-by-count":97,"title":["Does Infliximab Infusion Impact Results of Operative Treatment for Crohn's Perianal Fistulas?"],"prefix":"10.1097","volume":"50","author":[{"given":"Wolfgang B.","family":"Gaertner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Decanini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Mellgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C.","family":"Lowry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley M.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Madoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"9077_CR1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1053\/gast.2002.32362","volume":"122","author":"DA Schwartz","year":"2002","unstructured":"Schwartz DA, Loftus EV Jr, Tremaine WJ, et al. The natural history of fistulizing Crohn\u2019s disease in Olmsted County, Minnesota. Gastroenterology 2002;122:875-0.","journal-title":"Gastroenterology"},{"key":"9077_CR2","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/bjs.1800781004","volume":"78","author":"JG Williams","year":"1991","unstructured":"Williams JG, MacLeod CA, Rothenberger DA, Goldberg SM. Seton treatment of high anal fistulae. Br J Surg 1991;78:1159-1.","journal-title":"Br J Surg"},{"key":"9077_CR3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0002-9610(80)90301-3","volume":"139","author":"N Sohn","year":"1980","unstructured":"Sohn N, Korelitz BI, Weinstein MA. Anorectal Crohn\u2019s disease: definitive surgery for fistulas and recurrent abscesses. Am J Surg 1980;139:394-.","journal-title":"Am J Surg"},{"key":"9077_CR4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/gut.40.4.443","volume":"40","author":"SJ van Deventer","year":"1997","unstructured":"van Deventer SJ. Tumour necrosis factor and Crohn\u2019s disease. Gut 1997;40:443-.","journal-title":"Gut"},{"key":"9077_CR5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000171464","volume":"12","author":"J Brynskov","year":"1994","unstructured":"Brynskov J, Nielsen OH, Ahnfelt-Ronne I, Bendtzen K. Cytokines (immunoinflammatory hormones) and their natural regulation in inflammatory bowel disease (Crohn\u2019s and ulcerative colitis): a review. Dig Dis 1994;12:290\u2013304.","journal-title":"Dig Dis"},{"key":"9077_CR6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0140-6736(92)90999-J","volume":"339","author":"CP Braegger","year":"1992","unstructured":"Braegger CP, Nicholls S, Murch SH, Stephens S, MacDonald TT. Tumour necrosis factor alpha in stool as a marker of intestinal inflammation. Lancet 1992;339:89\u201391.","journal-title":"Lancet"},{"key":"9077_CR7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/BF01540912","volume":"16","author":"J-M Reimund","year":"1996","unstructured":"Reimund J-M, Wittershiem C, Dumont S, et al. Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn\u2019s disease. J Clin Immunol 1996;16:144-0.","journal-title":"J Clin Immunol"},{"key":"9077_CR8","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/0016-5085(94)90398-0","volume":"106","author":"EJ Breese","year":"1994","unstructured":"Breese EJ, Michie CA, Nicholls SW, et al. Tumour necrosis factor-a producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology 1994;106:1455-6.","journal-title":"Gastroenterology"},{"key":"9077_CR9","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1056\/NEJM199710093371502","volume":"337","author":"SR Targan","year":"1997","unstructured":"Targan SR, Hanauer SB, van Deventer SJ, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn\u2019s disease. Crohn\u2019s Disease cA2 Study Group. N Engl J Med 1997;337:1029-5.","journal-title":"N Engl J Med"},{"key":"9077_CR10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00054725-200303000-00003","volume":"9","author":"M Regueiro","year":"2003","unstructured":"Regueiro M, Mardini H. Treatment of perianal fistulizing Crohn\u2019s disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement. Inflamm Bowel Dis 2003;9:98\u2013103.","journal-title":"Inflamm Bowel Dis"},{"key":"9077_CR11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1463-1318.2004.00749.x","volume":"7","author":"C Talbot","year":"2005","unstructured":"Talbot C, Sagar PM, Johnston MJ, Finan PJ, Burke D. Infliximab in the surgical management of complex fistulating anal Crohn\u2019s disease. Colorectal Dis 2005;7:164-.","journal-title":"Colorectal Dis"},{"key":"9077_CR12","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0002-9270(02)05909-9","volume":"98","author":"G Van Assche","year":"2003","unstructured":"Van Assche G, Vanbeckevoort D, Bielen D, et al. Magnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn\u2019s disease. Am J Gastroenterol 2003;98:332-.","journal-title":"Am J Gastroenterol"},{"key":"9077_CR13","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s10350-004-0828-0","volume":"48","author":"SJ van der Hagen","year":"2005","unstructured":"van der Hagen SJ, Baeten CG, Soeters PB, Russel MG, Beets-Tan RG, van Gemert WG. Anti-TNF-alpha (infliximab) used as induction treatment in case of active proctitis in a multistep strategy followed by definitive surgery of complex anal fistulas in Crohn\u2019s disease: a preliminary report. Dis Colon Rectum 2005;48:758-7.","journal-title":"Dis Colon Rectum"},{"key":"9077_CR14","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1056\/NEJM199905063401804","volume":"340","author":"DH Present","year":"1999","unstructured":"Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn\u2019s disease. N Engl J Med 1999;340:1398-05.","journal-title":"N Engl J Med"},{"key":"9077_CR15","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1056\/NEJMoa030815","volume":"350","author":"BE Sands","year":"2004","unstructured":"Sands BE, Anderson FH, Bernstein CN, et al. Infliximab maintenance therapy for fistulizing Crohn\u2019s disease. N Engl J Med 2004;350:876-5.","journal-title":"N Engl J Med"},{"key":"9077_CR16","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s10350-004-6611-4","volume":"46","author":"DR Topstad","year":"2003","unstructured":"Topstad DR, Panaccione R, Heine JA, Johnson DR, MacLean AR, Buie WD. Combined seton placement, infliximab infusion, and maintenance immunosuppressives improve healing rate in fistulizing anorectal Crohn\u2019s disease: a single center experience. Dis Colon Rectum 2003;46:577-3.","journal-title":"Dis Colon Rectum"},{"key":"9077_CR17","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1007\/s10350-006-0656-5","volume":"49","author":"SA Hyder","year":"2006","unstructured":"Hyder SA, Travis SP, Jewell DP, McC Mortensen NJ, George BD. Fistulating anal Crohn\u2019s disease: results of combined surgical and infliximab treatment. Dis Colon Rectum 2006;49:1837-1.","journal-title":"Dis Colon Rectum"},{"key":"9077_CR18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/BF00341224","volume":"7","author":"S Nordgren","year":"1992","unstructured":"Nordgren S, Fasth S, Hulten L. Anal fistulas in Crohn\u2019s disease: incidence and outcome of surgical treatment. Int J Colorectal Dis 1992;7:214-.","journal-title":"Int J Colorectal Dis"},{"key":"9077_CR19","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.gastro.2003.08.025","volume":"125","author":"WJ Sandborn","year":"2003","unstructured":"Sandborn WJ, Fazio VW, Feagan BG, Hanauer SB; American Gastroenterological Association Clinical Practice Committee. AGA technical review on perianal Crohn\u2019s disease. Gastroenterology 2003;125:1508-0.","journal-title":"Gastroenterology"},{"key":"9077_CR20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF02053858","volume":"38","author":"L Halme","year":"1995","unstructured":"Halme L, Sainio AP. Factors related to frequency, type, and outcome of anal fistulas in Crohn\u2019s disease. Dis Colon Rectum 1995;38:55-.","journal-title":"Dis Colon Rectum"},{"key":"9077_CR21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bjs.1800630102","volume":"63","author":"AG Parks","year":"1976","unstructured":"Parks AG, Gordon PH, Hardcastle JD. A classification of fistula-in-ano. Br J Surg 1976;63:1\u201312.","journal-title":"Br J Surg"},{"key":"9077_CR22","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0140-6736(75)92438-1","volume":"1","author":"B Ursing","year":"1975","unstructured":"Ursing B, Kamme C. Metronidazole for Crohn\u2019s disease. Lancet 1975;1:775-.","journal-title":"Lancet"},{"key":"9077_CR23","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0016-5085(80)90155-9","volume":"79","author":"LH Bernstein","year":"1980","unstructured":"Bernstein LH, Frank MS, Brandt LJ, Boley SJ. Healing of perineal Crohn\u2019s disease with metronidazole. Gastroenterology 1980;79:357-5.","journal-title":"Gastroenterology"},{"key":"9077_CR24","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0016-5085(82)80332-6","volume":"83","author":"LJ Brandt","year":"1982","unstructured":"Brandt LJ, Bernstein LH, Boley SJ, Frank MS. Metronidazole therapy for perineal Crohn\u2019s disease: a follow-up study. Gastroenterology 1982;83:383-.","journal-title":"Gastroenterology"},{"key":"9077_CR25","first-page":"533","volume":"79","author":"J Jakobovits","year":"1984","unstructured":"Jakobovits J, Schuster MM. Metronidazole therapy for Crohn\u2019s disease and associated fistulae. Am J Gastroenterol 1984;79:533-0.","journal-title":"Am J Gastroenterol"},{"key":"9077_CR26","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0140-6736(71)90598-8","volume":"2","author":"J Rhodes","year":"1971","unstructured":"Rhodes J, Bainton D, Beck P, Campbell H. Controlled trial of azathioprine in Crohn\u2019s disease. Lancet 1971;2:1273-.","journal-title":"Lancet"},{"key":"9077_CR27","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/BF01318372","volume":"30","author":"BI Korelitz","year":"1985","unstructured":"Korelitz BI, Present DH. Favorable effect of 6-mercaptopurine on fistulae of Crohn\u2019s disease. Dig Dis Sci 1985;30:58\u201364.","journal-title":"Dig Dis Sci"},{"key":"9077_CR28","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/0016-5085(90)91160-8","volume":"99","author":"J Markowitz","year":"1990","unstructured":"Markowitz J, Rosa J, Grancher K, Aiges H, Daum F. Long-term 6-mercaptopurine treatment in adolescents with Crohn\u2019s disease. Gastroenterology 1990;99:1347-1.","journal-title":"Gastroenterology"},{"key":"9077_CR29","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJM198005013021801","volume":"302","author":"DH Present","year":"1980","unstructured":"Present DH, Korelitz BI, Wisch N, Glass JL, Sachar DB, Pasternack BS. Treatment of Crohn\u2019s disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med 1980;302:981-.","journal-title":"N Engl J Med"},{"key":"9077_CR30","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/BF02090211","volume":"39","author":"DH Present","year":"1994","unstructured":"Present DH, Lichtiger S. Efficacy of cyclosporine in treatment of fistula of Crohn\u2019s disease. Dig Dis Sci 1994;39:374-0.","journal-title":"Dig Dis Sci"},{"key":"9077_CR31","first-page":"646","volume":"88","author":"SB Hanauer","year":"1993","unstructured":"Hanauer SB, Smith MB. Rapid closure of Crohn\u2019s disease fistulas with continuous intravenous cyclosporine A. Am J Gastroenterol 1993;88:646-.","journal-title":"Am J Gastroenterol"},{"key":"9077_CR32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00054725-199911000-00001","volume":"5","author":"PW Lowry","year":"1999","unstructured":"Lowry PW, Weaver AL, Tremaine WJ, Sandborn WJ. Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment refractory Crohn\u2019s disease perianal fistulae. Inflamm Bowel Dis 1999;5:239-5.","journal-title":"Inflamm Bowel Dis"},{"key":"9077_CR33","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/BF02053687","volume":"34","author":"JG Williams","year":"1991","unstructured":"Williams JG, Rothenberger DA, Nemer FD, Goldberg SM. Fistula-in-ano in Crohn\u2019s disease. Results of aggressive surgical treatment. Dis Colon Rectum 1991;34:378-4.","journal-title":"Dis Colon Rectum"},{"key":"9077_CR34","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1111\/j.1365-2036.2005.02456.x","volume":"21","author":"V Vitton","year":"2005","unstructured":"Vitton V, Gasmi M, Barthet M, Desjeux A, Orsoni P, Grimaud JC. Long-term healing of Crohn\u2019s anal fistulas with fibrin glue injection. Aliment Pharmacol Ther 2005;21:1453-.","journal-title":"Aliment Pharmacol Ther"},{"key":"9077_CR35","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s10350-006-0695-y","volume":"49","author":"L O\u2019Connor","year":"2006","unstructured":"O\u2019Connor L, Champagne BJ, Ferguson MA, Orangio GR, Schertzer ME, Armstrong DN. Efficacy of anal fistula plug in closure of Crohn\u2019s anorectal fistulas. Dis Colon Rectum 2006;49:1569-3.","journal-title":"Dis Colon Rectum"},{"key":"9077_CR36","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0140-6736(02)08512-4","volume":"359","author":"SB Hanauer","year":"2002","unstructured":"Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn\u2019s disease: the ACCENT I randomized trial. Lancet 2002;359:1541-.","journal-title":"Lancet"},{"key":"9077_CR37","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/S1542-3565(04)00414-8","volume":"2","author":"BE Sands","year":"2004","unstructured":"Sands BE, Blank MA, Patel K, van Deventer SJ; ACCENT II Study. Long-term treatment of rectovaginal fistulas in Crohn\u2019s disease: response to infliximab in the ACCENT II Study. Clin Gastroenterol Hepatol 2004;2:912-0.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"9077_CR38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1046\/j.1365-2036.2003.01427.x","volume":"17","author":"SJ Bell","year":"2003","unstructured":"Bell SJ, Halligan S, Windsor AC, Williams AB, Wiesel P, Kamm MA. Response of fistulating Crohn\u2019s disease to Infliximab treatment assessed by magnetic resonance imaging. Aliment Pharmacol Ther 2003;17:387-3","journal-title":"Aliment Pharmacol Ther"},{"key":"9077_CR39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00054725-200403000-00005","volume":"10","author":"S Ardizzone","year":"2004","unstructured":"Ardizzone S, Maconi G, Colombo E, Manzionna G, Bollani S, Bianchi Porro G. Perianal fistulae following infliximab treatment: clinical and endosonographic outcome. Inflamm Bowel Dis 2004;10:91-.","journal-title":"Inflamm Bowel Dis"},{"key":"9077_CR40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10350-004-6111-6","volume":"5","author":"AA Van Bodegraven","year":"2002","unstructured":"Van Bodegraven AA, Sloots CE, Felt-Bersma RJ, Meuwissen SG. Endosonographic evidence of persistence of Crohn\u2019s disease related fistulas after Infliximab treatment, irrespective of clinical response. Dis Colon Rectum 2002;5:39\u201345.","journal-title":"Dis Colon Rectum"},{"issue":"Suppl C","key":"9077_CR41","doi-asserted-by":"crossref","first-page":"7C","DOI":"10.1155\/2000\/985045","volume":"14","author":"P Rutgeerts","year":"2000","unstructured":"Rutgeerts P. Management of perianal Crohn\u2019s disease. Can J Gastroenterol 2000;14(Suppl C):7C\u201312C.","journal-title":"Can J Gastroenterol"},{"key":"9077_CR42","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1136\/gut.2003.018515","volume":"53","author":"T Ljung","year":"2004","unstructured":"Ljung T, Karlen P, Schmidt D, et al. Infliximab in inflammatory bowel disease: clinical outcome in a population based cohort from Stockholm County. Gut 2004;53:849-3.","journal-title":"Gut"},{"key":"9077_CR43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1053\/j.gastro.2003.10.047","volume":"126","author":"JF Colombel","year":"2004","unstructured":"Colombel JF, Loftus EV Jr, Tremaine WJ, et al. The safety profile of infliximab in patients with Crohn\u2019s disease: the Mayo Clinic experience in 500 patients. Gastroenterology 2004;126:19\u201331.","journal-title":"Gastroenterology"},{"key":"9077_CR44","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/art.21841","volume":"55","author":"JT Giles","year":"2006","unstructured":"Giles JT, Bartlett SJ, Gelber AC, et al. Tumor necrosis factor inhibitor therapy and risk of serious postoperative orthopedic infection in rheumatoid arthritis. Arthritis Rheum 2006;55:333-.","journal-title":"Arthritis Rheum"}],"container-title":["Diseases of the Colon & Rectum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1007\/s10350-007-9077-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:50:02Z","timestamp":1786035002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003453-200750110-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1007\/s10350-007-9077-3","relation":{},"ISSN":["0012-3706"],"issn-type":[{"value":"0012-3706","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}