{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:44:44Z","timestamp":1791139484026,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"13-14","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wien Med Wochenschr"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1007\/s10354-009-0699-z","type":"journal-article","created":{"date-parts":[[2009,8,3]],"date-time":"2009-08-03T00:04:21Z","timestamp":1249257861000},"page":"337-341","source":"Crossref","is-referenced-by-count":38,"title":["Lymphocyte imbalance in vitiligo patients indicated by elevated CD4+\/CD8+ T-cell ratio","Lymphozytendysbalance bei Vitiligopatienten \u2013 Hinweis durch erh\u00f6htes Verh\u00e4ltnis von CD4- zu CD8 T-Zellen"],"prefix":"10.1007","volume":"159","author":[{"given":"Robert","family":"Pichler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Sfetsos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Badics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Gutenbrunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Aub\u00f6ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"699_CR1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2005.10.001","volume":"25","author":"T Passeron","year":"2005","unstructured":"Passeron T, Ortonne JP. Physiopathology and genetics of vitiligo. J Autoimmun, 25: 63\u201366, 2005","journal-title":"J Autoimmun"},{"key":"699_CR2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1034\/j.1600-0749.2003.00023.x","volume":"16","author":"K Ongenae","year":"2003","unstructured":"Ongenae K, van Geel N, Naeyaert JM. Evidence for an autoimmune pathogenesis of vitiligo. Pigment Cell Res, 16: 90\u2013100, 2003","journal-title":"Pigment Cell Res"},{"key":"699_CR3","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/labinvest.3780318","volume":"81","author":"R van den Wijngaard","year":"2001","unstructured":"van den Wijngaard R, Wankowicz-Kalinska A, Pals S, Weening J, Das P. Autoimmune melanocyte destruction in vitiligo. Lab Invest, 81: 1061\u20131067, 2001","journal-title":"Lab Invest"},{"key":"699_CR4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1034\/j.1600-0749.2003.00032.x","volume":"16","author":"A Alkahateeb","year":"2003","unstructured":"Alkahateeb A, Fain PR, Thody A, Bennett DC, Spritz RA. Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families. Pigment Cell Res, 16: 208\u2013214, 2003","journal-title":"Pigment Cell Res"},{"key":"699_CR5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/08916930500050368","volume":"38","author":"R Pichler","year":"2005","unstructured":"Pichler R, Sfetsos K, Aub\u00f6ck J, Badics B, Gutenbrunner S, Berg J. Cytomegalovirus infection in central european vitiligo patients? Autoimmunity, 38: 121\u2013122, 2005","journal-title":"Autoimmunity"},{"key":"699_CR6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.npep.2006.03.001","volume":"40","author":"R Pichler","year":"2006","unstructured":"Pichler R, Sfetsos K, Badics B, Gutenbrunner S, Aub\u00f6ck J. Vitiligo patients present lower plasma levels of alpha-melanotropin immunoreactivities. Neuropeptides, 40: 177\u2013183, 2006","journal-title":"Neuropeptides"},{"key":"699_CR7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1258\/000456306776865043","volume":"43","author":"D Sinclair","year":"2006","unstructured":"Sinclair D. Clinical and laboratory aspects of thyroid antibodies. Ann Clin Biochem, 43: 173\u2013183, 2006","journal-title":"Ann Clin Biochem"},{"key":"699_CR8","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1515\/CCLM.1998.141","volume":"36","author":"P Fraunberger","year":"1998","unstructured":"Fraunberger P, Pfeiffer M, Cremer P, Holler E, Nagel D, Dehart I, Thein M, Walli AK, Seidel D. Validation of an automated enzyme immunoassay for interleukin-6 for routine clinical use. Clin Chem Lab Med, 36: 797\u2013801, 1998","journal-title":"Clin Chem Lab Med"},{"key":"699_CR9","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0952-7915(01)00276-X","volume":"13","author":"P Santamaria","year":"2001","unstructured":"Santamaria P. Effector lymphocytes in autoimmunity. Curr Opin Immunol, 13: 663\u2013669, 2001","journal-title":"Curr Opin Immunol"},{"key":"699_CR10","first-page":"3","volume":"77","author":"T Dorner","year":"2006","unstructured":"Dorner T. Crossroads of B cell activation in autoimmunity: rationale of targeting B cells. J Rheumatol Suppl, 77: 3\u201311, 2006","journal-title":"J Rheumatol Suppl"},{"key":"699_CR11","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S1074-7613(02)00327-8","volume":"16","author":"J Trcka","year":"2002","unstructured":"Trcka J, Moroi Y, Clynes RA, Goldberg SM, Bergtold A, Perales MA, Ma M, Ferrone CR, Carroll MC, Ravetch JV, Houghton AN. Redundant and alternative roles for activating Fc receptors and complement in antibody-dependent model of autoimmune vitiligo. Immunity, 16: 861\u2013868, 2002","journal-title":"Immunity"},{"key":"699_CR12","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/01.LAB.0000069521.42488.1B","volume":"83","author":"A Wa\u0144kowicz-Kali\u0144ska","year":"2003","unstructured":"Wa\u0144kowicz-Kali\u0144ska A, van den Wijngaard RM, Tigges BJ, Westerhof W, Ogg GS, Cerundolo V, Storkus WJ, Das PK. Immunopolarization of CD4+ and CD8+ T cells to Type-1-like is associated with melanocyte loss in human vitiligo. Lab Invest, 83: 683\u2013695, 2003","journal-title":"Lab Invest"},{"key":"699_CR13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1034\/j.1600-0749.2002.1o049.x","volume":"15","author":"S Moretti","year":"2002","unstructured":"Moretti S, Spallanzani A, Amato L, Hautmann G, Gallerani I, Fabiani M, Fabbri P. New insights into the pathogenesis of vitiligo: imbalance of epidermal cytokines at sites of lesions. Pigment Cell Res, 15: 87\u201392, 2002","journal-title":"Pigment Cell Res"},{"key":"699_CR14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1055\/s-2003-41624","volume":"35","author":"R Pichler","year":"2003","unstructured":"Pichler R, Maschek W, Hatzl-Griesenhofer M, Huber H, Crespillo-Gomez C, Berg J. Soluble tumour necrosis factor-alpha receptor I and interleukin-6 as markers of activity in thyrotoxic Graves' disease. Horm Metab Res, 35: 427\u2013433, 2003","journal-title":"Horm Metab Res"},{"key":"699_CR15","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jaad.2008.09.048","volume":"60","author":"PY Basak","year":"2009","unstructured":"Basak PY, Adiloglu AK, Ceyhan AM, Tas T, Akkaya VB. The role of helper and regulatory T cells in the pathogenesis of vitiligo. J Am Acad Dermatol, 60: 256\u2013260, 2009","journal-title":"J Am Acad Dermatol"},{"key":"699_CR16","first-page":"21","volume":"16","author":"J Morales-Montor","year":"2005","unstructured":"Morales-Montor J. The role of the pleiotropic cytokine interleukin-6 (IL-6) during disease. Mod Asp Immunobiol, 16: 21\u201326, 2005","journal-title":"Mod Asp Immunobiol"},{"key":"699_CR17","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0190-9622(92)70094-V","volume":"26","author":"N Mozzanica","year":"1992","unstructured":"Mozzanica N, Villa ML, Foppa S, Vignati G, Cattaneo A, Diotti R, Finzi AF. Plasma alpha-melanocyte-stimulating hormone, beta-endorphin, met-enkephalin, and natural killer cell activity in vitiligo. J Am Acad Dermatol, 26: 693\u2013700, 1992","journal-title":"J Am Acad Dermatol"},{"key":"699_CR18","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0190-9622(86)70085-6","volume":"14","author":"RM Halder","year":"1986","unstructured":"Halder RM, Walters CS, Johnson BA, Chakrabarti SG, Kenney JA. Aberrations in T lymphocytes and natural killer cells in vitiligo: a flow cytometric study. J Am Acad Dermatol, 14: 733\u2013737, 1986","journal-title":"J Am Acad Dermatol"},{"key":"699_CR19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0190-9622(90)70029-H","volume":"22","author":"N Mozzanica","year":"1990","unstructured":"Mozzanica N, Frigerio U, Finzi AF, Cattaneo A, Negri M, Scaglione F, Fraschini F, Foppa S. T cell subpopulations in vitiligo: a chronobiologic study. J Am Acad Dermatol, 22: 223\u2013230, 1990","journal-title":"J Am Acad Dermatol"},{"key":"699_CR20","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1346-8138.2004.tb00514.x","volume":"31","author":"K Gunduz","year":"2004","unstructured":"Gunduz K, Ozturk G, Terzioglu E, Sebik F. T cell subpopulations and IL-2R in vitiligo. J Dermatol, 31: 94\u201397, 2004","journal-title":"J Dermatol"},{"key":"699_CR21","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/01.mjt.0000178767.67857.63","volume":"12","author":"JW Yoon","year":"2005","unstructured":"Yoon JW, Jun HS. Autoimmune destruction of pancreatic beta cells. Am J Ther, 12: 580\u2013591, 2005","journal-title":"Am J Ther"},{"key":"699_CR22","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.23.021704.115825","volume":"24","author":"F Castellino","year":"2006","unstructured":"Castellino F, Germain RN. Cooperation between CD4+ and CD8+ T cells: when, where and how. Annu Rev Immunol, 24: 519\u2013540, 2006","journal-title":"Annu Rev Immunol"},{"key":"699_CR23","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.coi.2005.09.014","volume":"17","author":"U Walter","year":"2005","unstructured":"Walter U, Santamaria P. CD8+ T cells in autoimmunity. Curr Opin Immunol, 17: 624\u2013631, 2005","journal-title":"Curr Opin Immunol"}],"container-title":["Wiener Medizinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-009-0699-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10354-009-0699-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-009-0699-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T12:03:50Z","timestamp":1559131430000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10354-009-0699-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":23,"journal-issue":{"issue":"13-14","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["699"],"URL":"https:\/\/doi.org\/10.1007\/s10354-009-0699-z","relation":{},"ISSN":["0043-5341","1563-258X"],"issn-type":[{"value":"0043-5341","type":"print"},{"value":"1563-258X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}