{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:55:21Z","timestamp":1769842521263,"version":"3.49.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5-6","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Med Wochenschr"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1007\/s10354-010-0767-4","type":"journal-article","created":{"date-parts":[[2010,4,2]],"date-time":"2010-04-02T09:21:32Z","timestamp":1270200092000},"page":"124-128","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mortality, morbidity and special issues of obese ICU patients","Mortalit\u00e4t, Morbidit\u00e4t und spezielle Probleme bei adip\u00f6sen Intensivpatienten"],"prefix":"10.1007","volume":"160","author":[{"given":"Wolfgang","family":"Miehsler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"767_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1093\/epirev\/mxm007","volume":"29","author":"Y Wang","year":"2007","unstructured":"Wang Y, Beydun M. The obesity epidemic in the United States \u2013 gender, age, socioeconomic, racial\/ethnic and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev, 29: 6\u201328, 2007","journal-title":"Epidemiol Rev"},{"key":"767_CR2","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1056\/NEJMoa0801891","volume":"359","author":"T Pischon","year":"2008","unstructured":"Pischon T, Boeing H, Hoffmann K, et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med, 359: 2105\u20132120, 2008","journal-title":"N Engl J Med"},{"key":"767_CR3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s10654-009-9312-4","volume":"24","author":"J Klenk","year":"2009","unstructured":"Klenk J, Nagel G, Ulmer H, et al. Body mass index and mortality: results of a cohort of 184,697 adults in Austria. Europ J Epidemiol, 24: 83\u201391, 2009","journal-title":"Europ J Epidemiol"},{"key":"767_CR4","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1007\/s00134-008-1243-0","volume":"34","author":"Y Sakr","year":"2008","unstructured":"Sakr Y, Madl C, Filipescu D, et al. Obesity is associated with increased morbidity but not mortality in critically ill patients. Intensive Care Med, 34: 1999\u20132009, 2008","journal-title":"Intensive Care Med"},{"key":"767_CR5","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/oby.2007.102","volume":"16","author":"H Oliveros","year":"2008","unstructured":"Oliveros H, Villamor E. Obesity and mortality in critically ill adults: a systematic review and meta-analysis. Obesity, 16: 515\u2013521, 2008","journal-title":"Obesity"},{"key":"767_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/01.CCM.0000297885.60037.6E","volume":"36","author":"M Akinnusi","year":"2008","unstructured":"Akinnusi M, Pineda L, Solh A. Effect of obesity on intensive care morbidity and mortality: a meta-analysis. Crit Care Med, 36: 151\u2013158, 2008","journal-title":"Crit Care Med"},{"key":"767_CR7","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1378\/chest.120.6.1989","volume":"120","author":"A El-Solh","year":"2001","unstructured":"El-Solh A, Sikka P, Bozkanat E, et al. Morbid obesity in the medical ICU. Chest, 120: 1989\u20131997, 2001","journal-title":"Chest"},{"key":"767_CR8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.jamcollsurg.2006.07.001","volume":"203","author":"G Bochicchio","year":"2006","unstructured":"Bochicchio G, Joshi M, Bochicchio K, et al. Impact of obesity in the critically ill trauma patient: a prospective study. J Am Coll Surg, 203: 533\u2013538, 2006","journal-title":"J Am Coll Surg"},{"key":"767_CR9","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.jamcollsurg.2006.12.042","volume":"204","author":"M Newell","year":"2007","unstructured":"Newell M, Bard M, Goettler C, et al. Body mass index and outcomes in critically injured blunt trauma patients: weighing the impact. J Am Coll Surg, 204: 1056\u20131061, 2007","journal-title":"J Am Coll Surg"},{"key":"767_CR10","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1007\/s00134-008-1245-y","volume":"34","author":"JP Frat","year":"2008","unstructured":"Frat JP, Gissot V, Ragot S, et al. Impact of obesity in mechanically ventilated patients. Intensive Care Med, 34: 1991\u20131998, 2008","journal-title":"Intensive Care Med"},{"key":"767_CR11","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1136\/thx.2007.086835","volume":"63","author":"A Malhotra","year":"2008","unstructured":"Malhotra A, Hillman D. Obesity and the lung: obesity, respiration and intensive care. Thorax, 63: 925\u2013931, 2008","journal-title":"Thorax"},{"key":"767_CR12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/SMJ.0b013e31818c9585","volume":"102","author":"E Ceylan","year":"2009","unstructured":"Ceylan E, C\u00f6mlekci A, Akkoclu A, et al. The effects of body fat distribution on pulmonary function tests in the overweight and obese. South Med J, 102: 30\u201335, 2009","journal-title":"South Med J"},{"key":"767_CR13","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1213\/01.ANE.0000072547.75928.B0","volume":"97","author":"P Juvin","year":"2003","unstructured":"Juvin P, Lavaut E, Dupont H, et al. Difficult tracheal intubation is more common in obese than in lean patients. Anesth Analg, 97: 595\u2013600, 2003","journal-title":"Anesth Analg"},{"key":"767_CR14","first-page":"1453","volume":"32","author":"M Malbrain","year":"2006","unstructured":"Malbrain M, Cheatham M, Kirkpatrick A, et al. Results from the international Conference of experts on intra-abdominal hypertension and abdominal compartment syndrome. I. Definitions. Intensive Care Med, 32: 1453\u20131458, 2006","journal-title":"Intensive Care Med"},{"key":"767_CR15","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1164\/rccm.200807-1195OC","volume":"179","author":"N Leone","year":"2009","unstructured":"Leone N, Courbon D, Thomas F, et al. Lung function impairment and metabolic syndrom; the critical role of abdominal obesity. Am J Resp Crit Care Med, 179: 509\u2013516, 2009","journal-title":"Am J Resp Crit Care Med"},{"key":"767_CR16","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1378\/chest.113.2.492","volume":"113","author":"P Marik","year":"1998","unstructured":"Marik P, Varon J. The obese patient in the ICU. Chest, 113: 492\u2013498, 1998","journal-title":"Chest"},{"key":"767_CR17","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1097\/01.CCM.0000215515.49001.A2","volume":"34","author":"D Talmor","year":"2006","unstructured":"Talmor D, Sarge T, O'Donnel C, et al. Esophageal and transpulmonary pressure in acute respiratory failure. Crit Care Med, 34: 1389\u20131394, 2006","journal-title":"Crit Care Med"},{"key":"767_CR18","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.pcad.2008.08.001","volume":"51","author":"N Al Lawati","year":"2009","unstructured":"Al Lawati N, Patel S, Ayas N. Epidemiology, risk factors, and consequences of obstructive sleep apnea and short sleep duration. Prog Cardiovasc Dis, 51: 285\u2013293, 2009","journal-title":"Prog Cardiovasc Dis"},{"key":"767_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.amjmed.2003.08.022","volume":"116","author":"S Nowbar","year":"2004","unstructured":"Nowbar S, Burkart K, Gonzales R, et al. Obesity-associated hypoventilation in hospitalized patients: prevalence, effects and outcome. Am J Med, 116: 1\u20137, 2004","journal-title":"Am J Med"},{"key":"767_CR20","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1183\/09031936.06.00150705","volume":"28","author":"A El-Solh","year":"2006","unstructured":"El-Solh A, Aquilina A, Pineda L, et al. Noninvasive ventilation for prevention of post-extubation respiratory failure in obese patients. Eur Resp J, 28: 588\u2013595, 2006","journal-title":"Eur Resp J"},{"key":"767_CR21","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1164\/rccm.200404-552OC","volume":"172","author":"R Heinzer","year":"2005","unstructured":"Heinzer R, Stanchina M, Malhotra A, et al. Lung volume and continuous positive airway pressure requirements in obstructive sleep apnoea. Am J Resp Crit Care Med, 172: 114\u2013117, 2005","journal-title":"Am J Resp Crit Care Med"},{"key":"767_CR22","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ccc.2008.02.003","volume":"24","author":"W Lee","year":"2008","unstructured":"Lee W, Mokhlesi B. Diagnosis and management of obesity hypoventilation syndrome in the ICU. Crit Care Clin, 24: 533\u2013549, 2008","journal-title":"Crit Care Clin"},{"key":"767_CR23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1089\/sur.2008.028","volume":"10","author":"L Dossett","year":"2009","unstructured":"Dossett L, Dageforde L, Swenson B, et al. Obesity and site-specific nosocomial infection risk in the intensive care unit. Surg Infect, 10: 137\u2013142, 2009","journal-title":"Surg Infect"},{"key":"767_CR24","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.jamcollsurg.2006.12.042","volume":"204","author":"M Newell","year":"2007","unstructured":"Newell M, Bard M, Goettler C, et al. Body mass index and outcome in critically injures blunt trauma patients: weighing the impact. J Am Coll Surg, 204: 1056\u20131064, 2007","journal-title":"J Am Coll Surg"},{"key":"767_CR25","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1089\/sur.2006.079","volume":"8","author":"R Smith","year":"2007","unstructured":"Smith R, Chong T, Hedrick T, et al. Does body mass index affect infection-related outcomes in the intensive care unit? Surg Infect, 8: 581\u2013588, 2007","journal-title":"Surg Infect"},{"key":"767_CR26","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1056\/NEJM200103083441001","volume":"344","author":"G Bernard","year":"2001","unstructured":"Bernard G, Vincent J, Laterre P, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med, 344: 699\u2013709, 2001","journal-title":"N Engl J Med"},{"key":"767_CR27","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","volume":"342","author":"The Acute Respiratory Distress Syndrome Network","year":"2000","unstructured":"The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med, 342: 1301\u20131308, 2000","journal-title":"N Engl J Med"},{"key":"767_CR28","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.pathophys.2008.04.008","volume":"15","author":"V Vachharajani","year":"2008","unstructured":"Vachharajani V. Influence of obesity on sepsis. Pathophysiology, 15: 123\u2013134, 2008","journal-title":"Pathophysiology"},{"key":"767_CR29","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1079\/PNS2005428","volume":"64","author":"H Hauner","year":"2005","unstructured":"Hauner H. Secretory factors from human adipous tissue and their functional role. Proc Nutr Soc, 64: 163\u2013169, 2005","journal-title":"Proc Nutr Soc"},{"key":"767_CR30","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/29795","volume":"394","author":"G Lord","year":"1998","unstructured":"Lord G, Matarese G, Howard J, et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature, 394: 897\u2013901, 1998","journal-title":"Nature"},{"key":"767_CR31","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/j.1365-2249.2007.03361.x","volume":"148","author":"L Rodriguez","year":"2007","unstructured":"Rodriguez L, Graniel J, Ortitz R. Effect of leptin on activation and cytokine synthesis in peripheral blood lymphocytes of malnurishes infected children. Clin Exp Immunol, 148: 478\u2013485, 2007","journal-title":"Clin Exp Immunol"},{"key":"767_CR32","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1056\/NEJM199602013340503","volume":"334","author":"R Considine","year":"1996","unstructured":"Considine R, Sinha M, Heiman M, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med, 334: 292\u2013295, 1996","journal-title":"N Engl J Med"},{"key":"767_CR33","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1365-2249.2007.03491.x","volume":"150","author":"A Hsu","year":"2007","unstructured":"Hsu A, Aronoff D, Phipps J, et al. Leptin improves pulmonary bacterial clearance and survival in ob\/ob mice during pneumococcal pneumonia. Clin Exp Immunol, 150: 332\u2013339, 2007","journal-title":"Clin Exp Immunol"},{"key":"767_CR34","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1210\/jc.83.1.280","volume":"83","author":"S Bornstein","year":"1998","unstructured":"Bornstein S, Licinio J, Tauchnitz R, et al. Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm, in cortisol and leptin secretion. J Clin Endocrinol Metab, 83: 280\u2013283, 1998","journal-title":"J Clin Endocrinol Metab"},{"key":"767_CR35","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1159\/000136480","volume":"41","author":"R Bracho-Riquelme","year":"2008","unstructured":"Bracho-Riquelme R, Reyes-Romero M, Pescador N, et al. A leptin serum concentration less than 10 ng\/ml is a predictive marker of outcome in patients with moderate to severe secondary peritonitis. Eur Surg Res, 41: 238\u2013244, 2008","journal-title":"Eur Surg Res"},{"key":"767_CR36","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1157\/13066426","volume":"61","author":"A Blanco-Quir\u00f3s","year":"2004","unstructured":"Blanco-Quir\u00f3s A, Casado-Flores J, Nieto-Moro M, et al. Meningococcal sepsis in pediatrics. Parameters associated with poor outcome. An Pediatr, 61: 305\u2013313, 2004","journal-title":"An Pediatr"},{"key":"767_CR37","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1080\/080352502760069007","volume":"91","author":"A Blanco-Quiros","year":"2002","unstructured":"Blanco-Quiros A, Casado-Flores J, Arranz E, et al. Influence of leptin levels and body weight in survival of children with sepsis. Acta Paediatr, 91: 626\u2013631, 2002","journal-title":"Acta Paediatr"},{"issue":"25","key":"767_CR38","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1161\/01.CIR.100.25.2473","volume":"100","author":"N Ouchi","year":"1999","unstructured":"Ouchi N, Kihara S, Arita Y, et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation, 100(25): 2473\u20132476, 1999","journal-title":"Circulation"},{"key":"767_CR39","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.surg.2009.01.010","volume":"145","author":"Y Uji","year":"2009","unstructured":"Uji Y, Yamamoto H, Tsuchihashi H, et al. Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortality. Surgery, 145: 550\u2013557, 2009","journal-title":"Surgery"}],"container-title":["Wiener Medizinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-010-0767-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10354-010-0767-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-010-0767-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-010-0767-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T18:02:14Z","timestamp":1589479334000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10354-010-0767-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":39,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["767"],"URL":"https:\/\/doi.org\/10.1007\/s10354-010-0767-4","relation":{},"ISSN":["0043-5341","1563-258X"],"issn-type":[{"value":"0043-5341","type":"print"},{"value":"1563-258X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"20 January 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}