{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:17:33Z","timestamp":1787861853798,"version":"build-2784847793"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"9-10","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wien Med Wochenschr"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1007\/s10354-012-0075-2","type":"journal-article","created":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T09:31:24Z","timestamp":1340184684000},"page":"220-224","source":"Crossref","is-referenced-by-count":23,"title":["The feto-placental endothelium in pregnancy pathologies","Ver\u00e4nderungen des feto-plazentaren Endothels bei Schwangerschaftspathologien"],"prefix":"10.1007","volume":"162","author":[{"given":"Christian","family":"Wadsack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Desoye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Hiden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"75_CR1","first-page":"126","volume-title":"Textbook of diabetes in pregnancy","author":"G Desoye","year":"2003","unstructured":"Desoye G, Hauguel-de Mouzon S, Shafrir E. The placenta in diabetic pregnancy. In: Hod M, Jovanovic L, DiRenzo G-C, deLeiva A, Langer O (eds) Textbook of diabetes in pregnancy. Martin Dunitz, London, pp. 126\u2013147, 2003"},{"key":"75_CR2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/9781444315196.ch3","volume-title":"Diabetes in pregnancy","author":"U Hiden","year":"2010","unstructured":"Hiden U, Desoye G. The placenta in diabetes in pregnancy. In: McCance DR, Maresh M, Sacks DA (eds) Diabetes in pregnancy. 1st edn. Wiley-Blackwell, Chichester, pp. 26\u201333, 2010","edition":"1"},{"issue":"Suppl 1","key":"75_CR3","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.2337\/dc07-S042","volume":"30","author":"American Diabetes Association","year":"2007","unstructured":"American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care, 30 (Suppl 1): S42\u2013S47, 2007","journal-title":"Diabetes Care"},{"key":"75_CR4","doi-asserted-by":"crossref","unstructured":"HAPO Study Cooperative Research Group: Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations with neonatal anthropometrics. Diabetes, 58: 453\u2013459, 2009","DOI":"10.2337\/db08-1112"},{"key":"75_CR5","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.bbrc.2007.06.044","volume":"360","author":"F Haubner","year":"2007","unstructured":"Haubner F, Lehle K, Munzel D, et al. Hyperglycemia increases the levels of vascular cellular adhesion molecule-1 and monocyte-chemoattractant-protein-1 in the diabetic endothelial cell. Biochem Biophys Res Commun, 360: 560\u2013565, 2007","journal-title":"Biochem Biophys Res Commun"},{"key":"75_CR6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s11906-008-0082-2","volume":"10","author":"JD Knudson","year":"2008","unstructured":"Knudson JD, Payne GA, Borbouse L, et al. Leptin and mechanisms of endothelial dysfunction and cardiovascular disease. Curr Hypertens Rep, 10: 434\u2013439, 2008","journal-title":"Curr Hypertens Rep"},{"key":"75_CR7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/13813450903136791","volume":"115","author":"G Anfossi","year":"2009","unstructured":"Anfossi G, Russo I, Doronzo G, et al. Contribution of insulin resistance to vascular dysfunction. Arch Physiol Biochem, 115: 199\u2013217, 2009","journal-title":"Arch Physiol Biochem"},{"key":"75_CR8","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.2337\/diacare.22.7.1201","volume":"22","author":"R Schwartz","year":"1999","unstructured":"Schwartz R, Teramo KA. What is the significance of macrosomia? Diabetes Care, 22: 1201\u20131205, 1999","journal-title":"Diabetes Care"},{"key":"75_CR9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0002-9378(93)90137-8","volume":"169","author":"J Verhaeghe","year":"1993","unstructured":"Verhaeghe J, Van Bree R, Van Herck E, et al. C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: correlations with birth weight. Am J Obstet Gynecol, 169: 89\u201397, 1993","journal-title":"Am J Obstet Gynecol"},{"key":"75_CR10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000113045","volume":"65","author":"R Madazli","year":"2008","unstructured":"Madazli R, Tuten A, Calay Z, et al. The incidence of placental abnormalities, maternal and cord plasma malondialdehyde and vascular endothelial growth factor levels in women with gestational diabetes mellitus and nondiabetic controls. Gynecol Obstet Invest, 65: 227\u2013232, 2008","journal-title":"Gynecol Obstet Invest"},{"key":"75_CR11","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.placenta.2005.04.010","volume":"27","author":"E Jauniaux","year":"2006","unstructured":"Jauniaux E, Burton GJ. Villous histomorphometry and placental bed biopsy investigation in Type I diabetic pregnancies. Placenta, 27: 468\u2013474, 2006","journal-title":"Placenta"},{"key":"75_CR12","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/BF02374479","volume":"36","author":"TM Mayhew","year":"1993","unstructured":"Mayhew TM, Sorensen FB, Klebe JG, et al. Oxygen diffusive conductance in placentae from control and diabetic women. Diabetologia, 36: 955\u2013960, 1993","journal-title":"Diabetologia"},{"key":"75_CR13","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2337\/diacare.25.3.560","volume":"25","author":"G Paradisi","year":"2002","unstructured":"Paradisi G, Biaggi A, Ferrazzani S, et al. Abnormal carbohydrate metabolism during pregnancy : association with endothelial dysfunction. Diabetes Care, 25: 560\u2013564, 2002","journal-title":"Diabetes Care"},{"key":"75_CR14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1549-8719.2011.00091.x","volume":"18","author":"L Leach","year":"2011","unstructured":"Leach L. Placental vascular dysfunction in diabetic pregnancies: intimations of fetal cardiovascular disease? Microcirculation, 18: 263\u2013269, 2011","journal-title":"Microcirculation"},{"issue":"Suppl 2","key":"75_CR15","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1016\/j.placenta.2010.12.011","volume":"32","author":"L Sobrevia","year":"2011","unstructured":"Sobrevia L, Abarzua F, Nien JK, et al. Review: differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes. Placenta, 32 (Suppl 2): S159\u2013S164, 2011","journal-title":"Placenta"},{"key":"75_CR16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000063692","volume":"39","author":"M Jirkovska","year":"2002","unstructured":"Jirkovska M, Kubinova L, Janacek J, et al. Topological properties and spatial organization of villous capillaries in normal and diabetic placentas. J Vasc Res, 39: 268\u2013278, 2002","journal-title":"J Vasc Res"},{"key":"75_CR17","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.2337\/dc05-1677","volume":"29","author":"JA Westgate","year":"2006","unstructured":"Westgate JA, Lindsay RS, Beattie J, et al. Hyperinsulinemia in cord blood in mothers with type 2 diabetes and gestational diabetes mellitus in New Zealand. Diabetes Care, 29: 1345\u20131350, 2006","journal-title":"Diabetes Care"},{"key":"75_CR18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1469-7580.2008.01035.x","volume":"215","author":"U Hiden","year":"2009","unstructured":"Hiden U, Glitzner E, Hartmann M, et al. Insulin and the IGF system in the human placenta of normal and diabetic pregnancies. J Anat, 215: 60\u201368, 2009","journal-title":"J Anat"},{"key":"75_CR19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00125-005-0054-x","volume":"49","author":"U Hiden","year":"2006","unstructured":"Hiden U, Maier A, Bilban M, et al. Insulin control of placental gene expression shifts from mother to foetus over the course of pregnancy. Diabetologia, 49: 123\u2013131, 2006","journal-title":"Diabetologia"},{"key":"75_CR20","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/molehr\/6.8.763","volume":"6","author":"RG Lea","year":"2000","unstructured":"Lea RG, Howe D, Hannah LT, et al. Placental leptin in normal, diabetic and fetal growth-retarded pregnancies. Mol Hum Reprod, 6: 763\u2013769, 2000","journal-title":"Mol Hum Reprod"},{"key":"75_CR21","first-page":"157","volume":"20","author":"MC Lygnos","year":"2006","unstructured":"Lygnos MC, Pappa KI, Papadaki HA, et al. Changes in maternal plasma levels of VEGF, bFGF, TGF-beta1, ET-1 and sKL during uncomplicated pregnancy, hypertensive pregnancy and gestational diabetes. In Vivo, 20: 157\u2013163, 2006","journal-title":"In Vivo"},{"key":"75_CR22","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1440-1827.1996.tb03585.x","volume":"46","author":"B Younes","year":"1996","unstructured":"Younes B, Baez-Giangreco A, al-Nuaim L, et al. Basement membrane thickening in the placentae from diabetic women. Pathol Int, 46: 100\u2013104, 1996","journal-title":"Pathol Int"},{"key":"75_CR23","doi-asserted-by":"crossref","first-page":"46230","DOI":"10.1074\/jbc.M305420200","volume":"278","author":"F Coulet","year":"2003","unstructured":"Coulet F, Nadaud S, Agrapart M, et al. Identification of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter. J Biol Chem, 278: 46230\u201346240, 2003","journal-title":"J Biol Chem"},{"key":"75_CR24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/molehr\/5.5.487","volume":"5","author":"WG Rossmanith","year":"1999","unstructured":"Rossmanith WG, Hoffmeister U, Wolfahrt S, et al. Expression and functional analysis of endothelial nitric oxide synthase (eNOS) in human placenta. Mol Hum Reprod, 5: 487\u2013494, 1999","journal-title":"Mol Hum Reprod"},{"key":"75_CR25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000291514","volume":"44","author":"S Dollberg","year":"1997","unstructured":"Dollberg S, Brockman DE, Myatt L. Nitric oxide synthase activity in umbilical and placental vascular tissue of gestational diabetic pregnancies. Gynecol Obstet Invest, 44: 177\u2013181, 1997","journal-title":"Gynecol Obstet Invest"},{"key":"75_CR26","doi-asserted-by":"crossref","first-page":"H706","DOI":"10.1152\/ajpheart.2000.278.3.H706","volume":"278","author":"R Figueroa","year":"2000","unstructured":"Figueroa R, Martinez E, Fayngersh RP, et al. Alterations in relaxation to lactate and H[2]O[2] in human placental vessels from gestational diabetic pregnancies. Am J Physiol Heart Circ Physiol, 278: H706\u2013H713, 2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"75_CR27","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s001250051511","volume":"43","author":"MO Babawale","year":"2000","unstructured":"Babawale MO, Lovat S, Mayhew TM, et al. Effects of gestational diabetes on junctional adhesion molecules in human term placental vasculature. Diabetologia, 43: 1185\u20131196, 2000","journal-title":"Diabetologia"},{"key":"75_CR28","first-page":"1384","volume":"58","author":"RC Vandenbosche","year":"1998","unstructured":"Vandenbosche RC, Kirchner JT. Intrauterine growth retardation. Am Fam Physician, 58: 1384\u20131390, 1998. 93\u201394","journal-title":"Am Fam Physician"},{"key":"75_CR29","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1046\/j.1469-0705.2000.00208.x","volume":"16","author":"E Ferrazzi","year":"2000","unstructured":"Ferrazzi E, Rigano S, Bozzo M, et al. Umbilical vein blood flow in growth-restricted fetuses. Ultrasound Obstet Gynecol, 16: 432\u2013438, 2000","journal-title":"Ultrasound Obstet Gynecol"},{"key":"75_CR30","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1111\/j.1476-5381.1995.tb15111.x","volume":"116","author":"RA Rutherford","year":"1995","unstructured":"Rutherford RA, McCarthy A, Sullivan MH, et al. Nitric oxide synthase in human placenta and umbilical cord from normal, intrauterine growth-retarded and pre-eclamptic pregnancies. Br J Pharmacol, 116: 3099\u20133109, 1995","journal-title":"Br J Pharmacol"},{"key":"75_CR31","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.placenta.2009.04.010","volume":"30","author":"P Casanello","year":"2009","unstructured":"Casanello P, Krause B, Torres E, et al. Reduced l-arginine transport and nitric oxide synthesis in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies is not further altered by hypoxia. Placenta, 30: 625\u2013633, 2009","journal-title":"Placenta"},{"key":"75_CR32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000082622","volume":"59","author":"D Szukiewicz","year":"2005","unstructured":"Szukiewicz D, Szewczyk G, Watroba M, et al. Isolated placental vessel response to vascular endothelial growth factor and placenta growth factor in normal and growth-restricted pregnancy. Gynecol Obstet Invest, 59: 102\u2013107, 2005","journal-title":"Gynecol Obstet Invest"},{"key":"75_CR33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1746-1596-5-24","volume":"5","author":"F Barut","year":"2010","unstructured":"Barut F, Barut A, Gun BD, et al. Intrauterine growth restriction and placental angiogenesis. Diagn Pathol, 5: 24, 2010","journal-title":"Diagn Pathol"},{"key":"75_CR34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jsgi.2005.09.010","volume":"13","author":"S Padavala","year":"2006","unstructured":"Padavala S, Pope N, Baker P, et al. An imbalance between vascular endothelial growth factor and its soluble receptor in placental villous explants of intrauterine growth-restricted pregnancies. J Soc Gynecol Investig, 13: 40\u201347, 2006","journal-title":"J Soc Gynecol Investig"},{"key":"75_CR35","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1095\/biolreprod.105.043893","volume":"73","author":"CS Rutland","year":"2005","unstructured":"Rutland CS, Mukhopadhyay M, Underwood S, et al. Induction of intrauterine growth restriction by reducing placental vascular growth with the angioinhibin TNP-470. Biol Reprod, 73: 1164\u20131173, 2005","journal-title":"Biol Reprod"},{"key":"75_CR36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-121808-102149","volume":"5","author":"BC Young","year":"2010","unstructured":"Young BC, Levine RJ, Karumanchi SA. Pathogenesis of preeclampsia. Annu Rev Pathol, 5: 173\u2013192, 2010","journal-title":"Annu Rev Pathol"},{"key":"75_CR37","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s11906-011-0214-y","volume":"13","author":"CM Brown","year":"2011","unstructured":"Brown CM, Garovic VD. Mechanisms and management of hypertension in pregnant women. Curr Hypertens Rep, 13: 338\u2013346, 2011","journal-title":"Curr Hypertens Rep"},{"key":"75_CR38","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1471-0528.1997.tb11977.x","volume":"104","author":"K Harrington","year":"1997","unstructured":"Harrington K, Carpenter RG, Goldfrad C, et al. Transvaginal Doppler ultrasound of the uteroplacental circulation in the early prediction of pre-eclampsia and intrauterine growth retardation. Br J Obstet Gynaecol, 104: 674\u2013681, 1997","journal-title":"Br J Obstet Gynaecol"},{"key":"75_CR39","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.placenta.2008.02.008","volume":"29","author":"C Escudero","year":"2008","unstructured":"Escudero C, Sobrevia L. A hypothesis for preeclampsia: adenosine and inducible nitric oxide synthase in human placental microvascular endothelium. Placenta, 29: 469\u2013483, 2008","journal-title":"Placenta"},{"key":"75_CR40","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1210\/jc.87.4.1871","volume":"87","author":"M Ito","year":"2002","unstructured":"Ito M, Itakura A, Ohno Y, et al. Possible activation of the renin-angiotensin system in the feto-placental unit in preeclampsia. J Clin Endocrinol Metab, 87: 1871\u20131878, 2002","journal-title":"J Clin Endocrinol Metab"},{"key":"75_CR41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1365-2362.1996.87238.x","volume":"26","author":"M Cervar","year":"1996","unstructured":"Cervar M, Kainer F, Jones CJ, et al. Altered release of endothelin-1,2 and thromboxane B2 from trophoblastic cells in pre-eclampsia. Eur J Clin Invest, 26: 30\u201337, 1996","journal-title":"Eur J Clin Invest"},{"key":"75_CR42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1034\/j.1600-0412.2001.080002099.x","volume":"80","author":"HJ Singh","year":"2001","unstructured":"Singh HJ, Rahman A, Larmie ET, et al. Endothelin-l in feto-placental tissues from normotensive pregnant women and women with pre-eclampsia. Acta Obstet Gynecol Scand, 80: 99\u2013103, 2001","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"Suppl 4","key":"75_CR43","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1038\/sj.ijo.0803517","volume":"30","author":"L Tappy","year":"2006","unstructured":"Tappy L. Adiposity in children born small for gestational age. Int J Obes (Lond), 30 (Suppl 4): S36\u2013S40, 2006","journal-title":"Int J Obes (Lond)"},{"key":"75_CR44","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1651-2227.1997.tb18410.x","volume":"423","author":"CN Hales","year":"1997","unstructured":"Hales CN. Metabolic consequences of intrauterine growth retardation. Acta Paediatr Suppl, 423: 184\u2013187, 1997; discussion 188","journal-title":"Acta Paediatr Suppl"}],"container-title":["Wiener Medizinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-012-0075-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10354-012-0075-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-012-0075-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T04:49:17Z","timestamp":1642567757000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10354-012-0075-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":44,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["75"],"URL":"https:\/\/doi.org\/10.1007\/s10354-012-0075-2","relation":{},"ISSN":["0043-5341","1563-258X"],"issn-type":[{"value":"0043-5341","type":"print"},{"value":"1563-258X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}