{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:12:12Z","timestamp":1780506732067,"version":"3.54.1"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"13-14","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Med Wochenschr"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s10354-016-0495-5","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T09:11:36Z","timestamp":1472202696000},"page":"402-410","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Algorithmus zur Diagnose von Eisenmangelan\u00e4mie","Diagnostic approach to iron deficiency anemia"],"prefix":"10.1007","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0947-948X","authenticated-orcid":false,"given":"Kristine","family":"Jimenez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,26]]},"reference":[{"key":"495_CR1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","volume":"123","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum NJ, Jasrasaria R, Naghavi M, et\u00a0al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014;123:615\u201324.","journal-title":"Blood"},{"key":"495_CR2","doi-asserted-by":"crossref","first-page":"676S","DOI":"10.1093\/jn\/131.2.676S","volume":"131","author":"JD Haas","year":"2001","unstructured":"Haas JD, Brownlie T. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J\u00a0Nutr. 2001;131:676S\u2013688S, discussion 88S\u201390S.","journal-title":"J. Nutr."},{"key":"495_CR3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.18553\/jmcp.2005.11.7.565","volume":"11","author":"AR Nissenson","year":"2005","unstructured":"Nissenson AR, Wade S, Goodnough T, et\u00a0al. Economic burden of anemia in an insured population. J\u00a0Manag Care Pharm. 2005;11:565\u201374.","journal-title":"J Manag Care Pharm"},{"key":"495_CR4","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1093\/ndt\/gft338","volume":"28","author":"R Minutolo","year":"2013","unstructured":"Minutolo R, Locatelli F, Gallieni M, et al. Anaemia management in non-dialysis chronic kidney disease (CKD) patients: a multicentre prospective study in renal clinics. Nephrol Dial Transplant. 2013;28:3035\u201345.","journal-title":"Nephrol. Dial. Transplant."},{"key":"495_CR5","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1093\/eurheartj\/ehq158","volume":"31","author":"EA Jankowska","year":"2010","unstructured":"Jankowska EA, Rozentryt P, Witkowska A. et\u00a0al. Iron deficiency: an ominous sign in patients with systolic chronic heart failure. Eur Heart J. 2010;31:1872\u201380.","journal-title":"Eur. Heart J."},{"key":"495_CR6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ahj.2013.01.017","volume":"165","author":"IT Klip","year":"2013","unstructured":"Klip IT, Comin-Colet J, Voors AA, et al. Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J. 2013;165:575\u201382, e3.","journal-title":"Am. Heart J."},{"key":"495_CR7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1159\/000321468","volume":"32","author":"L Nicola De","year":"2010","unstructured":"De Nicola L, Minutolo R, Chiodini P, et al. Prevalence and prognosis of mild anemia in non-dialysis chronic kidney disease: a prospective cohort study in outpatient renal clinics. Am J Nephrol. 2010;32:533\u201340.","journal-title":"Am. J. Nephrol."},{"issue":"Suppl 1","key":"495_CR8","doi-asserted-by":"crossref","first-page":"181S","DOI":"10.1097\/01.AOG.0000447200.43420.e9","volume":"123","author":"MH Seid","year":"2014","unstructured":"Seid MH, Dahl NV, Lau G, et\u00a0al. Effect of ferumoxytol on quality of life in iron deficiency anemia from abnormal uterine bleeding. Obstet Gynecol. 2014;123(Suppl 1):181S\u2013182S.","journal-title":"Obstet Gynecol"},{"key":"495_CR9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/eurheartj\/ehr504","volume":"34","author":"J Comin-Colet","year":"2013","unstructured":"Comin-Colet J, Lainscak M, Dickstein K, et al. The effect of intravenous ferric carboxymaltose on health-related quality of life in patients with chronic heart failure and iron deficiency: a subanalysis of the FAIR-HF study. Eur Heart J. 2013;34:30\u20138.","journal-title":"Eur. Heart J."},{"key":"495_CR10","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1136\/bmj.326.7399.1124","volume":"326","author":"F Verdon","year":"2003","unstructured":"Verdon F, Burnand B, Stubi CL, et al. Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial. BMJ. 2003;326:1124.","journal-title":"BMJ"},{"key":"495_CR11","doi-asserted-by":"crossref","first-page":"e94217","DOI":"10.1371\/journal.pone.0094217","volume":"9","author":"B Favrat","year":"2014","unstructured":"Favrat B, Balck K, Breymann C, et al. Evaluation of a single dose of ferric carboxymaltose in fatigued, iron-deficient women \u2013 PREFER a randomized, placebo-controlled study. PLoS ONE. 2014;9:e94217.","journal-title":"PLoS ONE"},{"key":"495_CR12","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1182\/blood-2011-04-346304","volume":"118","author":"PA Krayenbuehl","year":"2011","unstructured":"Krayenbuehl PA, Battegay E, Breymann C, et\u00a0al. Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration. Blood. 2011;118:3222\u20137.","journal-title":"Blood"},{"key":"495_CR13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/ajh.23397","volume":"88","author":"RP Allen","year":"2013","unstructured":"Allen RP, Auerbach S, Bahrain H, et\u00a0al. The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia. Am J Hematol. 2013;88:261\u20134.","journal-title":"Am. J. Hematol."},{"key":"495_CR14","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0140-6736(96)02341-0","volume":"348","author":"AB Bruner","year":"1996","unstructured":"Bruner AB, Joffe A, Duggan AK, et al. Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet. 1996;348:992\u20136.","journal-title":"Lancet"},{"key":"495_CR15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev.nutr.23.020102.075739","volume":"23","author":"JL Beard","year":"2003","unstructured":"Beard JL, Connor JR. Iron status and neural functioning. Annu Rev Nutr. 2003;23:41\u201358.","journal-title":"Annu. Rev. Nutr."},{"key":"495_CR16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2891-9-4","volume":"9","author":"M Falkingham","year":"2010","unstructured":"Falkingham M, Abdelhamid A, Curtis P, et al. The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis. Nutr J. 2010;9:4.","journal-title":"Nutr J"},{"key":"495_CR17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/eurjhf\/hfs017","volume":"14","author":"T Avni","year":"2012","unstructured":"Avni T, Leibovici L, Gafter-Gvili A. Iron supplementation for the treatment of chronic heart failure and iron deficiency: systematic review and meta-analysis. Eur J Heart Fail. 2012;14:423\u20139.","journal-title":"Eur. J. Heart Fail."},{"key":"495_CR18","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu385","author":"P Ponikowski","year":"2014","unstructured":"Ponikowski P, van Veldhuisen DJ, Comin-Colet J, et al. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J. 2014. doi:10.1093\/eurheartj\/ehu385","journal-title":"Eur. Heart J."},{"key":"495_CR19","first-page":"398","volume":"98","author":"G Kadikoylu","year":"2006","unstructured":"Kadikoylu G, Yavasoglu I, Bolaman Z, et\u00a0al. Platelet parameters in women with iron deficiency anemia. J\u00a0Natl Med Assoc. 2006;98:398\u2013402.","journal-title":"J Natl Med Assoc"},{"key":"495_CR20","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3109\/09537104.2012.699641","volume":"24","author":"MJ Park","year":"2013","unstructured":"Park MJ, Park PW, Seo YH, et\u00a0al. The relationship between iron parameters and platelet parameters in women with iron deficiency anemia and thrombocytosis. Platelets. 2013;24:348\u201351.","journal-title":"Platelets"},{"key":"495_CR21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/107602960401000412","volume":"10","author":"YK Keung","year":"2004","unstructured":"Keung YK, Owen J. Iron deficiency and thrombosis: literature review. Clin Appl Thromb Hemost. 2004;10:387\u201391.","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"495_CR22","doi-asserted-by":"crossref","first-page":"e82952","DOI":"10.1371\/journal.pone.0082952","volume":"8","author":"YL Chang","year":"2013","unstructured":"Chang YL, Hung SH, Ling W, et al. Association between ischemic stroke and iron-deficiency anemia: a population-based study. PLoS ONE. 2013;8:e82952.","journal-title":"PLoS ONE"},{"key":"495_CR23","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1136\/gut.2010.214312","volume":"61","author":"R Evstatiev","year":"2012","unstructured":"Evstatiev R, Gasche C. Iron sensing and signalling. Gut. 2012;61:933\u201352.","journal-title":"Gut"},{"key":"495_CR24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(04)00343-5","volume":"117","author":"MW Hentze","year":"2004","unstructured":"Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism. Cell. 2004;117:285\u201397.","journal-title":"Cell"},{"key":"495_CR25","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00277-013-1901-3","volume":"93","author":"M Napolitano","year":"2014","unstructured":"Napolitano M, Dolce A, Celenza G, et al. Iron-dependent erythropoiesis in women with excessive menstrual blood losses and women with normal menses. Ann Hematol. 2014;93:557\u201363.","journal-title":"Ann. Hematol."},{"key":"495_CR26","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMra041809","volume":"352","author":"G Weiss","year":"2005","unstructured":"Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011\u201323.","journal-title":"N. Engl. J. Med."},{"key":"495_CR27","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.crohns.2011.03.010","volume":"5","author":"P Oustamanolakis","year":"2011","unstructured":"Oustamanolakis P, Koutroubakis IE, Kouroumalis EA. Diagnosing anemia in inflammatory bowel disease: beyond the established markers. J\u00a0Crohns Colitis. 2011;5:381\u201391.","journal-title":"J Crohns Colitis"},{"key":"495_CR28","unstructured":"World Health Organization CfDCaP. Assessing the Iron Status of Populations: report of a joint World Health Organization\/Centers for Disease Control and Prevention. Technical consultation on the assessment of iron status at the population level, Geneva, Switzerland, 6\u20138 April 2004, 2.\u00a0Aufl. Geneva: 2007."},{"key":"495_CR29","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1182\/blood-2005-07-3046","volume":"107","author":"E Beutler","year":"2006","unstructured":"Beutler E, Waalen J. The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Blood. 2006;107:1747\u201350.","journal-title":"Blood"},{"key":"495_CR30","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1182\/blood-2004-12-4782","volume":"106","author":"JD Cook","year":"2005","unstructured":"Cook JD, Boy E, Flowers C, et al. The influence of high-altitude living on body iron. Blood. 2005;106:1441\u20136.","journal-title":"Blood"},{"key":"495_CR31","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1001\/jama.1990.03450120068031","volume":"264","author":"D Nordenberg","year":"1990","unstructured":"Nordenberg D, Yip R, Binkin NJ. The effect of cigarette smoking on hemoglobin levels and anemia screening. JAMA. 1990;264:1556\u20139.","journal-title":"JAMA"},{"key":"495_CR32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1600-0838.2012.01481.x","volume":"24","author":"P Robach","year":"2014","unstructured":"Robach P, Boisson RC, Vincent L, et al. Hemolysis induced by an extreme mountain ultra-marathon is not associated with a decrease in total red blood cell volume. Scand J Med Sci Sports. 2014;24:18\u201327.","journal-title":"Scand J Med Sci Sports"},{"key":"495_CR33","doi-asserted-by":"crossref","first-page":"192173","DOI":"10.1155\/2014\/192173","volume":"2014","author":"G Lippi","year":"2014","unstructured":"Lippi G, Salvagno GL, Danese E, et\u00a0al. Variation of red blood cell distribution width and mean platelet volume after moderate endurance exercise. Adv Hematol. 2014;2014:192173.","journal-title":"Adv Hematol"},{"key":"495_CR34","first-page":"117","volume":"1","author":"WL Marsh Jr.","year":"1987","unstructured":"Marsh WL Jr., Bishop JW, Darcy TP. Evaluation of red cell volume distribution width (RDW). Hematol Pathol. 1987;1:117\u201323.","journal-title":"Hematol Pathol"},{"key":"495_CR35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/clinchem\/44.1.45","volume":"44","author":"AE Mast","year":"1998","unstructured":"Mast AE, Blinder MA, Gronowski AM, et\u00a0al. Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem. 1998;44:45\u201351.","journal-title":"Clin. Chem."},{"key":"495_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2009.03.010","volume":"73","author":"DH Rushton","year":"2010","unstructured":"Rushton DH, Barth JH. What is the evidence for gender differences in ferritin and haemoglobin? Crit Rev Oncol Hematol. 2010;73:1\u20139.","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"495_CR37","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1017\/S0029665199000634","volume":"58","author":"JD Cook","year":"1999","unstructured":"Cook JD. Defining optimal body iron. Proc Nutr Soc. 1999;58:489\u201395.","journal-title":"Proc Nutr Soc"},{"key":"495_CR38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3324\/haematol.2009.017046","volume":"95","author":"G Weiss","year":"2010","unstructured":"Weiss G, Gasche C. Pathogenesis and treatment of anemia in inflammatory bowel disease. Haematologica. 2010;95:175\u20138.","journal-title":"Haematologica"},{"issue":"Suppl. 2012","key":"495_CR39","first-page":"279","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO)","year":"2012","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO), Anemia Work Group. KDIGO Clinical practice guideline for anemia in chronic kidney disease. Kidney Int. 2012;2(Suppl. 2012):279\u2013335.","journal-title":"Kidney Int"},{"key":"495_CR40","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","volume":"33","author":"JJ McMurray","year":"2012","unstructured":"McMurray JJ, Adamopoulos S, Anker SD, et\u00a0al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012;33:1787\u2013847.","journal-title":"Eur. Heart J."},{"key":"495_CR41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0009-8981(03)00005-6","volume":"329","author":"Y Beguin","year":"2003","unstructured":"Beguin Y. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta. 2003;329:9\u201322.","journal-title":"Clin Chim Acta"},{"key":"495_CR42","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/ajh.22108","volume":"86","author":"BS Skikne","year":"2011","unstructured":"Skikne BS, Punnonen K, Caldron PH, et\u00a0al. Improved differential diagnosis of anemia of chronic disease and iron deficiency anemia: a prospective multicenter evaluation of soluble transferrin receptor and the sTfR\/log ferritin index. Am J Hematol. 2011;86:923\u20137.","journal-title":"Am. J. Hematol."},{"key":"495_CR43","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1309\/AJCP16NTXZLZFAIB","volume":"138","author":"I Infusino","year":"2012","unstructured":"Infusino I, Braga F, Dolci A, et al. Soluble Transferrin Receptor (sTfR) and sTfR\/log ferritin index for the diagnosis of iron-deficiency anemia. A meta-analysis. Am J Clin Pathol. 2012;138:642\u20139.","journal-title":"Am. J. Clin. Pathol."},{"key":"495_CR44","doi-asserted-by":"crossref","first-page":"E158","DOI":"10.1002\/ibd.21881","volume":"17","author":"P Oustamanolakis","year":"2011","unstructured":"Oustamanolakis P, Koutroubakis IE. Soluble transferrin receptor-ferritin index is the most efficient marker for the diagnosis of iron deficiency anemia in patients with IBD. Inflamm Bowel Dis. 2011;17:E158\u20139.","journal-title":"Inflamm. Bowel Dis."},{"key":"495_CR45","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/ajcn\/79.3.437","volume":"79","author":"T Brownlie","year":"2004","unstructured":"Brownlie T, Utermohlen V, Hinton PS, et\u00a0al. Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women. Am J Clin Nutr. 2004;79:437\u201343.","journal-title":"Am. J. Clin. Nutr."},{"key":"495_CR46","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1001\/archpedi.160.11.1108","volume":"160","author":"B Lozoff","year":"2006","unstructured":"Lozoff B, Jimenez E, Smith JB. Double burden of iron deficiency in infancy and low socioeconomic status: a longitudinal analysis of cognitive test scores to age 19 years. Arch Pediatr Adolesc Med. 2006;160:1108\u201313.","journal-title":"Arch Pediatr Adolesc Med"},{"key":"495_CR47","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1053\/j.gastro.2011.06.005","volume":"141","author":"R Evstatiev","year":"2011","unstructured":"Evstatiev R, Marteau P, Iqbal T, et\u00a0al. FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease. Gastroenterology. 2011;141:846\u201353, e1\u2013e2.","journal-title":"Gastroenterology"},{"key":"495_CR48","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/01.MIB.0000196646.64615.db","volume":"12","author":"CW Wells","year":"2006","unstructured":"Wells CW, Lewis S, Barton JR, et\u00a0al. Effects of changes in hemoglobin level on quality of life and cognitive function in inflammatory bowel disease patients. Inflamm Bowel Dis. 2006;12:123\u201330.","journal-title":"Inflamm. Bowel Dis."},{"key":"495_CR49","doi-asserted-by":"crossref","first-page":"f4822","DOI":"10.1136\/bmj.f4822","volume":"347","author":"E Litton","year":"2013","unstructured":"Litton E, Xiao J, Ho KM. Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: systematic review and meta-analysis of randomised clinical trials. BMJ. 2013;347:f4822.","journal-title":"BMJ"},{"key":"495_CR50","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1097\/00042737-200511000-00008","volume":"17","author":"MW James","year":"2005","unstructured":"James MW, Chen CM, Goddard WP, et al. Risk factors for gastrointestinal malignancy in patients with iron-deficiency anaemia. Eur J Gastroenterol Hepatol. 2005;17:1197\u2013203.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"495_CR51","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/gut.2009.179804","volume":"59","author":"SR Cairns","year":"2010","unstructured":"Cairns SR, Scholefield JH, Steele RJ, et\u00a0al. Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002). Gut. 2010;59:666\u201389.","journal-title":"Gut"},{"key":"495_CR52","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/sj.bjc.6604165","volume":"98","author":"W Hamilton","year":"2008","unstructured":"Hamilton W, Lancashire R, Sharp D, et al. The importance of anaemia in diagnosing colorectal cancer: a case-control study using electronic primary care records. Br J Cancer. 2008;98:323\u20137.","journal-title":"Br. J. Cancer"},{"key":"495_CR53","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1007\/s10620-008-0298-7","volume":"53","author":"D Carter","year":"2008","unstructured":"Carter D, Maor Y, Bar-Meir S, et al. Prevalence and predictive signs for gastrointestinal lesions in premenopausal women with iron deficiency anemia. Dig Dis Sci. 2008;53:3138\u201344.","journal-title":"Dig. Dis. Sci."},{"key":"495_CR54","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0002-9343(98)00260-5","volume":"105","author":"EJ Bini","year":"1998","unstructured":"Bini EJ, Micale PL, Weinshel EH. Evaluation of the gastrointestinal tract in premenopausal women with iron deficiency anemia. Am J Med. 1998;105:281\u20136.","journal-title":"Am. J. Med."},{"key":"495_CR55","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s10620-012-2496-6","volume":"58","author":"D Carter","year":"2013","unstructured":"Carter D, Levi G, Tzur D, et\u00a0al. Prevalence and predictive factors for gastrointestinal pathology in young men evaluated for iron deficiency anemia. Dig Dis Sci. 2013;58:1299\u2013305.","journal-title":"Dig. Dis. Sci."},{"key":"495_CR56","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0002-9343(02)01214-7","volume":"113","author":"GN Ioannou","year":"2002","unstructured":"Ioannou GN, Rockey DC, Bryson CL, et al. Iron deficiency and gastrointestinal malignancy: a population-based cohort study. Am J Med. 2002;113:276\u201380.","journal-title":"Am. J. Med."},{"key":"495_CR57","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0016-5107(04)00348-7","volume":"59","author":"G Capurso","year":"2004","unstructured":"Capurso G, Baccini F, Osborn J, et\u00a0al. Can patient characteristics predict the outcome of endoscopic evaluation of iron deficiency anemia: a multiple logistic regression analysis. Gastrointest Endosc. 2004;59:766\u201371.","journal-title":"Gastrointest. Endosc."},{"key":"495_CR58","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1365-2796.2010.02251.x","volume":"268","author":"A Khalafallah","year":"2010","unstructured":"Khalafallah A, Dennis A, Bates J, et\u00a0al. A prospective randomized, controlled trial of intravenous versus oral iron for moderate iron deficiency anaemia of pregnancy. J\u00a0Intern Med. 2010;268:286\u201395.","journal-title":"J. Intern. Med."},{"key":"495_CR59","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.ajog.2003.11.015","volume":"190","author":"PE Warner","year":"2004","unstructured":"Warner PE, Critchley HO, Lumsden MA, et al. Menorrhagia I: measured blood loss, clinical features, and outcome in women with heavy periods: a survey with follow-up data. Am J Obstet Gynecol. 2004;190:1216\u201323.","journal-title":"Am. J. Obstet. Gynecol."},{"key":"495_CR60","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1365-2036.2008.03741.x","volume":"28","author":"L Vannella","year":"2008","unstructured":"Vannella L, Aloe Spiriti MA, Cozza G, et\u00a0al. Benefit of concomitant gastrointestinal and gynaecological evaluation in premenopausal women with iron deficiency anaemia. Aliment Pharmacol Ther. 2008;28:422\u201330.","journal-title":"Aliment. Pharmacol. Ther."},{"key":"495_CR61","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/00365520310000690a","volume":"38","author":"B Annibale","year":"2003","unstructured":"Annibale B, Lahner E, Chistolini A, et al. Endoscopic evaluation of the upper gastrointestinal tract is worthwhile in premenopausal women with iron-deficiency anaemia irrespective of menstrual flow. Scand J Gastroenterol. 2003;38:239\u201345.","journal-title":"Scand. J. Gastroenterol."},{"key":"495_CR62","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/00004836-200402000-00004","volume":"38","author":"BT Green","year":"2004","unstructured":"Green BT, Rockey DC. Gastrointestinal endoscopic evaluation of premenopausal women with iron deficiency anemia. J\u00a0Clin Gastroenterol. 2004;38:104\u20139.","journal-title":"J. Clin. Gastroenterol."},{"key":"495_CR63","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1007\/s10620-008-0562-x","volume":"54","author":"K Robson","year":"2009","unstructured":"Robson K, Barto A, Liberman RF. The evaluation of premenopausal women with anemia: what is the yield of gastrointestinal endoscopy? Dig Dis Sci. 2009;54:1667\u201371.","journal-title":"Dig. Dis. Sci."},{"key":"495_CR64","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0002-9343(01)00883-X","volume":"111","author":"B Annibale","year":"2001","unstructured":"Annibale B, Capurso G, Chistolini A, et\u00a0al. Gastrointestinal causes of refractory iron deficiency anemia in patients without gastrointestinal symptoms. Am J Med. 2001;111:439\u201345.","journal-title":"Am. J. Med."},{"key":"495_CR65","first-page":"585","volume":"90","author":"C Hershko","year":"2005","unstructured":"Hershko C, Hoffbrand AV, Keret D, et\u00a0al. Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia. Haematologica. 2005;90:585\u201395.","journal-title":"Haematologica"},{"key":"495_CR66","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1111\/j.1572-0241.2008.02121.x","volume":"103","author":"PV Kaye","year":"2008","unstructured":"Kaye PV, Garsed K, Ragunath K, et al. The clinical utility and diagnostic yield of routine gastric biopsies in the investigation of iron deficiency anemia: a case-control study. Am J Gastroenterol. 2008;103:2883\u20139.","journal-title":"Am. J. Gastroenterol."},{"key":"495_CR67","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3109\/00365529709025083","volume":"32","author":"W Dickey","year":"1997","unstructured":"Dickey W, Kenny BD, McMillan SA, et\u00a0al. Gastric as well as duodenal biopsies may be useful in the investigation of iron deficiency anaemia. Scand J Gastroenterol. 1997;32:469\u201372.","journal-title":"Scand. J. Gastroenterol."},{"key":"495_CR68","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/00365529509093254","volume":"30","author":"GR Corazza","year":"1995","unstructured":"Corazza GR, Valentini RA, Andreani ML, et al. Subclinical coeliac disease is a frequent cause of iron-deficiency anaemia. Scand J Gastroenterol. 1995;30:153\u20136.","journal-title":"Scand. J. Gastroenterol."},{"key":"495_CR69","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1523-5378.2008.00617.x","volume":"13","author":"K Muhsen","year":"2008","unstructured":"Muhsen K, Cohen D. Helicobacter pylori infection and iron stores: a systematic review and meta-analysis. Helicobacter. 2008;13:323\u201340.","journal-title":"Helicobacter"},{"key":"495_CR70","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1055\/s-0033-1359200","volume":"46","author":"K Barada","year":"2014","unstructured":"Barada K, Habib RH, Malli A, et\u00a0al. Prediction of celiac disease at endoscopy. Endoscopy. 2014;46:110\u20139.","journal-title":"Endoscopy"},{"key":"495_CR71","doi-asserted-by":"crossref","first-page":"e90552","DOI":"10.1371\/journal.pone.0090552","volume":"9","author":"K Robson","year":"2014","unstructured":"Robson K, Alizart M, Martin J, et\u00a0al. Coeliac patients are undiagnosed at routine upper endoscopy. PLoS ONE. 2014;9:e90552.","journal-title":"PLoS ONE"},{"key":"495_CR72","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.cgh.2013.10.037","volume":"12","author":"M Srinivas","year":"2014","unstructured":"Srinivas M, Basumani P, Podmore G, et\u00a0al. Utility of testing patients, on presentation, for serologic features of celiac disease. Clin Gastroenterol Hepatol. 2014;12:946\u201352.","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"495_CR73","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.3748\/wjg.15.2748","volume":"15","author":"L Vannella","year":"2009","unstructured":"Vannella L, Gianni D, Lahner E, et al. Pre-endoscopic screening for Helicobacter pylori and celiac disease in young anemic women. World J Gastroenterol. 2009;15:2748\u201353.","journal-title":"World J. Gastroenterol."},{"key":"495_CR74","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1136\/gut.2010.228874","volume":"60","author":"AF Goddard","year":"2011","unstructured":"Goddard AF, James MW, McIntyre AS, et\u00a0al. Guidelines for the management of iron deficiency anaemia. Gut. 2011;60:1309\u201316.","journal-title":"Gut"},{"key":"495_CR75","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-230X-8-52","volume":"8","author":"S Majid","year":"2008","unstructured":"Majid S, Salih M, Wasaya R, et\u00a0al. Predictors of gastrointestinal lesions on endoscopy in iron deficiency anemia without gastrointestinal symptoms. BMC Gastroenterol. 2008;8:52.","journal-title":"BMC Gastroenterol"},{"key":"495_CR76","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.dld.2011.08.002","volume":"43","author":"A Cilona","year":"2011","unstructured":"Cilona A, Zullo A, Hassan C, et al. Is faecal-immunochemical test useful in patients with iron deficiency anaemia and without overt bleeding? Dig Liver Dis. 2011;43:1022\u20134.","journal-title":"Dig Liver Dis"},{"key":"495_CR77","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3748\/wjg.v21.i1.326","volume":"21","author":"Y Kobayashi","year":"2015","unstructured":"Kobayashi Y, Watabe H, Yamada A, et\u00a0al. Impact of fecal occult blood on obscure gastrointestinal bleeding: observational study. World J Gastroenterol. 2015;21:326\u201332.","journal-title":"World J. Gastroenterol."},{"key":"495_CR78","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1053\/j.gastro.2007.06.008","volume":"133","author":"GS Raju","year":"2007","unstructured":"Raju GS, Gerson L, Das A, et\u00a0al. American Gastroenterological Association (AGA) Institute medical position statement on obscure gastrointestinal bleeding. Gastroenterology. 2007;133:1694\u20136.","journal-title":"Gastroenterology"},{"key":"495_CR79","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1055\/s-0028-1105464","volume":"102","author":"E Werner","year":"1977","unstructured":"Werner E, Kaltwasser JP, Ihm P. Oral iron treatment: intestinal absorption and the influence of a meal (author\u2019s transl). Dtsch Med Wochenschr. 1977;102:1061\u20134.","journal-title":"Dtsch. Med. Wochenschr."},{"key":"495_CR80","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1185\/03007995.2012.761599","volume":"29","author":"MJ Cancelo-Hidalgo","year":"2013","unstructured":"Cancelo-Hidalgo MJ, Castelo-Branco C, Palacios S, et al. Tolerability of different oral iron supplements: a systematic review. Curr Med Res Opin. 2013;29:291\u2013303.","journal-title":"Curr Med Res Opin"},{"key":"495_CR81","doi-asserted-by":"crossref","first-page":"e0117383","DOI":"10.1371\/journal.pone.0117383","volume":"10","author":"Z Tolkien","year":"2015","unstructured":"Tolkien Z, Stecher L, Mander AP, et al. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS ONE. 2015;10:e0117383.","journal-title":"PLoS ONE"},{"key":"495_CR82","volume-title":"World Health Organiszation technical report series Nutritional Anaemias. 405","author":"World Health Organization","year":"1968","unstructured":"World Health Organization. World Health Organiszation technical report series Nutritional Anaemias. 405. Geneva: World Health Organization; 1968."},{"key":"495_CR83","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/sj.ejcn.1602926","volume":"63","author":"SJ Zhou","year":"2009","unstructured":"Zhou SJ, Gibson RA, Crowther CA, et al. Should we lower the dose of iron when treating anaemia in pregnancy? A randomized dose-response trial. Eur J Clin Nutr. 2009;63:183\u201390.","journal-title":"Eur J Clin Nutr"},{"key":"495_CR84","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/ajcn\/78.1.145","volume":"78","author":"M Makrides","year":"2003","unstructured":"Makrides M, Crowther CA, Gibson RA, et al. Efficacy and tolerability of low-dose iron supplements during pregnancy: a randomized controlled trial. Am J Clin Nutr. 2003;78:145\u201353.","journal-title":"Am. J. Clin. Nutr."},{"key":"495_CR85","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.amjmed.2005.01.065","volume":"118","author":"E Rimon","year":"2005","unstructured":"Rimon E, Kagansky N, Kagansky M, et al. Are we giving too much iron? Low-dose iron therapy is effective in octogenarians. Am J Med. 2005;118:1142\u20137.","journal-title":"Am J Med"},{"key":"495_CR86","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1182\/blood-2015-05-642223","volume":"126","author":"D Moretti","year":"2015","unstructured":"Moretti D, Goede JS, Zeder C, et al. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. Blood. 2015;126:1981\u20139.","journal-title":"Blood"},{"key":"495_CR87","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/gutjnl-2014-307720","volume":"64","author":"T Jaeggi","year":"2015","unstructured":"Jaeggi T, Kortman GA, Moretti D, et\u00a0al. Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut. 2015;64:731\u201342.","journal-title":"Gut"},{"key":"495_CR88","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/j.1365-2036.2005.02700.x","volume":"22","author":"AD Silva De","year":"2005","unstructured":"De Silva AD, Tsironi E, Feakins RM, et\u00a0al. Efficacy and tolerability of oral iron therapy in inflammatory bowel disease: a prospective, comparative trial. Aliment Pharmacol Ther. 2005;22:1097\u2013105.","journal-title":"Aliment Pharmacol Ther"},{"key":"495_CR89","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1097\/00000478-199910000-00009","volume":"23","author":"SC Abraham","year":"1999","unstructured":"Abraham SC, Yardley JH, Wu TT. Erosive injury to the upper gastrointestinal tract in patients receiving iron medication: an underrecognized entity. Am J Surg Pathol. 1999;23:1241\u20137.","journal-title":"Am. J. Surg. Pathol."},{"key":"495_CR90","doi-asserted-by":"crossref","first-page":"e75540","DOI":"10.1371\/journal.pone.0075540","volume":"8","author":"T Avni","year":"2013","unstructured":"Avni T, Bieber A, Steinmetz T, et al. Treatment of anemia in inflammatory bowel disease \u2013 systematic review and meta-analysis. PLoS ONE. 2013;8:e75540.","journal-title":"PLoS ONE"},{"key":"495_CR91","first-page":"CD007857","volume":"1","author":"J Albaramki","year":"2012","unstructured":"Albaramki J, Hodson EM, Craig JC, et\u00a0al. Parenteral versus oral iron therapy for adults and children with chronic kidney disease. Cochrane Database Syst Rev. 2012;1:CD007857.","journal-title":"Cochrane Database Syst Rev"},{"key":"495_CR92","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mayocp.2014.10.007","volume":"90","author":"T Avni","year":"2015","unstructured":"Avni T, Bieber A, Grossman A, et al. The safety of intravenous iron preparations: systematic review and meta-analysis. Mayo Clin Proc. 2015;90:12\u201323.","journal-title":"Mayo Clin. Proc."},{"key":"495_CR93","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.crohns.2010.01.007","volume":"4","author":"P Bager","year":"2010","unstructured":"Bager P, Dahlerup JF. The health care cost of intravenous iron treatment in IBD patients depends on the economic evaluation perspective. J\u00a0Crohns Colitis. 2010;4:427\u201330.","journal-title":"J Crohns Colitis"},{"key":"495_CR94","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1001\/jama.2015.15572","volume":"314","author":"C Wang","year":"2015","unstructured":"Wang C, Graham DJ, Kane RC, et\u00a0al. Comparative risk of anaphylactic reactions associated with intravenous iron products. JAMA. 2015;314:2062\u20138.","journal-title":"JAMA"},{"key":"495_CR95","first-page":"301","volume":"100","author":"AM Ganzoni","year":"1970","unstructured":"Ganzoni AM. Intravenous iron-dextran: therapeutic and experimental possibilities. Schweiz Med Wochenschr. 1970;100:301\u20133.","journal-title":"Schweiz Med Wochenschr"},{"key":"495_CR96","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/j.1572-0241.2007.01744.x","volume":"103","author":"S Kulnigg","year":"2008","unstructured":"Kulnigg S, Stoinov S, Simanenkov V, et\u00a0al. A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: the ferric carboxymaltose (FERINJECT) randomized controlled trial. Am J Gastroenterol. 2008;103:1182\u201392.","journal-title":"Am. J. Gastroenterol."},{"key":"495_CR97","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/ajg.2013.335","volume":"108","author":"W Reinisch","year":"2013","unstructured":"Reinisch W, Staun M, Tandon RK, et al. A randomized, open-label, non-inferiority study of intravenous iron isomaltoside 1000 (Monofer) compared with oral iron for treatment of anemia in IBD (PROCEED). Am J Gastroenterol. 2013;108:1877\u201388.","journal-title":"Am. J. Gastroenterol."},{"issue":"87","key":"495_CR98","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1053\/j.gastro.2010.05.026","volume":"139","author":"G Novacek","year":"2010","unstructured":"Novacek G, Weltermann A, Sobala A, et\u00a0al. Inflammatory bowel disease is a risk factor for recurrent venous thromboembolism. Gastroenterology. 2010;139(87):779\u201387.","journal-title":"Gastroenterology"},{"key":"495_CR99","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S0140-6736(82)92204-8","volume":"1","author":"M Ali","year":"1982","unstructured":"Ali M, Rigolosi R, Fayemi AO, et al. Failure of serum ferritin levels to predict bone-marrow iron content after intravenous iron-dextran therapy. Lancet. 1982;1:652\u20135.","journal-title":"Lancet"},{"key":"495_CR100","doi-asserted-by":"crossref","first-page":"49","DOI":"10.7326\/0003-4819-157-1-201206190-00429","volume":"157","author":"JL Carson","year":"2012","unstructured":"Carson JL, Grossman BJ, Kleinman S, et\u00a0al. Red blood cell transfusion: a clinical practice guideline from the AABB. Ann Intern Med. 2012;157:49\u201358.","journal-title":"Ann. Intern. Med."},{"key":"495_CR101","first-page":"10","volume":"11","author":"K Jimenez","year":"2015","unstructured":"Jimenez K, Kulnigg-Dabsch S, Gasche C. Management of Iron Deficiency Anemia. Gastroenterolgy Hepatol. 2015;11:10.","journal-title":"Gastroenterolgy Hepatol"}],"container-title":["Wiener Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-016-0495-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10354-016-0495-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-016-0495-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T03:10:00Z","timestamp":1657163400000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10354-016-0495-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,26]]},"references-count":101,"journal-issue":{"issue":"13-14","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["495"],"URL":"https:\/\/doi.org\/10.1007\/s10354-016-0495-5","relation":{},"ISSN":["0043-5341","1563-258X"],"issn-type":[{"value":"0043-5341","type":"print"},{"value":"1563-258X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,26]]}}}