{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:28:45Z","timestamp":1768904925693,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Steigerwald Arzneimittelwerk, Darmstadt"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Med Wochenschr"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s10354-017-0578-y","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T05:06:41Z","timestamp":1500959201000},"page":"89-98","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Early onset of efficacy in patients with functional and motility-related gastrointestinal disorders","Fr\u00fchzeitiger Wirkungsbeginn bei Patienten mit funktionellen und motilit\u00e4tsbedingten gastrointestinalen Erkrankungen"],"prefix":"10.1007","volume":"168","author":[{"given":"Richard","family":"Raedsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Vinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-6165","authenticated-orcid":false,"given":"Bertram","family":"Ottillinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Holtmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"578_CR1","series-title":"Arzneiverordnung in der Praxis","first-page":"1","volume-title":"Empfehlungen zur Therapie bei Funktioneller Dyspepsie und Reizdarmsyndrom","author":"Arzneimittelkommission der deutschen \u00c4rzteschaft","year":"2010","unstructured":"Arzneimittelkommission der deutschen \u00c4rzteschaft. Empfehlungen zur Therapie bei Funktioneller Dyspepsie und Reizdarmsyndrom, 2nd ed. Arzneiverordnung in der Praxis. vol 37. 2010, pp\u00a01\u201329.","edition":"2"},{"key":"578_CR2","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1055\/s-2001-18536","volume":"39","author":"P Malfertheiner","year":"2001","unstructured":"Malfertheiner P, Holtmann G, Peitz U, et al. Leitlinien der Deutschen Gesellschaft f\u00fcr Verdauungs- und Stoffwechselkrankheiten zur Behandlung der Dyspepsie. Z\u00a0Gastroenterol. 2001;39:937\u201355.","journal-title":"Z Gastroenterol"},{"key":"578_CR3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1055\/s-0029-1245976","volume":"49","author":"P Layer","year":"2011","unstructured":"Layer P, Andresen V, Pehl C, et al. S3-Leitlinie Reizdarmsyndrom: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft f\u00fcr Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft f\u00fcr Neurogastroenterologie und Motilit\u00e4t (DGNM). AWMF-Registriernummer: 021\/016,2011. Z\u00a0Gastroenterol. 2011;49:237\u201393.","journal-title":"Z Gastroenterol"},{"issue":"6","key":"578_CR4","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.bpg.2014.10.001","volume":"28","author":"G Holtmann","year":"2014","unstructured":"Holtmann G, Talley NJ. The stomach-brain axis. Best Pract Res Clin Gastroenterol. 2014;28(6):967\u2013679.","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"5","key":"578_CR5","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1053\/j.gastro.2006.03.008","volume":"130","author":"DA Drossmann","year":"2006","unstructured":"Drossmann DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 2006;130(5):1377\u201390.","journal-title":"Gastroenterology"},{"issue":"6","key":"578_CR6","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00535-015-1076-x","volume":"50","author":"NJ Talley","year":"2015","unstructured":"Talley NJ, Holtmann G, Walker MM. Therapeutic strategies for functional dyspepsia and irritable bowel syndrome based on pathophysiology. J\u00a0Gastroenterol. 2015;50(6):601\u201313.","journal-title":"J Gastroenterol"},{"issue":"4","key":"578_CR7","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1023\/B:DDAS.0000026317.00071.75","volume":"49","author":"G Holtmann","year":"2004","unstructured":"Holtmann G, Kutscher SU, Haag S, Langkafel M, Heuft G, Neufang-Hueber J, et al. Clinical presentation and personality factors are predictors of the response to treatment in patients with functional dyspepsia; a\u00a0randomized, double-blind placebo-controlled crossover study. Dig Dis Sci. 2004;49(4):672\u20139.","journal-title":"Dig Dis Sci"},{"issue":"4","key":"578_CR8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2036.2005.02572.x","volume":"22","author":"B Adam","year":"2005","unstructured":"Adam B, Liebregts T, Saadat-Gilani K, Vinson B, Holtmann G. Validation of the gastrointestinal symptom score for the assessment of symptoms in patients with functional dyspepsia. Aliment Pharmacol Ther. 2005;22(4):357\u201363.","journal-title":"Aliment Pharmacol Ther"},{"issue":"3\u20134","key":"578_CR10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10354-012-0169-x","volume":"163","author":"B Ottillinger","year":"2013","unstructured":"Ottillinger B, Storr M, Malfertheiner P, Allescher HD. STW 5 (Iberogast\u00ae) \u2013 a\u00a0safe and effective standard in the treatment of functional gastrointestinal disorders. Wien Med Wochenschr. 2013;163(3\u20134):65\u201372.","journal-title":"Wien Med Wochenschr"},{"key":"578_CR11","first-page":"1","volume":"39","author":"A Madisch","year":"2001","unstructured":"Madisch A, Melderis H, Mayr G, Sassin I, Hotz J. Ein Phytotherapeutikum und seine modifizierte Rezeptur bei funktioneller Dyspepsie. Z\u00a0Gastroenterol. 2001;39:1\u20138.","journal-title":"Z Gastroenterol"},{"issue":"11\u201312","key":"578_CR12","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/j.1365-2036.2004.02275.x","volume":"20","author":"J Melzer","year":"2004","unstructured":"Melzer J, R\u00f6sch W, Reichling J, Brignoli R, Saller R. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Aliment Pharmacol Ther. 2004;20(11\u201312):1279\u201387.","journal-title":"Aliment Pharmacol Ther"},{"key":"578_CR13","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/j.1572-0241.2006.01183.x","volume":"102","author":"U Arnim von","year":"2007","unstructured":"von Arnim U, Peitz U, Vinson B, Gundermann KJ, Malfertheiner P. STW 5, a\u00a0phytopharmacon for patients with functional dyspepsia: results of a\u00a0multicenter, placebo-controlled double-blind study. Am J Gastroenterol. 2007;102:1268\u201375.","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"578_CR14","first-page":"45","volume":"15","author":"D Buchert","year":"1994","unstructured":"Buchert D. Wirksamkeit und Vertr\u00e4glichkeit von Iberogast bei Patienten mit gesicherter Non Ulcus Dyspepsie. Z\u00a0Phytother. 1994;15(1):45\u20136.","journal-title":"Z Phytother"},{"issue":"6","key":"578_CR15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1055\/s-2002-32130","volume":"40","author":"W R\u00f6sch","year":"2002","unstructured":"R\u00f6sch W, Vinson B, Sassin I. A randomised clinical trial comparing the efficacy of a\u00a0herbal preparation STW 5 with the prokinetic drug cisapride in patients with dysmotility type of functional dyspepsia. Z\u00a0Gastroenterol. 2002;40(6):401\u20138.","journal-title":"Z Gastroenterol"},{"issue":"3","key":"578_CR16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2036.2004.01859.x","volume":"19","author":"A Madisch","year":"2004","unstructured":"Madisch A, Holtmann G, Plein K, Hotz J. Treatment of irritable bowel syndrome with herbal preparations: results of a\u00a0double-blind, randomized, placebo-controlled, multi-centre trial. Aliment Pharmacol Ther. 2004;19(3):271\u20139.","journal-title":"Aliment Pharmacol Ther"},{"issue":"Suppl II","key":"578_CR17","first-page":"69","volume":"7","author":"I Sassin","year":"2000","unstructured":"Sassin I, Buchert D. Efficacy and tolerability of the herbal preparation Iberogast\u00ae in the therapy of functional dyspepsia. Phytomedicine. 2000;7(Suppl II):69\u201392.","journal-title":"Phytomedicine"},{"key":"578_CR18","first-page":"P25","volume":"125","author":"C Klein-Galczinsky","year":"1999","unstructured":"Klein-Galczinsky C, Sassin I. Anwendungsbeobachtung zur Wirksamkeit und Vertr\u00e4glichkeit von Iberogast\u00ae in der Therapie des Colon irritabile. Phytother Schwelle Neuen Jahrtausend. 1999;125:P25, Abstracts.","journal-title":"Phytother Schwelle Neuen Jahrtausend"},{"key":"578_CR19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.17660\/ActaHortic.1993.332.29","volume":"332","author":"SN Okpanyi","year":"1993","unstructured":"Okpanyi SN, Mark M, Wahl MA. Gastrointestinal motility with Iberogast\u00ae. Acta Hortic. 1993;332:227\u201335.","journal-title":"Acta Hortic"},{"key":"578_CR20","first-page":"501","volume-title":"Hagers Handbuch der Pharmazeutischen Praxis","year":"1998","unstructured":"Blaschek W, H\u00e4nsel R, Keller K, Reichling J, Rimpler H, Schneider G. (editors) Hagers Handbuch der Pharmazeutischen Praxis, 5th ed. Berlin Heidelberg New York: Springer; 1998, pp\u00a0501\u20136.","edition":"5"},{"key":"578_CR21","unstructured":"Commission E Monograph Angelicae radix. German Bundesanzeiger No.\u00a0101. 1\u00a0June\u00a01990."},{"key":"578_CR22","unstructured":"Commission E Monograph Matricariae flos. German Bundesanzeiger 1\u00a0November 1984, revised 6\u00a0March\u00a01990."},{"key":"578_CR23","unstructured":"Commission E Monograph Carvi fructus. German Bundesanzeiger 14\u00a0December\u00a01989."},{"key":"578_CR24","unstructured":"Commission E Monograph Cardui mariae fructus. German Bundesanzeiger 18\u00a0February\u00a01986."},{"key":"578_CR25","unstructured":"Commission E Monograph Melissae folium. German Bundesanzeiger 1\u00a0November 1984, revised 6\u00a0March\u00a01990."},{"key":"578_CR26","unstructured":"Commission E Monograph Chelidonii herba. German Bundesanzeiger 6\u00a0May\u00a01985."},{"key":"578_CR27","unstructured":"Commission E Monograph Liquiritiae radix. German Bundesanzeiger 6\u00a0May\u00a01985, revised 6\u00a0March\u00a01990."},{"key":"578_CR28","first-page":"59, 60, 64, 149","volume-title":"Lehrbuch der Phytotherapie","author":"RF Wei\u00df","year":"1991","unstructured":"Wei\u00df RF. Lehrbuch der Phytotherapie, 7th ed. Stuttgart: Hippokrates; 1991, p\u00a059, 60, 64, 149.","edition":"7"},{"issue":"13\u201314","key":"578_CR29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10354-007-0429-3","volume":"157","author":"H Allescher","year":"2007","unstructured":"Allescher H, Wagner H. STW 5\/Iberogast: Multi-Target-Wirkung bei funktioneller Dyspepsie und Reizdarmsyndrom. Wien Med Wochenschr. 2007;157(13\u201314):301\u20137.","journal-title":"Wien Med Wochenschr"},{"issue":"Suppl 5","key":"578_CR30","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.phymed.2006.03.020","volume":"13","author":"M Schemann","year":"2006","unstructured":"Schemann M, Michel K, Zeller F, Hohenester B, R\u00fchl A. Region-specific effects of STW 5 (Iberogast) and its components in gastric fundus, corpus and antrum. Phytomedicine. 2006;13(Suppl 5):90\u20139.","journal-title":"Phytomedicine"},{"issue":"6","key":"578_CR31","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1111\/j.1572-0241.2007.01142.x","volume":"102","author":"AN Pilichiewicz","year":"2007","unstructured":"Pilichiewicz AN, Horowitz M, Russo A, Maddox AF, Jones KL, Schemann M, et\u00a0al. Effects of Iberogast on proximal gastric volume, antropyloroduodenal motility and gastric emptying in healthy men. Am J Gastroenterol. 2007;102(6):1276\u201383.","journal-title":"Am J Gastroenterol"},{"key":"578_CR32","volume-title":"Iberogast\u00ae \u2013 Focus regionenspezifische Motilit\u00e4t","author":"M Schemann","year":"2010","unstructured":"Schemann M. Iberogast\u00ae \u2013 Focus regionenspezifische Motilit\u00e4t. Iberogast\u00ae Symposium, Bad W\u00f6rishofen, Germany, 29\u00a0Jan\u00a02010. 2010."},{"issue":"15","key":"578_CR33","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.2165\/00003495-200565150-00001","volume":"65","author":"S Masson","year":"2005","unstructured":"Masson S, Nylander D, Mansfield JC. How important is onset of action in ulcerative colitis therapy? Drugs. 2005;65(15):2069\u201383.","journal-title":"Drugs"},{"issue":"3","key":"578_CR34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1368-5031.2006.00800.x","volume":"60","author":"PW Dettmar","year":"2006","unstructured":"Dettmar PW, Sykes J, Little SL, Bryan J. Rapid onset of effect of sodium alginate on gastro-oesophageal reflux compared with ranitidine and omeprazole, and relationship between symptoms and reflux episodes. Int J Clin Pract. 2006;60(3):275\u201383.","journal-title":"Int J Clin Pract"},{"issue":"10","key":"578_CR35","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1080\/00365520600615781","volume":"41","author":"P Bytzer","year":"2006","unstructured":"Bytzer P, Morocutti A, Kennerly P, Ravic M, Miller N, ROSE Trial Investigators.. Effect of rabeprazole and omeprazole on the onset of gastrooesophageal reflux disease symptom relief during the first seven days of treatment. Scand J Gastroenterol. 2006;41(10):1132\u201340.","journal-title":"Scand J Gastroenterol"},{"key":"578_CR36","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1046\/j.1365-2036.1999.00654.x","volume":"13","author":"RA Faaij","year":"1999","unstructured":"Faaij RA, Van Gerven JM, Jolivet-Landreau I, Masclee AA, Vendrig EM, Schoemaker RC, et al. Onset of action during on-demand treatment with maalox suspension or low-dose ranitidine for heartburn. Aliment Pharmacol Ther. 1999;13:1605\u201310.","journal-title":"Aliment Pharmacol Ther"},{"key":"578_CR37","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1097\/mcg.0b013e31802e7efb","volume":"41","author":"W Holtmeier","year":"2007","unstructured":"Holtmeier W, Holtmann G, Caspary WF, Weing\u00e4rtner U. On-demand treatment of acute heartburn with the antacid hydrotalcite compared with famotidine and placebo: randomized double-blind cross-over study. J\u00a0Clin Gastroenterol. 2007;41:564\u201370. doi:\n                        10.1097\/mcg.0b013e31802e7efb\n                        \n                    .","journal-title":"J Clin Gastroenterol"},{"key":"578_CR38","first-page":"CR44","volume":"13","author":"JW Konturek","year":"2007","unstructured":"Konturek JW, Beneke M, Koppermann R, Petersen-Braun M, Weing\u00e4rtner U. The efficacy of hydrotalcite compared with OTC famotidine in the on-demand treatment of gastroesophageal reflux disease: a\u00a0non-inferiority trial. Med Sci Monit. 2007;13:CR44\u2013CR9.","journal-title":"Med Sci Monit"},{"key":"578_CR39","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","volume":"130","author":"J Tack","year":"2006","unstructured":"Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada J\u2011R, et al. Functional gastroduodenal disorders. Gastroenterology. 2006;130:1466\u201379. doi:\n                        10.1053\/j.gastro.2005.11.059\n                        \n                    .","journal-title":"Gastroenterology"},{"key":"578_CR40","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","volume":"130","author":"GF Longstreth","year":"2006","unstructured":"Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology. 2006;130:1480\u201391. doi:\n                        10.1053\/j.gastro.2005.11.061\n                        \n                    .","journal-title":"Gastroenterology"},{"key":"578_CR41","first-page":"167","volume-title":"Botanical medicine: from bench to bedside","author":"B Vinson","year":"2009","unstructured":"Vinson B. Development of Iberogast: clinical evidence for multicomponent herbal mixtures. In: Cooper R, Kronenberg F, editors. Botanical medicine: from bench to bedside. New Rochelle: Mary Ann Liebert; 2009. pp.\u00a0167\u201389."},{"key":"578_CR42","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1053\/j.gastro.2005.08.063","volume":"130","author":"A Rasquin","year":"2006","unstructured":"Rasquin A, Di Lorenzo C, Forbes D, Guiraldes E, Hyams JS, Staiano A, Walker LS. Childhood functional gastrointestinal disorders: child\/asdolescent. Gastroenterology. 2006;130:1527\u201337. doi:\n                        10.1053\/j.gastro.2005.08.063\n                        \n                    .","journal-title":"Gastroenterology"},{"issue":"Suppl 5","key":"578_CR43","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.phymed.2006.03.021","volume":"13","author":"H Wagner","year":"2006","unstructured":"Wagner H. Multitarget therapy: the future of treatment for more than just functional dyspepsia. Phytomedicine. 2006;13(Suppl 5):122\u201399.","journal-title":"Phytomedicine"},{"issue":"Suppl 5","key":"578_CR44","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.phymed.2006.07.001","volume":"13","author":"T Wegener","year":"2006","unstructured":"Wegener T, Wagner H. The active components and the pharmacological multi-target principle of STW 5 (Iberogast). Phytomedicine. 2006;13(Suppl 5):20\u201335.","journal-title":"Phytomedicine"}],"container-title":["Wiener Medizinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10354-017-0578-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-017-0578-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-017-0578-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T12:35:40Z","timestamp":1519130140000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10354-017-0578-y"}},"subtitle":["A\u00a0noninterventional study with Iberogast\u00ae","Eine nichtinterventionelle Studie mit Iberogast\u00ae"],"short-title":[],"issued":{"date-parts":[[2017,7,25]]},"references-count":43,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["578"],"URL":"https:\/\/doi.org\/10.1007\/s10354-017-0578-y","relation":{},"ISSN":["0043-5341","1563-258X"],"issn-type":[{"value":"0043-5341","type":"print"},{"value":"1563-258X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,25]]}}}