{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:09Z","timestamp":1740126429012,"version":"3.37.3"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Med Wochenschr"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Varicella-zoster virus (VZV) infection, also known as chickenpox, is a\u00a0common childhood affliction. Generalized small itchy single-standing vesicles on erythematous skin are typical. Both cutaneous and systemic complications of the VZV infection may commonly occur. A\u00a0three-year-old girl with a\u00a0previous history of mild atopic dermatitis presented in our Pediatric Dermatology Clinic in poor general condition, with a\u00a0skin rash predominantly consisting of generalized large blisters with hypopyon sign and erosions. On a\u00a0closer look, scattered erythematous papules and vesicles were also visible. A\u00a0positive Tzanck smear from an intact pinhead-sized vesicle and VZV PCR confirmed the clinical diagnosis of chickenpox. Cultures from hypopyon material revealed <jats:italic>Staphylococcus aureus<\/jats:italic> superinfection. We report an exceptional, not-yet described complication of chickenpox with hypopyon-forming superinfection in an atopic child. In addition, our case nicely underscores the necessity of early VZV vaccination, which has been available and recommended now for more than 10\u00a0years in pediatric vaccination programs to avoid severe complications.<\/jats:p>","DOI":"10.1007\/s10354-020-00790-x","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T11:03:40Z","timestamp":1607598220000},"page":"61-64","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypopyon sign as an unusual complication of varicella infection in a\u00a0girl with atopic dermatitis","Hypopyonzeichen als ungew\u00f6hnliche Komplikation einer Varizelleninfektion bei einem M\u00e4dchen mit atopischer Dermatitis"],"prefix":"10.1007","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8818-9877","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Gorris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Kogler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Sz\u00e9pfalusi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Karlhofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Handisurya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3133-8699","authenticated-orcid":false,"given":"Wolfgang","family":"Weninger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8238-2561","authenticated-orcid":false,"given":"Tamar","family":"Kinaciyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"issue":"3","key":"790_CR1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrmicro3215","volume":"12","author":"L Zerboni","year":"2014","unstructured":"Zerboni\u00a0L, Sen\u00a0N, Oliver\u00a0SL, Arvin\u00a0AM. Molecular mechanisms of varicella zoster virus pathogenesis. Nat Rev Microbiol. 2014;12(3):197\u2013210. https:\/\/doi.org\/10.1038\/nrmicro3215.","journal-title":"Nat Rev Microbiol"},{"issue":"6","key":"790_CR2","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s40272-015-0150-4","volume":"17","author":"ER Notaro","year":"2015","unstructured":"Notaro\u00a0ER, Sidbury\u00a0R. Systemic agents for severe atopic dermatitis in children. Paediatr Drugs. 2015;17(6):449\u201357. https:\/\/doi.org\/10.1007\/s40272-015-0150-4.","journal-title":"Paediatr Drugs"},{"key":"790_CR3","doi-asserted-by":"publisher","first-page":"159","DOI":"10.4103\/2229-5178.101824","volume":"3","author":"B Madke","year":"2012","unstructured":"Madke\u00a0B, Nayak\u00a0C. Eponymous signs in dermatology. 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Wien Med Wochenschr. 2012;162(7\u20138):164\u20137. https:\/\/doi.org\/10.1007\/s10354-012-0076-1.","journal-title":"Wien Med Wochenschr"},{"issue":"5","key":"790_CR6","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1128\/JCM.02018-09","volume":"48","author":"O Raulin","year":"2010","unstructured":"Raulin\u00a0O, Durand\u00a0G, Gillet\u00a0Y, et\u00a0al. Toxin profiling of Staphylococcus aureus strains involved in varicella superinfection. J\u00a0Clin Microbiol. 2010;48(5):1696\u2013700. https:\/\/doi.org\/10.1128\/JCM.02018-09.","journal-title":"J Clin Microbiol"},{"issue":"7","key":"790_CR7","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.ijid.2012.11.024","volume":"17","author":"E Gowin","year":"2013","unstructured":"Gowin\u00a0E, Wysocki\u00a0J, Michalak\u00a0M. Don\u2019t forget how severe varicella can be-complications of varicella in children in a\u00a0defined Polish population. 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All studies performed were in accordance with the ethical standards indicated in each case. For images or other information within the manuscript which identify patients, consent was obtained from them and\/or their legal guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}