{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:30:36Z","timestamp":1773984636197,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"11-12","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsmedizin Rostock"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Med Wochenschr"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The influenza season 2017\u20132018 of the northern hemisphere was the highest since 2001 and was caused predominantly by influenza\u00a0B virus.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We performed a\u00a0retrospective analysis of all patients in a\u00a0university hospital in northern Germany with laboratory-confirmed influenza during the winter season 2017\u20132018 and analyzed underlying conditions, complications, and outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A\u00a0total of 272 cases of influenza were diagnosed: 70\u00a0influenza\u00a0A (25.7%), 201 influenza\u00a0B (73.9%), and 1\u00a0co-infection. Of 182 adults, 145 were hospitalized, 73\u00a0developed pneumonia, 11\u00a0developed myocardial infarction, two a\u00a0transient ischemic attack, one a\u00a0stroke, and one perimyocarditis. Eleven of the 145 hospitalized adult patients (7.6%) died, ten of them because of pneumonia. All of them had preexisting diseases. Pneumonia was associated with a\u00a0mortality of 13.7%. Underlying cardiac insufficiency was correlated with higher mortality (7\/51 with versus 4\/126 patients without cardiac insufficiency; <jats:italic>p<\/jats:italic>\u202f&lt;\u20090.05). Ninety cases of influenza were diagnosed in 89\u00a0children (30\u00a0A, 60\u00a0B), one child had first influenza\u00a0B, then influenza\u00a0A. Twenty-eight children (31%) were hospitalized, 15\u00a0children developed one or more complications (lower respiratory tract infections, meningeal irritations, febrile seizures, otitis media, myositis). No child died. Influenza vaccination status was known in 149 adult patients, pneumonia occurred more frequently in non-vaccinated individuals (43\/90; 47.8%) than in vaccinated patients (18\/59; 30.5%, <jats:italic>p<\/jats:italic>\u202f&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Patients with influenza should be monitored for secondary pneumonia and myocardial infarction, and vaccination should be enforced especially in patients with coronary heart disease and cardiac insufficiency.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10354-021-00884-0","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T08:25:25Z","timestamp":1632817525000},"page":"280-286","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Complications of influenza in 272 adult and pediatric patients in a\u00a0German university hospital during the seasonal epidemic 2017\u20132018"],"prefix":"10.1007","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2839-0015","authenticated-orcid":false,"given":"Hilte F.","family":"Geerdes-Fenge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Martin","family":"Schuldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha","family":"L\u00f6bermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"K\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"D\u00e4britz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil Christian","family":"Reisinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"884_CR1","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/S0140-6736(17)33293-2","volume":"391","author":"AD Iuliano","year":"2018","unstructured":"Iuliano\u00a0AD, Roguski\u00a0KM, Chang\u00a0HH, et al. Estimates of global seasonal influenza-associated respiratory mortality: a\u00a0modelling study. Lancet. 2018;391:1285\u2013300.","journal-title":"Lancet"},{"key":"884_CR2","doi-asserted-by":"publisher","first-page":"e497","DOI":"10.1016\/S2214-109X(19)30545-5","volume":"8","author":"X Wang","year":"2020","unstructured":"Wang\u00a0X, Li\u00a0Y, O\u2019Brien\u00a0KL, et\u00a0al. Respiratory Virus Global Epidemiology Network. Global burden of respiratory infections associated with seasonal influenza in children under 5\u00a0years in 2018: a\u00a0systematic review and modelling study. Lancet Glob Health. 2020;8:e497\u2013e510. https:\/\/doi.org\/10.1016\/S2214-109X(19)30545-5.","journal-title":"Lancet Glob Health"},{"key":"884_CR3","volume-title":"Bericht zur Epidemiologie der Influenza in Deutschland, Saison 2017\/18","author":"Robert Koch-Institut","year":"2018","unstructured":"Robert Koch-Institut. Bericht zur Epidemiologie der Influenza in Deutschland, Saison 2017\/18. 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Lancet. 2015;385:1729\u201337.","journal-title":"Lancet"}],"container-title":["Wiener Medizinische Wochenschrift"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-021-00884-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10354-021-00884-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10354-021-00884-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T19:07:34Z","timestamp":1662750454000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10354-021-00884-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,28]]},"references-count":20,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["884"],"URL":"https:\/\/doi.org\/10.1007\/s10354-021-00884-0","relation":{},"ISSN":["0043-5341","1563-258X"],"issn-type":[{"value":"0043-5341","type":"print"},{"value":"1563-258X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,28]]},"assertion":[{"value":"29 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"H.F.\u00a0Geerdes-Fenge, S.\u00a0Klein, H.M.\u00a0Schuldt, M.\u00a0L\u00f6bermann, K.\u00a0K\u00f6ller, J.\u00a0D\u00e4britz, and E.C.\u00a0Reisinger declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. The ethical committee of the Rostock University Medical Centre approved the study (A\u00a02018-0039).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}