{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:14Z","timestamp":1740126434361,"version":"3.37.3"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"15-16","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012940","name":"Universit\u00e4tsklinikum T\u00fcbingen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012940","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Med Wochenschr"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We here report on a\u00a060-year-old woman with familial Mediterranean fever (FMF) who developed cognitive impairment 16\u00a0years after initial diagnosis. On MRI, a\u00a0new extensive white matter lesion in the right frontal lobe with mild local mass effect but without contrast enhancement was detectable and classified as a\u00a0tumefactive lesion. Additional MR spectroscopy showed markedly increased choline levels accompanied by a\u00a0significant lactate peak, highly suggestive of a\u00a0low-florid demyelinating process. Although diffuse central nervous system (CNS) lesions have been described in single FMF cases, tumefactive lesions have not been observed in FMF patients without concomitant multiple sclerosis. In summary, this case highlights rare differential diagnoses of atypical, inflammatory CNS lesions and the clinical utility of MR spectroscopy.<\/jats:p>","DOI":"10.1007\/s10354-021-00893-z","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T14:09:26Z","timestamp":1636121366000},"page":"379-382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tumefactive demyelinating CNS lesion in a\u00a060-year-old woman with familial Mediterranean fever","Tumefaktive demyelinisierende ZNS-L\u00e4sion bei einer 60-j\u00e4hrigen Frau mit famili\u00e4rem Mittelmeerfieber"],"prefix":"10.1007","volume":"172","author":[{"given":"Constanze","family":"Trostel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kornelia","family":"Laichinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till-Karsten","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Saur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Krumbholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Henes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Ziemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus C.","family":"Kowarik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"issue":"9","key":"893_CR1","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1177\/1352458512437813","volume":"18","author":"T K\u00fcmpfel","year":"2012","unstructured":"K\u00fcmpfel\u00a0T, Gerdes\u00a0L, Wacker\u00a0T, et al. Familial Mediterranean fever-associated mutation pyrin E148Q as a\u00a0potential risk factor for multiple sclerosis. Mult Scler. 2012;18(9):1229\u201338.","journal-title":"Mult Scler"},{"issue":"11","key":"893_CR2","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s00011-019-01272-6","volume":"68","author":"B Balci-Peynircioglu","year":"2019","unstructured":"Balci-Peynircioglu\u00a0B, Akkaya-Ulum\u00a0YZ, Akbaba\u00a0TH, et al. Potential of miRNAs to predict and treat inflammation from the perspective of familial Mediterranean fever. Inflamm Res. 2019;68(11):905\u201313.","journal-title":"Inflamm Res"},{"issue":"2","key":"893_CR3","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.4049\/jimmunol.179.2.1274","volume":"179","author":"S Seshadri","year":"2007","unstructured":"Seshadri\u00a0S, Duncan\u00a0MD, Hart\u00a0JM, et al. Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1\u03b2 processing and release. J\u00a0Immunol. 2007;179(2):1274\u201381. https:\/\/doi.org\/10.4049\/jimmunol.179.2.1274.","journal-title":"J Immunol"},{"issue":"8","key":"893_CR4","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1177\/1352458516641776","volume":"22","author":"TA Hardy","year":"2016","unstructured":"Hardy\u00a0TA, Tobin\u00a0WO, Lucchinetti\u00a0CF. Exploring the overlap between multiple sclerosis, tumefactive demyelination and Bal\u00f3\u2019s concentric sclerosis. Mult Scler. 2016;22(8):986\u201392.","journal-title":"Mult Scler"},{"key":"893_CR5","first-page":"505","volume":"156","author":"M I\u015f\u0131k","year":"2014","unstructured":"I\u015f\u0131k\u00a0M. Familial Mediterranean fever and demyelinating plaques in the central nervous system. 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