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Increased creatinine values (&gt;\u202f1.1\u202fmg\/dl) were found in 71\u00a0of 166 (43%) patients. The median survival of patients with increased creatinine values was significantly shorter than in patients without impairment of renal function (20\u00a0vs. 52\u00a0months, <jats:italic>p<\/jats:italic>\u202f&lt;\u20090.001). Patients with increased creatinine values were older, were more often male, had higher leukocyte counts, higher monocyte counts, and higher lactatdehydrogenase (LDH) values. There was a\u00a0trend toward a\u00a0higher prevalence of <jats:italic>CBL<\/jats:italic> and <jats:italic>ASXL1<\/jats:italic> mutations in patients with renal impairment. Our findings show a\u00a0high prevalence of renal abnormalities in patients with CMML. Increased creatinine values were identified as a\u00a0new prognostic marker. These findings may be important for the individualized management of this heterogenous group of patients.<\/jats:p>","DOI":"10.1007\/s10354-022-00977-4","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T07:03:09Z","timestamp":1666681389000},"page":"3-8","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Significance of reduced renal function in patients with chronic myelomonocytic leukemia","Bedeutung einer verminderten Nierenfunktion bei Patienten mit chronischer myelomonozyt\u00e4rer Leuk\u00e4mie"],"prefix":"10.1007","volume":"173","author":[{"given":"Julia","family":"Heschl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-7034","authenticated-orcid":false,"given":"Klaus","family":"Geissler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"issue":"2","key":"977_CR1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","volume":"51","author":"JM Bennett","year":"1982","unstructured":"Bennett\u00a0JM, Catovsky\u00a0D, Daniel\u00a0MT, et\u00a0al. 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