{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:27:46Z","timestamp":1744864066321},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"11-12","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"EU Danube Transnational Programme CD SKILLS","award":["DTP 571"],"award-info":[{"award-number":["DTP 571"]}]},{"name":"EU Danube Transnational Programme CD SKILLS","award":["DTP 571"],"award-info":[{"award-number":["DTP 571"]}]},{"name":"EU Danube Transnational Programme CD SKILLS","award":["DTP 571"],"award-info":[{"award-number":["DTP 571"]}]},{"name":"EU Danube Transnational Programme CD SKILLS","award":["DTP 571"],"award-info":[{"award-number":["DTP 571"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Med Wochenschr"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Over the past decade, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) proposed the option of diagnosing coeliac disease (CD) in children without duodenal biopsy. The aim of our study was to assess the diagnostic approach in newly diagnosed children with CD in Slovenia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this prospective study, Slovenian paediatric gastroenterologists were invited to provide medical records of children under 19\u00a0years diagnosed with CD from March 2021 to October 2023. The analysis focused on tissue transglutaminase antibody (TGA) levels at diagnosis, diagnostic approach, adherence to ESPGHAN CD guidelines and diagnostic delays.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Data from 160 newly diagnosed CD patients (61.9% female; median age\u00a08\u00a0years; 16.9% asymptomatic) were available for the analysis. No-biopsy approach was used in 65% (<jats:italic>N<\/jats:italic>\u202f=\u2009104) of children and the majority (<jats:italic>N<\/jats:italic>\u202f=\u2009101) fulfilled all the criteria for the no-biopsy approach. Of 56\u00a0children diagnosed using duodenal biopsy, a\u00a0further 10 (17.8%) would have also been eligible for the no-biopsy approach based on the very high levels of TGA. Median diagnostic delay from first symptoms to confirmation of diagnosis was 6\u00a0months (min 0\u00a0months, max 87\u00a0months). Use of the no-biopsy approach has risen significantly since 2016 (37.8% vs. 65.0%; <jats:italic>p<\/jats:italic>\u202f=\u20090.001) and diagnostic delays have shortened (6 vs. 7\u00a0months; <jats:italic>p<\/jats:italic>\u202f&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This prospective study highlights the frequent use of a\u00a0no-biopsy approach for diagnosing CD in children in Slovenia, showing large adherence to ESPGHAN guidelines. Also, diagnostic delays have shortened over recent years, likely due to various awareness-raising projects on CD conducted during this period.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10354-024-01045-9","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T07:01:41Z","timestamp":1717570901000},"page":"257-261","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Insights into coeliac disease diagnosis: a\u00a02021\u20132023 overview of diagnostic approach and delays in children in Slovenia","Einblicke in die Diagnose der Z\u00f6liakie: eine \u00dcbersicht von 2021\u20132023 \u00fcber diagnostische Ans\u00e4tze und Verz\u00f6gerungen bei Kindern in Slowenien"],"prefix":"10.1007","volume":"174","author":[{"given":"Petra","family":"Ri\u017enik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Kamhi Trop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Klemenak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toma\u017e","family":"Kren\u010dnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Milani\u010d-Koron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Miler Moj\u0161kerc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Pavlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Po\u017eek \u0160avs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janez","family":"Zupan\u010di\u010d","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jernej","family":"Dolin\u0161ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"issue":"1","key":"1045_CR1","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/MPG.0000000000002497","volume":"70","author":"S Husby","year":"2020","unstructured":"Husby\u00a0S, Koletzko\u00a0S, Korponay-Szab\u00f3\u00a0I, Kurppa\u00a0K, Mearin\u00a0ML, Ribes-Koninckx\u00a0C, et\u00a0al. 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Informed consent was obtained from all individual participants included in the study. The study was approved by the National Medical Ethics Committee of the Republic of Slovenia (0120-12\/2021\/9).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}