{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:38:19Z","timestamp":1773797899358,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universidad de M\u00e1laga\/CBUA"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Med Wochenschr"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are few studies that have analyzed the characteristics of hypercalcemia in hospitalized oncological patients. Our objectives were to describe the clinical characteristics of hospitalized patients with paraneoplastic hypercalcemia and to identify prognostic variables for mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an observational, longitudinal, retrospective, and bicentric study. It included adult patients admitted to two hospitals in M\u00e1laga, Spain (2014\u20132018). The minimum follow-up period was 2\u00a0years or until death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A\u00a0total of 154 patients were included; the majority (71.4%) were admitted to the internal medicine department. The median follow-up was 3.5\u00a0weeks (interquartile range [IQR] 1.1\u201311.5). The mean (standard deviation) age was 67.6 (12.3) years, with a\u00a0predominance of males (58.4%). The median (IQR) serum calcium at admission was 13.2 (11.8\u201314.6) mg\/dl. The most common neoplasms were pulmonary (27.3%), hematologic (23.4%), urological (13%), and breast (12.3%). Furthermore, 56.5% of cases had a\u00a0known history of neoplasia at the time of diagnosis. The parathyroid hormone (PTH) level was determined in 24%; of these, 10.8% had elevated levels. In all, 95.5% of patients died during follow-up. The median survival was 3.4\u00a0weeks (95% confidence interval 2.6\u20134.3). Factors associated with higher mortality were age, serum calcium at admission, previous history of neoplasia, etiology other than multiple myeloma, and noncorrection of hypercalcemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In hospitalized patients, paraneoplastic hypercalcemia was associated with high short-term mortality. Several factors associated with a\u00a0worse prognosis were identified in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10354-024-01051-x","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T06:09:51Z","timestamp":1721714991000},"page":"38-44","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and epidemiologic characteristics of hospitalized oncological patients with hypercalcemia: a\u00a0longitudinal, multicenter study"],"prefix":"10.1007","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2661-3812","authenticated-orcid":false,"given":"Guillermo","family":"Ropero-Luis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Sanz-C\u00e1novas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almudena","family":"L\u00f3pez-Sampalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Ruiz-Cantero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"G\u00f3mez-Huelgas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"1051_CR1","doi-asserted-by":"publisher","first-page":"1039490","DOI":"10.3389\/fendo.2023.1039490","volume":"14","author":"E Almuradova","year":"2023","unstructured":"Almuradova\u00a0E, Cicin\u00a0I. Cancer-related hypercalcemia and potential treatments. Front Endocrinol. 2023;14:1039490. https:\/\/doi.org\/10.3389\/fendo.2023.1039490.","journal-title":"Front Endocrinol"},{"key":"1051_CR2","doi-asserted-by":"publisher","first-page":"e935821","DOI":"10.12659\/MSM.935821","volume":"28","author":"CR Tonon","year":"2022","unstructured":"Tonon\u00a0CR, Silva\u00a0TAAL, Pereira\u00a0FWL, Queiroz\u00a0DAR, Junior\u00a0ELF, Martins\u00a0D, et\u00a0al. A\u00a0review of current clinical concepts in the Pathophysiology, etiology, diagnosis, and management of hypercalcemia. Med Sci Monit. 2022;28:e935821. https:\/\/doi.org\/10.12659\/MSM.935821.","journal-title":"Med Sci Monit"},{"issue":"16","key":"1051_CR3","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1001\/jama.2022.18331","volume":"328","author":"MD Walker","year":"2022","unstructured":"Walker\u00a0MD, Shane\u00a0E. Hypercalcemia: a\u00a0review. 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