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The diagnosis remains challenging since the disease is labeled as \u201cthe great imitator\u201d due to its broad clinical and histopathological appearances. Due to a\u00a0significant rise in its incidence rates, syphilis should always be considered as a\u00a0differential diagnosis of any painless, newly developed, oropharyngeal ulcerated lesion. This case demonstrates the rare clinical appearance of a\u00a0chancre on the tongue as the primary clinical sign of syphilis.<\/jats:p>","DOI":"10.1007\/s10354-025-01102-x","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T12:04:33Z","timestamp":1755777873000},"page":"355-357","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A\u00a0solitary ulcer on the tongue","Solit\u00e4res Ulcus an der Zunge"],"prefix":"10.1007","volume":"175","author":[{"given":"Annalina","family":"Meyka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Schadelbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birger","family":"Kr\u00e4nke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2342-022X","authenticated-orcid":false,"given":"Birgit","family":"Sadoghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"issue":"3","key":"1102_CR1","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1111\/jdv.16946","volume":"35","author":"M Janier","year":"2021","unstructured":"Janier\u00a0M, Unemo\u00a0M, Dupin\u00a0N, et\u00a0al. 2020 European guideline on the management of syphilis. 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All studies mentioned were in accordance with the ethical standards indicated in each case. For images or other information within the manuscript which identifies patients, additional patient consent was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}