{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:15:52Z","timestamp":1792782952835,"version":"4.5.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"13-14","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","id":[{"id":"https:\/\/ror.org\/00ggpsq73","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Wien Med Wochenschr"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recurrent fever and acute abdominal pain are common reasons for emergency visits, particularly in adolescents. These symptoms often lead to misdiagnosis and unnecessary surgeries like appendectomy. Familial Mediterranean fever (FMF), a\u00a0rare autoinflammatory disorder, should be considered in patients with periodic febrile abdominal episodes, especially in those with a\u00a0migration background.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A\u00a019-year-old male of Syrian origin presented with acute right lower quadrant abdominal pain, fever, arthralgia, and pleuritic chest pain. Similar episodes had occurred in the past and resolved spontaneously. Physical examination revealed signs of peritonism; laboratory results showed elevated C\u2011reactive protein (CRP; 35\u202fmg\/L) with normal white blood cell counts. Abdominal ultrasound excluded appendicitis. Conservative treatment (fluids, analgesics, dietary rest) led to full symptom resolution within 2\u00a0days. After recovery, a\u00a0detailed family history revealed consanguinity and a\u00a0relative with similar symptoms. The diagnosis of FMF was made based on the Tel Hashomer criteria. Colchicine therapy (1.0\u202fmg\/day) was initiated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This report illustrates a\u00a0case of late-onset FMF in a\u00a0migrant adolescent, with typical symptoms but without definitive serositis or confirmed genetic diagnosis at the time of treatment. The case underscores the importance of thorough history-taking and highlights the need to avoid unnecessary CT scans in similar settings. Awareness of FMF is crucial in nonendemic regions experiencing increased migration from high-incidence countries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10354-025-01114-7","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:57:19Z","timestamp":1762498639000},"page":"340-344","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Late-onset-case of Familial Mediterranean fever (FMF)\u2014exotic but rising differential diagnosis of \u201cunclear abdominal illness\u201d in Germany due to increasing migration over the past decade","Sp\u00e4tmanifestation von famili\u00e4rem Mittelmeerfieber (FMF)\u00a0\u2013 exotische, aber aufgrund der zunehmenden Migration im letzten Jahrzehnt wichtige Differenzialdiagnose des \u201eunklaren Abdomens\u201c in Deutschland"],"prefix":"10.1007","volume":"176","author":[{"given":"M. R.","family":"Kanaan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"1114_CR1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/GIM.0b013e31820e27b1","volume":"13","author":"N Zadeh","year":"2011","unstructured":"Zadeh\u00a0N, Getzug\u00a0T, Grody\u00a0WW. Diagnosis and management of familial mediterranean fever: integrating medical genetics in a\u00a0dedicated interdisciplinary clinic. Genet Med. 2011;13:263\u20139.","journal-title":"Genet Med"},{"key":"1114_CR2","doi-asserted-by":"publisher","first-page":"205427042211234","DOI":"10.1177\/20542704221123433","volume":"13","author":"N Cliff-Patel","year":"2022","unstructured":"Cliff-Patel\u00a0N, Yusuf\u00a0BS, Hamdani\u00a0S, et\u00a0al. Familial mediterranean fever: a\u00a0differential diagnosis for the surgical abdomen. JRSM Open. 2022;13:20542704221123433.","journal-title":"JRSM Open"},{"key":"1114_CR3","doi-asserted-by":"publisher","first-page":"523","DOI":"10.2169\/internalmedicine.48.1602","volume":"48","author":"T Ka\u015fifo\u011flu","year":"2009","unstructured":"Ka\u015fifo\u011flu\u00a0T, Cansu\u00a0DU, Korkmaz\u00a0C. Frequency of abdominal surgery in patients with familial mediterranean fever. Intern Med. 2009;48:523\u20136.","journal-title":"Intern Med"},{"key":"1114_CR4","unstructured":"Foeldvari I, Boehm K, Kramps T, et al. Prevalence and incidence of FMF in Germany-results of the first retrospective analysis of representative claims data (abstract no. 2148). Arthritis Rheumatol. 2018;70(9). https:\/\/acrabstracts.org\/abstract\/prevalence-and-incidence-of-fmf-in-germany-results-of-the-first-retrospective-analysis-of-representative-claims-data\/ Accessed 25 Nov 2023."},{"key":"1114_CR5","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s11739-021-02912-8","volume":"17","author":"O Aydin","year":"2022","unstructured":"Aydin\u00a0O, Egeli\u00a0BH, Ozdogan\u00a0H, et\u00a0al. Late-onset familial mediterranean fever: single-center experience and literature review. Intern Emerg Med. 2022;17:1301\u20136.","journal-title":"Intern Emerg Med"},{"key":"1114_CR6","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1007\/s00431-012-1803-8","volume":"171","author":"E Lainka","year":"2012","unstructured":"Lainka\u00a0E, Bielak\u00a0M, Lohse\u00a0P, et\u00a0al. Familial mediterranean fever in Germany: epidemiological, clinical, and genetic characteristics of a\u00a0pediatric population. Eur J Pediatr. 2012;171:1775\u201385.","journal-title":"Eur J Pediatr"},{"key":"1114_CR7","unstructured":"Orphanet. Familial mediterranean fever. Orphanet (2023) https:\/\/www.orpha.net\/consor\/cgi-bin\/OC_Exp.php?lng=en&Expert=342. Accessed 25 Nov 2023."},{"key":"1114_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12969-015-0057-1","volume":"13","author":"A Kilic","year":"2015","unstructured":"Kilic\u00a0A, Varkal\u00a0MA, Durmus\u00a0MS, et\u00a0al. Relationship between clinical findings and genetic mutations in patients with familial mediterranean fever. Pediatr Rheumatol Online\u00a0J. 2015;13:59.","journal-title":"Pediatr Rheumatol Online J"},{"key":"1114_CR9","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1136\/annrheumdis-2012-202932","volume":"73","author":"G Twig","year":"2014","unstructured":"Twig\u00a0G, Livneh\u00a0A, Vivante\u00a0A, et\u00a0al. 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