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A total of 126 patients with abdominal pain\/cramps or a\u00a0sensation of being bloated without organic cause received 1\u00a0capsule Menthacarin twice a\u00a0day for 8\u00a0weeks. Assessments included abdominal symptoms, stool parameters, and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During treatment, all assessed abdominal symptoms showed significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.001), clinically meaningful improvements, with standardized effect sizes of 0.83\u20131.05 for change from baseline. The number of days\/week with symptom impact or incomplete spontaneous bowel movements almost halved, while days\/week with normal stool consistency increased (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.001). Health-related quality of life significantly improved (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.001) and Menthacarin was well tolerated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study demonstrates patient-relevant improvement in gastrointestinal symptoms during treatment with Menthacarin while underlining its favorable tolerability profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10354-025-01119-2","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:54:23Z","timestamp":1765961663000},"page":"157-167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of disorders of gut\u2013brain interaction with peppermint oil and caraway oil combination Menthacarin","Behandlung von Darm-Hirn-Interaktionsst\u00f6rungen mit der Pfefferminz\u00f6l-K\u00fcmmel\u00f6l-Kombination Menthacarin"],"prefix":"10.1007","volume":"176","author":[{"given":"Ioannis","family":"Linas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan R.","family":"Vavricka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jost","family":"Langhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Pohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berenike","family":"Stracke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Funk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingolf","family":"Schiefke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Madisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"1119_CR1","doi-asserted-by":"crossref","unstructured":"Drossman DA. 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KG, Karlsruhe, Germany. B.\u00a0Stracke is an employee of Dr. Schwabe Holding SE & Co. KG with a\u00a0fixed salary. A.\u00a0Zimmermann and P.\u00a0Funk are employees of Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe with fixed salaries. The authors declare that this study received funding from Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany. The funder was involved in the study design, analysis, and interpretation of the manuscript. Medical writing services were provided by Dr. Andreas V\u00f6lp, psy consult scientific services, Hamburg, Germany, on behalf of Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe. Final decision to submit the manuscript for publication remained with the authors.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}