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The prevalence of this criterion in the general population and its potential association with demographic parameters and comorbidities is unclear. In order to answer these questions, we used the previously published LEAD (lung, heart, social, body) cohort (ClinicalTrials.gov; NCT01727518), which is a\u00a0longitudinal, observational, population-based Austrian cohort aiming to investigate the impact of genetic, environmental, social, developmental, and ageing factors on respiratory health and associated comorbidities through life. The prevalence of the 2022 criterion was 11.976% in the general population, as compared to 0.747% of the 2016 criterion. In the descriptive analysis, individuals with the 2022 criterion as compared to those without this criterion were more often males, had a\u00a0greater height and bodyweight, more frequently suffered from cardiovascular (CVD) and chronic obstructive pulmonary disease (COPD), and had higher C\u2011reactive protein (CRP) values. In the multivariable logistic regression, higher CRP, COPD, and CVD were significantly associated with the 2022 criterion. Our results show that in the general population, the 2022 CMML blood diagnostic criterion is 16\u00a0times more common than the 2016 criterion. The 2022 criterion is associated with CVD, COPD, and inflammation, which should be considered in the interpretation of this criterion in clinical practice.<\/jats:p>","DOI":"10.1007\/s10354-026-01172-5","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:32:25Z","timestamp":1783931545000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and potential associations of the 2022 newly introduced monocyte value for diagnosis of chronic myelomonocytic leukemia in a\u00a0general Austrian population","Pr\u00e4valenz und potenzielle Assoziation des 2022 neu eingef\u00fchrten Monozytengrenzwerts f\u00fcr die Diagnostik der chronischen myelomonozyt\u00e4ren Leuk\u00e4mie in einer Stichprobe der \u00f6sterreichischen Allgemeinbev\u00f6lkerung"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-7034","authenticated-orcid":false,"given":"K.","family":"Geissler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Azizzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Benetka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Prinz-Wohlgenannt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Breyer-Kohansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hartl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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M.\u00a0Prinz-Wohlgenannt reports personal fees for lectures from ThermoFischer, AstraZeneca, and Stemline Therapetics. R.\u00a0Breyer-Kohansal reports personal fees for presentations and\/or participation for AstraZeneca, Boehringer Ingelheim, Chiesi, and Novartis outside the submitted work. S.\u00a0Hartl has received personal fees for advisory boards for GSK, Boehringer Ingelheim, Novartis, Menarini, Chiesi, AstraZeneca, MSD, Roche, Abbvie, Takeda, and TEVA for respiratory oncology and COPD. M.K.\u00a0Breyer reports unrestricted grants for the LEAD study from GlaxoSmithKline, Novartis Pharma, AstraZeneca, Chiesi Pharma, Menarini Pharma, TEVA Ratiopharm, MSD, Air Liquide Health Care, Pfizer Corporation, Boehringer Ingelheim, and Mundipharma. M.\u00a0Azizzadeh, C.\u00a0Gross and G.\u00a0Benetka declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}