{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:49:27Z","timestamp":1793825367795,"version":"4.6.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Jpn J Ophthalmol"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1007\/s10384-011-0004-8","type":"journal-article","created":{"date-parts":[[2011,5,2]],"date-time":"2011-05-02T03:14:36Z","timestamp":1304306076000},"page":"256-263","source":"Crossref","is-referenced-by-count":162,"title":["Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion"],"prefix":"10.1007","volume":"55","author":[{"given":"Yukihiko","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Miyagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"key":"4_CR1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0014-4835(89)90018-3","volume":"48","author":"TC Hohman","year":"1989","unstructured":"Hohman TC, Nishimura C, Robison WG Jr. Aldose reductase and polyol in cultured pericytes of human retinal capillaries. Exp Eye Res. 1989;48:55\u201360.","journal-title":"Exp Eye Res"},{"key":"4_CR2","doi-asserted-by":"publisher","first-page":"3216","DOI":"10.1167\/iovs.07-1643","volume":"49","author":"Y Takamura","year":"2008","unstructured":"Takamura Y, Tomomatsu T, Kubo E, Tsuzuki S, Akagi Y. Role of the polyol pathway in high glucose-induced apoptosis of retinal pericytes and proliferation of endothelial cells. Invest Ophthalmol Vis Sci. 2008;49:3216\u201323.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4_CR3","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1001\/archopht.1961.00960010368014","volume":"66","author":"D Cogan","year":"1961","unstructured":"Cogan D, Toussaint D, Kuwabara T. Retinal vascular pattern. IV. Diabetic retinopathy. Arch Ophthalmol. 1961;66:366\u201378.","journal-title":"Arch Ophthalmol"},{"key":"4_CR4","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.2337\/diabetes.51.10.3107","volume":"51","author":"H-P Hammes","year":"2002","unstructured":"Hammes H-P, Lin J, Renner O, Shani M, Lundqvist A, Betsholtz C, et al. Pericytes and the pathogenesis of diabetic retinopathy. Diabetes. 2002;51:3107\u201312.","journal-title":"Diabetes"},{"key":"4_CR5","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/eye.1993.58","volume":"7","author":"A Garner","year":"1993","unstructured":"Garner A. Histopathology of diabetic retinopathy in man. Eye. 1993;7:250\u20133.","journal-title":"Eye"},{"key":"4_CR6","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0161-6420(83)34388-8","volume":"90","author":"GH Bresnick","year":"1983","unstructured":"Bresnick GH. Diabetic maculopathy: a critical review highlighting diffuse macular edema. Ophthalmology. 1983;90:1301\u201317.","journal-title":"Ophthalmology"},{"key":"4_CR7","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.2337\/diab.46.2.S26","volume":"46","author":"A Pfeiffer","year":"1997","unstructured":"Pfeiffer A, Spranger J, Meyer-Schwickerath R, Schatz H. Growth factor alterations in advanced diabetic retinopathy: a possible role of blood retina barrier breakdown. Diabetes. 1997;46:S26\u201330.","journal-title":"Diabetes"},{"key":"4_CR8","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/jemt.10092","volume":"57","author":"RG Tilton","year":"2002","unstructured":"Tilton RG. Diabetic vascular dysfunction: links to glucose-induced reductive stress and VEGF. Microsc Res Tech. 2002;57:390\u2013407.","journal-title":"Microsc Res Tech"},{"key":"4_CR9","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","volume":"331","author":"LP Aiello","year":"1994","unstructured":"Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994;331:1480\u20137.","journal-title":"N Engl J Med"},{"key":"4_CR10","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/S0002-9394(02)01568-4","volume":"134","author":"N Ogata","year":"2002","unstructured":"Ogata N, Nishikawa M, Nishimura T, Mitsuma Y, Matsumura M. Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Am J Ophthalmol. 2002;134:348\u201353.","journal-title":"Am J Ophthalmol"},{"key":"4_CR11","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1016\/S0161-6420(03)00568-2","volume":"110","author":"H Funatsu","year":"2003","unstructured":"Funatsu H, Yamashita H, Ikeda T, Mimura T, Eguchi S, Hori S. Vitreous levels of interleukin-6 and vascular endothelial growth factor are related to diabetic macular edema. Ophthalmology. 2003;110:1690\u20136.","journal-title":"Ophthalmology"},{"key":"4_CR12","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.ophtha.2004.11.045","volume":"112","author":"H Funatsu","year":"2005","unstructured":"Funatsu H, Yamashita H, Sakata K, Noma H, Mimura T, Suzuki M, et al. Vitreous levels of vascular endothelial growth factor and intercellular adhesion molecule 1 are related to diabetic macular edema. Ophthalmology. 2005;112:806\u201316.","journal-title":"Ophthalmology"},{"key":"4_CR13","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.ophtha.2005.10.030","volume":"113","author":"H Funatsu","year":"2006","unstructured":"Funatsu H, Yamashita H, Nakamura S, Mimura T, Eguchi S, Noma H, et al. Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor are related to diabetic macular edema. Ophthalmology. 2006;113:294\u2013301.","journal-title":"Ophthalmology"},{"key":"4_CR14","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ajo.2005.08.066","volume":"141","author":"E Ishizaki","year":"2006","unstructured":"Ishizaki E, Takai S, Ueki M, Maeno T, Maruichi M, Sugiyama T, et al. Correlation between angiotensin-converting enzyme, vascular endothelial growth factor, and matrix metalloproteinase-9 in the vitreous of eyes with diabetic retinopathy. Am J Ophthalmol. 2006;141:129\u201334.","journal-title":"Am J Ophthalmol"},{"key":"4_CR15","first-page":"596","volume":"109","author":"M Kawashima","year":"2005","unstructured":"Kawashima M, Shoji J, Yoshimura Y, Sato Y. Role of chemokines in the vitreous of proliferative diabetic retinopathy. Nippom Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc). 2005;109:596\u2013602.","journal-title":"Nippom Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc)"},{"key":"4_CR16","first-page":"2627","volume":"40","author":"K Chen","year":"1999","unstructured":"Chen K, Wu C, Roy S, Lee SM, Liu JH. Increased interleukin-6 in aqueous humor of neovascular glaucoma. Int Ophthalmol Vis Sci. 1999;40:2627\u201332.","journal-title":"Int Ophthalmol Vis Sci"},{"key":"4_CR17","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1001\/archopht.120.12.1644","volume":"120","author":"SR Boyd","year":"2002","unstructured":"Boyd SR, Zachary I, Chakravarthy U, Allen GJ, Wisdom GB, Cree IA, et al. Correlation of increased vascular endothelial growth factor with neovascularization and permeability in ischemic central vein occlusion. Arch Ophthalmol. 2002;120:1644\u201350.","journal-title":"Arch Ophthalmol"},{"key":"4_CR18","first-page":"125","volume":"48","author":"M Kawashima","year":"2006","unstructured":"Kawashima M, Shoji J, Nakajima M, Kamura Y, Sato Y. Investigation of angiogenic factors in the vitreous and serum of proliferative diabetic retinopathy patients, using a simultaneous detection method with an antibody array. Nihon Univ J Med. 2006;48:125\u201335.","journal-title":"Nihon Univ J Med"},{"key":"4_CR19","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1001\/archopht.1993.01090080083022","volume":"111","author":"Central Vein Occlusion Study Group","year":"1993","unstructured":"Central Vein Occlusion Study Group. Baseline and early natural history report: the Central Vein Occlusion Study. Arch Ophthalmol. 1993;111:1087\u201395.","journal-title":"Arch Ophthalmol"},{"key":"4_CR20","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.ajo.2005.03.003","volume":"140","author":"H Noma","year":"2005","unstructured":"Noma H, Funatsu H, Yamasaki M, Tsukamoto H, Mimura T, Sone T, et al. Pathogenesis of macular edema with branch retinal vein occlusion and intraocular levels of vascular endothelial growth factor and interleukin-6. Am J Ophthalmol. 2005;140:256\u201361.","journal-title":"Am J Ophthalmol"},{"key":"4_CR21","first-page":"637","volume":"14","author":"R Maier","year":"2008","unstructured":"Maier R, Weger M, Haller-Schober E-M, El-Shabrawi Y, Wedrich A, Theisel A, et al. Multiplex bead analysis of vitreous and serum concentrations of inflammatory and proangiogenic factors in diabetic patients. Mol Vis. 2008;14:637\u201343.","journal-title":"Mol Vis"},{"key":"4_CR22","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/IAE.0b013e3181bd2f44","volume":"30","author":"Y Wakabayashi","year":"2010","unstructured":"Wakabayashi Y, Usui Y, Okunuki Y, Kezuka T, Takeuchi M, Goto H, et al. Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathy. Retina. 2010;30:339\u201344.","journal-title":"Retina"},{"key":"4_CR23","doi-asserted-by":"publisher","first-page":"e8158","DOI":"10.1371\/journal.pone.0008158","volume":"4","author":"T Yoshimura","year":"2009","unstructured":"Yoshimura T, Sonoda K, Sugahara M, Mochizuki Y, Enaida H, Oshima Y, et al. Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases. PLoS ONE. 2009;4:e8158.","journal-title":"PLoS ONE"},{"key":"4_CR24","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1016\/j.ophtha.2009.04.026","volume":"116","author":"T Sato","year":"2009","unstructured":"Sato T, Kusaka S, Shimojo H, Fujikado T. Simultaneous analysis of vitreous levels of 27 cytokines in eyes with retinopathy of prematurity. Ophthalmology. 2009;116:2165\u20139.","journal-title":"Ophthalmology"},{"key":"4_CR25","first-page":"1971","volume":"41","author":"E Rungger-Br\u00e4ndle","year":"2000","unstructured":"Rungger-Br\u00e4ndle E, Dosso AA, Leuenberger PM. Glial reactivity, an early feature of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2000;41:1971\u201380.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4_CR26","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1097\/01.iae.0000247165.38655.bf","volume":"26","author":"C Haritoglou","year":"2006","unstructured":"Haritoglou C, Kook D, Neubauer A, Wolf A, Priglinger S, Strauss R, et al. Intravitreal bevacizumab (avastin) therapy for persistent diffuse diabetic macular edema. Retina. 2006;26:999\u20131005.","journal-title":"Retina"},{"key":"4_CR27","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.ophtha.2006.12.028","volume":"114","author":"JF Arevalo","year":"2007","unstructured":"Arevalo JF, Fromow-Guerra J, Quiroz-Mercado H, Sanchez JG, Wu L, Maia M, et al. Primary intravitreal bevacizumab (avastin) for diabetic macular edema. Ophthalmology. 2007;114:743\u201350.","journal-title":"Ophthalmology"},{"key":"4_CR28","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/S0161-6420(02)00975-2","volume":"109","author":"A Martidis","year":"2002","unstructured":"Martidis A, Duker JS, Greenberg PB, Rogers AH, Puliafito CA, Reichel E, et al. Intravitreal triamcinolone for refractory diabetic macular edema. Ophthalmology. 2002;109:920\u20137.","journal-title":"Ophthalmology"},{"key":"4_CR29","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1001\/archopht.121.1.57","volume":"121","author":"JB Jonas","year":"2003","unstructured":"Jonas JB, Kreissig I, S\u00f6fker A, Degenring RF. Intravitreal injection of triamcinolone for diffuse diabetic macular edema. Arch Ophthalmol. 2003;121:57\u201361.","journal-title":"Arch Ophthalmol"},{"key":"4_CR30","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1089\/1080768041725308","volume":"20","author":"LK Verma","year":"2004","unstructured":"Verma LK, Vivek MB, Kumar A, Tewari HK, Venkatesh P. A prospective controlled trial to evaluate the adjunctive role of posterior subtenon triamcinolone in the treatment of diffuse macular edema. J Ocul Pharmacol Ther. 2004;20:277\u201384.","journal-title":"J Ocul Pharmacol Ther"},{"key":"4_CR31","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1007\/s00417-003-0853-z","volume":"242","author":"N Ohguro","year":"2004","unstructured":"Ohguro N, Okada AA, Tano Y. Trans-Tenon\u2019s retrobulbar triamcinolone infusion for diffuse diabetic macular edema. Graefes Arch Clin Exp Ophthalmol. 2004;242:444\u20135.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4_CR32","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1136\/bjo.86.2.247","volume":"86","author":"PB Greenberg","year":"2002","unstructured":"Greenberg PB, Martidis A, Rogers AH, Duker JS, Reichel E. Intravitreal triamcinolone acetonide for macular oedema due to central retinal vein occlusion. Br J Ophthalmol. 2002;86:247\u20138.","journal-title":"Br J Ophthalmol"},{"key":"4_CR33","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1007\/s00417-002-0529-0","volume":"240","author":"JB Jonas","year":"2002","unstructured":"Jonas JB, Kreissig I, Degenring RF. Intravitreal triamcinolone acetonide as treatment of macular edema in central retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2002;240:782\u20133.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4_CR34","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3928\/1542-8877-20050701-15","volume":"36","author":"PJ Rosenfeld","year":"2005","unstructured":"Rosenfeld PJ, Fung AE, Puliafito CA. Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for macular edema from central retinal vein occlusion. Ophthalmic Surg Lasers Imaging. 2005;36:336\u20139.","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"4_CR35","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/IAE.0b013e31802eff83","volume":"27","author":"RA Costa","year":"2007","unstructured":"Costa RA, Jorge R, Calucci D, Melo LA, Cardillo JA, Scott IU. Intravitreal bevacizumab (avastin) for central and hemicentral retinal vein occlusion: IBeVO study. Retina. 2007;27:141\u20139.","journal-title":"Retina"}],"container-title":["Japanese Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10384-011-0004-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10384-011-0004-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10384-011-0004-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10384-011-0004-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T08:27:27Z","timestamp":1560155247000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10384-011-0004-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["4"],"URL":"https:\/\/doi.org\/10.1007\/s10384-011-0004-8","relation":{},"ISSN":["0021-5155","1613-2246"],"issn-type":[{"value":"0021-5155","type":"print"},{"value":"1613-2246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}