{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:14:47Z","timestamp":1773281687829,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Jpn J Ophthalmol"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s10384-018-0630-5","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T05:07:38Z","timestamp":1539580058000},"page":"699-705","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genetic diversity and persistent colonization of Enterococcus faecalis on ocular surfaces"],"prefix":"10.1007","volume":"62","author":[{"given":"Daisuke","family":"Todokoro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruyuki","family":"Nakayama-Imaohji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Kuwahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruyoshi","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"key":"630_CR1","volume-title":"Enterococci: from commensals to leading causes of drug resistant infection","author":"F Lebreton","year":"2014","unstructured":"Lebreton F, Willems RJL, Gilmore MS. Enterococcus diversity, origins in nature, and gut colonization. In: Gilmore MS, Clewell DB, Ike Y, Shankar N, editors. Enterococci: from commensals to leading causes of drug resistant infection. Boston: Massachusetts Eye and Ear Infirmary; 2014."},{"key":"630_CR2","doi-asserted-by":"publisher","first-page":"e582","DOI":"10.1371\/journal.pone.0000582","volume":"2","author":"SM McBride","year":"2007","unstructured":"McBride SM, Fischetti VA, Leblanc DJ, Moellering RC Jr, Gilmore MS. Genetic diversity among Enterococcus faecalis. PLoS One. 2007;2:e582. https:\/\/doi.org\/10.1371\/journal.pone.0000582 .","journal-title":"PLoS One"},{"key":"630_CR3","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1128\/jcm.02596-05","volume":"44","author":"P Ruiz-Garbajosa","year":"2006","unstructured":"Ruiz-Garbajosa P, Bonten MJ, Robinson DA, Top J, Nallapareddy SR, Torres C, et al. Multilocus sequence typing scheme for Enterococcus faecalis reveals hospital-adapted genetic complexes in a background of high rates of recombination. J Clin Microbiol. 2006;44:2220\u20138. https:\/\/doi.org\/10.1128\/jcm.02596-05 .","journal-title":"J Clin Microbiol."},{"key":"630_CR4","doi-asserted-by":"publisher","first-page":"788","DOI":"10.3389\/fmicb.2016.00788","volume":"7","author":"AM Guzman Prieto","year":"2016","unstructured":"Guzman Prieto AM, van Schaik W, Rogers MR, Coque TM, Baquero F, Corander J, et al. Global emergence and dissemination of enterococci as nosocomial pathogens: attack of the clones? Front Microbiol. 2016;7:788. https:\/\/doi.org\/10.3389\/fmicb.2016.00788 .","journal-title":"Front Microbiol."},{"key":"630_CR5","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s10384-008-0517-y","volume":"52","author":"Y Inoue","year":"2008","unstructured":"Inoue Y, Usui M, Ohashi Y, Shiota H, Yamazaki T. Preoperative disinfection of the conjunctival sac with antibiotics and iodine compounds: a prospective randomized multicenter study. Jpn J Ophthalmol. 2008;52:151\u201361. https:\/\/doi.org\/10.1007\/s10384-008-0517-y .","journal-title":"Jpn J Ophthalmol."},{"key":"630_CR6","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1038\/eye.2016.143","volume":"30","author":"S Hoshi","year":"2016","unstructured":"Hoshi S, Hashida M, Urabe K. Risk factors for aerobic bacterial conjunctival flora in preoperative cataract patients. Eye (Lond). 2016;30:1439\u201346. https:\/\/doi.org\/10.1038\/eye.2016.143 .","journal-title":"Eye (Lond)."},{"key":"630_CR7","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.ajo.2014.07.038","volume":"158","author":"AE Kuriyan","year":"2014","unstructured":"Kuriyan AE, Sridhar J, Flynn HW Jr, Smiddy WE, Albini TA, Berrocal AM, et al. Endophthalmitis caused by Enterococcus faecalis: clinical features, antibiotic sensitivities, and outcomes. Am J Ophthalmol. 2014;158:1018\u201323. https:\/\/doi.org\/10.1016\/j.ajo.2014.07.038 .","journal-title":"Am J Ophthalmol."},{"key":"630_CR8","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/s10384-017-0527-8","volume":"61","author":"D Todokoro","year":"2017","unstructured":"Todokoro D, Suzuki T, Kobayakawa S, Tomita H, Ohashi Y, Akiyama H. Postoperative Enterococcus faecalis endophthalmitis: virulence factors leading to poor visual outcome. Jpn J Ophthalmol. 2017;61:408\u201314. https:\/\/doi.org\/10.1007\/s10384-017-0527-8 .","journal-title":"Jpn J Ophthalmol."},{"key":"630_CR9","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1099\/jmm.0.46636-0","volume":"55","author":"Y Oyamada","year":"2006","unstructured":"Oyamada Y, Ito H, Inoue M, Yamagishi J. Topoisomerase mutations and efflux are associated with fluoroquinolone resistance in Enterococcus faecalis. J Med Microbiol. 2006;55:1395\u2013401. https:\/\/doi.org\/10.1099\/jmm.0.46636-0 .","journal-title":"J Med Microbiol."},{"key":"630_CR10","doi-asserted-by":"publisher","first-page":"6955","DOI":"10.1128\/aem.00934-06","volume":"72","author":"D Todokoro","year":"2006","unstructured":"Todokoro D, Tomita H, Inoue T, Ike Y. Genetic analysis of bacteriocin 43 of vancomycin-resistant Enterococcus faecium. Appl Environ Microbiol. 2006;72:6955\u201364. https:\/\/doi.org\/10.1128\/aem.00934-06 .","journal-title":"Appl Environ Microbiol."},{"key":"630_CR11","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1128\/JCM.36.9.2460-2464.1998","volume":"36","author":"X Ma","year":"1998","unstructured":"Ma X, Kudo M, Takahashi A, Tanimoto K, Ike Y. Evidence of nosocomial infection in Japan caused by high-level gentamicin-resistant Enterococcus faecalis and identification of the pheromone-responsive conjugative plasmid encoding gentamicin resistance. J Clin Microbiol. 1998;36:2460\u20134.","journal-title":"J Clin Microbiol."},{"key":"630_CR12","volume-title":"Statcel: the useful add-in software forms on excel","author":"H Yanai","year":"2011","unstructured":"Yanai H. Statcel: the useful add-in software forms on excel. 3rd ed. Tokyo: OMS; 2011.","edition":"3"},{"key":"630_CR13","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s12325-014-0162-4","volume":"31","author":"M Yamaguchi","year":"2014","unstructured":"Yamaguchi M, Nishijima T, Shimazaki J, Takamura E, Yokoi N, Watanabe H, et al. Clinical usefulness of diquafosol for real-world dry eye patients: a prospective, open-label, non-interventional, observational study. Adv Ther. 2014;31:1169\u201381. https:\/\/doi.org\/10.1007\/s12325-014-0162-4 .","journal-title":"Adv Ther."},{"key":"630_CR14","doi-asserted-by":"publisher","first-page":"327","DOI":"10.2147\/opth.s39699","volume":"8","author":"OC Lau","year":"2014","unstructured":"Lau OC, Samarawickrama C, Skalicky SE. P2Y2 receptor agonists for the treatment of dry eye disease: a review. Clin Ophthalmol. 2014;8:327\u201334. https:\/\/doi.org\/10.2147\/opth.s39699 .","journal-title":"Clin Ophthalmol."},{"key":"630_CR15","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.preteyeres.2012.03.004","volume":"31","author":"A Sadaka","year":"2012","unstructured":"Sadaka A, Durand ML, Gilmore MS. Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: host-microbe interactions in intraocular infection. Prog Retin Eye Res. 2012;31:316\u201331. https:\/\/doi.org\/10.1016\/j.preteyeres.2012.03.004 .","journal-title":"Prog Retin Eye Res."},{"key":"630_CR16","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jcjo.2013.09.008","volume":"49","author":"SJ Dorrepaal","year":"2014","unstructured":"Dorrepaal SJ, Gale J, El-Defrawy S, Sharma S. Resistance of ocular flora to gatifloxacin in patients undergoing intravitreal injections. Can J Ophthalmol. 2014;49:66\u201371. https:\/\/doi.org\/10.1016\/j.jcjo.2013.09.008 .","journal-title":"Can J Ophthalmol."},{"key":"630_CR17","volume-title":"Enterococci: From Commensals to Leading Causes of Drug Resistant Infection","author":"CJ Kristich","year":"2014","unstructured":"Kristich CJ, Rice LB, Arias CA. Enterococcus infection: treatment and antibiotic resistance. In: Gilmore MS, Clewell DB, Ike Y, Shankar N, editors. Enterococci: From Commensals to Leading Causes of Drug Resistant Infection. Boston: Massachusetts Eye and Ear Infirmary; 2014."},{"key":"630_CR18","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.1128\/aac.45.12.3574-3579.2001","volume":"45","author":"BM Jonas","year":"2001","unstructured":"Jonas BM, Murray BE, Weinstock GM. Characterization of emeA, a NorA homolog and multidrug resistance efflux pump, in Enterococcus faecalis. Antimicrob Agents Chemother. 2001;45:3574\u20139. https:\/\/doi.org\/10.1128\/aac.45.12.3574-3579.2001 .","journal-title":"Antimicrob Agents Chemother."},{"key":"630_CR19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s12864-015-1367-x","volume":"16","author":"M Zischka","year":"2015","unstructured":"Zischka M, Kunne CT, Blom J, Wobser D, Sakiotanc T, Schmidt-Hohagen K, et al. Comprehensive molecular, genomic and phenotypic analysis of a major clone of Enterococcus faecalis MLST ST40. BMC Genom. 2015;16:175. https:\/\/doi.org\/10.1186\/s12864-015-1367-x .","journal-title":"BMC Genom."},{"key":"630_CR20","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1089\/mdr.2009.0028","volume":"15","author":"D Quinones","year":"2009","unstructured":"Quinones D, Kobayashi N, Nagashima S. Molecular epidemiologic analysis of Enterococcus faecalis isolates in Cuba by multilocus sequence typing. Microb Drug Resist. 2009;15:287\u201393. https:\/\/doi.org\/10.1089\/mdr.2009.0028 .","journal-title":"Microb Drug Resist."},{"key":"630_CR21","doi-asserted-by":"publisher","first-page":"682","DOI":"10.3201\/eid1604.090500","volume":"16","author":"J Larsen","year":"2010","unstructured":"Larsen J, Schonheyder HC, Lester CH, Olsen SS, Porsbo LJ, Garcia-Migura L, et al. Porcine-origin gentamicin-resistant Enterococcus faecalis in humans, Denmark. Emerg Infect Dis. 2010;16:682\u20134. https:\/\/doi.org\/10.3201\/eid1604.090500 .","journal-title":"Emerg Infect Dis."},{"key":"630_CR22","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/1348-0421.12190","volume":"58","author":"M Kudo","year":"2014","unstructured":"Kudo M, Nomura T, Yomoda S, Tanimoto K, Tomita H. Nosocomial infection caused by vancomycin-susceptible multidrug-resistant Enterococcus faecalis over a long period in a university hospital in Japan. Microbiol Immunol. 2014;58:607\u201314. https:\/\/doi.org\/10.1111\/1348-0421.12190 .","journal-title":"Microbiol Immunol."},{"key":"630_CR23","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1007\/s10096-011-1412-x","volume":"31","author":"A Matsushima","year":"2012","unstructured":"Matsushima A, Takakura S, Yamamoto M, Matsumura Y, Shirano M, Nagao M, et al. Regional spread and control of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis in Kyoto, Japan. Eur J Clin Microbiol Infect Dis. 2012;31:1095\u2013100. https:\/\/doi.org\/10.1007\/s10096-011-1412-x .","journal-title":"Eur J Clin Microbiol Infect Dis."}],"container-title":["Japanese Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10384-018-0630-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10384-018-0630-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10384-018-0630-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T00:15:00Z","timestamp":1662250500000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10384-018-0630-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,15]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["630"],"URL":"https:\/\/doi.org\/10.1007\/s10384-018-0630-5","relation":{},"ISSN":["0021-5155","1613-2246"],"issn-type":[{"value":"0021-5155","type":"print"},{"value":"1613-2246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,15]]},"assertion":[{"value":"15 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"D. Todokoro, None; H. Eguchi, None; T. Suzuki, None; M. Suzuki, None; H. N. -Imaohji, None; T. Kuwahara, None; T. Nomura, None; H. Tomita, None; H. Akiyama, None.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}