{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:45:33Z","timestamp":1790649933468,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Senju Pharmaceutical Co., Ltd."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Jpn J Ophthalmol"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s10384-022-00947-8","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T02:03:11Z","timestamp":1664589791000},"page":"579-589","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Analysis of treatment protocols using azithromycin eye drops for bacterial blepharitis: second report\u2014bacteriological investigation"],"prefix":"10.1007","volume":"66","author":[{"given":"Ryohei","family":"Nejima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Todokoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saichi","family":"Hoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsugu","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,1]]},"reference":[{"key":"947_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ophtha.2018.10.019","volume":"126","author":"G Amescua","year":"2019","unstructured":"Amescua G, Akpek EK, Farid M, Garcia-Ferrer FJ, Lin A, Rhee MK, et al. Blepharitis preferred practice Pattern\u00ae. Ophthalmology. 2019;126:56\u201393.","journal-title":"Ophthalmology"},{"key":"947_CR2","unstructured":"Eberhardt M, Rammohan G. Blepharitis. In: StatPearls [Internet]. StatPearls Publishing. 2021. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459305. Accessed 14 Sept 2021."},{"key":"947_CR3","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jcrs.2016.10.024","volume":"43","author":"R Nejima","year":"2017","unstructured":"Nejima R, Shimizu K, Ono T, Noguchi Y, Yagi A, Iwasaki T, et al. Effect of the administration period of perioperative topical levofloxacin on normal conjunctival bacterial flora. J Cataract Refract Surg. 2017;43:42\u20138.","journal-title":"J Cataract Refract Surg"},{"key":"947_CR4","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1097\/ICO.0b013e3181ca38a0","volume":"29","author":"RM Haque","year":"2010","unstructured":"Haque RM, Torkildsen GL, Brubaker K, Zink RC, Kowalski RP, Mah FS, et al. Multicenter open-label study evaluating the efficacy of azithromycin ophthalmic solution 1% on the signs and symptoms of subjects with blepharitis. Cornea. 2010;29:871\u20137.","journal-title":"Cornea"},{"key":"947_CR5","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1136\/bjo.68.8.524","volume":"68","author":"JM Dougherty","year":"1984","unstructured":"Dougherty JM, McCulley JP. Comparative bacteriology of chronic blepharitis. Br J Ophthalmol. 1984;68:524\u20138.","journal-title":"Br J Ophthalmol"},{"key":"947_CR6","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/BF00167872","volume":"229","author":"V Huber-Spitzy","year":"1991","unstructured":"Huber-Spitzy V, Baumgartner I, B\u00f6hler-Sommeregger K, Grabner G. Blepharitis\u2014a diagnostic and therapeutic challenge. A report on 407 consecutive cases. Graefes Arch Clin Exp Ophthalmol. 1991;229:224\u20137.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"947_CR7","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/00003226-199110010-00010","volume":"10","author":"LR Groden","year":"1991","unstructured":"Groden LR, Murphy B, Rodnite J, Genvert GI. Lid flora in blepharitis. Cornea. 1991;10:50\u20133.","journal-title":"Cornea"},{"key":"947_CR8","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.3389\/fmicb.2018.01719","volume":"9","author":"M Zhu","year":"2018","unstructured":"Zhu M, Cheng C, Yi H, Lin L, Wu K. Quantitative analysis of the bacteria in blepharitis with demodex infestation. Front Microbiol. 2018;9:1719.","journal-title":"Front Microbiol"},{"key":"947_CR9","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1177\/1120672119854985","volume":"30","author":"A de Paula","year":"2020","unstructured":"de Paula A, Oliva G, Barraquer RI, de la Paz MF. Prevalence and antibiotic susceptibility of bacteria isolated in patients affected with blepharitis in a tertiary eye centre in Spain. Eur J Ophthalmol. 2020;30:991\u20137.","journal-title":"Eur J Ophthalmol"},{"key":"947_CR10","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ajo.2005.02.039","volume":"140","author":"T Suzuki","year":"2005","unstructured":"Suzuki T, Mitsuishi Y, Sano Y, Yokoi N, Kinoshita S. Phlyctenular keratitis associated with Meibomitis in young patients. Am J Ophthalmol. 2005;140:77\u201382.","journal-title":"Am J Ophthalmol"},{"key":"947_CR11","first-page":"389","volume":"35","author":"T Suzuki","year":"2018","unstructured":"Suzuki T, Yokoi N, Kinoshita S. Clinical features of Meibomitis-relates keratoconjunctivitis in elderly patients. Atarashii Ganka (J Eye). 2018;35:389\u201394 (in Japanese).","journal-title":"Atarashii Ganka (J Eye)."},{"key":"947_CR12","first-page":"801","volume":"115","author":"Y Inoue","year":"2011","unstructured":"Inoue Y, Ohashi Y, Hatano H, Shimomura Y, Sakamoto M, Okamoto Y, et al. Determination of causative agents in ocular infection of external adnexa and anterior segments-multicenter study of causative agents and drug sensitivity of ocular infection by the Japanese Association for Ocular Infection part I. Nippon Ganka Gakkai Zasshi. 2011;115:801\u201313 (In Japanese).","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"947_CR13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1128\/jcm.19.2.187-190.1984","volume":"19","author":"LJ La Scolea Jr","year":"1984","unstructured":"La Scolea Jr LJ, Dryja D. Quantitation of bacteria in cerebrospinal fluid and blood of children with meningitis and its diagnostic significance. J Clin Microbiol. 1984;19:187\u201390.","journal-title":"J Clin Microbiol"},{"key":"947_CR14","first-page":"999","volume":"39","author":"R Nejima","year":"2022","unstructured":"Nejima R, Inoue T, Kaji Y, Suzuki T, Hattori T, Hoshi S, et al. Analysis of treatment protocols using azithromycin eye drops for bacterial blepharitis\u2014first report: study of clinical course. Atarashii Ganka (J Eye). 2022;39:999\u20131004 (in Japanese).","journal-title":"Atarashii Ganka (J Eye)."},{"key":"947_CR15","unstructured":"Azimycin ophthalmic solution 1%. Package insert. Senju Pharmaceutical Co., Ltd; 2020. https:\/\/www.pmda.go.jp\/PmdaSearch\/iyakuDetail\/ResultDataSetPDF\/380086_1317714Q1024_1_03 Accessed 11 Jan 2022 (in Japanese)."},{"key":"947_CR16","unstructured":"Clinical and Laboratory Standards Institute. M100. http:\/\/em100.edaptivedocs.net\/dashboard.aspx Accessed 8 Nov 2021."},{"key":"947_CR17","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1097\/00003226-199507000-00006","volume":"14","author":"SL Everett","year":"1995","unstructured":"Everett SL, Kowalski RP, Karenchak LM, Landsittel D, Day R, Gordon YJ. An in vitro comparison of the susceptibilities of bacterial isolates from patients with conjunctivitis and blepharitis to newer and established topical antibiotics. Cornea. 1995;14:382\u20137.","journal-title":"Cornea"},{"key":"947_CR18","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s10384-008-0517-y","volume":"52","author":"Y Inoue","year":"2008","unstructured":"Inoue Y, Usui M, Ohashi Y, Shiota H, Yamazaki T, Preoperative Disinfection Study Group. Preoperative disinfection of the conjunctival sac with antibiotics and iodine compounds: a prospective randomized multicenter study. Jpn J Ophthalmol. 2008;52:151\u201361.","journal-title":"Jpn J Ophthalmol"},{"key":"947_CR19","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1089\/jop.2013.0146","volume":"29","author":"T Suzuki","year":"2013","unstructured":"Suzuki T, Tanaka H, Toriyama K, Okamoto S, Urabe K, Hashida M, et al. Prospective clinical evaluation of 1.5% levofloxacin ophthalmic solution in ophthalmic perioperative disinfection. J Ocul Pharmacol Ther. 2013;29:887\u201392.","journal-title":"J Ocul Pharmacol Ther"},{"key":"947_CR20","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.jcrs.2017.06.037","volume":"43","author":"T Ono","year":"2017","unstructured":"Ono T, Nejima R, Iwasaki T, Mori Y, Noguchi Y, Yagi A, et al. Long-term effects of cataract surgery with topical levofloxacin on ocular bacterial flora. J Cataract Refract Surg. 2017;43:1129\u201334.","journal-title":"J Cataract Refract Surg"},{"key":"947_CR21","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.jcrs.2016.07.022","volume":"42","author":"V Papa","year":"2016","unstructured":"Papa V, Blanco AR, Santocono M. Ocular flora and their antibiotic susceptibility in patients having cataract surgery in Italy. J Cataract Refract Surg. 2016;42:1312\u20137.","journal-title":"J Cataract Refract Surg"},{"key":"947_CR22","first-page":"22","volume":"118","author":"T Suzuki","year":"2014","unstructured":"Suzuki T, Todokoro D, Kobayakawa S, Sotozono C, Eguchi S, Miyata K, et al. Postcataract endophthalmitis caused by Enterococcus faecalis. Nippon Ganka Gakkai Zasshi. 2014;118:22\u20137 (in Japanese).","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"947_CR23","doi-asserted-by":"publisher","first-page":"455","DOI":"10.2133\/dmpk.DMPK-14-RG-013","volume":"29","author":"Y Kitamura","year":"2014","unstructured":"Kitamura Y, Yoshida K, Kusama M, Sugiyama Y. A proposal of a pharmacokinetic\/pharmacodynamic (PK\/PD) index map for selecting an optimal PK\/PD index from conventional indices (AUC\/MIC, Cmax\/MIC, and TAM) for antibiotics. Drug Metab Pharmacokinet. 2014;29:455\u201362.","journal-title":"Drug Metab Pharmacokinet"},{"key":"947_CR24","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1089\/jop.2009.0026","volume":"25","author":"EK Akpek","year":"2009","unstructured":"Akpek EK, Vittitow J, Verhoeven RS, Brubaker K, Amar T, Powell KD, et al. Ocular surface distribution and pharmacokinetics of a novel ophthalmic 1% azithromycin formulation. J Ocul Pharmacol Ther. 2009;25:433\u20139.","journal-title":"J Ocul Pharmacol Ther"}],"updated-by":[{"DOI":"10.1007\/s10384-022-00965-6","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000}}],"container-title":["Japanese Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10384-022-00947-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10384-022-00947-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10384-022-00947-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T01:09:01Z","timestamp":1670548141000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10384-022-00947-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["947"],"URL":"https:\/\/doi.org\/10.1007\/s10384-022-00947-8","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s10384-022-00965-6","asserted-by":"object"}]},"ISSN":["0021-5155","1613-2246"],"issn-type":[{"value":"0021-5155","type":"print"},{"value":"1613-2246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,1]]},"assertion":[{"value":"26 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10384-022-00965-6","URL":"https:\/\/doi.org\/10.1007\/s10384-022-00965-6","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"R. Nejima, Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events (Novartis, Santen, Senju); H. Eguchi, Grants or contracts (Alcon, Novartis, SEED), Consulting fees (Otsuka), Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events (Senju, Novartis, Santen, Alcon, Otsuka); D. Todokoro, None; T. Inoue, None; Y. Kaji, None; T. Suzuki, Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events (Senju); T. Hattori, None; S. Hoshi, None; Y. Sasaki, None; Y. Inoue, Grants (Senju), Consulting fees (Senju).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}