{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T03:05:15Z","timestamp":1763348715728,"version":"3.30.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Jpn J Ophthalmol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To investigate the visual prognosis of ocular surface squamous neoplasia (OSSN) after tumor resection and ocular surface reconstruction, and clarify factors that influence recurrence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Study design<\/jats:title>\n                <jats:p>Retrospective cohort study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Medical records of all patients who underwent surgical treatment for OSSN at our hospital between January 1996 and December 2019 were reviewed. Tumor size\/location, histological classification, surgical procedure, intraoperative mitomycin-C use, and postoperative topical 5-fluorouracil (5-FU) administration were examined, and pre and postoperative visual acuity (VA) were compared to elucidate factors that influence disease recurrence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Tumor excision was performed in 70 eyes of 70 cases (43 men, 27 women; average age: 71.6\u2009\u00b1\u200912.6 years) with dysplasia (8 eyes), carcinoma in situ (26 eyes), and invasive squamous cell carcinoma (36 eyes). Tumors were found in the limbus (<jats:italic>N<\/jats:italic>\u2009=\u200959 eyes), palpebral conjunctiva (<jats:italic>N<\/jats:italic>\u2009=\u20098 eyes), and from the bulbar to palpebral conjunctiva (<jats:italic>N<\/jats:italic>\u2009=\u20093 eyes). Surgical procedures performed were limbal transplantation\/keratoepithelioplasty (<jats:italic>N<\/jats:italic>\u2009=\u200929 eyes), cultivated oral mucosal epithelial transplantation (<jats:italic>N<\/jats:italic>\u2009=\u20093 eyes), and auto-conjunctival epithelium transplantation (<jats:italic>N<\/jats:italic>\u2009=\u20092 eyes). Ocular surface was reconstructed using amniotic membrane, donor cornea, or cultivated epithelial sheet. The mean follow-up was 38.6\u2009\u00b1\u200938.6 months (range, 2 months to 13.8 years). VA postoperatively improved in 25 (61.0%) cases. Recurrence occurred in 19 (27.1%) cases at from 2 to 50 months (median: 12.5 months) postoperative. Uni- and multivariate analyses revealed that presurgical tumor size and postoperative administration of 5-FU were significantly related to recurrence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Combined surgical excision and postoperative topical 5-FU administration effectively prevented OSSN recurrence, and ocular surface reconstruction contributed to improvement of VA.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10384-024-01111-0","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T06:02:02Z","timestamp":1727848922000},"page":"731-740","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Excision combined with ocular surface reconstruction followed by topical chemotherapy for ocular surface squamous neoplasia"],"prefix":"10.1007","volume":"68","author":[{"given":"Hiroko","family":"Nakai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kitazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Fukuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Inatomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Yokoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go","family":"Horiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Teramukai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Sotozono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"1111_CR1","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0039-6257(05)80054-2","volume":"39","author":"GA Lee","year":"1995","unstructured":"Lee GA, Hirst LW. 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Nakai, None; K. Ueda, None; K. Kitazawa, Payment or honoraria for Seminars (Otsuka, Santen, Senju) ; H. Fukuoka, None; T. Inatomi, None; N. Yokoi, Payment or honoraria for Seminars (Lumenis Be, Santen, Senju), Patents planned, issued or pending (Rexxam, Kowa); S. Kinoshita, Research grant (Santen, Otsuka, Senju, HOYA, CorneaGen), Patent Licence Fee (Aurion Biotechnologies, CorneaGen, Kowa), Honorarium for consulting (Santen, Otsuka, Alcon, Novartis, Tarsus, Aurion Biotechnologies), Honorarium for lecture (Santen, Otsuka, Senju, Kowa, Alcon, Johnson & Johnson), Stock (Aurion Biotechnologies); G. Horiguchi, None; S. Teramukai, Research Grant (Sun Contact Lens), Statistical Advisor (Daiichi-Sankyo, Sysmex, Solasia, Sanofi, NapaJen, Nipro, AtWorking, Kringle, Kaneka), Payment or honoraria for Seminars (Chugai, Bayer); C. Sotozono, Grant to the author\u2019s institution (Otsuka, Senju, Santen, Pfizer), Payment or honoraria for lectures (Otsuka, Senju, Santen, KOWA).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Coauthor Kosuke Ueda, MD, died April 11, 2023.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Additional Information"}}]}}