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The median age at diagnosis was 73 (range 39\u201395) years old. The tumor was located in the upper eyelid in 33 patients (63%), in the lower eyelid in 16 patients (31%), and in both eyelids in 3 patients (6%). The initial curative treatment included surgical resection with or without eyelid reconstruction in 41 cases (79%), orbital exenteration in 4 cases (8%), and radiation therapy in 7 cases (13%). Two- and five-year adjusted survival rates were 97.4% and 93.7%, respectively. Local recurrence occurred in 15 cases (29%). Lymph node metastasis was confirmed in 13 cases (27%), distant metastasis in 5 cases (10%), and 3 patients (6%) died of lung metastasis. T2b or more advanced T stage was associated with a risk of shorter overall survival (HR = 5.3, 95% CI = 1.2\u201323, <jats:italic>p<\/jats:italic> = 0.024) compared with T2a or earlier stage, as well as lymph node metastasis (HR = 82, 95% CI = 2.6\u20132.6e+03, <jats:italic>p<\/jats:italic> = 0.013). A positive surgical margin increased the risk of local recurrence (HR = 37, 95% CI = 5.9- 235, <jats:italic>p<\/jats:italic> = 0.00012).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Proper diagnosis and margin-free resection are necessary before eyelid sebaceous carcinoma can further develop.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10384-025-01187-2","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T09:41:42Z","timestamp":1748166102000},"page":"595-605","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical presentation and prognostic factors of eyelid sebaceous carcinoma"],"prefix":"10.1007","volume":"69","author":[{"given":"Yukiko","family":"Aihara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masachika","family":"Ikegami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Suehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takane","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Mano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Kohsaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8311-2045","authenticated-orcid":false,"given":"Shigenobu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"1187_CR1","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1038\/s41433-022-02113-3","volume":"37","author":"Z Lin","year":"2023","unstructured":"Lin Z, Sheikh U, Igali L, Hemmant B. 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Aihara, none; M. Ikegami, none; Y. Suehara, none; T. Watanabe, none; S. Yoshimoto, none; T. Mori, none; H. Mano, none; S. Kohsaka, none; S. Suzuki, none.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}