{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:15:11Z","timestamp":1792782911563,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Health Sciences"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Jpn J Ophthalmol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the relationship between phacoparameters and inflammation parameters (anterior chamber flare (ACF), macular and peripapillary choroidal vascular index (mCVI and pCVI)) changes after cataract surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Prospective study<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational study included patients without systemic and ocular diseases who underwent uncomplicated cataract surgery that may have affected intraocular inflammation. Preoperative, postoperative 1st week, 1st, 3rd and 6th months ACF were measured. At the same visits, mCVI and pCVI were calculated. The relationship between phacoparameters and postoperative ACF, mCVI and pCVI values were evaluated by correlation analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty eyes of 50 patients were included in the study. Postoperative 1st week ACF was significantly higher than preoperative ACF (p&lt;0.001). ACF decreased significantly from postoperative 1st week to 6th months. Postoperative 1st month and 3rd month mCVI were significantly higher than preoperative mCVI (p&lt;0.001, p=0.04, respectively). It was observed that pCVI reached its peak value in the 1st postoperative week and decreased to base value in the postoperative 6th month. A strong positive linear correlation was found between total cumulative dissipated energy (CDE) and the difference between postoperative 1st week and preoperative ACF (p&lt;0.001, r=0.68).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Particularly in the early period after phacoemulsification, ACF, mCVI and pCVI increased. The increase in ACF lost its significance at the third month and the increase in mCVI and pCVI remained significant, which may indicate that the inflammatory effect of cataract surgery lasts longer in the posterior segment. Total CDE can be used to predict postoperative inflammation levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10384-025-01220-4","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T23:17:08Z","timestamp":1749683828000},"page":"813-822","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantitative evaluation of inflammation after phacoemulsification surgery: anterior chamber flare and choroidal vascular index"],"prefix":"10.1007","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5348-9829","authenticated-orcid":false,"given":"Metehan","family":"Simsek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6248-5902","authenticated-orcid":false,"given":"Gulay Yalc\u0131nkaya","family":"Cakir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9750-0092","authenticated-orcid":false,"given":"Efe","family":"Koser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0908-6619","authenticated-orcid":false,"given":"Cigdem","family":"Altan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-7782","authenticated-orcid":false,"given":"Muhittin","family":"Ta\u015fkap\u0131l\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"1220_CR1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0140-6736(22)01839-6","volume":"401","author":"MV Cicinelli","year":"2023","unstructured":"Cicinelli MV, Buchan JC, Nicholson M, Varadaraj V, Khanna RC. Cataracts. The Lancet. 2023;401:377\u201389.","journal-title":"The Lancet"},{"key":"1220_CR2","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1080\/02713683.2024.2302545","volume":"49","author":"X Qiu","year":"2024","unstructured":"Qiu X, Zhang S, Zhang Y, Cai L, Li D, Lu Y. Reduction of ETV1 is identified as a prominent feature of age-related cataract. Curr Eye Res. 2024;49:496\u2013504.","journal-title":"Curr Eye Res"},{"key":"1220_CR3","doi-asserted-by":"crossref","unstructured":"Petrash JM. Aging and age-related diseases of the ocular lens and vitreous body. Invest Opthalmol Vis Sci. 2013;54:ORSF54-9.","DOI":"10.1167\/iovs.13-12940"},{"key":"1220_CR4","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/S0886-3350(00)00433-8","volume":"26","author":"ML Nordlund","year":"2000","unstructured":"Nordlund ML, Sugar A, Moroi SE. Phacoemulsification and intraocular lens placement in eyes with cataract and congenital coloboma: visual acuity and complications. J Cataract Refract Surg. 2000;26:1035\u201340.","journal-title":"J Cataract Refract Surg"},{"key":"1220_CR5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0039-6257(99)00085-5","volume":"44","author":"EJ Linebarger","year":"1999","unstructured":"Linebarger EJ, Hardten DR, Shah GK, Lindstrom RL. Phacoemulsification and modern cataract surgery. Surv Ophthalmol. 1999;44:123\u201347.","journal-title":"Surv Ophthalmol"},{"key":"1220_CR6","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/S0886-3350(13)80071-5","volume":"18","author":"T Oshika","year":"1992","unstructured":"Oshika T, Yoshimura K, Miyata N. Postsurgical inflammation after phacoemulsification and extracapsular extraction with soft or conventional intraocular lens implantation. J Cataract Refract Surg. 1992;18:356\u201361.","journal-title":"J Cataract Refract Surg"},{"key":"1220_CR7","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1097\/j.jcrs.0000000000001364","volume":"50","author":"M Ma","year":"2024","unstructured":"Ma M, Wang M, Zhang X, Shao Y, Li X. Effects of a fortified balanced salt solution and Ringer\u2019s lactate solution on anterior chamber inflammation after phacoemulsification in diabetes. J Cataract Refract Surg. 2024;50:352\u20139.","journal-title":"J Cataract Refract Surg"},{"key":"1220_CR8","first-page":"344","volume":"105","author":"GN Holland","year":"2007","unstructured":"Holland GN. A reconsideration of anterior chamber flare and its clinical relevance for children with chronic anterior uveitis (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc. 2007;105:344\u201364.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"1220_CR9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12969-020-0417-3","volume":"18","author":"A Baytaro\u011flu","year":"2020","unstructured":"Baytaro\u011flu A, Kadayif\u00e7ilar S, A\u011fin A, Delikta\u015f \u00d6, Demir S, Bilginer Y, et al. Choroidal vascularity index as a biomarker of systemic inflammation in childhood Polyarteritis Nodosa and adenosine deaminase-2 deficiency. Pediatr Rheumatol Online J. 2020;18:29.","journal-title":"Pediatr Rheumatol Online J"},{"key":"1220_CR10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ophtha.2012.07.048","volume":"120","author":"WB Wei","year":"2013","unstructured":"Wei WB, Xu L, Jonas JB, Shao L, Du KF, Wang S, et al. Subfoveal choroidal thickness: the Beijing Eye Study. Ophthalmology. 2013;120:175\u201380.","journal-title":"Ophthalmology"},{"key":"1220_CR11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/09273948.2015.1056810","volume":"24","author":"Z Szepessy","year":"2016","unstructured":"Szepessy Z, Barsi \u00c1, N\u00e9meth J. Macular changes correlate with the degree of acute anterior uveitis in patients with spondyloarthropathy. Ocul Immunol Inflamm. 2016;24:153\u20138.","journal-title":"Ocul Immunol Inflamm"},{"key":"1220_CR12","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1038\/s41433-022-02369-9","volume":"37","author":"R Han","year":"2023","unstructured":"Han R, Chang W, Ding X, Jiang R, Chang Q, Xu G, et al. The choroid vascular index and its association with visual acuity in children and young adults with high myopia. Eye (Lond). 2023;37:2542\u20137.","journal-title":"Eye (Lond)"},{"key":"1220_CR13","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.ajo.2015.02.001","volume":"159","author":"Y Murakami","year":"2015","unstructured":"Murakami Y, Yoshida N, Ikeda Y, Nakatake S, Fujiwara K, Notomi S, et al. Relationship between aqueous flare and visual function in retinitis pigmentosa. Am J Ophthalmol. 2015;159:958-63.e1.","journal-title":"Am J Ophthalmol"},{"key":"1220_CR14","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1001\/archopht.1993.01090060119035","volume":"111","author":"LT Chylack","year":"1993","unstructured":"Chylack LT. The lens opacities classification system III. Arch Ophthalmol. 1993;111:831.","journal-title":"Arch Ophthalmol"},{"key":"1220_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.survophthal.2004.10.004","volume":"50","author":"JG Ladas","year":"2005","unstructured":"Ladas JG, Wheeler NC, Morhun PJ, Rimmer SO, Holland GN. Laser flare-cell photometry: methodology and clinical applications. Surv Ophthalmol. 2005;50:27\u201347.","journal-title":"Surv Ophthalmol"},{"key":"1220_CR16","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1080\/09273948.2021.1934036","volume":"30","author":"MD de Smet","year":"2022","unstructured":"de Smet MD, Haim-Langford D, Neumann R, Kramer M, Cunningham E, Deutsch L, et al. Tarsier anterior chamber cell grading: improving the SUN grading scheme with a visual analog scale. Ocul Immunol Inflamm. 2022;30:1686\u201391.","journal-title":"Ocul Immunol Inflamm"},{"key":"1220_CR17","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s10792-009-9310-2","volume":"30","author":"I Tugal-Tutkun","year":"2010","unstructured":"Tugal-Tutkun I, Herbort CP. Laser flare photometry: a noninvasive, objective, and quantitative method to measure intraocular inflammation. Int Ophthalmol. 2010;30:453\u201364.","journal-title":"Int Ophthalmol"},{"key":"1220_CR18","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1097\/IAE.0000000000001040","volume":"36","author":"R Agrawal","year":"2016","unstructured":"Agrawal R, Chhablani J, Tan K-A, Shah S, Sarvaiya C, Banker A. Choroidal vascularity index in central serous chorioretinopathy. Retina. 2016;36:1646\u201351.","journal-title":"Retina"},{"key":"1220_CR19","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","volume":"15","author":"TK Koo","year":"2016","unstructured":"Koo TK, Li MY. A Guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med. 2016;15:155\u201363.","journal-title":"J Chiropr Med"},{"key":"1220_CR20","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/S0886-3350(13)80239-8","volume":"20","author":"PS Koch","year":"1994","unstructured":"Koch PS, Katzen LE. Stop and chop phacoemulsification. J Cataract Refract Surg. 1994;20:566\u201370.","journal-title":"J Cataract Refract Surg"},{"key":"1220_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2022.102805","volume":"38","author":"I Cakir","year":"2022","unstructured":"Cakir I, Altan C, Yalcinkaya G, Ozveren M, Kabakci AK, Taskapili M. Evaluation of post phacoemulsification inflammation in eyes with and without pseudoexfoliation syndrome according to phaco parameters via laser flare photometry. Photodiagnosis Photodyn Ther. 2022;38: 102805.","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"1220_CR22","volume-title":"Using multivariate statistics","author":"BG Tabachnick","year":"2013","unstructured":"Tabachnick BG, Fidell LS. Using multivariate statistics. 6th ed. Boston: Pearson; 2013.","edition":"6"},{"key":"1220_CR23","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1097\/IJG.0000000000002265","volume":"32","author":"AS Balci","year":"2023","unstructured":"Balci AS, Cakir I, Altan C. Optic nerve head, peripapillary and macular microvascular characteristics in patients with unilateral pseudoexfoliation Glaucoma. J Glaucoma. 2023;32:989\u201397.","journal-title":"J Glaucoma"},{"key":"1220_CR24","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.2147\/OPTH.S312350","volume":"15","author":"NC Hansen","year":"2021","unstructured":"Hansen NC, Erichsen JH, Holm LM, Kessel L. Corneal thickness and anterior chamber flare after cataract surgery: a randomized controlled trial comparing five regimens for anti-inflammatory prophylaxis. Clin Ophthalmol. 2021;15:2835\u201345.","journal-title":"Clin Ophthalmol"},{"key":"1220_CR25","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.1007\/s12325-020-01383-1","volume":"37","author":"M De Maria","year":"2020","unstructured":"De Maria M, Coassin M, Mastrofilippo V, Cimino L, Iannetta D, Fontana L. Persistence of inflammation after uncomplicated cataract surgery: a 6-month laser flare photometry analysis. Adv Ther. 2020;37:3223\u201333.","journal-title":"Adv Ther"},{"key":"1220_CR26","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1007\/s10792-021-01779-0","volume":"41","author":"M De Maria","year":"2021","unstructured":"De Maria M, Coassin M, Iannetta D, Fontana L. Laser flare and cell photometry to measure inflammation after cataract surgery: a tool to predict the risk of cystoid macular edema. Int Ophthalmol. 2021;41:2293\u2013300.","journal-title":"Int Ophthalmol"},{"key":"1220_CR27","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1136\/bjo.84.9.1056","volume":"84","author":"D Siriwardena","year":"2000","unstructured":"Siriwardena D. Anterior chamber flare after trabeculectomy and after phacoemulsification. Br J Ophthalmol. 2000;84:1056\u20137.","journal-title":"Br J Ophthalmol"},{"key":"1220_CR28","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/j.jcrs.2013.06.009","volume":"39","author":"RG Abell","year":"2013","unstructured":"Abell RG, Allen PL, Vote BJ. Anterior chamber flare after femtosecond laser\u2013assisted cataract surgery. J Cataract Refract Surg. 2013;39:1321\u20136.","journal-title":"J Cataract Refract Surg"},{"key":"1220_CR29","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1136\/bjo.78.2.91","volume":"78","author":"SM Shah","year":"1994","unstructured":"Shah SM, Spalton DJ. Changes in anterior chamber flare and cells following cataract surgery. Br J Ophthalmol. 1994;78:91\u20134.","journal-title":"Br J Ophthalmol"},{"key":"1220_CR30","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12886-018-0749-7","volume":"18","author":"H Chen","year":"2018","unstructured":"Chen H, Wu Z, Chen Y, He M, Wang J. Short-term changes of choroidal vascular structures after phacoemulsification surgery. BMC Ophthalmol. 2018;18:81.","journal-title":"BMC Ophthalmol"},{"key":"1220_CR31","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.jcrs.2018.09.022","volume":"45","author":"Y-C Liu","year":"2019","unstructured":"Liu Y-C, Setiawan M, Ang M, Yam GHF, Mehta JS. Changes in aqueous oxidative stress, prostaglandins, and cytokines: comparisons of low-energy femtosecond laser\u2013assisted cataract surgery versus conventional phacoemulsification. J Cataract Refract Surg. 2019;45:196\u2013203.","journal-title":"J Cataract Refract Surg"},{"key":"1220_CR32","doi-asserted-by":"publisher","first-page":"2856","DOI":"10.3390\/diagnostics13172856","volume":"13","author":"LHB Mackenbrock","year":"2023","unstructured":"Mackenbrock LHB, Baur ID, \u0141abuz G, Auffarth GU, Khoramnia R. Impact of phacoemulsification parameters on central retinal thickness change following cataract surgery. Diagnostics (Basel). 2023;13:2856.","journal-title":"Diagnostics (Basel)."},{"key":"1220_CR33","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/ICU.0b013e32834cd5f8","volume":"23","author":"Y Yonekawa","year":"2012","unstructured":"Yonekawa Y, Kim IK. Pseudophakic cystoid macular edema. Curr Opin Ophthalmol. 2012;23:26\u201332.","journal-title":"Curr Opin Ophthalmol"},{"key":"1220_CR34","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1097\/IAE.0000000000001747","volume":"38","author":"E Fleissig","year":"2018","unstructured":"Fleissig E, Cohen S, Iglicki M, Goldstein M, Zur D. Changes in choroidal thickness in clinically significant pseudophakic cystoid macular edema. Retina. 2018;38:1629\u201335.","journal-title":"Retina"},{"key":"1220_CR35","doi-asserted-by":"publisher","first-page":"9053932","DOI":"10.1155\/2017\/9053932","volume":"2017","author":"P Lourthai","year":"2017","unstructured":"Lourthai P, Bhurayanontachai P. Pattern of contrast sensitivity changes in acute central serous chorioretinopathy. J Ophthalmol. 2017;2017:9053932.","journal-title":"J Ophthalmol"},{"key":"1220_CR36","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1016\/j.jcrs.2007.07.009","volume":"33","author":"DF Chang","year":"2007","unstructured":"Chang DF, Braga-Mele R, Mamalis N, Masket S, Miller KM, Nichamin LD, et al. Prophylaxis of postoperative endophthalmitis after cataract surgery: results of the 2007 ASCRS member survey. J Cataract Refract Surg. 2007;33:1801\u20135.","journal-title":"J Cataract Refract Surg"},{"key":"1220_CR37","doi-asserted-by":"publisher","first-page":"219","DOI":"10.2147\/OPTH.S4820","volume":"3","author":"G Cervantes-Coste","year":"2009","unstructured":"Cervantes-Coste G, S\u00e1nchez-Castro YG, Orozco-Carroll M, Mendoza-Schuster E, Velasco-Barona C. Inhibition of surgically induced miosis and prevention of postoperative macular edema with nepafenac. Clin Ophthalmol. 2009;3:219\u201326.","journal-title":"Clin Ophthalmol"},{"key":"1220_CR38","first-page":"25","volume":"29","author":"A Haripriya","year":"2016","unstructured":"Haripriya A, Baam ZR, Ravindran RD. Postoperative cataract care: the Aravind perspective. Community Eye Health. 2016;29:25\u20136.","journal-title":"Community Eye Health."},{"key":"1220_CR39","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10792-024-02959-4","volume":"44","author":"G Yal\u00e7\u0131nkaya \u00c7ak\u0131r","year":"2024","unstructured":"Yal\u00e7\u0131nkaya \u00c7ak\u0131r G, Altan \u00c7, \u00c7ak\u0131r \u0130. Anterior chamber flare and choroidal vascular index as inflammatory markers after uncomplicated phacoemulsification surgery. Int Ophthalmol. 2024;44:35.","journal-title":"Int Ophthalmol"},{"key":"1220_CR40","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1097\/ICU.0b013e32834cd60e","volume":"23","author":"P Taravati","year":"2012","unstructured":"Taravati P, Lam DL, Leveque T, Van Gelder RN. Postcataract surgical inflammation. Curr Opin Ophthalmol. 2012;23:12\u20138.","journal-title":"Curr Opin Ophthalmol"},{"key":"1220_CR41","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/S0886-3350(96)80200-8","volume":"22","author":"G Pirazzoli","year":"1996","unstructured":"Pirazzoli G, D\u2019Eliseo D, Ziosi M, Acciarri R. Effects of phacoemulsification time on the corneal endothelium using phacofracture and phaco chop techniques. J Cataract Refract Surg. 1996;22:967\u20139.","journal-title":"J Cataract Refract Surg"},{"key":"1220_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100916","volume":"83","author":"C Baudouin","year":"2021","unstructured":"Baudouin C, Kolko M, Melik-Parsadaniantz S, Messmer EM. Inflammation in glaucoma: from the back to the front of the eye, and beyond. Prog Retin Eye Res. 2021;83: 100916.","journal-title":"Prog Retin Eye Res"}],"container-title":["Japanese Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10384-025-01220-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10384-025-01220-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10384-025-01220-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T21:10:03Z","timestamp":1757193003000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10384-025-01220-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,12]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["1220"],"URL":"https:\/\/doi.org\/10.1007\/s10384-025-01220-4","relation":{},"ISSN":["0021-5155","1613-2246"],"issn-type":[{"value":"0021-5155","type":"print"},{"value":"1613-2246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,12]]},"assertion":[{"value":"28 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M. Simsek, None; G. Y. Cakir, None; E. Koser, None; C. Altan, None; M. Ta\u015fkap\u0131l\u0131, None.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}